Collective Molecular Activities of the Plant: Triadica Sebifera
Country/Region:
Vietnam; IndiaTraditional Medicine System:
Unani; AyurvedaSouth Africa; Cuba; India; United States; Vietnam; China; Japan
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
154 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
115 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
28 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98272
Ingredient ID: NPC98041
Ingredient ID: NPC96700
Ingredient ID: NPC95952
Ingredient ID: NPC89010
Ingredient ID: NPC86177
Ingredient ID: NPC8180
Ingredient ID: NPC81198
Ingredient ID: NPC80131
Ingredient ID: NPC79529
Ingredient ID: NPC76513
Ingredient ID: NPC76306
Ingredient ID: NPC74898
Ingredient ID: NPC73804
Ingredient ID: NPC73497
Ingredient ID: NPC69750
Ingredient ID: NPC68889
Ingredient ID: NPC68153
Ingredient ID: NPC65182
Ingredient ID: NPC64568
Ingredient ID: NPC59217
Ingredient ID: NPC58082
Ingredient ID: NPC57615
Ingredient ID: NPC54597
Ingredient ID: NPC53820
Ingredient ID: NPC48175
Ingredient ID: NPC45271
Ingredient ID: NPC43920
Ingredient ID: NPC39654
Ingredient ID: NPC394
Ingredient ID: NPC34247
Ingredient ID: NPC34220
Ingredient ID: NPC32806
Ingredient ID: NPC311626
Ingredient ID: NPC310513
Ingredient ID: NPC309932
Ingredient ID: NPC309799
Ingredient ID: NPC309225
Ingredient ID: NPC305518
Ingredient ID: NPC302857
Ingredient ID: NPC30013
Ingredient ID: NPC297643
Ingredient ID: NPC296024
Ingredient ID: NPC295390
Ingredient ID: NPC295148
Ingredient ID: NPC294902
Ingredient ID: NPC294225
Ingredient ID: NPC286005
Ingredient ID: NPC285399
Ingredient ID: NPC284827
Ingredient ID: NPC283521
Ingredient ID: NPC282804
Ingredient ID: NPC281270
Ingredient ID: NPC278804
Ingredient ID: NPC277718
Ingredient ID: NPC274739
Ingredient ID: NPC271489
Ingredient ID: NPC271138
Ingredient ID: NPC267612
Ingredient ID: NPC266841
Ingredient ID: NPC263774
Ingredient ID: NPC25253
Ingredient ID: NPC251418
Ingredient ID: NPC249980
Ingredient ID: NPC249168
Ingredient ID: NPC248733
Ingredient ID: NPC247359
Ingredient ID: NPC245130
Ingredient ID: NPC244776
Ingredient ID: NPC243728
Ingredient ID: NPC24327
Ingredient ID: NPC241573
Ingredient ID: NPC241442
Ingredient ID: NPC238950
Ingredient ID: NPC238193
Ingredient ID: NPC23146
Ingredient ID: NPC231336
Ingredient ID: NPC229785
Ingredient ID: NPC228227
Ingredient ID: NPC22602
Ingredient ID: NPC225773
Ingredient ID: NPC225710
Ingredient ID: NPC225205
Ingredient ID: NPC224389
Ingredient ID: NPC222001
Ingredient ID: NPC213650
Ingredient ID: NPC213056
Ingredient ID: NPC20985
Ingredient ID: NPC208698
Ingredient ID: NPC208281
Ingredient ID: NPC20791
Ingredient ID: NPC207627
Ingredient ID: NPC206902
Ingredient ID: NPC206876
Ingredient ID: NPC206231
Ingredient ID: NPC200412
Ingredient ID: NPC198672
Ingredient ID: NPC197356
Ingredient ID: NPC196107
Ingredient ID: NPC195435
Ingredient ID: NPC195057
Ingredient ID: NPC195055
Ingredient ID: NPC193942
Ingredient ID: NPC192831
Ingredient ID: NPC192266
Ingredient ID: NPC191409
Ingredient ID: NPC189238
Ingredient ID: NPC188661
Ingredient ID: NPC186896
Ingredient ID: NPC186320
Ingredient ID: NPC185312
Ingredient ID: NPC182497
Ingredient ID: NPC182258
Ingredient ID: NPC179950
Ingredient ID: NPC17985
Ingredient ID: NPC179505
Ingredient ID: NPC176740
Ingredient ID: NPC176605
Ingredient ID: NPC176365
Ingredient ID: NPC170404
Ingredient ID: NPC169529
Ingredient ID: NPC168295
Ingredient ID: NPC16620
Ingredient ID: NPC164008
Ingredient ID: NPC159728
Ingredient ID: NPC158334
Ingredient ID: NPC154715
Ingredient ID: NPC150628
Ingredient ID: NPC147969
Ingredient ID: NPC147796
Ingredient ID: NPC145525
Ingredient ID: NPC14121
Ingredient ID: NPC139717
Ingredient ID: NPC13818
Ingredient ID: NPC136167
Ingredient ID: NPC135468
Ingredient ID: NPC133671
Ingredient ID: NPC130249
Ingredient ID: NPC130210
Ingredient ID: NPC128940
Ingredient ID: NPC125832
Ingredient ID: NPC123881
Ingredient ID: NPC123836
Ingredient ID: NPC121759
Ingredient ID: NPC116775
Ingredient ID: NPC113389
Ingredient ID: NPC110373
Ingredient ID: NPC109813
Ingredient ID: NPC108405
Ingredient ID: NPC105542
Ingredient ID: NPC103777
Ingredient ID: NPC101888
Ingredient ID: NPC101352
Ingredient ID: NPC10078
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 37 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791) | NP level |
| NCT01348204 | Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators | cystic fibrosis | Quercetin (NPC20791) | NP level |
| NCT01375101 | Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus | oral lichen planus | Quercetin (NPC20791) | NP level |
| NCT01438320 | Q-Trial in Patients With Hepatitis C | chronic hepatitis C virus infection | Quercetin (NPC20791) | NP level |
| NCT01705652 | Study to Assess the Activity of Nexrutine® in Prostate Cancer Patients | prostate cancer | Rutin (NPC176740) | NP level |
| NCT01708278 | Beneficial Effects of Quercetin in Chronic Obstructive Pulmonary Disease (COPD) | chronic obstructive pulmonary disease | Quercetin (NPC20791) | NP level |
| NCT01720147 | Quercetin in Children With Fanconi Anemia; a Pilot Study | Fanconi anemia | Quercetin (NPC20791) | NP level |
| NCT01839344 | Effects of Quercetin on Blood Sugar and Blood Vessel Function in Type 2 Diabetes. | type 2 diabetes mellitus | Quercetin (NPC20791) | NP level |
| NCT01912820 | Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery | prostate adenocarcinoma | Quercetin (NPC20791) | NP level |
| NCT02136342 | Phase 1 Trial of Chlorogenic Acid in Patients With Advanced Cancer | cancer | Chlorogenic Acid (NPC302857) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKB,KDR,AKR1B1,DPP4
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TP53,SRC,PIM1,FLT3,AXL,KDM1A,NFKB1,AURKB
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,AKR1B10,CDK1,AURKB,MMP9,ACHE,XDH,MMP1,NPSR1,CA7,CYP2C9
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
RECQL,POLB,ACHE,XDH,MMP2,MET,AKR1B10,LMNA,AURKB,PIM1,CYP1B1,CA7,HSD17B2,DPP4,CISD1,CA2,FUT7,CNR2,NPSR1,MMP1,ALOX15,ALOX5,CYP2C9,AXL,ABCG2
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
ALOX15,NOX4
NCT01912820 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CDK1,NOX4,AURKB,MMP9,MMP1,NPSR1,ALOX15,CYP19A1,MET
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
