Collective Molecular Activities of the Plant: Bituminaria Bituminosa
Country/Region:
SpainTraditional Medicine System:
Turkey; Eritrea; Romania; Australia; Italy; Libya; Algeria; Tunisia; India; France; Portugal; Morocco; Albania; Greece; Cyprus; Russia; Spain; Bulgaria
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
142 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
63 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
54 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC97534
Ingredient ID: NPC93201
Ingredient ID: NPC92319
Ingredient ID: NPC89909
Ingredient ID: NPC88584
Ingredient ID: NPC88354
Ingredient ID: NPC83425
Ingredient ID: NPC81831
Ingredient ID: NPC78441
Ingredient ID: NPC77625
Ingredient ID: NPC75441
Ingredient ID: NPC74017
Ingredient ID: NPC72447
Ingredient ID: NPC72402
Ingredient ID: NPC71690
Ingredient ID: NPC69513
Ingredient ID: NPC68426
Ingredient ID: NPC64190
Ingredient ID: NPC51700
Ingredient ID: NPC49074
Ingredient ID: NPC48128
Ingredient ID: NPC41481
Ingredient ID: NPC40394
Ingredient ID: NPC39730
Ingredient ID: NPC39602
Ingredient ID: NPC37649
Ingredient ID: NPC37087
Ingredient ID: NPC33103
Ingredient ID: NPC32311
Ingredient ID: NPC31187
Ingredient ID: NPC309066
Ingredient ID: NPC308489
Ingredient ID: NPC307063
Ingredient ID: NPC307050
Ingredient ID: NPC304962
Ingredient ID: NPC304905
Ingredient ID: NPC293908
Ingredient ID: NPC293664
Ingredient ID: NPC292705
Ingredient ID: NPC29157
Ingredient ID: NPC290598
Ingredient ID: NPC289774
Ingredient ID: NPC287430
Ingredient ID: NPC287063
Ingredient ID: NPC285965
Ingredient ID: NPC285951
Ingredient ID: NPC284288
Ingredient ID: NPC283389
Ingredient ID: NPC283184
Ingredient ID: NPC280576
Ingredient ID: NPC279886
Ingredient ID: NPC27790
Ingredient ID: NPC277458
Ingredient ID: NPC27377
Ingredient ID: NPC272824
Ingredient ID: NPC270043
Ingredient ID: NPC268794
Ingredient ID: NPC267856
Ingredient ID: NPC265077
Ingredient ID: NPC264317
Ingredient ID: NPC261933
Ingredient ID: NPC26029
Ingredient ID: NPC248830
Ingredient ID: NPC248521
Ingredient ID: NPC248355
Ingredient ID: NPC248132
Ingredient ID: NPC242733
Ingredient ID: NPC241943
Ingredient ID: NPC241427
Ingredient ID: NPC237875
Ingredient ID: NPC232673
Ingredient ID: NPC231810
Ingredient ID: NPC23060
Ingredient ID: NPC230387
Ingredient ID: NPC230124
Ingredient ID: NPC228383
Ingredient ID: NPC227467
Ingredient ID: NPC225467
Ingredient ID: NPC220825
Ingredient ID: NPC219876
Ingredient ID: NPC219205
Ingredient ID: NPC217635
Ingredient ID: NPC215833
Ingredient ID: NPC215072
Ingredient ID: NPC214243
Ingredient ID: NPC212556
Ingredient ID: NPC211230
Ingredient ID: NPC209846
Ingredient ID: NPC201459
Ingredient ID: NPC196238
Ingredient ID: NPC194882
Ingredient ID: NPC194251
Ingredient ID: NPC193210
Ingredient ID: NPC189417
Ingredient ID: NPC1890
Ingredient ID: NPC18872
Ingredient ID: NPC185977
Ingredient ID: NPC18536
Ingredient ID: NPC185045
Ingredient ID: NPC184613
Ingredient ID: NPC179256
Ingredient ID: NPC178383
Ingredient ID: NPC176679
Ingredient ID: NPC174205
Ingredient ID: NPC173790
Ingredient ID: NPC173501
Ingredient ID: NPC171434
Ingredient ID: NPC169497
Ingredient ID: NPC168615
Ingredient ID: NPC167317
Ingredient ID: NPC164365
Ingredient ID: NPC161875
Ingredient ID: NPC158168
Ingredient ID: NPC152384
Ingredient ID: NPC147124
Ingredient ID: NPC145876
Ingredient ID: NPC145009
Ingredient ID: NPC142990
Ingredient ID: NPC142754
Ingredient ID: NPC142415
Ingredient ID: NPC137037
Ingredient ID: NPC136099
Ingredient ID: NPC13114
Ingredient ID: NPC129228
Ingredient ID: NPC126029
Ingredient ID: NPC124492
Ingredient ID: NPC123965
Ingredient ID: NPC123463
Ingredient ID: NPC123324
Ingredient ID: NPC121162
Ingredient ID: NPC120968
Ingredient ID: NPC118971
Ingredient ID: NPC11724
Ingredient ID: NPC114590
Ingredient ID: NPC105863
Ingredient ID: NPC105189
Ingredient ID: NPC103754
Ingredient ID: NPC103647
Ingredient ID: NPC103082
Ingredient ID: NPC101475
Ingredient ID: NPC100702
Ingredient ID: NPC100127
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Enzyme | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Therapeutic Target | Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
| Therapeutic Target | Surface antigen | F3 | Coagulation factor III | P13726 | CHEMBL4081 |
| Therapeutic Target | Transcription factor | RELA | Nuclear factor NF-kappa-B p65 subunit | Q04206 | CHEMBL5533 |
| Therapeutic Target | Transcription factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 8 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT03216876 | A Study Of Ursolic Acid For Primary Sclerosing Cholangitis | sclerosing cholangitis | Ursolic Acid (NPC51700) | NP level |
| NCT00701987 | Safety, Tolerability, and Preliminary Efficacy Study of ALS-357 in Patients With Cutaneous Metastatic Melanoma | melanoma | Betulinic Acid (NPC264317) | NP level |
| NCT03236662 | (-)- Epicatechin Becker Muscular Dystrophy | Becker muscular dystrophy | (-)-Epicatechin (NPC126029) | NP level |
| NCT01880866 | (-)-Epicatechin and Pulmonary Arterial Hypertension | pulmonary arterial hypertension | (-)-Epicatechin (NPC126029) | NP level |
| NCT00346502 | Evaluation of 20% Betulinic Acid Ointment for Treatment of Dysplastic Nevi (Moderate to Severe Dysplasia) | dysplastic nevus | Betulinic Acid (NPC264317) | NP level |
| NCT04403568 | Testing the Synergism of Phytonutrients, Curcumin and Ursolic Acid, to Target Molecular Pathways in the Prostate | prostate cancer | Ursolic Acid (NPC51700) | NP level |
| NCT01856868 | Use of (-)-Epicatechin in the Treatment of Becker Muscular Dystrophy (Pilot Study) | Becker muscular dystrophy | (-)-Epicatechin (NPC126029) | NP level |
| NCT02337933 | Effect of Ursolic Acid Administration on Insulin Sensitivity and Metabolic Syndrome | metabolic syndrome | Ursolic Acid (NPC51700) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CES1,SNCA,RECQL,CDC25B,PTPN1,AKR1B10,PTPRC
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
SNCA,RECQL,CDC25B,AKR1B10,PTPRC
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
RELA,NFKB1,F3,RORC
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
NFKB1,RORC,RELA
AKR1B10 |
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
HSD17B10,RORC,ALPL,AKR1B10
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
RORC,ALPL,AKR1B10,PTPRC
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
ALPL,CDC25B,PTPN1,AKR1B10
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
HSD17B10,RECQL,PTPN1,F3
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
NFKB1,HSD17B10,AKR1B10,PTPRC
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
RELA,PTPN1,NFKB1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1,RELA,PTPRC
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
RORC,RELA,NFKB1
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
AKR1B10,CDC25B,AKR1B10
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
SNCA,CDC25B,PTPRC
|
Lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40 |
RELA,NFKB1
|
Metabolic disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5D2Z |
PTPN1
NCT02337933 |
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
NFKB1,RELA
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
RELA,NFKB1
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
RORC
ALPL |
Muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70 |
RELA,NFKB1
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1,RELA
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
RELA,NFKB1
|
Skin and skin-structure infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F28-1G0Z |
RELA,NFKB1
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
RORC,CDC25B
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
NFKB1,RELA
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
NFKB1,RELA
|
Irritable bowel syndromeDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD91 |
RELA,NFKB1
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
RELA,NFKB1
|
Becker muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70.0 |
NCT01856868,NCT03236662
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
RORC,SNCA
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
AKR1B10,PTPRC
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
F3,RORC
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
ALPL,AKR1B10
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
AKR1B10,PTPRC
|
Nasopharyngeal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6B |
CDC25B
|
BCR-ABL1-negative chronic myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A41 |
PTPRC
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
SNCA
|
Peroxisomal diseaseDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C57 |
CES1
|
Synthesis disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52-5C59 |
CES1
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
PTPRC
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
F3
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PTPN1
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
PTPN1
|
Colon cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90 |
ALPL
|
Diffuse large B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
PTPRC
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
CES1
|
Autonomic nervous system disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87 |
SNCA
|
Ophthalmic devices/implants/grafts injuryDisease Category: 23.External causes of morbidity or mortalityDisease ICD-11 Code: PK97 |
PTPN1
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
PTPRC
|
Transplanted organ/tissueDisease Category: 24.Factors influencing health status or contact with health servicesDisease ICD-11 Code: QB63 |
PTPRC
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
PTPN1
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
Autoimmune diseaseDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40-4A45 |
RORC
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
SNCA
|
Genetic prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E02 |
ALPL
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F3
|
Transplant rejectionDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE84 |
PTPRC
|
Postoperative inflammationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-CA43 |
PTPN1
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
CES1
|
Parasitic infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D0Y-1G2Z |
ALPL
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
NCT01880866
|
Primary sclerosing cholangitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB96.2 |
NCT03216876
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
NCT04403568
|
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
NCT00701987
|
Dysplastic naevusDisease Category: X.Extension CodesDisease ICD-11 Code: XH9035 |
NCT00346502
|
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
ALPL
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
ALPL
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
F3
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
AKR1B10
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CDC25B
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
AKR1B10
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
NFKB1
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
CDC25B
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
PTPRC
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
AKR1B10
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
SNCA
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
CDC25B
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
F3
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
ALPL
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
AKR1B10
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
F3
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
SNCA
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
AKR1B10
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
