Collective Molecular Activities of the Plant: Taxus Cuspidata
Country/Region:
South Korea; ChinaTraditional Medicine System:
TCMMedicinal Functions:
Cancer
Japan; South Korea; China; Russia; South Africa
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
156 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
38 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
90 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99266
Ingredient ID: NPC9905
Ingredient ID: NPC98488
Ingredient ID: NPC97435
Ingredient ID: NPC97202
Ingredient ID: NPC95449
Ingredient ID: NPC94602
Ingredient ID: NPC93632
Ingredient ID: NPC86412
Ingredient ID: NPC84455
Ingredient ID: NPC8196
Ingredient ID: NPC80895
Ingredient ID: NPC80599
Ingredient ID: NPC77174
Ingredient ID: NPC67926
Ingredient ID: NPC67246
Ingredient ID: NPC63737
Ingredient ID: NPC62044
Ingredient ID: NPC58439
Ingredient ID: NPC58061
Ingredient ID: NPC52929
Ingredient ID: NPC49016
Ingredient ID: NPC48733
Ingredient ID: NPC486046
Ingredient ID: NPC475586
Ingredient ID: NPC475493
Ingredient ID: NPC475470
Ingredient ID: NPC475400
Ingredient ID: NPC475328
Ingredient ID: NPC475135
Ingredient ID: NPC475128
Ingredient ID: NPC473749
Ingredient ID: NPC473541
Ingredient ID: NPC473443
Ingredient ID: NPC472439
Ingredient ID: NPC472437
Ingredient ID: NPC472418
Ingredient ID: NPC472417
Ingredient ID: NPC472416
Ingredient ID: NPC472395
Ingredient ID: NPC472394
Ingredient ID: NPC472389
Ingredient ID: NPC472388
Ingredient ID: NPC472374
Ingredient ID: NPC472373
Ingredient ID: NPC472372
Ingredient ID: NPC472371
Ingredient ID: NPC472361
Ingredient ID: NPC472360
Ingredient ID: NPC471880
Ingredient ID: NPC471754
Ingredient ID: NPC471629
Ingredient ID: NPC469917
Ingredient ID: NPC469916
Ingredient ID: NPC469742
Ingredient ID: NPC45821
Ingredient ID: NPC453583
Ingredient ID: NPC44315
Ingredient ID: NPC42793
Ingredient ID: NPC4242
Ingredient ID: NPC41226
Ingredient ID: NPC38696
Ingredient ID: NPC37884
Ingredient ID: NPC36041
Ingredient ID: NPC34846
Ingredient ID: NPC328571
Ingredient ID: NPC328256
Ingredient ID: NPC327158
Ingredient ID: NPC326503
Ingredient ID: NPC326016
Ingredient ID: NPC321830
Ingredient ID: NPC320662
Ingredient ID: NPC320285
Ingredient ID: NPC320263
Ingredient ID: NPC319077
Ingredient ID: NPC31829
Ingredient ID: NPC31826
Ingredient ID: NPC317994
Ingredient ID: NPC309559
Ingredient ID: NPC306001
Ingredient ID: NPC304742
Ingredient ID: NPC302607
Ingredient ID: NPC301946
Ingredient ID: NPC300827
Ingredient ID: NPC29896
Ingredient ID: NPC298550
Ingredient ID: NPC295149
Ingredient ID: NPC287301
Ingredient ID: NPC286620
Ingredient ID: NPC284365
Ingredient ID: NPC284022
Ingredient ID: NPC280164
Ingredient ID: NPC277053
Ingredient ID: NPC275170
Ingredient ID: NPC273433
Ingredient ID: NPC266374
Ingredient ID: NPC263650
Ingredient ID: NPC260194
Ingredient ID: NPC259082
Ingredient ID: NPC254274
Ingredient ID: NPC252553
Ingredient ID: NPC250689
Ingredient ID: NPC249004
Ingredient ID: NPC243526
Ingredient ID: NPC242697
Ingredient ID: NPC242662
Ingredient ID: NPC237309
Ingredient ID: NPC237059
Ingredient ID: NPC225663
Ingredient ID: NPC225103
Ingredient ID: NPC225091
Ingredient ID: NPC221801
Ingredient ID: NPC217918
Ingredient ID: NPC217091
Ingredient ID: NPC215892
Ingredient ID: NPC212485
Ingredient ID: NPC209851
Ingredient ID: NPC208553
Ingredient ID: NPC206211
Ingredient ID: NPC204918
Ingredient ID: NPC201759
Ingredient ID: NPC197143
Ingredient ID: NPC195224
Ingredient ID: NPC188968
Ingredient ID: NPC184289
Ingredient ID: NPC184109
Ingredient ID: NPC182826
Ingredient ID: NPC181964
Ingredient ID: NPC181676
Ingredient ID: NPC177861
Ingredient ID: NPC168816
Ingredient ID: NPC168071
Ingredient ID: NPC161924
Ingredient ID: NPC15850
Ingredient ID: NPC155329
Ingredient ID: NPC152006
Ingredient ID: NPC151393
Ingredient ID: NPC148825
Ingredient ID: NPC143609
Ingredient ID: NPC138015
Ingredient ID: NPC137430
Ingredient ID: NPC134130
Ingredient ID: NPC131462
Ingredient ID: NPC129569
Ingredient ID: NPC124455
Ingredient ID: NPC12016
Ingredient ID: NPC118930
Ingredient ID: NPC118123
Ingredient ID: NPC11772
Ingredient ID: NPC114707
Ingredient ID: NPC114357
Ingredient ID: NPC112780
Ingredient ID: NPC111952
Ingredient ID: NPC110070
Ingredient ID: NPC107353
Ingredient ID: NPC102640
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Drug Transporter | Potassium channels | KCNH2 | HERG | Q12809 | CHEMBL240 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A4 | Serotonin transporter | P31645 | CHEMBL228 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | Hydrolase | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | THRB | Thyroid hormone receptor beta-1 | P10828 | CHEMBL1947 |
| Therapeutic Target | Protein Kinase | MTOR | Serine/threonine-protein kinase mTOR | P42345 | CHEMBL2842 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA2A | Alpha-2a adrenergic receptor | P08913 | CHEMBL1867 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HTR2C | Serotonin 2c (5-HT2c) receptor | P28335 | CHEMBL225 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HTR2A | Serotonin 2a (5-HT2a) receptor | P28223 | CHEMBL224 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 2168 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000556 | Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) | atrial fibrillation | Verapamil (NPC42793) | NP level |
| NCT00001272 | A Phase I Study of Taxol, Cisplatin, Cyclophosphamide and Granulocyte Colony-Stimulating Factor (G-CSF) in Previously Nontreated Ovarian Cancer Patients | ovarian neoplasm | Paclitaxel (NPC208553) | NP level |
| NCT00001383 | A Phase I Study of Infusional Paclitaxel With the P-Glycoprotein Antagonist PSC 833 | renal cell carcinoma;lymphoma;ovarian cancer;breast cancer | Paclitaxel (NPC208553) | NP level |
| NCT00001384 | A Pilot Trial of AC (Adriamycin, Cyclophosphamide) Chemotherapy With G-CSF (Granulocyte Colony-Stimulating Factor) Followed by Infusional Taxol (Paclitaxel) as Adjuvant Treatment for High Risk Stage II and Stage III Breast Cancer Patients | breast cancer | Paclitaxel (NPC208553) | NP level |
| NCT00001387 | Phase I and Pharmacokinetic Trial of Paclitaxel (Taxol) Given as a 3-Hour Infusion in Pediatric Patients With Refractory Malignancy | neoplasm | Paclitaxel (NPC208553) | NP level |
| NCT00001426 | A Multi-Institutional Phase II Study of Cyclophosphamide, Paclitaxel, Cisplatin With G-CSF for Patients With Newly Diagnosed Advanced Stage Ovarian Cancer | ovarian neoplasm | Paclitaxel (NPC208553) | NP level |
| NCT00001442 | A Pilot Study of Paclitaxel With Radiation Therapy for Locally Advanced Head and Neck Cancer | squamous cell carcinoma;upper aerodigestive tract neoplasm | Paclitaxel (NPC208553) | NP level |
| NCT00001450 | Phase II Trial of a 96-Hour Continuous Infusion of Paclitaxel Followed by Cisplatin for Patients With Stage III/IV and Relapsed NSCLC | non-small cell lung carcinoma | Paclitaxel (NPC208553) | NP level |
| NCT00001498 | A Pilot Trial of Sequential Chemotherapy With Antimetabolite Induction, High-Dose Alkylating Agent Consolidation With Peripheral Blood Progenitor Cell Support, and Intensification With Paclitaxel and Doxorubicin for Patients With High-Risk Breast Cancer | breast cancer | Paclitaxel (NPC208553) | NP level |
| NCT00001499 | Phase II Neoadjuvant Trial of a Continuous Infusion of Paclitaxel Plus Cisplatin Followed by Chest Radiotherapy for Patients With Stage III Non-Small Cell Lung Cancer | non-small cell lung carcinoma | Paclitaxel (NPC208553) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Actinic keratosisDisease Category: X.Extension CodesDisease ICD-11 Code: XH36H6 |
NCT03083470
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
HTR2A,HTR2C
|
Acute upper respiratory infectionDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA07 |
DRD3
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ADRA2A,KCNH2,SLCO1B1,GMNN,SLCO1B3,HTR2C,HTR2B
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA,KCNH2,NPC1,PMP22,SLCO1B3,ITGAV,CACNA1C,HTR2A,TUBB6,HTR2B,ABCB1,ABCG2
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
SLCO1B3,SLCO1B1
NCT00521781,NCT04221828 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
SLCO1B1,SLCO1B3,HTR2C
NCT02625623,NCT01336062,NCT03281369,NCT04190745,NCT04510064,NCT02448329,NCT02449655,NCT03193918,NCT03990103,NCT04572542,NCT04209686,NCT02615730,NCT04604132,NCT01641783,NCT04077255 |
Adenocarcinoma, endocervical typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH0GS9 |
NCT00295789,NCT01755897,NCT04516616,NCT04723875,NCT02020707,NCT00064077
|
AdenocarcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D40 |
NCT02583477,NCT02732938,NCT05042128,NCT04134468,NCT04935359,NCT04827953,NCT01676259,NCT01431794,NCT02186847,NCT03915444,NCT03410030,NCT02047513,NCT03345810,NCT04481204,NCT00226746,NCT02426281,NCT03697239,NCT03496662,NCT04469556,NCT03517176,NCT00384826,NCT02723331,NCT05257993,NCT02993731,NCT01253525,NCT04329949,NCT02754726,NCT00368992,NCT03908333,NCT02501902,NCT03361319,NCT04390763,NCT02243007,NCT01218516,NCT02487277,NCT00201734,NCT02101021,NCT01578551,NCT00002852,NCT00005838,NCT02715804,NCT04046887,NCT02059967,NCT00040794,NCT04634539,NCT04581343,NCT02468557,NCT04929041,NCT00955305,NCT02926183,NCT04821284,NCT00021060,NCT00369551,NCT05254171,NCT02048943,NCT00042835,NCT02303977,NCT04257448,NCT01506973
|
Adrenal cortical carcinomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH4KH2 |
NCT00786110
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
