Collective Molecular Activities of the Plant: Taiwania Cryptomerioides
Unknown.
Taiwan; Vietnam; China; Myanmar
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
59 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
52 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
26 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC96547
Ingredient ID: NPC91186
Ingredient ID: NPC90276
Ingredient ID: NPC84025
Ingredient ID: NPC8091
Ingredient ID: NPC79576
Ingredient ID: NPC76966
Ingredient ID: NPC75879
Ingredient ID: NPC73545
Ingredient ID: NPC72893
Ingredient ID: NPC72448
Ingredient ID: NPC69168
Ingredient ID: NPC54179
Ingredient ID: NPC53394
Ingredient ID: NPC50269
Ingredient ID: NPC4982
Ingredient ID: NPC485999
Ingredient ID: NPC485998
Ingredient ID: NPC485997
Ingredient ID: NPC48105
Ingredient ID: NPC47663
Ingredient ID: NPC33075
Ingredient ID: NPC321351
Ingredient ID: NPC306691
Ingredient ID: NPC305648
Ingredient ID: NPC297436
Ingredient ID: NPC296193
Ingredient ID: NPC288317
Ingredient ID: NPC283301
Ingredient ID: NPC283087
Ingredient ID: NPC282694
Ingredient ID: NPC278775
Ingredient ID: NPC276815
Ingredient ID: NPC262292
Ingredient ID: NPC25850
Ingredient ID: NPC257774
Ingredient ID: NPC254609
Ingredient ID: NPC2505
Ingredient ID: NPC242517
Ingredient ID: NPC23778
Ingredient ID: NPC223807
Ingredient ID: NPC222332
Ingredient ID: NPC218628
Ingredient ID: NPC218290
Ingredient ID: NPC202691
Ingredient ID: NPC200596
Ingredient ID: NPC198796
Ingredient ID: NPC194208
Ingredient ID: NPC19331
Ingredient ID: NPC186554
Ingredient ID: NPC185138
Ingredient ID: NPC181464
Ingredient ID: NPC176814
Ingredient ID: NPC162678
Ingredient ID: NPC162051
Ingredient ID: NPC136467
Ingredient ID: NPC133084
Ingredient ID: NPC110958
Ingredient ID: NPC103281
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Drug Transporter | Voltage-gated sodium channel | SCN4A | Sodium channel protein type IV alpha subunit | P35499 | CHEMBL2072 |
| Drug Transporter | Voltage-gated sodium channel | SCN8A | Sodium channel protein type VIII alpha subunit | Q9UQD0 | CHEMBL5202 |
| Drug Transporter | Voltage-gated sodium channel | SCN9A | Sodium channel protein type IX alpha subunit | Q15858 | CHEMBL4296 |
| Drug Transporter | Voltage-gated sodium channel | SCN1A | Sodium channel protein type I alpha subunit | P35498 | CHEMBL1845 |
| Therapeutic Target | Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
| Therapeutic Target | Protein Kinase | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Q02750 | CHEMBL3587 |
| Therapeutic Target | Voltage-gated sodium channel | SCN5A | Sodium channel protein type V alpha subunit | Q14524 | CHEMBL1980 |
| Therapeutic Target | Voltage-gated sodium channel | SCN3A | Sodium channel protein type III alpha subunit | Q9NY46 | CHEMBL5163 |
| Therapeutic Target | Voltage-gated sodium channel | SCN2A | Sodium channel protein type II alpha subunit | Q99250 | CHEMBL4187 |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abnormal micturitionDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MF50 |
SCN5A
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
SCN8A,SCN4A,SCN5A
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CYP2C19,ALOX5,SCN5A
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
SCN5A,SCN3A
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
ALOX5
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
ALOX5
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
SCN5A
|
Bipolar disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60 |
SCN9A
|
Carcinoid syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B10 |
ALOX5
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
SCN8A,SCN4A,SCN5A,SCN1A,SCN9A
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
