Collective Molecular Activities of the Plant: Inula Racemosa
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PLANiTS DNA barcode
Taxonomic Information
Plant ID: NPO23861
Plant Latin Name: Inula Racemosa
Taxonomy Genus: Inula
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
483693
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary
Overview of Ingredients
30 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
29 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
28 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC97505
Ingredient ID: NPC92489
Ingredient ID: NPC90014
Ingredient ID: NPC85968
Ingredient ID: NPC56369
Ingredient ID: NPC56345
Ingredient ID: NPC53373
Ingredient ID: NPC470948
Ingredient ID: NPC43565
Ingredient ID: NPC43049
Ingredient ID: NPC35574
Ingredient ID: NPC288689
Ingredient ID: NPC269586
Ingredient ID: NPC260610
Ingredient ID: NPC226988
Ingredient ID: NPC222009
Ingredient ID: NPC214329
Ingredient ID: NPC205177
Ingredient ID: NPC19596
Ingredient ID: NPC195448
Ingredient ID: NPC181103
Ingredient ID: NPC178676
Ingredient ID: NPC176283
Ingredient ID: NPC169436
Ingredient ID: NPC166577
Ingredient ID: NPC164690
Ingredient ID: NPC148762
Ingredient ID: NPC139867
Ingredient ID: NPC123816
Ingredient ID: NPC106340
Classification of Human Proteins Collectively Targeted by the Plant
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
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Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Clinical Trials Summary
Overview
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 147 | |
Clinical trial details
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT02307487 | Safety of Pre-TURBT Intravesical Instillation of Escalating Doses of TC-3 Gel and MMC in NMIBC Patients | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT00004887 | Paclitaxel and Carboplatin Chemotherapy Compared With Standard Chemotherapy in Treating Patients With Stage III or Stage IV Non-small Cell Lung Cancer That Cannot Be Removed During Surgery | lung cancer | Mitomycin (NPC139867) | NP level |
| NCT02982395 | Study to Evaluate the Efficacy and Safety Of Intravesical Nanoxel®M In BCG Refractory NMIBC | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT02901236 | Bevacizumab Versus Mitomycin C as Trabeculectomy Adjuvant in Uncontrolled Glaucoma | glaucoma | Mitomycin (NPC139867) | NP level |
| NCT00201396 | A Multicenter Trial Comparing Induction C/T Followed by CCRT v.s. CCRT Alone in Stage IV Nasopharyngeal Carcinoma | nasopharyngeal neoplasm | Mitomycin (NPC139867) | NP level |
| NCT01688024 | Mitomycin C Therapy for Patients With Primary Sclerosing Cholangitis | sclerosing cholangitis | Mitomycin (NPC139867) | NP level |
| NCT02560220 | MIC Cell Therapy for Individualized Immunosuppression in Living Donor Kidney Transplant Recipients | chronic kidney disease | Mitomycin (NPC139867) | NP level |
| NCT00974818 | Mitomycin C Versus Bacillus Calmette-Guerin in the Intravesical Treatment of Non-Muscle-Invasive Bladder Cancer Patients | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT04172675 | A Study of Erdafitinib Versus Investigator Choice of Intravesical Chemotherapy in Participants Who Received Bacillus Calmette-Guérin (BCG) and Recurred With High Risk Non-Muscle-Invasive Bladder Cancer (NMIBC) | bladder tumor | Mitomycin (NPC139867) | NP level |
| NCT02614534 | Clinical Trial to Evaluate Safety and Efficacy of Hyperthermic Intra-peritoneal Chemotherapy (HIPEC) With Mitomycin C Used During Surgery for Treatment of Locally Advanced Colorectal Carcinoma | colorectal carcinoma | Mitomycin (NPC139867) | NP level |
| NCT00005674 | Clinical Trial of Creatine in Amyotrophic Lateral Sclerosis [ALS] | amyotrophic lateral sclerosis | Creatine (NPC195448) | NP level |
| NCT00023842 | BCG With or Without Mitomycin in Treating Patients With Bladder Cancer | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT00068744 | Radiation Therapy, Mitomycin, and Either Fluorouracil or Cisplatin in Treating Patients With Locally Advanced Anal Cancer | anus cancer | Mitomycin (NPC139867) | NP level |
| NCT02030990 | The Use of MMC During PRK and Its Effect on Postoperative Topical Steroid Requirements | Corneal opacity | Mitomycin (NPC139867) | NP level |
| NCT00626782 | Lucentis Versus Mitomycin C During Glaucoma Surgery | glaucoma | Mitomycin (NPC139867) | NP level |
| NCT01327521 | Transarterial Chemoembolization vs CyberKnife for Recurrent Hepatocellular Carcinoma | hepatocellular carcinoma | Mitomycin (NPC139867) | NP level |
| NCT02299999 | SAFIR02_Breast - Efficacy of Genome Analysis as a Therapeutic Decision Tool for Patients With Metastatic Breast Cancer | breast cancer | Mitomycin (NPC139867) | NP level |
| NCT01858025 | Concurrent Chemoradiation + 5-FU + Mitomycin-C in Anal Carcinoma | carcinoma | Mitomycin (NPC139867) | NP level |
| NCT00025090 | Radiation Therapy Plus Fluorouracil With or Without Additional Chemotherapy in Treating Patients With Primary Anal Cancer | anus cancer | Mitomycin (NPC139867) | NP level |
| NCT00999973 | Study on the Effect of Mitomycin C 0.02% on the Corneal Endothelial After Photorefractive Keratectomy in Moderate Myopia | Myopia | Mitomycin (NPC139867) | NP level |
| NCT00003596 | Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer | anus cancer | Mitomycin (NPC139867) | NP level |
| NCT02710734 | Risk Enabled Therapy After Initiating Neoadjuvant Chemotherapy for Bladder Cancer (RETAIN) | urinary bladder carcinoma | Mitomycin (NPC139867) | NP level |
| NCT01115517 | Safety Study of Avastin Used as Adjunctive Therapy in Pterygium Surgery | pterygium | Mitomycin (NPC139867) | NP level |
| NCT00449098 | Ologen (OculusGen)-Glaucoma MMC Control Trial in India | glaucoma | Mitomycin (NPC139867) | NP level |
| NCT00002490 | Radiation Therapy, Chemotherapy, or Observation in Treating Patients With Bladder Cancer | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT02994251 | A Trial of Systemic Chemotherapy in Combination With Conventional Transarterial Chemoembolization in Patients With Advanced Intra-Hepatic Cholangiocarcinoma | cholangiocarcinoma | Mitomycin (NPC139867) | NP level |
| NCT00002993 | Combination Chemotherapy in Treating Patients With Recurrent or Advanced Cancer of the Uterus | sarcoma | Mitomycin (NPC139867) | NP level |
| NCT00003003 | Mitomycin and Mitoxantrone in Treating Patients With Acute Myelogenous Leukemia | leukemia | Mitomycin (NPC139867) | NP level |
| NCT01442519 | Sequential Bacillus Calmette-Guérin (BCG) and Electromotive Mitomycin-C Versus Bacillus Calmette-Guérin (BCG) Alone for High Risk Superficial Bladder Cancer | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT02695771 | The Bladder Instillation Comparison Study | bladder tumor | Mitomycin (NPC139867) | NP level |
| NCT00661583 | Use of Ranibizumab With Mitomycin C During Trabeculectomy | glaucoma | Mitomycin (NPC139867) | NP level |
| NCT00005870 | Nitrocamptothecin Compared With Other Chemotherapy in Treating Patients With Recurrent or Refractory Cancer of the Pancreas | pancreatic carcinoma | Mitomycin (NPC139867) | NP level |
| NCT00318643 | Safety Study of Recombinant Human Hyaluronidase (Chemophase) in Combination With Mitomycin in Participants With Superficial Bladder Cancer | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT00967291 | Mitomycin C and Ifosfamide in Treating Patients With Metastatic Pancreatic Cancer | pancreatic carcinoma | Mitomycin (NPC139867) | NP level |
| NCT01489566 | Study of Tyroserleutide for Injection in Hepatocellular Carcinoma (HCC) Patients | carcinoma | Mitomycin (NPC139867) | NP level |
| NCT01411150 | Premanifest Huntington's Disease: Creatine Safety & Tolerability Extension Study | Huntington disease | Creatine (NPC195448) | NP level |
| NCT02070120 | Investigating Bladder Chemotherapy Instead of Surgery for Low Risk Bladder Cancer | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT00276744 | Individualized Drug Treatment for Treating Patients With Pancreatic Cancer | pancreatic carcinoma | Mitomycin (NPC139867) | NP level |
| NCT02805257 | Ahmed Glaucoma Valve Surgery With Mitomycin-C | neovascular glaucoma;open-angle glaucoma | Mitomycin (NPC139867) | NP level |
| NCT01440751 | Comparative Study of Ologen Collagen Matrix Versus Mitomycin-C in Glaucoma Filtering Surgery | glaucoma | Mitomycin (NPC139867) | NP level |
| NCT00921531 | Adjuvant Therapy With Thalidomide for Chemoembolization in Advanced Hepatocellular Carcinoma | hepatocellular carcinoma | Mitomycin (NPC139867) | NP level |
| NCT01004978 | Chemoembolization With or Without Sorafenib Tosylate in Treating Patients With Liver Cancer That Cannot Be Removed by Surgery | hepatocellular carcinoma | Mitomycin (NPC139867) | NP level |
| NCT00026988 | Creatine Therapy for Huntington's Disease | Huntington disease | Creatine (NPC195448) | NP level |
| NCT02369939 | Effects of Deep Regional Hyperthermia in Patients With Anal Carcinoma Treated by Standard Radiochemotherapy | anal carcinoma | Mitomycin (NPC139867) | NP level |
| NCT01171482 | Comparison Study of Sorafenib and 5-fluorouracil/Mitomycin for Metastatic Hepatocellular Carcinoma | hepatocellular carcinoma | Mitomycin (NPC139867) | NP level |
| NCT03766425 | Comparison of Efficacy and Safety of Mitomycin and Aflibercept Used to Support Primary Trabeculectomy. | glaucoma | Mitomycin (NPC139867) | NP level |
| NCT00003710 | Irinotecan Plus Mitomycin in Treating Patients With Advanced Solid Tumors | neoplasm | Mitomycin (NPC139867) | NP level |
| NCT03924544 | Decorin in Sub Scleral Trabeculectomy | glaucoma | Mitomycin (NPC139867) | NP level |
| NCT00024271 | Surgery, Chemotherapy, and Radiation Therapy in Treating Patients With Peritoneal Cancer | mesothelioma | Mitomycin (NPC139867) | NP level |
| NCT01953406 | The Efficacy of 5-fluorouracil/Mitomycin for the Patients With Pulmonary Metastasis of Hepatocellular Carcinoma | hepatocellular carcinoma | Mitomycin (NPC139867) | NP level |
| NCT00851006 | Creatine Treatment for Female Adolescents With Depression Who Are Non-Responders to Fluoxetine or Escitalopram | major depressive disorder | Creatine (NPC195448) | NP level |
| NCT00271011 | A Study of Mitomycin C, Irinotecan, and Cetuximab | colorectal carcinoma | Mitomycin (NPC139867) | NP level |
| NCT01543139 | Cytidine- and Creatine-Containing Drug in Treating Bipolar Depression | bipolar disorder | Creatine (NPC195448) | NP level |
| NCT00192049 | A Randomized Study Comparing Single Agent Gemcitabine Intravesical Therapy Versus Mitomycin C in Patients With Intermediate Risk Superficial Bladder Cancer | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT00918528 | Effect of Mitomycin C on Urethral Stricture Recurrence After Internal Urethrotomy | Urethral stricture | Mitomycin (NPC139867) | NP level |
| NCT00030459 | Palliative Therapy With or Without Chemotherapy in Treating Patients With Malignant Mesothelioma | mesothelioma | Mitomycin (NPC139867) | NP level |
| NCT02385370 | Bleb Function and Morphology With Intratendon Injection of MMC Compared With Standard Method | glaucoma | Mitomycin (NPC139867) | NP level |
| NCT03664869 | Electromotive Mitomycin-C (EMDA-MMC) in Preventing Recurrences in High-risk Non-muscle-invasive Bladder Cancer | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT02369458 | Mitomycin C in Patients With Incurable p16 Positive Oropharyngeal and p16 Negative Head and Neck Squamous Cell Carcinoma (HNSCC) Resistant to Standard Therapies | head and neck squamous cell carcinoma | Mitomycin (NPC139867) | NP level |
| NCT01149174 | Preoperative Intravesical Electromotive Mitomycin-c for Primary Non-muscle Invasive Bladder Cancer | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT02106572 | Therapeutic Instillation of Mistletoe | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT03658304 | Trial of Mitomycin C During Nephroureterectomy for Urothelial Carcinoma | urothelial carcinoma | Mitomycin (NPC139867) | NP level |
| NCT02638857 | Immunotherapy Using Precision T Cells Specific to Multiple Common Tumor-Associated Antigen Combined With Transcatheter Arterial Chemoembolization for the Treatment of Advanced Hepatocellular Carcinoma | hepatocellular carcinoma | Mitomycin (NPC139867) | NP level |
| NCT04037072 | Efficacy of Topical Mitomycin C for Complex Benign Esophageal Anastomotic Strictures | Esophageal stenosis | Mitomycin (NPC139867) | NP level |
| NCT01042782 | Phase I Study of Daily RAD001 in Combination With Mitomycin C in Patients With Advanced Gastric Cancer or Cancer of the Esophagogastric Junction | gastric cancer | Mitomycin (NPC139867) | NP level |
| NCT04471792 | Creatine Use and Muscle Stretching in Peripheral Artery Disease | peripheral arterial disease | Creatine (NPC195448) | NP level |
| NCT00070993 | Creatine for the Treatment of Amyotrophic Lateral Sclerosis | amyotrophic lateral sclerosis | Creatine (NPC195448) | NP level |
| NCT01815359 | ICARuS Post-operative Intraperitoneal Chemotherapy (EPIC) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) After Optimal Cytoreductive Surgery (CRS) for Neoplasms of the Appendix, Colon or Rectum With Isolated Peritoneal Metastasis | appendix cancer;colorectal carcinoma | Mitomycin (NPC139867) | NP level |
| NCT00023868 | Combination Chemotherapy With or Without Chemoembolization in Treating Patients With Colorectal Cancer Metastatic to the Liver (6655) | colorectal carcinoma | Mitomycin (NPC139867) | NP level |
| NCT01671488 | A Phase I/II Evaluation of ADXS11-001, Mitomycin, 5-fluorouracil (5-FU) and IMRT for Anal Cancer | anus cancer | Mitomycin (NPC139867) | NP level |
| NCT00734994 | Mitomycin C With Hyperthermia and Intravesical Mitomycin C to Treat Recurrent Bladder Cancer | urinary bladder carcinoma | Mitomycin (NPC139867) | NP level |
| NCT00712426 | Creatine Safety, Tolerability, & Efficacy in Huntington's Disease (CREST-E) | Huntington disease | Creatine (NPC195448) | NP level |
| NCT00981656 | Radiation Therapy and Chemotherapy in Treating Patients With Stage I Bladder Cancer | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT01381354 | Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS) | multiple sclerosis | Creatine (NPC195448) | NP level |
| NCT00183885 | A Phase II Study of Intra-arterial Chemotherapy With Cisplatin and Mitomycin-C in Patients With Hepatocellular Carcinoma | hepatocellular carcinoma | Mitomycin (NPC139867) | NP level |
| NCT00003240 | Standard Therapy Given With or Without Combination Chemotherapy in Treating Patients With Non-small Cell Lung Cancer | lung cancer | Mitomycin (NPC139867) | NP level |
| NCT01167725 | Standard Therapy With or Without Surgery and Mitomycin C in Treating Patients With Advanced Limited Peritoneal Dissemination of Colon Cancer | colorectal carcinoma | Mitomycin (NPC139867) | NP level |
| NCT02311101 | Phase I Mitomycin Combined With Bacillus Calmette-Guérin (BCG) for Bladder Cancer | bladder tumor | Mitomycin (NPC139867) | NP level |
| NCT05024734 | Guiding Instillation in Non Muscle-invasive Bladder Cancer Based on Drug Screens in Patient Derived Organoids | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT00472810 | Ologen (OculusGen)-Glaucoma MMC Control in Pakistan | glaucoma | Mitomycin (NPC139867) | NP level |
| NCT01094964 | Hyperthermia and Mitomycin C, Bacillus Calmette-Guerin, or Standard Therapy as Second-Line Therapy in Treating Patients With Recurrent Bladder Cancer | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT01411163 | Premanifest Huntington's Disease Extension Study II: Creatine Safety & Tolerability | Huntington disease | Creatine (NPC195448) | NP level |
| NCT03381352 | Study of IMRT Radiotherapy Concurrent Chemothrerapy for Anal Cancer | anus cancer | Mitomycin (NPC139867) | NP level |
| NCT02701088 | Study of SIB-IMRT in Combination With 5-FU and Mitomycin-C Among Patients With Locally Advanced Anal Canal Cancer: Efficacy, Safety and Quality of Life | anus cancer | Mitomycin (NPC139867) | NP level |
| NCT00042887 | Chemotherapy With or Without Surgery in Treating Patients With Bladder Cancer | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT00355576 | Combination Therapy Selection Trial in Amyotrophic Lateral Sclerosis | amyotrophic lateral sclerosis | Creatine (NPC195448) | NP level |
| NCT00449865 | NET-PD LS-1 Creatine in Parkinson's Disease | Parkinson disease | Creatine (NPC195448) | NP level |
| NCT00003159 | Surgery With or Without Preoperative Chemotherapy in Treating Patients With Resectable Non-small Cell Lung Cancer | lung cancer | Mitomycin (NPC139867) | NP level |
| NCT00346489 | Outcomes of Intraoperative 5-Fluorouracil Versus Mitomycin C | glaucoma | Mitomycin (NPC139867) | NP level |
| NCT01601210 | Dose-Ranging Trial of Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder | major depressive disorder | Creatine (NPC195448) | NP level |
| NCT01412151 | Creatine Safety & Tolerability in Huntington's Disease | Huntington disease | Creatine (NPC195448) | NP level |
| NCT00289445 | Study With Mitomycin c/5-FU/FA in Pretreated Gastrointestinal Cancer Patients With Metastases (>= Second-line Treatment) | metastasis;neoplasm | Mitomycin (NPC139867) | NP level |
| NCT03058757 | The Effectiveness and Safety of Neoadjuvant Intravesical Mitomycin-C Instillation | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT02301091 | Combine TACE and RFA Versus TACE Alone for HCC With PVTT | hepatocellular carcinoma | Mitomycin (NPC139867) | NP level |
| NCT04241185 | Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992) | bladder tumor | Mitomycin (NPC139867) | NP level |
| NCT02625779 | Combined Cytidine and Creatine-containing Drug in the Treatment of the Bipolar Depression | bipolar disorder | Creatine (NPC195448) | NP level |
| NCT01843452 | Phase II Study of Concomitant Intensity-modulated Radiotherapy Combined to Capecitabine, Mitomycin and Panitumumab in Patients With Stage II-IIIB Squamous-cell Carcinoma of the Anal Canal | carcinoma | Mitomycin (NPC139867) | NP level |
| NCT00148395 | Randomized Phase III-Study in Stage IIIb and IV Non-Small-Cell Lung Cancer. Sequential Single-Agent vs. Double-Agent vs. Triple-Agent Therapy. | non-small cell lung carcinoma | Mitomycin (NPC139867) | NP level |
| NCT00003907 | Chemoembolization in Treating Patients With Primary Liver Cancer or Metastases to the Liver | liver cancer | Mitomycin (NPC139867) | NP level |
| NCT01530503 | Second Line Therapy in Advanced Biliary Tract Cancer | biliary tract cancer | Mitomycin (NPC139867) | NP level |
| NCT00003893 | Adjuvant Chemotherapy Plus Radiation Therapy in Treating Women With Early-Stage Breast Cancer | breast cancer | Mitomycin (NPC139867) | NP level |
| NCT00016653 | Creatine and Glutamine in Steroid-Naive Duchenne Muscular Dystrophy | Duchenne muscular dystrophy | Creatine (NPC195448) | NP level |
| NCT00296335 | Trial of Adjuvant Chemotherapy for Gastric Cancer | gastric cancer | Mitomycin (NPC139867) | NP level |
| NCT00033644 | Combination Chemotherapy Plus Sargramostim in Treating Patients With Cancer of the Uterus | sarcoma | Mitomycin (NPC139867) | NP level |
| NCT00592995 | Creatine Safety and Tolerability in Premanifest HD: PRECREST | Huntington disease | Creatine (NPC195448) | NP level |
| NCT02316171 | CAVATAK (CVA21) in Non-muscle Invasive Bladder Cancer (VLA-012 CANON) | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT01941966 | A Study of Substitution of 5-FU (Fluorouracil) by Capecitabine in Scheme of Chemo-radiotherapy in Patients With Squamous Cell Carcinoma of the Anal Canal. | anus cancer | Mitomycin (NPC139867) | NP level |
| NCT01297803 | Comparison of Two Method Antimetabolites Application on Corneal Function in Trabeculectomy Surgery | glaucoma | Mitomycin (NPC139867) | NP level |
| NCT04395183 | 5-HTP and Creatine for Depression | major depressive disorder | Creatine (NPC195448) | NP level |
| NCT01675219 | Fluorescence Cystoscopy and Optimized MMC in Recurrent Bladder Cancer (FinnBladder 9) | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT02374112 | Creatine Supplementation in Chronic Fatigue Syndrome | chronic fatigue syndrome | Creatine (NPC195448) | NP level |
| NCT00024349 | Radiation Therapy With or Without Chemotherapy in Treating Patients With Stage II or Stage III Bladder Cancer | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT01905150 | Ph 2 Trial of Vitamin C & G-FLIP (Low Doses Gemcitabine, 5FU, Leucovorin, Irinotecan, Oxaliplatin) for Pancreatic Cancer | pancreatic carcinoma | Mitomycin (NPC139867) | NP level |
| NCT01296763 | Trial of ICM With or Without AZD2281 (Olaparib) in Patients With Advanced Pancreatic Cancer | pancreatic carcinoma | Mitomycin (NPC139867) | NP level |
| NCT00003209 | Radiation Therapy With or Without Chemotherapy After Surgery in Treating Patients With Stage IB or Stage IIA Cervical Cancer | cervical cancer | Mitomycin (NPC139867) | NP level |
| NCT01324141 | Topical MTS-01 for Dermatitis During Radiation and Chemotherapy for Anal Cancer | anus cancer | Mitomycin (NPC139867) | NP level |
| NCT01263834 | Results of Adjunctive Intraoperative Bevacizumab Injection on Trabeculectomy Outcome | glaucoma | Mitomycin (NPC139867) | NP level |
| NCT04504253 | A Pilot Study of Creatine Monohydrate as an Augmenting Agent for ECT in Persons With Major Depressive Disorder | major depressive disorder | Creatine (NPC195448) | NP level |
| NCT02463305 | Therapeutic Modulation of the Intestinal Creatine Kinase System in Inflammatory Bowel Disease (IBD) | ulcerative colitis | Creatine (NPC195448) | NP level |
| NCT00004209 | Combination Chemotherapy in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer | lung cancer | Mitomycin (NPC139867) | NP level |
| NCT00063193 | National Institute of Neurological Disorders and Stroke (NINDS) Parkinson's Disease Neuroprotection Trial | Parkinson disease | Creatine (NPC195448) | NP level |
| NCT00140192 | Creatine Treatment in Psychiatric Disorders | schizophrenia | Creatine (NPC195448) | NP level |
| NCT02188849 | Effects of Creatine Supplementation on Muscle Mass and Function Among Older Women Subjected to Resistance Training | muscular disease | Creatine (NPC195448) | NP level |
| NCT00128037 | Trial of Pre-operative Chemoradiotherapy Followed by Surgical Resection in Pancoast Tumors (JCOG 9806) | lung neoplasm | Mitomycin (NPC139867) | NP level |
| NCT01920269 | Intravesical Adjuvant Electromotive Mitomycin-C | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT01257581 | Safety and Efficacy Study of Creatine and Tamoxifen in Volunteers With Amyotrophic Lateral Sclerosis (ALS) | amyotrophic lateral sclerosis | Creatine (NPC195448) | NP level |
| NCT00002507 | Radiation Therapy and Chemotherapy in Treating Patients With Head and Neck Cancer | carcinoma;head and neck malignant neoplasia | Mitomycin (NPC139867) | NP level |
| NCT01621217 | Phase I Study of Cetuximab in Combination With 5-fluoruracil, Mitomycin C and Radiotherapy in Patients With Anal Cancer Stage T2 (>4 cm) - T4 N0-3 M0 or Any T N2-3 M0 | anal neoplasm | Mitomycin (NPC139867) | NP level |
| NCT00018109 | A Multicenter Randomized Placebo-Controlled Double-Blind Study to Assess Efficacy and Safety of Glutamine and Creatine Monohydrate in Duchenne Muscular Dystrophy (DMD) | Duchenne muscular dystrophy | Creatine (NPC195448) | NP level |
| NCT00296322 | Trial of Adjuvant Chemotherapy for Gastric Cancer | gastric cancer | Mitomycin (NPC139867) | NP level |
| NCT01200992 | Efficacy and Safety Evaluation of EN3348 (Mycobacterial Cell Wall-DNA Complex [MCC]) as Compared With Mitomycin C in the Intravesical Treatment of Subjects With BCG Recurrent/Refractory Non-muscle Invasive Bladder Cancer | in situ carcinoma;Transitional Cell Carcinoma | Mitomycin (NPC139867) | NP level |
| NCT01011010 | Sorafenib Tosylate and Chemoembolization With Doxorubicin Hydrochloride and Mitomycin in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery | liver cancer | Mitomycin (NPC139867) | NP level |
| NCT00075699 | Active Symptom Control With or Without Chemotherapy in Treating Patients With Malignant Pleural Mesothelioma | mesothelioma | Mitomycin (NPC139867) | NP level |
| NCT00666237 | Primary Tube Versus Trabeculectomy Study | glaucoma | Mitomycin (NPC139867) | NP level |
| NCT00005825 | Combination Chemotherapy in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer | lung cancer | Mitomycin (NPC139867) | NP level |
| NCT02016898 | The Effect of Sponge Versus No-Sponge Placement of Mitomycin-C on the Outcomes of Trabeculectomy With Ex-PRESS Glaucoma Filtration Device | open-angle glaucoma | Mitomycin (NPC139867) | NP level |
| NCT00069186 | Study of Creatine Monohydrate in Patients With Amyotrophic Lateral Sclerosis | amyotrophic lateral sclerosis | Creatine (NPC195448) | NP level |
| NCT00003018 | S9700 Combination Chemotherapy in Treating Patients With Stage II or Stage III Pancreatic Cancer | pancreatic carcinoma | Mitomycin (NPC139867) | NP level |
| NCT01017640 | Veliparib With or Without Mitomycin C in Treating Patients With Metastatic, Unresectable, or Recurrent Solid Tumors | neoplasm | Mitomycin (NPC139867) | NP level |
| NCT02948543 | Adding Mitomycin to BCG as Adjuvant Intravesical Therapy for High-risk Non-Muscle-invasive Bladder Cancer | urinary bladder cancer | Mitomycin (NPC139867) | NP level |
| NCT01042041 | Sorafenib Tosylate and Chemoembolization in Treating Patients With Unresectable Liver Cancer | hepatocellular carcinoma | Mitomycin (NPC139867) | NP level |
| NCT00423293 | Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer | anus cancer | Mitomycin (NPC139867) | NP level |
| NCT00949182 | Sorafenib Tosylate Before and After Hepatic Arterial Chemoembolization With Doxorubicin Hydrochloride and Mitomycin C in Treating Patients With Localized Liver Cancer That Cannot Be Removed by Surgery | liver cancer | Mitomycin (NPC139867) | NP level |
| NCT00893490 | Ahmed Glaucoma Valve Alone, With Amniotic Membrane or With Mitomycin C (MMC) for Treatment of Refractory Glaucoma | glaucoma | Mitomycin (NPC139867) | NP level |
| NCT03530202 | Effects of High-velocity Resistance Training and Creatine Supplementation in Healthy Aging Males | sarcopenia | Creatine (NPC195448) | NP level |
| NCT04811924 | The Effect of Mitomycin C on Corneal Haze and Scarring After Corneal Crosslinking in Keratoconus Patients | keratoconus | Mitomycin (NPC139867) | NP level |
| NCT00652860 | Combination Chemotherapy, Radiation Therapy, and Sargramostim Before and After Surgery in Treating Patients With Soft Tissue Sarcoma That Can Be Removed By Surgery | sarcoma | Mitomycin (NPC139867) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Hepatocellular carcinoma, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH4W48 |
NCT00183885,NCT02638857,NCT02301091,NCT00921531,NCT01327521,NCT01953406,NCT01004978,NCT01042041,NCT01171482
|
Neoplasms of unknown behaviour of urinary organsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F98 |
NCT02311101,NCT02710734,NCT00734994,NCT02695771,NCT04172675,NCT04241185
|
Huntington diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01.10 |
NCT00026988,NCT00592995,NCT00712426,NCT01411163,NCT01411150,NCT01412151
|
Malignant neoplasm of pancreas, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.Z |
NCT01296763,NCT00276744,NCT00005870,NCT00967291,NCT01905150,NCT00003018
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
NCT00005825,NCT00004209,NCT00003240,NCT00003159,NCT00004887
|
Amyotrophic lateral sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B60.0 |
NCT00070993,NCT00069186,NCT01257581,NCT00355576,NCT00005674
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
NCT01167725,NCT02614534,NCT00023868,NCT00271011,NCT01815359
|
Neuroendocrine carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C34 |
NCT00002507,NCT01858025,NCT01489566,NCT01843452
|
Single episode depressive disorder, severe, without psychotic symptomsDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70.3 |
NCT04504253,NCT04395183,NCT01601210,NCT00851006
|
Malignant neoplasms of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
NCT00296322,NCT01042782,NCT00296335
|
NeoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 02 |
NCT00003710,NCT00289445,NCT01017640
|
Pleural mesotheliomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26 |
NCT00030459,NCT00024271,NCT00075699
|
Pleomorphic sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B54 |
NCT00002993,NCT00652860,NCT00033644
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
NCT01011010,NCT00003907,NCT00949182
|
Malignant neoplasms of bladder, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.Z |
NCT00318643,NCT00023842,NCT00024349,NCT02982395,NCT00042887,NCT00192049,NCT00981656,NCT01094964,NCT00002490,NCT00974818,NCT02316171,NCT02948543,NCT01149174,NCT01442519,NCT05024734,NCT03058757,NCT01675219,NCT01920269,NCT02070120,NCT02106572,NCT03664869,NCT02307487
|
Bipolar disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60 |
NCT02625779,NCT01543139
|
Duchenne muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70.1 |
NCT00016653,NCT00018109
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
NCT00003893,NCT02299999
|
Transitional cell carcinoma, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH8EH1 |
NCT03658304,NCT01200992
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
NCT00063193,NCT00449865
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
NCT01297803,NCT00449098,NCT01263834,NCT00893490,NCT02385370,NCT00472810,NCT01440751,NCT00626782,NCT00346489,NCT02805257,NCT02805257,NCT00666237,NCT00661583,NCT02901236,NCT02016898,NCT03924544,NCT03766425
|
Malignant neoplasms of anus or anal canalDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C00 |
NCT02369939,NCT01621217,NCT03381352,NCT00025090,NCT01671488,NCT00003596,NCT02701088,NCT00068744,NCT01941966,NCT01324141,NCT00423293
|
Breast in situ carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E65 |
NCT01200992
|
Chronic arterial occlusive disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
NCT04471792
|
Malignant neoplasms of appendixDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B81 |
NCT01815359
|
Primary sclerosing cholangitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB96.2 |
NCT01688024
|
Non-small cell lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
NCT00148395
|
LeukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60-2B33 |
NCT00003003
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
NCT00002507
|
Urethral strictureDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GC03 |
NCT00918528
|
Disorders of muscles, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB3Z |
NCT02188849
|
Malignant neoplasm metastasis, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E2Z |
NCT00289445
|
Cervical cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C77 |
NCT00003209
|
Metastatic lung neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D70 |
NCT00128037
|
Corneal scars or opacitiesDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A77 |
NCT02030990
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
NCT02560220
|
PterygiumDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A61.1 |
NCT01115517
|
Biliary tract cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C17 |
NCT01530503
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
NCT02369458
|
CholangiocarcinomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH7M15 |
NCT02994251
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
NCT01381354
|
Malignant neoplasms of nasopharynxDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6B |
NCT00201396
|
Ulcerative colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD71 |
NCT02463305
|
Postviral fatigue syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E49 |
NCT02374112
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
NCT00140192
|
Other specified disorders of musclesDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB32.Y |
NCT03530202
|
Oesophageal obstructionDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA20.0 |
NCT04037072
|
Degenerative high myopiaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B76 |
NCT00999973
|
KeratoconusDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A78.50 |
NCT04811924
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
Plant-Targeted Human Disease Network
>> Targets derived from weak experimental activities
