Collective Molecular Activities of the Plant: Lupinus Luteus
Plant ID: NPO25469
Plant Latin Name: Lupinus Luteus
Taxonomy Genus: Lupinus
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
3873
Plant-of-the-World-Online:
n.a.
Country/Region:
China; Italy; IndiaTraditional Medicine System:
Indian Folk; TCMIndia; Italy; China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
80 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
66 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
27 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99321
Ingredient ID: NPC87466
Ingredient ID: NPC80962
Ingredient ID: NPC79027
Ingredient ID: NPC75485
Ingredient ID: NPC6616
Ingredient ID: NPC6072
Ingredient ID: NPC52214
Ingredient ID: NPC50488
Ingredient ID: NPC48919
Ingredient ID: NPC47294
Ingredient ID: NPC45173
Ingredient ID: NPC4509
Ingredient ID: NPC45083
Ingredient ID: NPC42564
Ingredient ID: NPC40175
Ingredient ID: NPC39426
Ingredient ID: NPC36002
Ingredient ID: NPC35655
Ingredient ID: NPC321650
Ingredient ID: NPC31409
Ingredient ID: NPC313163
Ingredient ID: NPC304429
Ingredient ID: NPC300098
Ingredient ID: NPC298410
Ingredient ID: NPC295038
Ingredient ID: NPC293427
Ingredient ID: NPC292952
Ingredient ID: NPC285802
Ingredient ID: NPC277907
Ingredient ID: NPC277525
Ingredient ID: NPC276466
Ingredient ID: NPC273965
Ingredient ID: NPC273069
Ingredient ID: NPC272471
Ingredient ID: NPC262094
Ingredient ID: NPC25694
Ingredient ID: NPC256040
Ingredient ID: NPC250667
Ingredient ID: NPC249122
Ingredient ID: NPC247945
Ingredient ID: NPC246392
Ingredient ID: NPC246224
Ingredient ID: NPC244942
Ingredient ID: NPC243728
Ingredient ID: NPC230301
Ingredient ID: NPC228980
Ingredient ID: NPC224224
Ingredient ID: NPC217727
Ingredient ID: NPC209451
Ingredient ID: NPC208094
Ingredient ID: NPC206276
Ingredient ID: NPC201767
Ingredient ID: NPC199703
Ingredient ID: NPC197896
Ingredient ID: NPC193142
Ingredient ID: NPC192875
Ingredient ID: NPC190358
Ingredient ID: NPC1898
Ingredient ID: NPC185556
Ingredient ID: NPC183671
Ingredient ID: NPC178464
Ingredient ID: NPC174362
Ingredient ID: NPC172193
Ingredient ID: NPC170084
Ingredient ID: NPC169275
Ingredient ID: NPC168990
Ingredient ID: NPC168248
Ingredient ID: NPC15702
Ingredient ID: NPC152506
Ingredient ID: NPC149496
Ingredient ID: NPC139954
Ingredient ID: NPC133485
Ingredient ID: NPC113733
Ingredient ID: NPC112398
Ingredient ID: NPC108758
Ingredient ID: NPC108292
Ingredient ID: NPC107712
Ingredient ID: NPC106508
Ingredient ID: NPC106021
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESRRA | Estrogen-related receptor alpha | P11474 | CHEMBL3429 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESRRB | Estrogen-related receptor beta | O95718 | CHEMBL3751 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESR1 | Estrogen receptor alpha | P03372 | CHEMBL206 |
| Therapeutic Target | Oxidoreductase | AOX1 | Aldehyde oxidase | Q06278 | CHEMBL3257 |
| Therapeutic Target | Protein Kinase | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | P45985 | CHEMBL2897 |
| Therapeutic Target | Serine protease | DPP4 | Dipeptidyl peptidase IV | P27487 | CHEMBL284 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 24 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00001696 | A Pharmacokinetic Study of Genistein, a Tyrosine Kinase Inhibitor | cancer | Genistein (NPC39426) | NP level |
| NCT00005827 | Genistein in Treating Patients With Stage II, Stage III, or Stage IV Prostate Cancer | prostate cancer | Genistein (NPC39426) | NP level |
| NCT00010686 | Dietary Phytoestrogens and Bone Metabolism | osteoporosis | Genistein (NPC39426) | NP level |
| NCT00016744 | Phenylbutyrate/Genistein Duotherapy in Delta F508-Homozygous(for Cystic Fibrosis) | cystic fibrosis | Genistein (NPC39426) | NP level |
| NCT00058266 | Genistein in Treating Patients With Localized Prostate Cancer Who Are Planning to Undergo Radical Prostatectomy | prostate cancer | Genistein (NPC39426) | NP level |
| NCT00118040 | Phase II Study of Isoflavone G-2535 (Genistein) in Patients With Bladder Cancer | urinary bladder carcinoma | Genistein (NPC39426) | NP level |
| NCT00244933 | Gemcitabine Hydrochloride and Genistein in Treating Women With Stage IV Breast Cancer | breast cancer | Genistein (NPC39426) | NP level |
| NCT00287690 | Isoflavones and the Coronary Circulation in Men and Women With Coronary Artery Disease | coronary artery disease | Genistein (NPC39426) | NP level |
| NCT00290758 | Genistein in Preventing Breast Cancer in Women at High Risk for Breast Cancer | breast cancer | Genistein (NPC39426) | NP level |
| NCT00376948 | Genistein, Gemcitabine, and Erlotinib in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer | pancreatic carcinoma | Genistein (NPC39426) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
DPP4
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
MAPT
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
BLM,CYP2C9,TSHR,F2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
BLM,DPP4,CYP2C9,MAOB,F2
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
NCT01126879,NCT01325311,NCT00546039
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
BLM,F2
|
Adrenal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
ESR1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
