Collective Molecular Activities of the Plant: Senna Siamea
Country/Region:
Philippines; Indonesia; India; Burkina Faso; Togo; Rwanda; Thailand; Kenya; Nigeria; TanzaniaTraditional Medicine System:
Indian Folk; SiddhaBrazil; Bangladesh; Mauritania; Sudan; Guinea; Nepal; Cambodia; Bahamas; Ethiopia; Rwanda; Tanzania; Swaziland; Laos; Nigeria; Cameroon; Cote d'Ivoire; Ecuador; Benin; Ghana; Australia; Cuba; El Salvador; Venezuela; Zambia; Burkina Faso; Togo; Trinidad and Tobago; Zimbabwe; Thailand; Dominican Republic; United States; Sierra Leone; Liberia; Maldives; Uganda; Philippines; Indonesia; Mauritius; Sri Lanka; Vietnam; Guinea-Bissau; Mali; Malawi; Pakistan; Angola; Myanmar; Chad; South Africa; India; Senegal; Congo; Mozambique; Colombia; Burundi; Kenya; Niger; Fiji
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
240 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
120 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
96 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99587
Ingredient ID: NPC9860
Ingredient ID: NPC95610
Ingredient ID: NPC95062
Ingredient ID: NPC94659
Ingredient ID: NPC92117
Ingredient ID: NPC91955
Ingredient ID: NPC91495
Ingredient ID: NPC87475
Ingredient ID: NPC86655
Ingredient ID: NPC86136
Ingredient ID: NPC85818
Ingredient ID: NPC85571
Ingredient ID: NPC83838
Ingredient ID: NPC83291
Ingredient ID: NPC83189
Ingredient ID: NPC81419
Ingredient ID: NPC75078
Ingredient ID: NPC7447
Ingredient ID: NPC73617
Ingredient ID: NPC73483
Ingredient ID: NPC72675
Ingredient ID: NPC72468
Ingredient ID: NPC7183
Ingredient ID: NPC71195
Ingredient ID: NPC70400
Ingredient ID: NPC69918
Ingredient ID: NPC68324
Ingredient ID: NPC66718
Ingredient ID: NPC65200
Ingredient ID: NPC63100
Ingredient ID: NPC617
Ingredient ID: NPC61341
Ingredient ID: NPC61001
Ingredient ID: NPC59593
Ingredient ID: NPC58877
Ingredient ID: NPC57891
Ingredient ID: NPC57393
Ingredient ID: NPC57380
Ingredient ID: NPC55925
Ingredient ID: NPC55906
Ingredient ID: NPC55098
Ingredient ID: NPC53757
Ingredient ID: NPC51004
Ingredient ID: NPC50315
Ingredient ID: NPC48666
Ingredient ID: NPC485541
Ingredient ID: NPC485540
Ingredient ID: NPC47933
Ingredient ID: NPC479205
Ingredient ID: NPC479204
Ingredient ID: NPC479203
Ingredient ID: NPC478793
Ingredient ID: NPC47826
Ingredient ID: NPC47584
Ingredient ID: NPC47521
Ingredient ID: NPC47234
Ingredient ID: NPC46869
Ingredient ID: NPC46274
Ingredient ID: NPC43918
Ingredient ID: NPC39806
Ingredient ID: NPC38775
Ingredient ID: NPC38771
Ingredient ID: NPC3658
Ingredient ID: NPC35270
Ingredient ID: NPC35022
Ingredient ID: NPC3474
Ingredient ID: NPC3224
Ingredient ID: NPC32109
Ingredient ID: NPC3146
Ingredient ID: NPC311389
Ingredient ID: NPC310581
Ingredient ID: NPC309701
Ingredient ID: NPC309493
Ingredient ID: NPC30869
Ingredient ID: NPC307411
Ingredient ID: NPC306397
Ingredient ID: NPC30560
Ingredient ID: NPC30515
Ingredient ID: NPC301077
Ingredient ID: NPC301058
Ingredient ID: NPC300911
Ingredient ID: NPC300389
Ingredient ID: NPC296589
Ingredient ID: NPC29549
Ingredient ID: NPC29506
Ingredient ID: NPC286137
Ingredient ID: NPC285034
Ingredient ID: NPC284934
Ingredient ID: NPC284752
Ingredient ID: NPC283506
Ingredient ID: NPC283174
Ingredient ID: NPC282818
Ingredient ID: NPC282431
Ingredient ID: NPC280008
Ingredient ID: NPC279943
Ingredient ID: NPC279121
Ingredient ID: NPC27871
Ingredient ID: NPC278127
Ingredient ID: NPC277686
Ingredient ID: NPC276202
Ingredient ID: NPC275048
Ingredient ID: NPC274773
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Ingredient ID: NPC272844
Ingredient ID: NPC272814
Ingredient ID: NPC271852
Ingredient ID: NPC271482
Ingredient ID: NPC270797
Ingredient ID: NPC267627
Ingredient ID: NPC267403
Ingredient ID: NPC26703
Ingredient ID: NPC266580
Ingredient ID: NPC265705
Ingredient ID: NPC263583
Ingredient ID: NPC261623
Ingredient ID: NPC259866
Ingredient ID: NPC257546
Ingredient ID: NPC256849
Ingredient ID: NPC256766
Ingredient ID: NPC256392
Ingredient ID: NPC254168
Ingredient ID: NPC25389
Ingredient ID: NPC252603
Ingredient ID: NPC25245
Ingredient ID: NPC250436
Ingredient ID: NPC248995
Ingredient ID: NPC24627
Ingredient ID: NPC245827
Ingredient ID: NPC245240
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Ingredient ID: NPC239943
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Ingredient ID: NPC226535
Ingredient ID: NPC225710
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Ingredient ID: NPC221758
Ingredient ID: NPC221231
Ingredient ID: NPC219876
Ingredient ID: NPC219502
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Ingredient ID: NPC218736
Ingredient ID: NPC215875
Ingredient ID: NPC212031
Ingredient ID: NPC211088
Ingredient ID: NPC209434
Ingredient ID: NPC208886
Ingredient ID: NPC20791
Ingredient ID: NPC20713
Ingredient ID: NPC202868
Ingredient ID: NPC202688
Ingredient ID: NPC202672
Ingredient ID: NPC201814
Ingredient ID: NPC200119
Ingredient ID: NPC195380
Ingredient ID: NPC194977
Ingredient ID: NPC192501
Ingredient ID: NPC191448
Ingredient ID: NPC186628
Ingredient ID: NPC186080
Ingredient ID: NPC184318
Ingredient ID: NPC184102
Ingredient ID: NPC180474
Ingredient ID: NPC18013
Ingredient ID: NPC179746
Ingredient ID: NPC178134
Ingredient ID: NPC176893
Ingredient ID: NPC176740
Ingredient ID: NPC176414
Ingredient ID: NPC174999
Ingredient ID: NPC173602
Ingredient ID: NPC172419
Ingredient ID: NPC171147
Ingredient ID: NPC17039
Ingredient ID: NPC170034
Ingredient ID: NPC169749
Ingredient ID: NPC165382
Ingredient ID: NPC162742
Ingredient ID: NPC161193
Ingredient ID: NPC161066
Ingredient ID: NPC160512
Ingredient ID: NPC157982
Ingredient ID: NPC15669
Ingredient ID: NPC155525
Ingredient ID: NPC153031
Ingredient ID: NPC151709
Ingredient ID: NPC148358
Ingredient ID: NPC142393
Ingredient ID: NPC141810
Ingredient ID: NPC141361
Ingredient ID: NPC14030
Ingredient ID: NPC138118
Ingredient ID: NPC137946
Ingredient ID: NPC137698
Ingredient ID: NPC136859
Ingredient ID: NPC136464
Ingredient ID: NPC135484
Ingredient ID: NPC135222
Ingredient ID: NPC134819
Ingredient ID: NPC133821
Ingredient ID: NPC132250
Ingredient ID: NPC129650
Ingredient ID: NPC128897
Ingredient ID: NPC128792
Ingredient ID: NPC128484
Ingredient ID: NPC125062
Ingredient ID: NPC123316
Ingredient ID: NPC122818
Ingredient ID: NPC12256
Ingredient ID: NPC12172
Ingredient ID: NPC118502
Ingredient ID: NPC117853
Ingredient ID: NPC116850
Ingredient ID: NPC116775
Ingredient ID: NPC115827
Ingredient ID: NPC112065
Ingredient ID: NPC111703
Ingredient ID: NPC111490
Ingredient ID: NPC108776
Ingredient ID: NPC108455
Ingredient ID: NPC107069
Ingredient ID: NPC106770
Ingredient ID: NPC106574
Ingredient ID: NPC106071
Ingredient ID: NPC105591
Ingredient ID: NPC104222
Ingredient ID: NPC103540
Ingredient ID: NPC101035
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Drug Transporter | ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| Drug Transporter | SLC superfamily of solute carriers | SLC22A6 | Solute carrier family 22 member 6 | Q4U2R8 | CHEMBL1641347 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | Cysteine protease | CASP6 | Caspase-6 | P55212 | CHEMBL3308 |
| Therapeutic Target | DNA methyltransferase | DNMT1 | DNA (cytosine-5)-methyltransferase 1 | P26358 | CHEMBL1993 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 212 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000578 | NHLBI/NICHD Collaborative Studies of Asthma in Pregnancy | asthma | Theophylline (NPC252603) | NP level |
| NCT00003197 | Green Tea Extract in Treating Patients With Advanced Solid Tumors | neoplasm | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00003684 | Theophylline in Treating Cancer Patients With Shortness of Breath | respiratory failure | Theophylline (NPC252603) | NP level |
| NCT00003808 | Theophylline in Treating Patients With In Situ, Stage I, or Stage II Chronic Lymphocytic Leukemia | leukemia | Theophylline (NPC252603) | NP level |
| NCT00005828 | Green Tea Extract in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy | prostate cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00033436 | Radiation Therapy With or Without Carbogen and Niacinamide in Treating Patients With Bladder Cancer | urinary bladder cancer | Niacinamide (NPC306397) | NP level |
| NCT00088946 | Erlotinib and Green Tea Extract (Polyphenon® E) in Preventing Cancer Recurrence in Former Smokers Who Have Undergone Surgery for Bladder Cancer | urinary bladder cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00091325 | Green Tea Extract (Polyphenon E) in Preventing Cancer in Healthy Participants | neoplasm | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00119496 | Rosiglitazone Versus Theophylline in Asthmatic Smokers | asthma | Theophylline (NPC252603) | NP level |
| NCT00175812 | Differentiation Induction in Acute Myelogenous Leukemia | acute myeloid leukemia | Theophylline (NPC252603) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
NCT03626298
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Actinic keratosisDisease Category: X.Extension CodesDisease ICD-11 Code: XH36H6 |
NCT04843553
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1,KDR,INSR,DPP4,AURKB
|
Acute kidney failure, stage unspecifiedDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB60.Z |
NCT02701127
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
BCL2,TP53,SRC,AXL,DNMT1,TOP2A,AURKB,TERT,GSK3B,PIM1,FLT3
NCT00175812 |
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
GPR35,CA7,AURKB,SLCO1B1,CYP2C9,ACHE,TOP2A,NPSR1,TERT,MMP12,CDK1,CA12,SLCO1B3,XDH,F2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA7,ALOX15,PGAM1,DPP4,CA2,RECQL,ABCB1,AURKB,CYP2C9,HIF1A,ACHE,NUAK1,ALOX5,AXL,PGD,NPSR1,TERT,F10,LMNA,ABCG2,PIM1,POLB,ADORA2A,IL6,CYP1B1,MET,HSD17B2,FUT7,APP,SLCO1B3,XDH,CISD1,ANTXR2,SNCA,F2,TEK
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
TERT,NOX4,ALOX15,SLCO1B3,SLCO1B1
NCT00459407,NCT01912820 |
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
