Collective Molecular Activities of the Plant: Acorus Calamus
Plant ID: NPO25682
Plant Latin Name: Acorus Calamus
Taxonomy Genus: Acorus
Taxonomy Family: Acoraceae
Plant External Links:
NCBI TaxonomyDB:
4465
Plant-of-the-World-Online:
n.a.
Country/Region:
Turkey; Finland; Italy; South Africa; India; Indonesia; Lithuania; China; Greece; Thailand; BulgariaTraditional Medicine System:
Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; TCMMedicinal Functions:
Abortifacient; Anodyne; Antirheumatic; Aphrodisiac; Aromatic; Carminative; Diaphoretic; Emmenagogue; Febrifuge; Hallucinogenic; Homeopathy; Odontalgic; Sedative; Stimulant; Stomachic; Tonic; Vermifuge
Turkey; Indonesia; Italy; South Africa; Lithuania; Finland; India; China; Greece; Thailand; Bulgaria
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
233 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
196 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
99 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99480
Ingredient ID: NPC99358
Ingredient ID: NPC9880
Ingredient ID: NPC98434
Ingredient ID: NPC95675
Ingredient ID: NPC91574
Ingredient ID: NPC90803
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Ingredient ID: NPC90506
Ingredient ID: NPC87828
Ingredient ID: NPC8780
Ingredient ID: NPC87384
Ingredient ID: NPC84772
Ingredient ID: NPC82862
Ingredient ID: NPC8011
Ingredient ID: NPC7965
Ingredient ID: NPC79273
Ingredient ID: NPC7927
Ingredient ID: NPC78551
Ingredient ID: NPC76817
Ingredient ID: NPC76512
Ingredient ID: NPC76145
Ingredient ID: NPC75158
Ingredient ID: NPC7494
Ingredient ID: NPC7491
Ingredient ID: NPC74474
Ingredient ID: NPC74304
Ingredient ID: NPC7343
Ingredient ID: NPC72738
Ingredient ID: NPC71853
Ingredient ID: NPC71703
Ingredient ID: NPC71506
Ingredient ID: NPC7057
Ingredient ID: NPC68889
Ingredient ID: NPC68873
Ingredient ID: NPC68052
Ingredient ID: NPC67986
Ingredient ID: NPC67761
Ingredient ID: NPC66577
Ingredient ID: NPC64141
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Ingredient ID: NPC60548
Ingredient ID: NPC60419
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Ingredient ID: NPC54264
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Ingredient ID: NPC51189
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Ingredient ID: NPC470541
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Ingredient ID: NPC200258
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Ingredient ID: NPC196924
Ingredient ID: NPC194586
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Ingredient ID: NPC188238
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Ingredient ID: NPC18449
Ingredient ID: NPC184049
Ingredient ID: NPC180871
Ingredient ID: NPC177112
Ingredient ID: NPC176589
Ingredient ID: NPC173996
Ingredient ID: NPC171665
Ingredient ID: NPC171139
Ingredient ID: NPC166816
Ingredient ID: NPC166362
Ingredient ID: NPC165695
Ingredient ID: NPC16452
Ingredient ID: NPC16157
Ingredient ID: NPC157944
Ingredient ID: NPC157781
Ingredient ID: NPC154792
Ingredient ID: NPC150809
Ingredient ID: NPC14930
Ingredient ID: NPC143639
Ingredient ID: NPC141777
Ingredient ID: NPC1403
Ingredient ID: NPC13991
Ingredient ID: NPC139546
Ingredient ID: NPC138347
Ingredient ID: NPC13789
Ingredient ID: NPC13565
Ingredient ID: NPC135238
Ingredient ID: NPC132807
Ingredient ID: NPC132382
Ingredient ID: NPC131981
Ingredient ID: NPC131742
Ingredient ID: NPC127997
Ingredient ID: NPC127993
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Ingredient ID: NPC126888
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Ingredient ID: NPC124885
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Ingredient ID: NPC12269
Ingredient ID: NPC122487
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Ingredient ID: NPC117771
Ingredient ID: NPC115385
Ingredient ID: NPC114764
Ingredient ID: NPC114239
Ingredient ID: NPC113877
Ingredient ID: NPC113278
Ingredient ID: NPC111108
Ingredient ID: NPC110899
Ingredient ID: NPC110639
Ingredient ID: NPC109813
Ingredient ID: NPC108494
Ingredient ID: NPC107482
Ingredient ID: NPC106250
Ingredient ID: NPC105209
Ingredient ID: NPC10455
Ingredient ID: NPC10407
Ingredient ID: NPC102091
Ingredient ID: NPC101285
Ingredient ID: NPC100879
Ingredient ID: NPC100570
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Methyl-lysine/arginine binding protein | SMN1 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Therapeutic Target | Other cytosolic protein | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Therapeutic Target | Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | CNR2 | Cannabinoid CB2 receptor | P34972 | CHEMBL253 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Therapeutic Target | Transcription factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 9 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT01118663 | Safety and Efficacy Study of a New Formulation of Acetylcysteine Injection | drug-induced liver injury | Acetic Acid (NPC68873) | NP level |
| NCT01119534 | Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin | Cough | Camphor (NPC131981) | NP level |
| NCT01119534 | Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin | Cough | Eucalyptol (NPC287331) | NP level |
| NCT01597401 | A Single Dose Study of the Safety, Blood Levels and Biological Effects of Aes-103 Compared to Placebo in Subjects With Stable Sickle Cell Disease | sickle cell anemia | 5-Hydroxymethyl-Furfural (NPC107482) | NP level |
| NCT01871142 | Evaluation of the Attenuation by Aes-103 of Hypoxia Mediated Decrements in Endurance Exercise Performance | hypoxia | 5-Hydroxymethyl-Furfural (NPC107482) | NP level |
| NCT01987908 | Evaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Disease | sickle cell anemia | 5-Hydroxymethyl-Furfural (NPC107482) | NP level |
| NCT04392622 | d-Limonene +Radiation +Platinum Based Chemo for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma | xerostomia | Limonene (NPC76145) | NP level |
| NCT04853082 | Limonene on Regulating Metabolism-related Fatty Liver Disease (MAFLD) and Analysis of TCM Constitution | Hepatic steatosis | Limonene (NPC76145) | NP level |
| NCT05022108 | Alpha-Bisabolol Gel With Antihistamine Action | injury | Alpha-Bisabolol (NPC157781) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TP53,MAPT
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
F2,ACHE
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
F2,CNR2,ACHE,LMNA
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
MAPT,ACHE
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
Arteries/arterioles disorderDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD52 |
MAPK1
|
AsphyxiaDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD11.1 |
NCT01871142
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CNR2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
