Collective Molecular Activities of the Plant: Lycium Barbarum
Plant ID: NPO23429
Plant Latin Name: Lycium Barbarum
Taxonomy Genus: Lycium
Taxonomy Family: Solanaceae
Plant External Links:
NCBI TaxonomyDB:
112863
Plant-of-the-World-Online:
n.a.
Country/Region:
China; South Korea; IndiaTraditional Medicine System:
Indian Folk; TCMMedicinal Functions:
Antibacterial; Anticholesterolemic; Antipyretic; Cancer; Diuretic; Hypoglycaemic; Ophthalmic; Purgative; Skin; Tonic; Vasodilator
India; South Korea; China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
212 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
158 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
132 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98307
Ingredient ID: NPC96294
Ingredient ID: NPC95952
Ingredient ID: NPC95539
Ingredient ID: NPC93081
Ingredient ID: NPC93077
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Ingredient ID: NPC91081
Ingredient ID: NPC87564
Ingredient ID: NPC85813
Ingredient ID: NPC84281
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Ingredient ID: NPC82648
Ingredient ID: NPC82460
Ingredient ID: NPC82164
Ingredient ID: NPC81010
Ingredient ID: NPC78500
Ingredient ID: NPC77448
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Ingredient ID: NPC76336
Ingredient ID: NPC76145
Ingredient ID: NPC72697
Ingredient ID: NPC70744
Ingredient ID: NPC68873
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Ingredient ID: NPC66681
Ingredient ID: NPC66303
Ingredient ID: NPC64370
Ingredient ID: NPC64022
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Ingredient ID: NPC60548
Ingredient ID: NPC59650
Ingredient ID: NPC59581
Ingredient ID: NPC56505
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Ingredient ID: NPC5326
Ingredient ID: NPC52955
Ingredient ID: NPC52403
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Ingredient ID: NPC50898
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Ingredient ID: NPC483739
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Ingredient ID: NPC483732
Ingredient ID: NPC468994
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Ingredient ID: NPC34764
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Ingredient ID: NPC290442
Ingredient ID: NPC290319
Ingredient ID: NPC29
Ingredient ID: NPC289974
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Ingredient ID: NPC211913
Ingredient ID: NPC211401
Ingredient ID: NPC209970
Ingredient ID: NPC209773
Ingredient ID: NPC209111
Ingredient ID: NPC205491
Ingredient ID: NPC203142
Ingredient ID: NPC203064
Ingredient ID: NPC197977
Ingredient ID: NPC195749
Ingredient ID: NPC195064
Ingredient ID: NPC194944
Ingredient ID: NPC193989
Ingredient ID: NPC190810
Ingredient ID: NPC185839
Ingredient ID: NPC18188
Ingredient ID: NPC181465
Ingredient ID: NPC1813
Ingredient ID: NPC179831
Ingredient ID: NPC17810
Ingredient ID: NPC176740
Ingredient ID: NPC176521
Ingredient ID: NPC173582
Ingredient ID: NPC171148
Ingredient ID: NPC169786
Ingredient ID: NPC169485
Ingredient ID: NPC167976
Ingredient ID: NPC167545
Ingredient ID: NPC164487
Ingredient ID: NPC163556
Ingredient ID: NPC162034
Ingredient ID: NPC161555
Ingredient ID: NPC16087
Ingredient ID: NPC158876
Ingredient ID: NPC158565
Ingredient ID: NPC154515
Ingredient ID: NPC152451
Ingredient ID: NPC151157
Ingredient ID: NPC149184
Ingredient ID: NPC148951
Ingredient ID: NPC148835
Ingredient ID: NPC14600
Ingredient ID: NPC142319
Ingredient ID: NPC140872
Ingredient ID: NPC140389
Ingredient ID: NPC139548
Ingredient ID: NPC139416
Ingredient ID: NPC136996
Ingredient ID: NPC131969
Ingredient ID: NPC125144
Ingredient ID: NPC122962
Ingredient ID: NPC122009
Ingredient ID: NPC113837
Ingredient ID: NPC111888
Ingredient ID: NPC10781
Ingredient ID: NPC1075
Ingredient ID: NPC107482
Ingredient ID: NPC103612
Ingredient ID: NPC102449
Ingredient ID: NPC100276
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Therapeutic Target | GABA-A receptor | GABRR1 | GABA receptor rho-1 subunit | P24046 | CHEMBL3561 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Isomerase | TOP2A | DNA topoisomerase II alpha | P11388 | CHEMBL1806 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 174 | |
 Plant level | 4 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction;Myocardial Ischemia | Beta Carotene (NPC17810) | NP level |
| NCT00001986 | 1-Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00006202 | Lutein for Age-Related Macular Degeneration | macular degeneration | Lutein (NPC313179) | NP level |
| NCT00016536 | Effects of BufferGel and PRO 2000/5 Gel in Men | HIV infection | Naphthalene (NPC291066) | NP level |
| NCT00016679 | 1-Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00029289 | Effects of Lutein in Retinitis Pigmentosa | retinitis pigmentosa | Lutein (NPC313179) | NP level |
| NCT00029679 | Borage Oil and Ginkgo Biloba (EGb 761) in Asthma | asthma | Linoleic Acid (NPC85813) | NP level |
| NCT00033436 | Radiation Therapy With or Without Carbogen and Niacinamide in Treating Patients With Bladder Cancer | urinary bladder cancer | Niacinamide (NPC306397) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
CHRM1
NCT00694564 |
Abnormal micturitionDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MF50 |
CHRM2,CHRM1,CHRM5
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
NCT03626298 |
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB,MAOA
|
Actinic keratosisDisease Category: X.Extension CodesDisease ICD-11 Code: XH36H6 |
NCT04843553
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
DPP4,FFAR1,AKR1B1
|
Acute kidney failure, stage unspecifiedDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB60.Z |
NCT02701127
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TOP2A,CDK8,NFKB1
|
Acute viral hepatitisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E50 |
NCT00108589
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
