Plant ID: NPO2494
Plant Latin Name: Xanthium Strumarium
Taxonomy Genus: Xanthium
Taxonomy Family: Asteraceae
NCBI TaxonomyDB:
318068
Plant-of-the-World-Online:
n.a.
Plant ID: NPO2494
Plant Latin Name: Xanthium Strumarium
Taxonomy Genus: Xanthium
Taxonomy Family: Asteraceae
NCBI TaxonomyDB:
318068
Plant-of-the-World-Online:
n.a.
Anodyne; Antibacterial; Antifungal; Antiperiodic; Antirheumatic; Antispasmodic; Antitussive; Appetizer; Cytotoxic; Diaphoretic; Diuretic; Emollient; Febrifuge; Hypoglycaemic; Laxative; Sedative; Stomachic
Thailand; India
Ingredient ID: NPC93708
Ingredient ID: NPC92864
Ingredient ID: NPC92774
Ingredient ID: NPC92430
Ingredient ID: NPC91696
Ingredient ID: NPC88804
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Ingredient ID: NPC85813
Ingredient ID: NPC85597
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Ingredient ID: NPC83546
Ingredient ID: NPC8313
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Ingredient ID: NPC302857
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Ingredient ID: NPC295978
Ingredient ID: NPC294902
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Ingredient ID: NPC290887
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Ingredient ID: NPC156655
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Ingredient ID: NPC116317
Ingredient ID: NPC115997
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Ingredient ID: NPC114682
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Ingredient ID: NPC113212
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Ingredient ID: NPC110699
Ingredient ID: NPC10866
Ingredient ID: NPC108047
Ingredient ID: NPC1075
Ingredient ID: NPC107482
Ingredient ID: NPC105817
Ingredient ID: NPC104743
Ingredient ID: NPC102177
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
Therapeutic Target | Fatty acid binding protein family | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Therapeutic Target | Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
Therapeutic Target | Membrane receptor | APP | Beta amyloid A4 protein | P05067 | CHEMBL2487 |
Therapeutic Target | Metallo protease | MMP1 | Matrix metalloproteinase-1 | P03956 | CHEMBL332 |
Therapeutic Target | Metallo protease | MMP9 | Matrix metalloproteinase 9 | P14780 | CHEMBL321 |
Therapeutic Target | Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
Therapeutic Target | Nuclear hormone receptor subfamily 1 | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
Therapeutic Target | Oxidoreductase | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
Therapeutic Target | Oxidoreductase | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
Therapeutic Target | Oxidoreductase | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
Therapeutic Target | Oxidoreductase | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
Therapeutic Target | Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
Therapeutic Target | Small molecule receptor (family A GPCR) | FFAR1 | Free fatty acid receptor 1 | O14842 | CHEMBL4422 |
Therapeutic Target | Small molecule receptor (family A GPCR) | FFAR4 | G-protein coupled receptor 120 | Q5NUL3 | CHEMBL5339 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Therapeutic Target | Transcription factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Therapeutic Target | Unclassified protein | SNCA | Alpha-synuclein | P37840 | CHEMBL6152 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 58 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00855881 | Metronomic Chemotherapy With Tegafur/Uracil for Head and Neck Squamous Cell Carcinoma | head and neck malignant neoplasia | Uracil (NPC27699) | NP level |
NCT02063802 | Metformin vs Conjugated Linoleic Acid and an Intervention Program With Healthy Habits in Obese Children | obesity | Linoleic Acid (NPC85813) | NP level |
NCT03751592 | Phase Ib/IIa Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Advanced Lung Cancer | lung cancer | Chlorogenic Acid (NPC302857) | NP level |
NCT02245204 | Phase I Studies of Chlorogenic Acid for Injection for Tolerance and Pharmacokinetic of Advanced Cancers | cancer | Chlorogenic Acid (NPC302857) | NP level |
NCT00037089 | A Phase II Study of Paclitaxel, UFT, and Leucovorin in Patients With Metastatic Esophageal Cancer | neoplasm of esophagus | Uracil (NPC27699) | NP level |
NCT00378716 | Combination Chemotherapy in Treating Patients With Resected Colon Cancer | colorectal carcinoma | Uracil (NPC27699) | NP level |
NCT00005608 | Fluorouracil-Uracil and Leucovorin in Treating Women With Metastatic Breast Cancer | breast cancer | Uracil (NPC27699) | NP level |
NCT01871142 | Evaluation of the Attenuation by Aes-103 of Hypoxia Mediated Decrements in Endurance Exercise Performance | hypoxia | 5-Hydroxymethyl-Furfural (NPC107482) | NP level |
NCT00951158 | A Molecular Pharmacodynamic Dose-titration Trial of Conjugated Linoleic Acid (CLA; Clarinol®) in Patients With Advanced Solid Tumors | neoplasm | Linoleic Acid (NPC85813) | NP level |
NCT02136342 | Phase 1 Trial of Chlorogenic Acid in Patients With Advanced Cancer | cancer | Chlorogenic Acid (NPC302857) | NP level |
NCT01474499 | A Trial of Docusate Sodium and Sorbitol Rectal Solution for the in Patients With Constipation | Constipation | Sorbitol (NPC66052) | NP level |
NCT00004860 | Fluorouracil-Uracil and Leucovorin in Treating Elderly Patients With Metastatic Colorectal Cancer | colorectal carcinoma | Uracil (NPC27699) | NP level |
NCT00384800 | A Phase II Study of Tegafur/Uracil (UFUR®)Plus Thalidomide for the Treatment of Advanced or Metastatic Hepatocellular Carcinoma (HCC) | hepatocellular carcinoma | Uracil (NPC27699) | NP level |
NCT00908791 | Proof of Principle Trial to Determine if Nutritional Supplement Conjugated Linoleic Acid (CLA) Can Modulate the Lipogenic Pathway in Breast Cancer Tissue | breast cancer | Linoleic Acid (NPC85813) | NP level |
NCT02728349 | Tolerance and Pharmacokinetic Study of Chlorogenic Acid to Advanced Glioblastoma | glioblastoma multiforme | Chlorogenic Acid (NPC302857) | NP level |
NCT00204932 | Effects of CLA Supplements on Body Weight and Fat Oxidation | obesity | Linoleic Acid (NPC85813) | NP level |
NCT00336947 | S-1 or Tegafur-Uracil in Treating Patients With Previously Treated Stage III or Stage IV Head and Neck Cancer | head and neck malignant neoplasia | Uracil (NPC27699) | NP level |
NCT00385970 | A Phase III Trial Comparing UFT+PSK to UFT+LV in Stage IIB, III Colorectal Cancer | colorectal carcinoma | Uracil (NPC27699) | NP level |
NCT00607945 | Dietary Fatty Acids as Complementary Therapy in Type 2 Diabetes Mellitus | type 2 diabetes mellitus | Linoleic Acid (NPC85813) | NP level |
NCT00152191 | A Randomized Controlled Study of Postoperative Adjuvant Therapy of Uracil-tegafur (UFT) Compared With Cyclophosphamide/Methotrexate/5-fluorouracil (CMF) in Breast Cancer (NSAS-BC) | breast cancer | Uracil (NPC27699) | NP level |
NCT00519688 | UFUR Plus Thalidomide for Advanced Hepatocellular Carcinoma | hepatocellular carcinoma | Uracil (NPC27699) | NP level |
NCT00010686 | Dietary Phytoestrogens and Bone Metabolism | osteoporosis | Formononetin (NPC209560) | NP level |
NCT00374881 | A Study of the Safety and Efficacy of Combination Therapy With Morphine, Phenylephrine and Sorbitol in Human Subjects | pain | Sorbitol (NPC66052) | NP level |
NCT00002801 | Combination Chemotherapy and Radiation Therapy in Treating Patients With Colorectal Cancer | colorectal carcinoma | Uracil (NPC27699) | NP level |
NCT02351622 | Caffeic Acid Tablets as a Second-line Therapy for ITP | autoimmune thrombocytopenic purpura | Caffeic Acid (NPC294902) | NP level |
NCT01528969 | Effect of Xylitol on Oral Microbiota in Children | bacterial disease | Sorbitol (NPC66052) | NP level |
NCT03758014 | Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Grade IV GBM Patients | glioblastoma multiforme | Chlorogenic Acid (NPC302857) | NP level |
NCT00152230 | A Randomized Controlled Study of Postoperative Adjuvant Chemotherapy of Uracil- Tegafur (UFT) Compared With Surgery Alone (NSAS-CC) | colorectal carcinoma | Uracil (NPC27699) | NP level |
NCT00152178 | The Comparative Trial of UFT + TAM With CMF + TAM in Adjuvant Therapy for Breast Cancer (CUBC) | breast cancer | Uracil (NPC27699) | NP level |
NCT00152243 | A Randomized Controlled Study of Postoperative Adjuvant Chemotherapy of Uracil- Tegafur (UFT) Compared With Surgery Alone (NSAS-GC) | gastric cancer | Uracil (NPC27699) | NP level |
NCT01987908 | Evaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Disease | sickle cell anemia | 5-Hydroxymethyl-Furfural (NPC107482) | NP level |
NCT00660894 | Tegafur-Uracil and Leucovorin or S-1 in Treating Patients With Stage III Colon Cancer That Has Been Completely Removed by Surgery | colorectal carcinoma | Uracil (NPC27699) | NP level |
NCT02621060 | Effect of Chlorogenic Acid on Patients With Impaired Glucose Tolerance | abnormal glucose tolerance | Chlorogenic Acid (NPC302857) | NP level |
NCT03636971 | Gait Analysis Following Knee Viscosupplementation | osteoarthritis | Sorbitol (NPC66052) | NP level |
NCT00905047 | Xeloda or UFT (Tegafur-uracil) With Folinic Acid in Advanced or Metastatic Colorectal Cancer | colorectal carcinoma | Uracil (NPC27699) | NP level |
NCT00705874 | Study of CGC-11047 When Used in Individual Combinations With 1) Gemcitabine or 2) Docetaxel or 3) Bevacizumab or 4) Erlotinib or 5) Cisplatin or 6) 5-Flurouracil or 7) Sunitinib in Patients With Advanced Solid Tumors or Lymphoma | cancer | Uracil (NPC27699) | NP level |
NCT01792310 | A Phase 1/2A Study of LAM561 in Adult Patients With Advanced Solid Tumours | glioma | Oleic Acid (NPC261831) | NP level |
NCT01037998 | UFUR (Tegafur/Uracil) Plus Iressa in Non-small-cell Lung Cancer | non-small cell lung carcinoma | Uracil (NPC27699) | NP level |
NCT00029679 | Borage Oil and Ginkgo Biloba (EGb 761) in Asthma | asthma | Linoleic Acid (NPC85813) | NP level |
NCT00638196 | Placebo vs. Linoleic Acid Controlled Assessment of Treatment Efficacy in MS | multiple sclerosis | Oleic Acid (NPC261831) | NP level |
NCT02447679 | Oral Thalidomide and Tegafur-uracil to Decrease Hepatocellular Carcinoma Recurrence | hepatocellular carcinoma | Uracil (NPC27699) | NP level |
NCT04330326 | Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease | non-alcoholic fatty liver disease | Sorbitol (NPC66052) | NP level |
NCT04649203 | Cytoflavin in the Treatment of Patients With Diabetic Polyneuropathy | diabetic neuropathy | Succinic Acid (NPC236709) | NP level |
NCT00009828 | Paclitaxel Combined With Fluorouracil-Uracil and Leucovorin in Treating Patients With Solid Tumors | neoplasm | Uracil (NPC27699) | NP level |
NCT04573153 | Metabolic Cofactor Supplementation and Hydroxychloroquine Combination in Covid-19 Patients | COVID-19 | Sorbitol (NPC66052) | NP level |
NCT04762758 | Phase III Trial Assessing the Efficacy and Safety of PXT3003 in CMT1A Patients | Charcot-Marie-Tooth disease | Sorbitol (NPC66052) | NP level |
NCT03747679 | Palatability (Taste) of Oral Formulations of Bosutinib | chronic myelogenous leukemia | Sorbitol (NPC66052) | NP level |
NCT04648917 | GASC1 Inhibitor Caffeic Acid for Squamous Esophageal Cell Cancer (ESCC) | esophageal cancer | Caffeic Acid (NPC294902) | NP level |
NCT00207831 | Trial Testing Ftorafur (UFT) Associated With Neoadjuvant Radiotherapy Versus Radiotherapy Alone in Rectal Adenocarcinoma | rectum cancer | Uracil (NPC27699) | NP level |
NCT05450458 | Hyaluronic Acid in Overuse Knee Pain | injury | Sorbitol (NPC66052) | NP level |
NCT01539018 | Sorafenib Plus Tegafur-uracil (UFT) Versus Sorafenib as First Line Systemic Treatment for Patients With Advanced Stage HCC, Unresectable & Not Eligible for Local Ablation and/or TACE | hepatocellular carcinoma | Uracil (NPC27699) | NP level |
NCT01082510 | Study of the Efficacy of Maintenance Therapy Using Uracil-tegafur (UFT) or Bacille Calmette-Guerin (BCG) for the Prevention of Recurrences of Superficial Bladder Cancer (EMBARK Study) | urinary bladder cancer | Uracil (NPC27699) | NP level |
NCT00009815 | Combination Chemotherapy in Treating Patients With Advanced Solid Tumors | neoplasm | Uracil (NPC27699) | NP level |
NCT01262274 | Randomized Phase II Trial of Anastrozole Plus Metronomic Tegafur-uracil as Neo-adjuvant Therapy in Postmenopausal Breast Cancer | breast neoplasm | Uracil (NPC27699) | NP level |
NCT03121313 | Maintenance Tegafur-uracil in Resected Oral Cavity Cancer With ECS+ | oral squamous cell carcinoma | Uracil (NPC27699) | NP level |
NCT01597401 | A Single Dose Study of the Safety, Blood Levels and Biological Effects of Aes-103 Compared to Placebo in Subjects With Stable Sickle Cell Disease | sickle cell anemia | 5-Hydroxymethyl-Furfural (NPC107482) | NP level |
NCT00003925 | Combination Chemotherapy In Treating Patients With Advanced Cancer | neoplasm | Uracil (NPC27699) | NP level |
NCT01661764 | Fish Oil Supplementation, Nutrigenomics and Colorectal Cancer Prevention | colorectal adenoma | Oleic Acid (NPC261831) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
AKR1B10,AKR1C3,MMP9,TSHR,F2,MMP1,CA9,OR51E2,CYP2C9
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
MMP9,PPARA,ESR1,APP,CA2,CA9,CA14,NFKB1
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA9,ESR1,CA2,CA14
NCT00005608,NCT00908791,NCT00152178,NCT00152191 |
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
NCT00002801,NCT01661764,NCT00385970,NCT00905047,NCT00152230,NCT00660894,NCT00378716,NCT00004860
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
CA14,APP,FABP5,MMP9,CA2,MMP1,SNCA,OR51E2
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
LMNA,AKR1B1,FABP5,MMP9,MMP2,MMP1,CA9,OR51E2
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
AKR1B10,AKR1C3,MMP9,TSHR,F2,MMP1,CA9,CYP2C9
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
AKR1B10,MMP9,CA2,F2,MMP1,CA9,ALOX15,CYP2C9
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
FABP5,MMP9,FFAR1,MMP1,CA9,FABP3,SNCA,OR51E2
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
AKR1B10,AKR1B1,MMP9,TSHR,MMP2,MMP1
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
AKR1C3,MMP9,F2,MMP1,CA9,FABP4
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
AKR1B1,MMP9,CA2,MMP1,CA9,CYP2C9
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
CA14,KDM4E,MMP9,CA2,ALOX15,CYP2C9
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
AKR1B10,LMNA,FABP5,CA2,TSHR,CA9
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
MMP9,CA2,MMP1,NFKB1,AKR1B1
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
PPARA,F2,FFAR1,NFKB1
NCT00607945 |
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
AKR1B10,AKR1C3,MMP9,MMP1,CA9
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
MMP9,MMP1,MMP2,ESR1
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
NFKB1,ESR1,F2
NCT00638196 |
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA2,CA14,CYP2C9
NCT01528969 |
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
MMP1,MMP9,MMP2
NCT03751592 |
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
PPARA
MMP9,FABP4 NCT04330326 |
Hepatocellular carcinoma, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH4W48 |
NCT01539018,NCT02447679,NCT00384800,NCT00519688
|
NeoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 02 |
NCT00009828,NCT00003925,NCT00951158,NCT00009815
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
ALOX15,MMP9,MMP1
NCT00037089 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
MMP9,F2,MMP1,ALOX15
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
SNCA,CA2,LMNA,FABP3
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
MMP9,MMP1,ESR1,CA9
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
MMP2,FFAR4,ESR1,OR51E2
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
ESR1,PPARA,NFKB1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PPARA,AKR1B1,FFAR1
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
CA9,MMP9,MMP2
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
MMP9
MMP9,MMP1 |
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
NFKB1
AKR1B10,FABP5 |
Unspecified malignant neoplasms of unspecified sitesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D4Z |
NCT00705874,NCT02136342,NCT02245204
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
F2,MMP1,CA9
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
APP,FABP3,FFAR1
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
FABP5,ALOX15,OR51E2
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
MMP9,CA9,MMP1
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA,FFAR1,MMP2
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
AKR1B10,AKR1C3,MMP9
|
Low bone mass disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83 |
ESR1,CA2
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
PPARA,F2
|
ThrombosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB61-GB90 |
AKR1B1,F2
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
AKR1C3,ESR1
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
MMP1,MMP2
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1,MMP2
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
CA2,AKR1B1
|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
F2,MMP9
|
Female pelvic painDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA34 |
ESR1,AKR1C3
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
NCT00029679 |
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
ESR1,PPARA
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
APP,SNCA
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
AKR1B1
NCT00374881 |
Sickle-cell disorderDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3A51 |
NCT01597401,NCT01987908
|
Malignant neoplasms of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
FABP4
NCT00152243 |
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
NCT02063802,NCT00204932
|
Glioblastoma, primary, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH0MB1 |
NCT02728349,NCT03758014
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
NCT00855881,NCT00336947
|
Myelodysplastic syndromes, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A3Z |
CYP2C9,TSHR
|
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
MMP9,MMP1
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
MMP9,MMP2
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
CA14,F2
|
Systemic sclerosisDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A42 |
FABP4,MMP1
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
FFAR1,MMP9
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
FFAR1,MMP1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
AKR1B10,CA14,LMNA,APP,AKR1C3,CA2,MMP2,F2,MMP1,FFAR4,CA9,FABP3,ALOX15,OR51E2,CYP2C9,SNCA
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
LMNA,TDP1,PPARA,AKR1B1,HSD17B10,TRIM24,FABP5,FFAR1,TSHR,MMP2,MMP1,FABP4,CA9,FABP3,OR51E2
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
AKR1B10,CA14,TDP1,AKR1B1,HSD17B10,FABP5,MMP9,CA2,FFAR1,TSHR,MMP1,FFAR4,CA9,ALOX15
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
AKR1B10,FABP5,MMP9,FFAR4,CA9,CYP2C9,FABP5,MMP9,TSHR,F2,MMP1,FFAR4,CA9,OR51E2
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
AKR1B10,FABP5,AKR1C3,MMP9,FABP4,MMP1,CA9,OR51E2,AKR1B10,AKR1C3,TRIM24,MMP9,MMP1,CA9
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
AKR1B10,TDP1,FABP5,MMP9,CA2,TSHR,MMP1,FFAR4,ESR1,CA9,FABP3,ALOX15
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
AKR1B10,LMNA,TDP1,MMP9,FFAR1,MMP1,FFAR4,CA9,ALOX15,OR51E2,SNCA
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
AKR1B10,AKR1B1,HSD17B10,NFKB1,MMP9,TRIM24,FABP5,FFAR4,CA9,ALOX15,CYP2C9
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
AKR1B10,AKR1B1,FABP5,TRIM24,MMP9,MMP2,MMP1,FABP4,FABP3,OR51E2
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
CA14,APP,AKR1B1,FABP5,MMP2,F2,MMP1,FABP3,CYP2C9,SNCA
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
CA2
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
SNCA
|
Irritable bowel syndromeDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD91 |
NFKB1
|
Menstrual cycle bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20 |
ESR1
|
DyslipidemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80-5C81 |
PPARA
|
Stomach cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
MMP9
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F2
|
Skin and skin-structure infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F28-1G0Z |
NFKB1
|
Unspecified viral infection of unspecified siteDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D9Z |
ESR1
|
Dystrophic epidermolysis bullosaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EC32 |
APP
|
Desmoid tumourDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F7C |
APP
|
Male infertilityDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB04 |
ESR1
|
Hepatic fibrosis/cirrhosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB93 |
MMP2
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
CA2
|
VaginitisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA02 |
ESR1
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Menopausal disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA30 |
ESR1
|
Lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40 |
NFKB1
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
CA2
|
Inborn lipid metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52 |
PPARA
|
HyperlipidemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
PPARA
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
CA9
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
F2
|
Skeletal anomalyDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD24 |
ESR1
|
Coronary thrombosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA43 |
F2
|
Breast in situ carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E65 |
ESR1
|
AmyloidosisDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5D00 |
APP
|
Duodenal ulcerDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA63 |
CA2
|
Metastatic tumourDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D50-2E2Z |
ESR1
|
Pituitary gland disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A60-5A61 |
ESR1
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
NFKB1
|
Hypo-thyroidismDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A00 |
TSHR
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
NFKB1
|
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
TNKS
|
Thyroid cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10 |
TSHR
|
RetinopathyDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B71 |
APP
|
Inborn metabolism deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5C59 |
CA14
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
NFKB1
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
AKR1B1
|
DyspareuniaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA12 |
ESR1
|
EndometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10 |
ESR1
|
Cerebral ischaemic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B11 |
F2
|
Muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70 |
NFKB1
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Diagnostic imagingDisease Category: NADisease ICD-11 Code: N.A. |
APP
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
Essential hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00 |
CA2
|
Female genital tract noninflammatory disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA1Y |
ESR1
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
F2
|
Autonomic nervous system disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87 |
SNCA
|
Coagulation defectDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B10 |
F2
|
Adrenal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
ESR1
|
CataractDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B10 |
AKR1B1
|
GoutDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA25 |
PPARA
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
NFKB1
|
Ulcerative colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD71 |
MMP9
|
Idiopathic interstitial pneumonitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03 |
FFAR1
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
AKR1B1
|
Nutritional deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B50-5B71 |
F2
|
Female infertilityDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA31 |
ESR1
|
Unspecific body region injuryDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: ND56 |
NCT05450458
|
Rectum cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B92 |
NCT00207831
|
Hereditary sensory or autonomic neuropathy, unspecifiedDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C21.Z |
NCT04762758
|
Esophageal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
NCT04648917
|
OsteoarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA00-FA05 |
NCT03636971
|
Glioma, malignantDisease Category: X.Extension CodesDisease ICD-11 Code: XH4RQ3 |
NCT01792310
|
Chronic myeloid leukaemia, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH4XG8 |
NCT03747679
|
Diabetic polyneuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C03.0 |
NCT04649203
|
AsphyxiaDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD11.1 |
NCT01871142
|
ConstipationDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME05.0 |
NCT01474499
|
Neoplasms of unknown behaviour of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F95 |
NCT01262274
|
Malignant neoplasms of bladder, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.Z |
NCT01082510
|
Immune thrombocytopenic purpuraDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64.10 |
NCT02351622
|
Non-small cell lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
NCT01037998
|
OsteoporosisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83.1 |
NCT00010686
|
Impaired glucose toleranceDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A40.1 |
NCT02621060
|
COVID-19Disease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D6Y |
NCT04573153
|
Squamous cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B60-2D01 |
NCT03121313
|
Coeliac diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA95 |
TSHR
|
Malignant neoplasms of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
FABP4
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
NFKB1
|
Pneumonia due to PseudomonasaeruginosaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA40.05 |
MMP9
|
Polycystic ovary syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80.1 |
FFAR4
|
Malaria, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F4Z |
MMP9
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
FFAR1
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CA2
|
Malignant neoplasm of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
FABP4
|
Lyme borreliosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C1G |
MMP9
|