Unknown.
Taiwan; Vietnam; China; Myanmar
Ingredient ID: NPC96547
Ingredient ID: NPC91186
Ingredient ID: NPC90276
Ingredient ID: NPC84025
Ingredient ID: NPC8091
Ingredient ID: NPC79576
Ingredient ID: NPC76966
Ingredient ID: NPC75879
Ingredient ID: NPC73545
Ingredient ID: NPC72893
Ingredient ID: NPC72448
Ingredient ID: NPC69168
Ingredient ID: NPC54179
Ingredient ID: NPC53394
Ingredient ID: NPC50269
Ingredient ID: NPC4982
Ingredient ID: NPC485999
Ingredient ID: NPC485998
Ingredient ID: NPC485997
Ingredient ID: NPC48105
Ingredient ID: NPC47663
Ingredient ID: NPC33075
Ingredient ID: NPC321351
Ingredient ID: NPC306691
Ingredient ID: NPC305648
Ingredient ID: NPC297436
Ingredient ID: NPC296193
Ingredient ID: NPC288317
Ingredient ID: NPC283301
Ingredient ID: NPC283087
Ingredient ID: NPC282694
Ingredient ID: NPC278775
Ingredient ID: NPC276815
Ingredient ID: NPC262292
Ingredient ID: NPC25850
Ingredient ID: NPC257774
Ingredient ID: NPC254609
Ingredient ID: NPC2505
Ingredient ID: NPC242517
Ingredient ID: NPC23778
Ingredient ID: NPC223807
Ingredient ID: NPC222332
Ingredient ID: NPC218628
Ingredient ID: NPC218290
Ingredient ID: NPC202691
Ingredient ID: NPC200596
Ingredient ID: NPC198796
Ingredient ID: NPC194208
Ingredient ID: NPC19331
Ingredient ID: NPC186554
Ingredient ID: NPC185138
Ingredient ID: NPC181464
Ingredient ID: NPC176814
Ingredient ID: NPC162678
Ingredient ID: NPC162051
Ingredient ID: NPC136467
Ingredient ID: NPC133084
Ingredient ID: NPC110958
Ingredient ID: NPC103281
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
Therapeutic Target | Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
Therapeutic Target | Protein Kinase | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Q02750 | CHEMBL3587 |
Drug Transporter | Voltage-gated sodium channel | SCN4A | Sodium channel protein type IV alpha subunit | P35499 | CHEMBL2072 |
Drug Transporter | Voltage-gated sodium channel | SCN8A | Sodium channel protein type VIII alpha subunit | Q9UQD0 | CHEMBL5202 |
Therapeutic Target | Voltage-gated sodium channel | SCN5A | Sodium channel protein type V alpha subunit | Q14524 | CHEMBL1980 |
Therapeutic Target | Voltage-gated sodium channel | SCN3A | Sodium channel protein type III alpha subunit | Q9NY46 | CHEMBL5163 |
Drug Transporter | Voltage-gated sodium channel | SCN9A | Sodium channel protein type IX alpha subunit | Q15858 | CHEMBL4296 |
Drug Transporter | Voltage-gated sodium channel | SCN1A | Sodium channel protein type I alpha subunit | P35498 | CHEMBL1845 |
Therapeutic Target | Voltage-gated sodium channel | SCN2A | Sodium channel protein type II alpha subunit | Q99250 | CHEMBL4187 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials |
---|
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
SCN8A,SCN4A,SCN5A,SCN1A,SCN9A
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
SCN8A,SCN5A,SCN9A,SCN7A,SCN3A
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
ALOX5,SCN4A,SCN1A,ALOX5
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
SCN5A,ALOX5,SCN9A
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
SCN4A,SCN1A,SCN5A
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CYP2C19,ALOX5,SCN5A
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
SCN8A,SCN9A,ALOX5
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
SCN8A,SCN1A,SCN9A
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
SCN4A,SCN5A,CYP2C19
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
SCN8A,SCN4A,SCN5A
|
Ebola virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D60.01 |
SCN4A,SCN3A,SCN5A
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
SCN5A,SCN3A
|
Epilepsy/seizureDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A61-8A6Z |
SCN8A,SCN5A
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
SCN8A,ALOX5
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
ALOX5,SCN5A
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
SCN8A,SCN9A
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
SCN8A,SCN5A
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
SCN4A,SCN1A
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
SCN9A,SCN7A
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
SCN5A,ALOX5
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
SCN5A
|
RadiculopathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B93 |
SCN9A
|
Idiopathic interstitial pneumonitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03 |
ALOX5
|
InfluenzaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E30-1E32 |
ALOX5
|
Carcinoid syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B10 |
ALOX5
|
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
SCN9A
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
ALOX5
|
Musculoskeletal disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA00-FC0Z |
SCN4A
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
ALOX5
|
Corneal diseaseDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A76-9A78 |
SCN5A
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
ALOX5
|
Extremities vasodilatationDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EG00 |
SCN9A
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
ALOX5
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
ALOX5
|
OsteoarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA00-FA05 |
SCN9A
|
Bipolar disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60 |
SCN9A
|
FilariasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F66 |
ALOX5
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
ALOX5
|
Cardiac arrhythmiaDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC9Z |
SCN5A
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
ALOX5
|
Trigeminal nerve disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B82 |
SCN9A
|
Genetic cardiac arrhythmiaDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC65 |
SCN5A
|
Pituitary gland disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A60-5A61 |
ALOX5
|
Ventricular tachyarrhythmiaDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC71 |
SCN5A
|
Nasopharyngeal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6B |
ALOX5
|
Abnormal micturitionDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MF50 |
SCN5A
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
ALOX5
|
MigraineDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A80 |
SCN5A
|
General pain disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E43 |
SCN9A
|
Postoperative inflammationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-CA43 |
ALOX5
|
CoughDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD12 |
SCN5A
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
SCN8A
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
SCN4A
|
KeratoconusDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A78.50 |
SCN3A
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
SCN3A
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
SCN8A
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
SCN5A
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
ALOX5
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
SCN1A
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
SCN1A
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
SCN3A
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
SCN7A
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
SCN3A
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
SCN5A
|