Collective Molecular Activities of the Plant: Pinus Halepensis
Country/Region:
Israel; ItalyTraditional Medicine System:
Turkey; Portugal; Israel; Australia; Italy; Libya; Algeria; Tunisia; France; Morocco; Albania; Greece; Argentina; New Zealand; Spain
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
99 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
27 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
50 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC97444
Ingredient ID: NPC9634
Ingredient ID: NPC90769
Ingredient ID: NPC89880
Ingredient ID: NPC85376
Ingredient ID: NPC82847
Ingredient ID: NPC81698
Ingredient ID: NPC77719
Ingredient ID: NPC7095
Ingredient ID: NPC69394
Ingredient ID: NPC6332
Ingredient ID: NPC60548
Ingredient ID: NPC60509
Ingredient ID: NPC57030
Ingredient ID: NPC55887
Ingredient ID: NPC51700
Ingredient ID: NPC48568
Ingredient ID: NPC37454
Ingredient ID: NPC35659
Ingredient ID: NPC31801
Ingredient ID: NPC306799
Ingredient ID: NPC304876
Ingredient ID: NPC303454
Ingredient ID: NPC300414
Ingredient ID: NPC296250
Ingredient ID: NPC294902
Ingredient ID: NPC294555
Ingredient ID: NPC291416
Ingredient ID: NPC286206
Ingredient ID: NPC286146
Ingredient ID: NPC282054
Ingredient ID: NPC278768
Ingredient ID: NPC275861
Ingredient ID: NPC266489
Ingredient ID: NPC265395
Ingredient ID: NPC264317
Ingredient ID: NPC261969
Ingredient ID: NPC26033
Ingredient ID: NPC257213
Ingredient ID: NPC256142
Ingredient ID: NPC250696
Ingredient ID: NPC250046
Ingredient ID: NPC249983
Ingredient ID: NPC249657
Ingredient ID: NPC249471
Ingredient ID: NPC249375
Ingredient ID: NPC246778
Ingredient ID: NPC242262
Ingredient ID: NPC241278
Ingredient ID: NPC239827
Ingredient ID: NPC239502
Ingredient ID: NPC237549
Ingredient ID: NPC23250
Ingredient ID: NPC230929
Ingredient ID: NPC230301
Ingredient ID: NPC228204
Ingredient ID: NPC22519
Ingredient ID: NPC221482
Ingredient ID: NPC215932
Ingredient ID: NPC213552
Ingredient ID: NPC205522
Ingredient ID: NPC201562
Ingredient ID: NPC198539
Ingredient ID: NPC198455
Ingredient ID: NPC195727
Ingredient ID: NPC195202
Ingredient ID: NPC187861
Ingredient ID: NPC184045
Ingredient ID: NPC183542
Ingredient ID: NPC182869
Ingredient ID: NPC181148
Ingredient ID: NPC18074
Ingredient ID: NPC1786
Ingredient ID: NPC178177
Ingredient ID: NPC168799
Ingredient ID: NPC165260
Ingredient ID: NPC163699
Ingredient ID: NPC161239
Ingredient ID: NPC160951
Ingredient ID: NPC15917
Ingredient ID: NPC158333
Ingredient ID: NPC156913
Ingredient ID: NPC154819
Ingredient ID: NPC14958
Ingredient ID: NPC146307
Ingredient ID: NPC145379
Ingredient ID: NPC142415
Ingredient ID: NPC133217
Ingredient ID: NPC129546
Ingredient ID: NPC127857
Ingredient ID: NPC121712
Ingredient ID: NPC1173
Ingredient ID: NPC115400
Ingredient ID: NPC114410
Ingredient ID: NPC112523
Ingredient ID: NPC112216
Ingredient ID: NPC108824
Ingredient ID: NPC10776
Ingredient ID: NPC101043
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Therapeutic Target | Lyase | CA5B | Carbonic anhydrase VB | Q9Y2D0 | CHEMBL3969 |
| Therapeutic Target | Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 7 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00346502 | Evaluation of 20% Betulinic Acid Ointment for Treatment of Dysplastic Nevi (Moderate to Severe Dysplasia) | dysplastic nevus | Betulinic Acid (NPC264317) | NP level |
| NCT00701987 | Safety, Tolerability, and Preliminary Efficacy Study of ALS-357 in Patients With Cutaneous Metastatic Melanoma | melanoma | Betulinic Acid (NPC264317) | NP level |
| NCT02337933 | Effect of Ursolic Acid Administration on Insulin Sensitivity and Metabolic Syndrome | metabolic syndrome | Ursolic Acid (NPC51700) | NP level |
| NCT02351622 | Caffeic Acid Tablets as a Second-line Therapy for ITP | autoimmune thrombocytopenic purpura | Caffeic Acid (NPC294902) | NP level |
| NCT03216876 | A Study Of Ursolic Acid For Primary Sclerosing Cholangitis | sclerosing cholangitis | Ursolic Acid (NPC51700) | NP level |
| NCT04403568 | Testing the Synergism of Phytonutrients, Curcumin and Ursolic Acid, to Target Molecular Pathways in the Prostate | prostate cancer | Ursolic Acid (NPC51700) | NP level |
| NCT04648917 | GASC1 Inhibitor Caffeic Acid for Squamous Esophageal Cell Cancer (ESCC) | esophageal cancer | Caffeic Acid (NPC294902) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKA,KDR,PTPN1,AURKB
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
AURKB,RELA,AURKA,NFKB1,PTPRC
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
RELA,NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA5A,AURKB,F2,CA7,AKR1B10,CA9,AURKA,MMP9,CA6,MMP1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
AURKB,CA7,CYP1B1,AKR1B10,CA9,PTPRC,PTPN1,CA14,AURKA,F2,MMP2,CDC25B,RECQL,CES1,MMP1
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
AURKB,F2,CDC25B,AURKA,MMP9,CA6,MMP1
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
KDR
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
