CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Helleborus Niger

Example Image

PLANiTS DNA barcode

Click for details-----ITS

TCGAAACCTGCTCTGCAGAACGACCCGCGAACGTGTAAAACAATATTGTTGTGAGCCGGGAAGGGGTGCGAGCCTCCGACCGGCCCATAAATCGGGTCACTGAACGTCTGCGTCACTCGTGCCTGCTGCCGTGCTTTGCCCCGAACCAACAAAAATCCGGCGCGAATTGCGCCAAGGAAATCTCAACGGAAAAGGGCGCTCTCCCCGTCCGCGGGGAGACGCTTCCAATCCGATACTCGAACGACTCTCGGCAACGGATATCTCGGCTCTTGCATCTCGATGAAGAACGTAGCGAAATGCCGATACTTGGTGTGAATTGCAGAATCCCGTGAACCATCGAGTCTTTGAACGCAAGTTGCGCCCGATACCTTTAGGTTGAGGGCACGTCTGCCTGGGCGTCACACAAAGCGTCGCACCCCACCAATCCCGTTTGGTTAGGAGCGGATATTGGCCCCCCGAACCCCTAGCGGGCACGGTTGGCACAAATATTGGTCTCCGGCGGCGAGCGTCGAAGTCAGCGGTGATTTAAAACACATGTGGACTTGTTGGCCTCGCCGACTGCGCGGCAAAATAACCCTTAGAACCCGTTCTCACGGCGTTCACC

Click for details-----ITS1

Click for details-----ITS2

AAAGCGTCGCACCCCACCAATCCCGTTTGGTTAGGAGCGGATATTGGCCCCCCGAACCCCTAGCGGGCACGGTTGGCACAAATATTGGTCTCCGGCGGCGAGCGTCGAAGTCAGCGGTGATTTAAAACACATGTGGACTTGTTGGCCTCGCCGACTGCGCGGCAAAATAACCCTTAGAACCCGTTCTCACGGCGTTCACC

Taxonomic Information

Plant ID: NPO25809
Plant Latin Name: Helleborus Niger
Taxonomy Genus: Helleborus
Taxonomy Family: Ranunculaceae

Plant External Links:

NCBI TaxonomyDB: 171896
Plant-of-the-World-Online: n.a.

Used in Medicines

Country/Region:

Italy; Germany; India; China

Traditional Medicine System:

Indian Folk; Unani; Siddha; Ayurveda; TCM; Homeopathy

Medicinal Functions:

Anthelmintic; Antiemetic; Cardiac; Cathartic; Diuretic; Emetic; Emmenagogue; Homeopathy; Irritant; Miscellany; Narcotic; Parasiticide; Purgative

Geographical Distribution

Germany; Italy; China; India

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

17 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

10 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)