Collective Molecular Activities of the Plant: Petunia Nyctaginiflora
Plant ID: NPO25031
Plant Latin Name: Petunia Nyctaginiflora
Taxonomy Genus: Petunia
Taxonomy Family: Solanaceae
Plant External Links:
NCBI TaxonomyDB:
310461
Plant-of-the-World-Online:
n.a.
Country/Region:
ChinaTraditional Medicine System:
TCMChina
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
88 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
78 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
40 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99445
Ingredient ID: NPC96484
Ingredient ID: NPC95701
Ingredient ID: NPC94818
Ingredient ID: NPC93699
Ingredient ID: NPC86324
Ingredient ID: NPC86268
Ingredient ID: NPC84790
Ingredient ID: NPC81615
Ingredient ID: NPC78540
Ingredient ID: NPC710
Ingredient ID: NPC66764
Ingredient ID: NPC61773
Ingredient ID: NPC60951
Ingredient ID: NPC53877
Ingredient ID: NPC46206
Ingredient ID: NPC36061
Ingredient ID: NPC309697
Ingredient ID: NPC307815
Ingredient ID: NPC305986
Ingredient ID: NPC294578
Ingredient ID: NPC294548
Ingredient ID: NPC294230
Ingredient ID: NPC292832
Ingredient ID: NPC28685
Ingredient ID: NPC281138
Ingredient ID: NPC274995
Ingredient ID: NPC274248
Ingredient ID: NPC271276
Ingredient ID: NPC271240
Ingredient ID: NPC266193
Ingredient ID: NPC264803
Ingredient ID: NPC263582
Ingredient ID: NPC262561
Ingredient ID: NPC261831
Ingredient ID: NPC257666
Ingredient ID: NPC255170
Ingredient ID: NPC253455
Ingredient ID: NPC251475
Ingredient ID: NPC247586
Ingredient ID: NPC247524
Ingredient ID: NPC245795
Ingredient ID: NPC24491
Ingredient ID: NPC244790
Ingredient ID: NPC243728
Ingredient ID: NPC243083
Ingredient ID: NPC242211
Ingredient ID: NPC241838
Ingredient ID: NPC241337
Ingredient ID: NPC230301
Ingredient ID: NPC229497
Ingredient ID: NPC224493
Ingredient ID: NPC223114
Ingredient ID: NPC215914
Ingredient ID: NPC214280
Ingredient ID: NPC208791
Ingredient ID: NPC20573
Ingredient ID: NPC203829
Ingredient ID: NPC203674
Ingredient ID: NPC197114
Ingredient ID: NPC188344
Ingredient ID: NPC185444
Ingredient ID: NPC182420
Ingredient ID: NPC180203
Ingredient ID: NPC178852
Ingredient ID: NPC171450
Ingredient ID: NPC17052
Ingredient ID: NPC169941
Ingredient ID: NPC169275
Ingredient ID: NPC168514
Ingredient ID: NPC16828
Ingredient ID: NPC165967
Ingredient ID: NPC163624
Ingredient ID: NPC163296
Ingredient ID: NPC162236
Ingredient ID: NPC161788
Ingredient ID: NPC156654
Ingredient ID: NPC152042
Ingredient ID: NPC135294
Ingredient ID: NPC134609
Ingredient ID: NPC132065
Ingredient ID: NPC127582
Ingredient ID: NPC127447
Ingredient ID: NPC120104
Ingredient ID: NPC110150
Ingredient ID: NPC10855
Ingredient ID: NPC104565
Ingredient ID: NPC103308
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Therapeutic Target | Fatty acid binding protein family | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
| Therapeutic Target | Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Therapeutic Target | Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 4 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00638196 | Placebo vs. Linoleic Acid Controlled Assessment of Treatment Efficacy in MS | multiple sclerosis | Oleic Acid (NPC261831) | NP level |
| NCT01661764 | Fish Oil Supplementation, Nutrigenomics and Colorectal Cancer Prevention | colorectal adenoma | Oleic Acid (NPC261831) | NP level |
| NCT01792310 | A Phase 1/2A Study of LAM561 in Adult Patients With Advanced Solid Tumours | glioma | Oleic Acid (NPC261831) | NP level |
| NCT02059785 | Phase ⅡStudy of Pinocembrin Injection to Treat Ischemic Stroke | Ischemic stroke | Pinocembrin (NPC243083) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOA
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PPARA
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA7,NR1I2,XDH,CBR1,F2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CYP1B1,CA14,CA7,NR1I2,XDH,CBR1,CYP2C19,ALOX15,CA2,F2
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
FABP5,ALOX15
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CYP19A1,ALOX15,F2
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
MAOA
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
CA4,F2,CBR1
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
CA7
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
