Collective Molecular Activities of the Plant: Smilax China
Plant ID: NPO25611
Plant Latin Name: Smilax China
Taxonomy Genus: Smilax
Taxonomy Family: Smilacaceae
Plant External Links:
NCBI TaxonomyDB:
49657
Plant-of-the-World-Online:
n.a.
Country/Region:
Philippines; Indonesia; India; Malaysia; Vietnam; China; South KoreaTraditional Medicine System:
TCM; Unani; Ayurveda; SiddhaMedicinal Functions:
Alterative; Antipsoriatic; Antiscrophulatic; Carminative; Depurative; Diaphoretic; Diuretic; Skin; Tonic; VD
Philippines; Indonesia; India; Malaysia; Vietnam; China; South Korea
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
101 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
37 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
69 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC92565
Ingredient ID: NPC89904
Ingredient ID: NPC87898
Ingredient ID: NPC79943
Ingredient ID: NPC7543
Ingredient ID: NPC72722
Ingredient ID: NPC70744
Ingredient ID: NPC70616
Ingredient ID: NPC70314
Ingredient ID: NPC68873
Ingredient ID: NPC62290
Ingredient ID: NPC61506
Ingredient ID: NPC61477
Ingredient ID: NPC61
Ingredient ID: NPC60523
Ingredient ID: NPC52382
Ingredient ID: NPC52197
Ingredient ID: NPC47844
Ingredient ID: NPC46190
Ingredient ID: NPC36835
Ingredient ID: NPC36288
Ingredient ID: NPC34864
Ingredient ID: NPC3460
Ingredient ID: NPC32643
Ingredient ID: NPC32441
Ingredient ID: NPC315084
Ingredient ID: NPC311485
Ingredient ID: NPC303422
Ingredient ID: NPC302857
Ingredient ID: NPC294902
Ingredient ID: NPC292461
Ingredient ID: NPC292452
Ingredient ID: NPC290613
Ingredient ID: NPC29
Ingredient ID: NPC287615
Ingredient ID: NPC28651
Ingredient ID: NPC275255
Ingredient ID: NPC273603
Ingredient ID: NPC27144
Ingredient ID: NPC270578
Ingredient ID: NPC267649
Ingredient ID: NPC262911
Ingredient ID: NPC262182
Ingredient ID: NPC261619
Ingredient ID: NPC260491
Ingredient ID: NPC257653
Ingredient ID: NPC254963
Ingredient ID: NPC248573
Ingredient ID: NPC246162
Ingredient ID: NPC243728
Ingredient ID: NPC242419
Ingredient ID: NPC240476
Ingredient ID: NPC236709
Ingredient ID: NPC233443
Ingredient ID: NPC230726
Ingredient ID: NPC230301
Ingredient ID: NPC222910
Ingredient ID: NPC219876
Ingredient ID: NPC216819
Ingredient ID: NPC216630
Ingredient ID: NPC215095
Ingredient ID: NPC21301
Ingredient ID: NPC212797
Ingredient ID: NPC20791
Ingredient ID: NPC201148
Ingredient ID: NPC187154
Ingredient ID: NPC181153
Ingredient ID: NPC18074
Ingredient ID: NPC177941
Ingredient ID: NPC177100
Ingredient ID: NPC176740
Ingredient ID: NPC174744
Ingredient ID: NPC173637
Ingredient ID: NPC173203
Ingredient ID: NPC167976
Ingredient ID: NPC166456
Ingredient ID: NPC163508
Ingredient ID: NPC162261
Ingredient ID: NPC161571
Ingredient ID: NPC15970
Ingredient ID: NPC158823
Ingredient ID: NPC157338
Ingredient ID: NPC156654
Ingredient ID: NPC15658
Ingredient ID: NPC153342
Ingredient ID: NPC150560
Ingredient ID: NPC149209
Ingredient ID: NPC143011
Ingredient ID: NPC142731
Ingredient ID: NPC142591
Ingredient ID: NPC139540
Ingredient ID: NPC126200
Ingredient ID: NPC126029
Ingredient ID: NPC116775
Ingredient ID: NPC111888
Ingredient ID: NPC110899
Ingredient ID: NPC110110
Ingredient ID: NPC1075
Ingredient ID: NPC104195
Ingredient ID: NPC101098
Ingredient ID: NPC100400
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Therapeutic Target | Enzyme | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 85 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00098969 | UMCC 2003-064 Resveratrol in Preventing Cancer in Healthy Participants | neoplasm | Resveratrol (NPC161571) | NP level |
| NCT00256334 | Resveratrol for Patients With Colon Cancer | malignant colon neoplasm | Resveratrol (NPC161571) | NP level |
| NCT00433576 | Resveratrol in Treating Patients With Colorectal Cancer That Can Be Removed By Surgery | colorectal adenocarcinoma;malignant colon neoplasm;rectum cancer | Resveratrol (NPC161571) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Resveratrol (NPC161571);Quercetin (NPC20791) | NP level |
| NCT00654667 | Mechanisms of Metabolic Regulation of Resveratrol on Humans With Metabolic Syndrome | insulin resistance | Resveratrol (NPC161571) | NP level |
| NCT01118663 | Safety and Efficacy Study of a New Formulation of Acetylcysteine Injection | drug-induced liver injury | Acetic Acid (NPC68873) | NP level |
| NCT01126229 | Resveratrol for Improved Performance in the Elderly | memory impairment | Resveratrol (NPC161571) | NP level |
| NCT01321151 | Use of Resveratrol to Decrease Acute Secondary Brain Injury Following Sports-Related Concussions in Boxers | concussion | Resveratrol (NPC161571) | NP level |
| NCT01339884 | A Study of Resveratrol as Treatment for Friedreich Ataxia | Friedreich ataxia | Resveratrol (NPC161571) | NP level |
| NCT01348204 | Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators | cystic fibrosis | Quercetin (NPC20791) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1,MMP2
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB,TYR
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1,AURKB,KDR,DPP4
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
PIM1,AURKB,SRC,NFKB1,TP53,FLT3,AXL
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE,CA7,TRPA1,XDH,AURKB,CDK1,CYP2C9,F2,MMP9,MMP1,CA9,CA12,NPSR1,TSHR
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ACHE,CA7,CISD1,TRPA1,POLB,DPP4,CA2,XDH,HSD17B2,RECQL,AURKB,CYP1B1,CYP2C9,F2,MMP1,SNCA,CA9,MET,OR51E2,MAOB,ALOX15,MMP2,PIM1,ABCG2,AXL,PTGS1,NPSR1,ALOX5,CA14,PTGS2,LMNA,CYP2C19
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
NOX4,OR51E2,FABP5,ALOX15
NCT01912820 |
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
