Collective Molecular Activities of the Plant: Achillea Millefolium
Plant ID: NPO25014
Plant Latin Name: Achillea Millefolium
Taxonomy Genus: Achillea
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
13329
Plant-of-the-World-Online:
n.a.
Country/Region:
Brazil; Turkey; Israel; Albania; Italy; Canada; India; Finland; Lithuania; Sweden; Vietnam; China; Switzerland; Russia; SpainTraditional Medicine System:
Unani; TCM; Homeopathy; SiddhaMedicinal Functions:
Antidiarrhoeal; Antiinflammatory; Antiseptic; Antispasmodic; Appetizer; Aromatic; Astringent; Carminative; Cholagogue; Diaphoretic; Digestive; Emmenagogue; Odontalgic; Stimulant; Tonic; Vasodilator; Vulnerary
Brazil; Canada; Israel; Albania; Italy; Lithuania; Turkey; Finland; India; Sweden; Vietnam; China; Switzerland; Russia; Spain
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
88 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
46 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
20 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99453
Ingredient ID: NPC9880
Ingredient ID: NPC9545
Ingredient ID: NPC89069
Ingredient ID: NPC88566
Ingredient ID: NPC80866
Ingredient ID: NPC7568
Ingredient ID: NPC75158
Ingredient ID: NPC7472
Ingredient ID: NPC70840
Ingredient ID: NPC59953
Ingredient ID: NPC59425
Ingredient ID: NPC50898
Ingredient ID: NPC46139
Ingredient ID: NPC42579
Ingredient ID: NPC41354
Ingredient ID: NPC4011
Ingredient ID: NPC36151
Ingredient ID: NPC328788
Ingredient ID: NPC326583
Ingredient ID: NPC321461
Ingredient ID: NPC318019
Ingredient ID: NPC317130
Ingredient ID: NPC316301
Ingredient ID: NPC3155
Ingredient ID: NPC310457
Ingredient ID: NPC307125
Ingredient ID: NPC299131
Ingredient ID: NPC294902
Ingredient ID: NPC292971
Ingredient ID: NPC282509
Ingredient ID: NPC277976
Ingredient ID: NPC277693
Ingredient ID: NPC270204
Ingredient ID: NPC264470
Ingredient ID: NPC263428
Ingredient ID: NPC262036
Ingredient ID: NPC259624
Ingredient ID: NPC259152
Ingredient ID: NPC257412
Ingredient ID: NPC257124
Ingredient ID: NPC249806
Ingredient ID: NPC249203
Ingredient ID: NPC247113
Ingredient ID: NPC23941
Ingredient ID: NPC237332
Ingredient ID: NPC234106
Ingredient ID: NPC231660
Ingredient ID: NPC231577
Ingredient ID: NPC230085
Ingredient ID: NPC230048
Ingredient ID: NPC222544
Ingredient ID: NPC218610
Ingredient ID: NPC216308
Ingredient ID: NPC216243
Ingredient ID: NPC213319
Ingredient ID: NPC204838
Ingredient ID: NPC197316
Ingredient ID: NPC196776
Ingredient ID: NPC196490
Ingredient ID: NPC195146
Ingredient ID: NPC190291
Ingredient ID: NPC177702
Ingredient ID: NPC176300
Ingredient ID: NPC173204
Ingredient ID: NPC168271
Ingredient ID: NPC167551
Ingredient ID: NPC167134
Ingredient ID: NPC165287
Ingredient ID: NPC160661
Ingredient ID: NPC159630
Ingredient ID: NPC159097
Ingredient ID: NPC154792
Ingredient ID: NPC14930
Ingredient ID: NPC148213
Ingredient ID: NPC14682
Ingredient ID: NPC145379
Ingredient ID: NPC144566
Ingredient ID: NPC142227
Ingredient ID: NPC135683
Ingredient ID: NPC126240
Ingredient ID: NPC12568
Ingredient ID: NPC122107
Ingredient ID: NPC120468
Ingredient ID: NPC11546
Ingredient ID: NPC1075
Ingredient ID: NPC104195
Ingredient ID: NPC103681
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Metallo protease | MMP1 | Matrix metalloproteinase-1 | P03956 | CHEMBL332 |
| Therapeutic Target | Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
| Therapeutic Target | Metallo protease | MMP9 | Matrix metalloproteinase 9 | P14780 | CHEMBL321 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Therapeutic Target | Oxidoreductase | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | P14061 | CHEMBL3181 |
| Therapeutic Target | Oxidoreductase | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 3 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT02351622 | Caffeic Acid Tablets as a Second-line Therapy for ITP | autoimmune thrombocytopenic purpura | Caffeic Acid (NPC294902) | NP level |
| NCT02662283 | Validity and Security of Reh-acteoside Therapy for Patients of IgA Nephropathy | IGA glomerulonephritis | Acetoside (NPC197316) | NP level |
| NCT04648917 | GASC1 Inhibitor Caffeic Acid for Squamous Esophageal Cell Cancer (ESCC) | esophageal cancer | Caffeic Acid (NPC294902) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
DPP4
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE,MMP9,THPO,TSHR,XDH,MMP1,TTR
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ACHE,LMNA,DPP4,XDH,CYP1B1,MMP1,MMP2,TTR
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
TTR
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
MMP9,CYP19A1,MMP1
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
ESR2,ACHE
|
AmyloidosisDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5D00 |
TTR
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
