Australia; Bangladesh; Myanmar; Thailand; Philippines; Indonesia; India; Cambodia; Mauritius; Tanzania; Vietnam; China; Papua New Guinea; Uganda; Laos; Sri Lanka; Mozambique; Nigeria; Nepal; Taiwan
Ingredient ID: NPC95864
Ingredient ID: NPC93569
Ingredient ID: NPC87268
Ingredient ID: NPC87224
Ingredient ID: NPC87125
Ingredient ID: NPC64623
Ingredient ID: NPC57499
Ingredient ID: NPC33759
Ingredient ID: NPC31881
Ingredient ID: NPC307821
Ingredient ID: NPC303696
Ingredient ID: NPC301178
Ingredient ID: NPC287550
Ingredient ID: NPC274721
Ingredient ID: NPC268494
Ingredient ID: NPC257756
Ingredient ID: NPC254157
Ingredient ID: NPC243728
Ingredient ID: NPC241721
Ingredient ID: NPC236723
Ingredient ID: NPC225710
Ingredient ID: NPC223592
Ingredient ID: NPC222658
Ingredient ID: NPC218078
Ingredient ID: NPC211871
Ingredient ID: NPC209971
Ingredient ID: NPC209872
Ingredient ID: NPC208679
Ingredient ID: NPC200740
Ingredient ID: NPC19825
Ingredient ID: NPC194808
Ingredient ID: NPC188947
Ingredient ID: NPC185538
Ingredient ID: NPC171780
Ingredient ID: NPC166863
Ingredient ID: NPC164787
Ingredient ID: NPC155392
Ingredient ID: NPC155185
Ingredient ID: NPC151224
Ingredient ID: NPC141212
Ingredient ID: NPC138925
Ingredient ID: NPC134570
Ingredient ID: NPC129206
Ingredient ID: NPC118229
Ingredient ID: NPC113849
Ingredient ID: NPC109240
Ingredient ID: NPC105512
Ingredient ID: NPC104257
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Therapeutic Target | Transferase | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Q11130 | CHEMBL3596077 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 6 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00977353 | N-methylglycine (Sarcosine) Treatment for Depression | major depressive disorder | Sarcosine (NPC134570) | NP level |
NCT00328276 | Sarcosine (N-Methylglycine) Monotherapy for Schizophrenia | schizophrenia | Sarcosine (NPC134570) | NP level |
NCT00276263 | Sarcosine Preventive Therapy for Individuals At High Risk for Schizophrenia | schizophrenia | Sarcosine (NPC134570) | NP level |
NCT00491569 | Sarcosine or D-Serine Add-on Treatment for Chronic Schizophrenia | schizophrenia | Sarcosine (NPC134570) | NP level |
NCT01047592 | Treatment of N-methyl-D-aspartate (NMDA) Enhancers for Schizophrenia | schizophrenia | Sarcosine (NPC134570) | NP level |
NCT01503359 | Effect of Sarcosine on Symptomatology, Quality of Life, Oxidative Stress and Glutamatergic Parameters in Schizophrenia | schizophrenia | Sarcosine (NPC134570) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
NCT01503359,NCT00491569,NCT00276263,NCT01047592,NCT00328276
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
TDP1,HSD17B10,FUT7
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
TDP1,HSD17B10,LMNA
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
TDP1,FUT7,LMNA
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
TDP1,FUT7
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
FUT7,LMNA
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
HSD17B10,FUT7
|
Single episode depressive disorder, severe, without psychotic symptomsDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70.3 |
NCT00977353
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
FUT7
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
LMNA
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
FUT7
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
FUT7
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
FUT7
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
LMNA
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
KDM4E
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Polycystic ovary syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80.1 |
FUT7
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
FUT7
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
FUT7
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
FUT7
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
FUT7
|