Collective Molecular Activities of the Plant: Cinchona Calisaya
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PLANiTS DNA barcode
Taxonomic Information
Used in Medicines
Country/Region:
IndiaTraditional Medicine System:
Indian Folk; Homeopathy; AyurvedaGeographical Distribution
Guatemala; Bolivia; India; Peru
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary
Overview of Ingredients
39 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
36 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
17 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC97338
Ingredient ID: NPC87555
Ingredient ID: NPC85651
Ingredient ID: NPC82843
Ingredient ID: NPC75865
Ingredient ID: NPC73587
Ingredient ID: NPC68566
Ingredient ID: NPC476464
Ingredient ID: NPC47059
Ingredient ID: NPC39257
Ingredient ID: NPC39142
Ingredient ID: NPC37206
Ingredient ID: NPC33638
Ingredient ID: NPC329708
Ingredient ID: NPC31799
Ingredient ID: NPC313528
Ingredient ID: NPC312916
Ingredient ID: NPC288611
Ingredient ID: NPC284856
Ingredient ID: NPC276917
Ingredient ID: NPC274291
Ingredient ID: NPC264166
Ingredient ID: NPC261003
Ingredient ID: NPC251430
Ingredient ID: NPC242808
Ingredient ID: NPC242631
Ingredient ID: NPC227320
Ingredient ID: NPC222342
Ingredient ID: NPC203754
Ingredient ID: NPC19426
Ingredient ID: NPC181631
Ingredient ID: NPC176085
Ingredient ID: NPC165349
Ingredient ID: NPC150048
Ingredient ID: NPC149618
Ingredient ID: NPC134288
Ingredient ID: NPC129939
Ingredient ID: NPC117614
Ingredient ID: NPC103540
Classification of Human Proteins Collectively Targeted by the Plant
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
.
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Therapeutic Target | Membrane receptor | SIGMAR1 | Sigma opioid receptor | Q99720 | CHEMBL287 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | THRB | Thyroid hormone receptor beta-1 | P10828 | CHEMBL1947 |
| Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Drug Transporter | Potassium channels | KCNH2 | HERG | Q12809 | CHEMBL240 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical Trials Summary
Overview
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 98 | |
Clinical trial details
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT04303299 | Fight COVID-19 Trial | COVID-19 | Chloroquine (NPC476464) | NP level |
| NCT01074905 | Study on the Treatment of Vivax Malaria | Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
| NCT00021697 | Safety/Efficacy of AVP-923 in the Treatment of Emotional Lability (Uncontrolled Crying & Laughing) in Patients With ALS | amyotrophic lateral sclerosis | Quinidine (NPC264166) | NP level |
| NCT00084227 | Azithromycin Plus Chloroquine Versus Atovaquone-Proguanil For The Treatment Of Uncomplicated Plasmodium Falciparum Malaria In South America | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
| NCT02176018 | Nuedexta for the Prevention and Modification of Disease Progression in Episodic Migraine | migraine disorder | Quinidine (NPC264166) | NP level |
| NCT02153502 | Efficacy, Safety, and Tolerability Study of AVP-786 as an Adjunctive Therapy in Patients With Major Depressive Disorder With an Inadequate Response to Antidepressant Treatment | depressive disorder | Quinidine (NPC264166) | NP level |
| NCT01546389 | Sanaria™ PfSPZ Challenge Vaccine | malaria | Chloroquine (NPC476464) | NP level |
| NCT00844207 | A Phase 1 Study To Estimate The Relative Bioavailability Of Fixed Combination Tablets Of Azithromycin And Chloroquine Compared To Co-Administered Individual Tablets Of Azithromycin And Chloroquine | malaria | Chloroquine (NPC476464) | NP level |
| NCT02071537 | Chloroquine in Combination With Carboplatin/Gemcitabine in Advanced Solid Tumors | cancer | Chloroquine (NPC476464) | NP level |
| NCT00959517 | Trial of Artesunate Combination Therapy in Pakistan | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
| NCT03610945 | Drug-drug Interaction Study Between EDP-305, Fluconazole and Quinidine in Healthy Volunteers | non-alcoholic steatohepatitis | Quinidine (NPC264166) | NP level |
| NCT04368910 | Safety and Efficacy of Pyronaridine Artesunate Vs Chloroquine in Children and Adult Patients With Acute Vivax Malaria | malaria | Chloroquine (NPC476464) | NP level |
| NCT01941095 | A Study of Subcutaneous Tocilizumab as Monotherapy and/or in Combination With Non-Biologic Disease Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Rheumatoid Arthritis | rheumatoid arthritis | Chloroquine (NPC476464) | NP level |
| NCT04353336 | Efficacay of Chloroquine or Hydroxychloroquine in COVID-19 Treatment | COVID-19 | Chloroquine (NPC476464) | NP level |
| NCT01292408 | Autophagy Inhibition Using Hydrochloroquine in Breast Cancer Patients | breast cancer | Chloroquine (NPC476464) | NP level |
| NCT00224978 | Chloroquine for Treatment of Glioblastoma Multiforme | glioblastoma multiforme | Chloroquine (NPC476464) | NP level |
| NCT02378532 | The Addition of Chloroquine to Chemoradiation for Glioblastoma | glioblastoma multiforme | Chloroquine (NPC476464) | NP level |
| NCT01443130 | Chloroquine for Malaria in Pregnancy | malaria | Chloroquine (NPC476464) | NP level |
| NCT00440999 | Pyronaridine Artesunate (3:1) in Children and Adults With Acute Plasmodium Vivax Malaria | malaria | Chloroquine (NPC476464) | NP level |
| NCT04783753 | Drug-Drug Interaction Study Between EDP-514, Itraconazole, Carbamazepine, and Quinidine in Healthy Subjects | hepatitis B virus infection | Quinidine (NPC264166) | NP level |
| NCT01777477 | Adjuvant Effect of Chloroquine on Gemcitabine | pancreatic carcinoma | Chloroquine (NPC476464) | NP level |
| NCT03503058 | Safety, Tolerability, Immunogenicity and Protective Efficacy of PfSPZ Vaccine and PfSPZ-CVac in Indonesian Adults Against Naturally-Transmitted Malaria | malaria | Chloroquine (NPC476464) | NP level |
| NCT00969306 | Chloroquine as an Anti-Autophagy Drug in Stage IV Small Cell Lung Cancer (SCLC) Patients | small cell lung carcinoma | Chloroquine (NPC476464) | NP level |
| NCT02216123 | Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malaria | Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
| NCT01376167 | Ph 2B/3 Tafenoquine (TFQ) Study in Prevention of Vivax Relapse | Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
| NCT04319900 | Clinical Trial of Favipiravir Tablets Combine With Chloroquine Phosphate in the Treatment of Novel Coronavirus Pneumonia | COVID-19 | Chloroquine (NPC476464) | NP level |
| NCT02432417 | The Addition of Chloroquine to Chemoradiation for Glioblastoma, | glioblastoma multiforme | Chloroquine (NPC476464) | NP level |
| NCT02691910 | Efficacy of Chloroquine (CQ) Alone Compared to Concomitant CQ and Primaquine for Plasmodium Vivax Infection | Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
| NCT00442403 | Safety and Efficacy of Chloroquine Associated With Dehydroepiandrosterone Sulphate to Treat Uncomplicated Falciparum Malaria | malaria | Chloroquine (NPC476464) | NP level |
| NCT02389374 | A Study to Assess Safety of Current Standard Malaria Treatment and an Assessment of G6PD Status in South-east Bangladesh | malaria | Chloroquine (NPC476464) | NP level |
| NCT00323375 | Studies of AQ-13, a Candidate Aminoquinoline Antimalarial, in Comparison With Chloroquine | malaria | Chloroquine (NPC476464) | NP level |
| NCT03883581 | Impact of Nuedexta on Bulbar Physiology and Function in ALS | amyotrophic lateral sclerosis | Quinidine (NPC264166) | NP level |
| NCT00084240 | Azithromycin Plus Chloroquine Versus Sulfadoxine-Pyrimethamine Plus Chloroquine For The Treatment Of Uncomplicated, Symptomatic Falciparum Malaria In Southeast Asia | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
| NCT00682578 | A Comparative Study of Artekin With Standard Malarial Treatment Regimes in Afghanistan | Plasmodium falciparum malaria;Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
| NCT00819390 | Chloroquine for Reducing Immune Activation in HIV- Infected Individuals | HIV infection | Chloroquine (NPC476464) | NP level |
| NCT00811096 | Pilot Human Study of Tinidazole Efficacy For Radical Cure Of Plasmodium Vivax | Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
| NCT00131703 | Efficacy and Safety of Sulphadoxine-pyrimethamine and Amodiaquine in Ghanaian Pregnant Women | pregnancy;malaria | Chloroquine (NPC476464) | NP level |
| NCT01533155 | Study in Healthy Volunteers to Investigate the Effects of Quinidine on the Pharmacokinetics of NKTR-118 | Constipation | Quinidine (NPC264166) | NP level |
| NCT01103063 | Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa | pregnancy | Chloroquine (NPC476464) | NP level |
| NCT01814423 | Pharmacokinetic Study of Multi-dose Chloroquine | malaria | Chloroquine (NPC476464) | NP level |
| NCT04627467 | Prevention With Chloroquine in Health Personnel Exposed to Infection With Coronavirus Disease 2019 (COVID-19) (TS-COVID) | COVID-19 | Chloroquine (NPC476464) | NP level |
| NCT04349371 | Saved From COVID-19 - Chloroquine (CQ) Prophylaxis for Health Care Workers at Risk for COVID | COVID-19 | Chloroquine (NPC476464) | NP level |
| NCT02348788 | Artemether-lumefantrine vs Chloroquine for Uncomplicated P. Vivax Malaria in Malaysia | Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
| NCT04397679 | Partial Brain RT, Temozolomide, Chloroquine, and TTF Therapy for the Treatment of Newly Diagnosed Glioblastoma | gliosarcoma | Chloroquine (NPC476464) | NP level |
| NCT00367653 | Azithromycin Plus Chloroquine Versus Mefloquine In the Treatment of Uncomplicated P. Falciparum Malaria. | malaria | Chloroquine (NPC476464) | NP level |
| NCT01946880 | Randomized MMF Withdrawal in Systemic Lupus Erythematosus (SLE) | systemic lupus erythematosus | Chloroquine (NPC476464) | NP level |
| NCT01100060 | A Phase 1 Study To Estimate The Relative Bioavailability Of Co-Administered Formulations Of Azithromycin Microsphere And Chloroquine Test Formulation Compared With Co-Administered Immediate Release Individual Azithromycin And Chloroquine Tablets In Healthy Adult Subjects | malaria | Chloroquine (NPC476464) | NP level |
| NCT01680406 | Ethiopia Antimalarial in Vivo Efficacy Study 2012 | malaria | Chloroquine (NPC476464) | NP level |
| NCT00082576 | Azithromycin Plus Chloroquine Versus Mefloquine for the Treatment of Uncomplicated Malaria in Africa | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
| NCT00379821 | Chloroquine Alone or in Combination for Malaria in Children in Malawi | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
| NCT00789165 | Empiric Quinidine for Asymptomatic Brugada Syndrome | cardiac arrhythmia | Quinidine (NPC264166) | NP level |
| NCT00871156 | Tafenoquine/Chloroquine DDI Study | malaria | Chloroquine (NPC476464) | NP level |
| NCT01460381 | A Study to Evaluate the Effect of Genotype on LY2216684 | major depressive disorder | Quinidine (NPC264166) | NP level |
| NCT00000464 | Cardiac Arrest in Seattle: Conventional Versus Amiodarone Drug Evaluation (CASCADE) | myocardial infarction;sudden cardiac arrest;ventricular fibrillation | Quinidine (NPC264166) | NP level |
| NCT01378286 | Efficacy and Tolerability of Artesunate Amodiaquine Versus Chloroquine in the Treatment of Uncomplicated Plasmodium Vivax Malaria | malaria | Chloroquine (NPC476464) | NP level |
| NCT01438177 | Chloroquine in Combination With VELCADE and Cyclophosphamide for Relapsed and Refractory Multiple Myeloma | multiple myeloma | Chloroquine (NPC476464) | NP level |
| NCT01290601 | Study to Evaluate the Efficacy and Safety of Tafenoquine for the Treatment of Plasmodium Vivax in Adults | malaria | Chloroquine (NPC476464) | NP level |
| NCT00282919 | A Three Day Trial of Azithromycin Plus Chloroquine for the Treatment of Uncomplicated Plasmodium Falciparum Malaria | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
| NCT01103713 | Evaluate Parasitological Clearance Rates And Pharmacokinetics Of The Combination Of Azithromycin And Chloroquine In Asymptomatic Pregnant Women With Falciparum Parasitemia In Africa | pregnancy | Chloroquine (NPC476464) | NP level |
| NCT01205178 | G6PD (Glucose-6-phosphate Dehydrogenase) Study to Evaluate Hemolysis Potential of TFQ (Tafenoquine) | malaria | Chloroquine (NPC476464) | NP level |
| NCT04351295 | Efficacy of Faviprevir in COVID-19 Treatment | COVID-19 | Chloroquine (NPC476464) | NP level |
| NCT00050232 | Safety and Efficacy of AVP-923 for Pseudobulbar Affect in Multiple Sclerosis Patients | multiple sclerosis | Quinidine (NPC264166) | NP level |
| NCT00972725 | Evaluation of the Immune Response of a HIV Candidate Vaccine After Administration of One Chloroquine Dose | AIDS | Chloroquine (NPC476464) | NP level |
| NCT03278808 | Chloroquine (CQ) and Azithromycin (AZ) Combination for Malaria Prophylaxis | malaria | Chloroquine (NPC476464) | NP level |
| NCT02610686 | Evaluating the Efficacy of Chloroquine for the Treatment of Plasmodium Vivax Infections in Central Vietnam | malaria | Chloroquine (NPC476464) | NP level |
| NCT00486694 | Artesunate Plus Sulfadoxine-Pyrimethamine Versus Chloroquine for Vivax Malaria | Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
| NCT01078779 | The Chloroquine for Influenza Prevention Trial | influenza | Chloroquine (NPC476464) | NP level |
| NCT02698748 | Evaluating the Role of Chloroquine for Malaria Elimination | malaria | Chloroquine (NPC476464) | NP level |
| NCT02996695 | Safety and Efficacy of Sanaria's PfSPZ-CVac in Malian Adults | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
| NCT02001012 | P. Knowlesi Trial of Artemether-lumefantrine vs Chloroquine | malaria | Chloroquine (NPC476464) | NP level |
| NCT00290420 | Prevention of P. Vivax Malaria During Pregnancy in Bolivia | malaria | Chloroquine (NPC476464) | NP level |
| NCT03755778 | Drug-Drug Interaction Study Between EDP-938, Itraconazole, Rifampin, and Quinidine in Healthy Subjects | Respiratory Syncytial Virus Infection | Quinidine (NPC264166) | NP level |
| NCT01708876 | P. Knowlesi Trial of Artesunate-mefloquine Versus Chloroquine | malaria | Chloroquine (NPC476464) | NP level |
| NCT01500980 | Malaria Challenge in Healthy Volunteers | malaria | Chloroquine (NPC476464) | NP level |
| NCT04447534 | Zinc With Chloroquine/Hydroxychloroquine in Treatment of COVID-19 | COVID-19 | Chloroquine (NPC476464) | NP level |
| NCT04333628 | Chloroquine for Mild Symptomatic and Asymptomatic COVID-19 | COVID-19 | Chloroquine (NPC476464) | NP level |
| NCT01575782 | Chloroquine as an Anti-autophagic Radiosensitizing Drug in Stage I-III Small Cell Lung Cancer | small cell lung carcinoma | Chloroquine (NPC476464) | NP level |
| NCT04420247 | Efficacy of Chloroquine or Hydroxychloroquine in Treating Pneumonia Caused by SARS-Cov-2 - COVID-19 | COVID-19 | Chloroquine (NPC476464) | NP level |
| NCT00082563 | Azithromycin in Combination With Chloroquine Versus Chloroquine in the Eradication of Asymptomatic Plasmodium Falciparum | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
| NCT02333890 | A Phase 2 Randomized, Double-blind Trial Evaluating the Effects of Chloroquine in Breast Cancer | breast cancer | Chloroquine (NPC476464) | NP level |
| NCT02511054 | Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Trial to Determine Safety and Protective Efficacy of Sanaria PfSPZ Challenge With Concurrent Pyrimethamine Treatment That Inhibits Development of Asexual B... | malaria | Chloroquine (NPC476464) | NP level |
| NCT00849602 | The Effect of Chloroquine in the Treatment of Patients With Dengue | Dengue Hemorrhagic Fever | Chloroquine (NPC476464) | NP level |
| NCT00521924 | Induction of Remission in RA Patients at Low Disease Activity by Additional Infliximab Therapy (Study P04644AM1) (TERMINATED) | rheumatoid arthritis | Chloroquine (NPC476464) | NP level |
| NCT00000556 | Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) | atrial fibrillation | Quinidine (NPC264166) | NP level |
| NCT00677833 | Azithromycin Plus Chloroquine Versus Artemether-Lumefantrine For The Treatment Of Uncomplicated P. Falciparum Malaria In Children In Africa | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
| NCT04360759 | Chloroquine Outpatient Treatment Evaluation for HIV-Covid-19 | COVID-19 | Chloroquine (NPC476464) | NP level |
| NCT02563496 | A Pharmacokinetics, Safety and Efficacy Study of Tafenoquine (TQ) in Pediatric Subjects With Plasmodium Vivax (P. Vivax) Malaria | Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
| NCT00158548 | ACT With Chloroquine, Amodiaquine & Sulphadoxine-pyrimethamine in Pakistan | Plasmodium falciparum malaria;Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
| NCT01640574 | Comparison Between 7 and 14 Day Primaquine Combined With Dihydroartemisinin-piperaquine or 3 Day Chloroquine Radical Cure of P. Vivax (BPD) | Plasmodium vivax malaria | Chloroquine (NPC476464) | NP level |
| NCT04345406 | Angiotensin Converting Enzyme Inhibitors in Treatment of Covid 19 | COVID-19 | Chloroquine (NPC476464) | NP level |
| NCT04351724 | Austrian CoronaVirus Adaptive Clinical Trial (COVID-19) | COVID-19 | Chloroquine (NPC476464) | NP level |
| NCT01894633 | Study of Whole-brain Irradiation With Chloroquine for Brain Metastases | brain disease | Chloroquine (NPC476464) | NP level |
| NCT01718054 | Vascular Function Intervention Trial in Sickle Cell Disease | sickle cell anemia | Chloroquine (NPC476464) | NP level |
| NCT00118807 | Trial of the Effectiveness of AQ/AS, SP/AQ and SP/CQ for Uncomplicated Malaria in Gambian Children | malaria | Chloroquine (NPC476464) | NP level |
| NCT01882829 | Nuedexta in Treatment-Resistant Major Depression | major depressive disorder | Quinidine (NPC264166) | NP level |
| NCT02773979 | PfSPZ Challenge in Healthy Malaria-Naïve Adults in the United States | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
| NCT01023477 | Study of the Efficacy of Chloroquine in the Treatment of Ductal Carcinoma in Situ (The PINC Trial) | breast ductal carcinoma in situ | Chloroquine (NPC476464) | NP level |
| NCT00074841 | Trial of Azithromycin Plus Chloroquine Versus Sulfadoxine-Pyrimethamine Plus Chloroquine for the Treatment of Uncomplicated Malaria in India | Plasmodium falciparum malaria | Chloroquine (NPC476464) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
TMEM97,TDP1,SIGMAR1,THRB,LMNA
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
TMEM97,TDP1,SIGMAR1,ABCB1,LMNA
|
MalariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F40-1F45 |
KCNH2,CYP2D6
NCT02610686,NCT01443130,NCT01546389,NCT02698748,NCT01500980,NCT00844207,NCT00082576,NCT00084240,NCT00082563,NCT01100060,NCT02389374,NCT00440999,NCT00959517,NCT00282919,NCT02001012,NCT00158548,NCT04368910,NCT00677833,NCT00379821,NCT00074841,NCT00131703,NCT02511054,NCT01814423,NCT00682578,NCT01290601,NCT00084227,NCT01680406,NCT03503058,NCT01708876,NCT01378286,NCT00367653,NCT01205178,NCT00442403,NCT00871156,NCT00118807,NCT03278808,NCT00290420,NCT00323375,NCT02996695,NCT02773979 |
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
TDP1,KCNH2,THRB,SIGMAR1
|
Pregnancy/childbirth/puerperium maternal infectionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JB63 |
NCT00131703,NCT01103063,NCT01103713
|
Glioblastoma, primary, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH0MB1 |
NCT02378532,NCT00224978,NCT02432417
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
KCNH2,ABCB1,LMNA
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
THRB,KCNH2,ABCB1
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
KCNH2,TMEM97,CYP3A4
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
TMEM97,SIGMAR1
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
TMEM97,SIGMAR1
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
KCNH2,SIGMAR1
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
ABCB1,CYP3A4
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
KCNH2
NCT00050232 |
Amyotrophic lateral sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B60.0 |
NCT00021697,NCT03883581
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
NCT01292408,NCT02333890
|
Small cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.1 |
NCT01575782,NCT00969306
|
Single episode depressive disorder, severe, without psychotic symptomsDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70.3 |
NCT01882829,NCT01460381
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
NCT01941095,NCT00521924
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
TDP1,TMEM97
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
KCNH2,LMNA
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
KCNH2,KCNH2
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
KCNH2,CYP2D6
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
KCNH2,CYP3A4
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
KCNH2,TMEM97
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
KCNH2,CYP3A4
|
COVID-19Disease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D6Y |
NCT04351724,NCT04333628,NCT04349371,NCT04360759,NCT04627467,NCT04319900,NCT04303299,NCT04447534,NCT04420247,NCT04353336,NCT04345406,NCT04351295
|
Malaria due to Plasmodium vivaxDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F41 |
NCT00158548,NCT01376167,NCT02348788,NCT01640574,NCT00811096,NCT00682578,NCT02216123,NCT02691910,NCT01074905,NCT00486694,NCT02563496
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
ABCB1
|
SomnolenceDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG42 |
SIGMAR1
|
CataractDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B10 |
SIGMAR1
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
SIGMAR1
|
Central nervous system diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A04-8D87 |
SIGMAR1
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
ABCB1
|
Cystic fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA25 |
SIGMAR1
|
Mood disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60-6E23 |
SIGMAR1
|
CoughDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD12 |
SIGMAR1
|
Epileptic encephalopathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A62 |
SIGMAR1
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
THRB
|
Immune system diseaseDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A01-4B41 |
SIGMAR1
|
Psychotic disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20-6A25 |
SIGMAR1
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
CYP2D6
|
Sexual dysfunctionDisease Category: 17.Conditions related to sexual healthDisease ICD-11 Code: HA00-HA01 |
SIGMAR1
|
Bulimia nervosaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B81 |
SIGMAR1
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CYP3A4
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
SIGMAR1
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
SIGMAR1
|
Hypo-thyroidismDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A00 |
THRB
|
DepressionDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70-6A7Z |
SIGMAR1
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
KCNH2
|
Sleep-wake disorderDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7B2Z |
KCNH2
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
CYP3A4
|
Neurobehavioral disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00-8A0Z |
SIGMAR1
|
Intellectual development disorderDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD90 |
SIGMAR1
|
Inborn lipid metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52 |
THRB
|
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62.Z |
NCT00819390
|
Chronic hepatitis B, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E51.0Z |
NCT04783753
|
Sickle-cell disorderDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3A51 |
NCT01718054
|
Cardiac arrhythmiaDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC9Z |
NCT00789165
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
NCT03610945
|
Brain diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70-8E61 |
NCT01894633
|
InfluenzaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E30-1E32 |
NCT01078779
|
Pneumonia due to Respiratory syncytial virusDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA40.11 |
NCT03755778
|
Cardiac arrestDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MC82 |
NCT00000464
|
Dengue with warning signsDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D21 |
NCT00849602
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
NCT01438177
|
Unspecified malignant neoplasms of unspecified sitesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D4Z |
NCT02071537
|
Depressive disorders, unspecifiedDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A7Z |
NCT02153502
|
GliosarcomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH9RC8 |
NCT04397679
|
Ventricular fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC71.1 |
NCT00000464
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
NCT00000464
|
Malignant neoplasm of pancreas, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.Z |
NCT01777477
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
NCT01946880
|
Ductal carcinoma in situ of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E65.2 |
NCT01023477
|
Congenital human immunodeficiency virus infectionDisease Category: 19.Certain conditions originating in the perinatal periodDisease ICD-11 Code: KA62.6 |
NCT00972725
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
NCT00000556
|
Migraine disorder(TM1)Disease Category: 26.Supplementary Chapter Traditional Medicine Conditions - Module IDisease ICD-11 Code: SD10 |
NCT02176018
|
ConstipationDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME05.0 |
NCT01533155
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
KCNH2
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
KCNH2
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
KCNH2
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
LMNA
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CYP3A4
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CYP2D6
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Polycystic ovary syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80.1 |
TMEM97
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
THRB
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
Plant-Targeted Human Disease Network
>> Targets derived from weak experimental activities
