Collective Molecular Activities of the Plant: Actinidia Deliciosa
Plant ID: NPO2300
Plant Latin Name: Actinidia Deliciosa
Taxonomy Genus: Actinidia
Taxonomy Family: Actinidiaceae
Plant External Links:
NCBI TaxonomyDB:
3627
Plant-of-the-World-Online:
n.a.
Unknown.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
101 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
60 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
52 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC97160
Ingredient ID: NPC94631
Ingredient ID: NPC94167
Ingredient ID: NPC91369
Ingredient ID: NPC84192
Ingredient ID: NPC81010
Ingredient ID: NPC78766
Ingredient ID: NPC74304
Ingredient ID: NPC72886
Ingredient ID: NPC71204
Ingredient ID: NPC63186
Ingredient ID: NPC59436
Ingredient ID: NPC57896
Ingredient ID: NPC56592
Ingredient ID: NPC55412
Ingredient ID: NPC491279
Ingredient ID: NPC491216
Ingredient ID: NPC47844
Ingredient ID: NPC47680
Ingredient ID: NPC46757
Ingredient ID: NPC46095
Ingredient ID: NPC37647
Ingredient ID: NPC35109
Ingredient ID: NPC34963
Ingredient ID: NPC323401
Ingredient ID: NPC318742
Ingredient ID: NPC313179
Ingredient ID: NPC310686
Ingredient ID: NPC309330
Ingredient ID: NPC308043
Ingredient ID: NPC306142
Ingredient ID: NPC302857
Ingredient ID: NPC300593
Ingredient ID: NPC296910
Ingredient ID: NPC293378
Ingredient ID: NPC292356
Ingredient ID: NPC290020
Ingredient ID: NPC282707
Ingredient ID: NPC279992
Ingredient ID: NPC276625
Ingredient ID: NPC27335
Ingredient ID: NPC272535
Ingredient ID: NPC263046
Ingredient ID: NPC256175
Ingredient ID: NPC246026
Ingredient ID: NPC242580
Ingredient ID: NPC241935
Ingredient ID: NPC237812
Ingredient ID: NPC237532
Ingredient ID: NPC229217
Ingredient ID: NPC22678
Ingredient ID: NPC221281
Ingredient ID: NPC220765
Ingredient ID: NPC220757
Ingredient ID: NPC215135
Ingredient ID: NPC213697
Ingredient ID: NPC201147
Ingredient ID: NPC200282
Ingredient ID: NPC200039
Ingredient ID: NPC193536
Ingredient ID: NPC192402
Ingredient ID: NPC18905
Ingredient ID: NPC188844
Ingredient ID: NPC187993
Ingredient ID: NPC187770
Ingredient ID: NPC184399
Ingredient ID: NPC181465
Ingredient ID: NPC180032
Ingredient ID: NPC179950
Ingredient ID: NPC17938
Ingredient ID: NPC17810
Ingredient ID: NPC178049
Ingredient ID: NPC176740
Ingredient ID: NPC175791
Ingredient ID: NPC173637
Ingredient ID: NPC167400
Ingredient ID: NPC156654
Ingredient ID: NPC156482
Ingredient ID: NPC150950
Ingredient ID: NPC147983
Ingredient ID: NPC144062
Ingredient ID: NPC141414
Ingredient ID: NPC137585
Ingredient ID: NPC134902
Ingredient ID: NPC131382
Ingredient ID: NPC126029
Ingredient ID: NPC125037
Ingredient ID: NPC124277
Ingredient ID: NPC124261
Ingredient ID: NPC119621
Ingredient ID: NPC111929
Ingredient ID: NPC1075
Ingredient ID: NPC10709
Ingredient ID: NPC106446
Ingredient ID: NPC10636
Ingredient ID: NPC10559
Ingredient ID: NPC103438
Ingredient ID: NPC102266
Ingredient ID: NPC10180
Ingredient ID: NPC100551
Ingredient ID: NPC100347
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | 5HT3 receptor | HTR3A | Serotonin 3a (5-HT3a) receptor | P46098 | CHEMBL1899 |
| Therapeutic Target | Enzyme | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Therapeutic Target | Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 431 | |
 Plant level | 1 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000116 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Ascorbate (NPC187770);Beta Carotene (NPC17810) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | Myocardial Ischemia | Ascorbate (NPC187770) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | Myocardial Ischemia | Beta Carotene (NPC17810);Folic Acid (NPC147983) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction | Ascorbate (NPC187770);Beta Carotene (NPC17810);Folic Acid (NPC147983) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
NCT02755545,NCT03522922,NCT04490967,NCT01706250,NCT03090048,NCT00361322,NCT02524665,NCT01706263,NCT03832647
|
Actinic keratosisDisease Category: X.Extension CodesDisease ICD-11 Code: XH36H6 |
NCT02289768
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1,HTR2A,HTR2C
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT01294462,NCT00855257
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1,KDM1A
NCT00184054,NCT00329498 |
Acute promyelocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH1A50 |
NCT03624270
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT04404387
|
Acute upper respiratory infectionDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA07 |
DRD2,DRD3
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,HTR2C,HTR1D,HTR2B,ACHE,TSHR,HTR3A,CA7,SLCO1B1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
