CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Gnidia Involucrata

Example Image

PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO22809
Plant Latin Name: Gnidia Involucrata
Taxonomy Genus: Gnidia
Taxonomy Family: Thymelaeaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

3 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

2 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

1 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC50539

Ingredient ID: NPC197087

Ingredient ID: NPC109759

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Enzyme	BLM	Bloom syndrome protein	P54132	CHEMBL1293237

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	51

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT01051999	Glutamine Supplementation in Cystic Fibrosis	cystic fibrosis	Glutamine (NPC197087)	NP level
NCT02701673	Belinostat Combined With Azacitidine/Gemcitabine/Busulfan/Melphalan With Autologous Stem-Cell Transplantation in Refractory or Relapsed Lymphoma	lymphoma	Glutamine (NPC197087)	NP level
NCT01534663	Supplementation of Glutamine and Fish Oil Versus Placebo in Patients With Heart Failure	heart failure	Glutamine (NPC197087)	NP level
NCT00645879	Anaplerotic Therapy in Propionic Acidemia	propionic acidemia	Glutamine (NPC197087)	NP level
NCT00133978	Trial of Glutamine and Antioxidant Supplementation in Critically Ill Patients	Multiple Organ Failure;Sepsis	Glutamine (NPC197087)	NP level
NCT00003170	Glutamine in Preventing Acute Diarrhea in Patients With Pelvic Cancer	cancer	Glutamine (NPC197087)	NP level
NCT01179217	A Phase III Safety and Efficacy Study of L-Glutamine to Treat Sickle Cell Disease or Sickle βo-thalassemia	sickle cell anemia	Glutamine (NPC197087)	NP level
NCT05371184	Glutamine Role in Preventing Vaso-occlusive Crisis Among SCD Patients	sickle cell anemia	Glutamine (NPC197087)	NP level
NCT00133406	Long-term Impact and Intervention for Diarrhea in Brazil	diarrheal disease	Glutamine (NPC197087)	NP level
NCT00455247	Efficacy of an Oral Formula in Prevention of Anti-cancer Therapy Side Effects	cancer	Glutamine (NPC197087)	NP level
NCT04634539	Trial of First-line L-glutamine With Gemcitabine and Nab-paclitaxel in Advanced Pancreatic Cancer	pancreatic ductal adenocarcinoma	Glutamine (NPC197087)	NP level
NCT02114502	Carfilzomib/SAHA Combined With High-Dose Gemcitabine/Busulfan/Melphalan With Autologous Stem Cell Transplant in Myeloma	multiple myeloma	Glutamine (NPC197087)	NP level
NCT00006994	S9908: Glutamine in Treating Mucositis Caused by Radiation Therapy in Patients With Newly Diagnosed Cancer of the Mouth or Throat	oral mucositis	Glutamine (NPC197087)	NP level
NCT00016653	Creatine and Glutamine in Steroid-Naive Duchenne Muscular Dystrophy	Duchenne muscular dystrophy	Glutamine (NPC197087)	NP level
NCT00133562	HIAS II - Study of Nutritional Supplementation in Hospitalized Children With Persistent Diarrhea or Malnutrition	malnutrition	Glutamine (NPC197087)	NP level
NCT01983969	Aza-SAHA-GBM With AutoSCT for Refractory Lymphoma	lymphoma;cancer	Glutamine (NPC197087)	NP level
NCT00586209	L-Glutamine Therapy for Sickle Cell Anemia	Thalassemia;sickle cell anemia	Glutamine (NPC197087)	NP level
NCT02961816	Panobinostat Combined With High-Dose Gemcitabine/Busulfan/Melphalan With Autologous Stem Cell Transplant for Patients With Refractory/Relapsed Lymphoma	lymphoma	Glutamine (NPC197087)	NP level
NCT02012608	Glutamine for the Prevention of Radiation Toxicity in Subjects Conserving Therapy	breast cancer	Glutamine (NPC197087)	NP level
NCT02589145	Lenalidomide Combined With Vorinostat/Gemcitabine/Busulfan/Melphalan With Autologous Stem-Cell Transplantation in Diffuse Large B-Cell Lymphoma of the ABC Subtype	lymphoma	Glutamine (NPC197087)	NP level
NCT04909905	Glutamine Supplementation and Short-term Mortality in Covid-19	COVID-19	Glutamine (NPC197087)	NP level
NCT02215083	L-glutamine Supplementation to Alleviate Symptoms of Taxane-Induced Neuropathy in Patients With Breast Cancer	peripheral neuropathy	Glutamine (NPC197087)	NP level
NCT02053350	Alanyl-glutamine Supplementation of Standard Treatment for C. Difficile Infection	clostridium difficile infection	Glutamine (NPC197087)	NP level
NCT00018109	A Multicenter Randomized Placebo-Controlled Double-Blind Study to Assess Efficacy and Safety of Glutamine and Creatine Monohydrate in Duchenne Muscular Dystrophy (DMD)	Duchenne muscular dystrophy	Glutamine (NPC197087)	NP level
NCT00125788	L-Glutamine Therapy for Sickle Cell Anemia and Sickle ß0 Thalassemia	Thalassemia;sickle cell anemia	Glutamine (NPC197087)	NP level
NCT01263041	Effect of L-arginine and Glutamine on Preterm	Sepsis	Glutamine (NPC197087)	NP level
NCT02282839	Oral Glutamine and Mucositis of Head and Neck Cancer Patients Undergoing Radiation	mucositis	Glutamine (NPC197087)	NP level
NCT04019769	Glutamine Supplementation in People With Immune Dysregulation	Eczema	Glutamine (NPC197087)	NP level
NCT04684381	Pharmacokinetics and Safety of Endari (L-glutamine) in Sickle Cell Disease Patients	sickle cell anemia	Glutamine (NPC197087)	NP level
NCT02351323	Novel Type 2 Diabetes Mellitus Preventive Therapies	diabetes mellitus	Glutamine (NPC197087)	NP level
NCT00005775	Glutamine Supplementation to Prevent Death or Infection in Extremely Premature Infants	fetal growth restriction;premature birth;Sepsis	Glutamine (NPC197087)	NP level
NCT01087658	Oral Glutamine in the Prevention of Oxaliplatin-induced Neurotoxicity	colorectal neoplasm	Glutamine (NPC197087)	NP level
NCT00296621	Effect of Oral Glutamine on Muscle Mass and Function in Duchenne Muscular Dystrophy	Duchenne muscular dystrophy	Glutamine (NPC197087)	NP level
NCT00195013	Randomized Placebo-Controlled Trial of Glutamine for Breast Cancer Patients With Peripheral Neuropathy	peripheral neuropathy	Glutamine (NPC197087)	NP level
NCT00395161	The CRISIS Prevention Study	Sepsis	Glutamine (NPC197087)	NP level
NCT00003898	Glutamine in Treating Side Effects in Children Who Are Undergoing Stem Cell Transplantation	neoplasm	Glutamine (NPC197087)	NP level
NCT01704430	Glutamine to Improve Outcomes in Cardiac Surgery	nosocomial infection	Glutamine (NPC197087)	NP level
NCT00338221	Clinical Trial of Alanyl-Glutamine or Glycine in Children With Persistent Diarrhea or Malnutrition	malnutrition	Glutamine (NPC197087)	NP level
NCT00010634	Complementary Naturopathic Medicine for Periodontitis	periodontitis	Glutamine (NPC197087)	NP level
NCT02024191	The Role of Glutamine for Preventing Oxaliplatin-Induced Peripheral Neuropathy	peripheral neuropathy	Glutamine (NPC197087)	NP level
NCT00838149	Effect of Glutamine on Intestinal Permeability in Crohn's Disease	Crohn's disease	Glutamine (NPC197087)	NP level
NCT01478126	Effects of Glutamine in Ischemic Heart Disease Patients Following Cardiopulmonary Bypass	coronary artery disease	Glutamine (NPC197087)	NP level
NCT00131508	Trial of Oral Glutamine in Patients With Sickle Cell Anemia	sickle cell anemia	Glutamine (NPC197087)	NP level
NCT00673894	Effects of Glutamine on GLP-1 and Insulin Secretion in Man	type 2 diabetes mellitus	Glutamine (NPC197087)	NP level
NCT01414244	Glutamine for the Treatment of Patients With Irritable Bowel Syndrome	irritable bowel syndrome	Glutamine (NPC197087)	NP level
NCT01353638	Safety and Efficacy of the Addition of Alanyl-Glutamine-Dipeptide to Dialysis Solution in Peritoneal Dialysis	chronic kidney disease	Glutamine (NPC197087)	NP level
NCT01250782	Effectiveness of Dipeptide N (2)-L-Alanyl-L-Glutamine in Trauma ICU Patients: Pilot, Prospective, Randomized and Double Blind Study.	injury	Glutamine (NPC197087)	NP level
NCT03947879	The Effect of Pharmaceutical Grade L-glutamine (Endari) on Glycemic Control in Patients With Diabetes Mellitus Type II	type 2 diabetes mellitus	Glutamine (NPC197087)	NP level
NCT04274114	Treatment of Adults With Generalized Anxiety Disorder Using Glutamine	generalized anxiety disorder	Glutamine (NPC197087)	NP level
NCT01607879	Use of β-hydroxy-β-methylbutyrate to Counteract Muscle Loss in Men With Prostate Cancer on Androgen Ablation	prostate cancer	Glutamine (NPC197087)	NP level
NCT01952847	Randomized Trial of Glutamine in Patients With Mucositis or Esophagitis	cancer	Glutamine (NPC197087)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Sickle-cell disorder Disease Category: 03.Diseases of the blood or blood-forming organs Disease ICD-11 Code: 3A51	NCT00125788,NCT05371184,NCT01179217,NCT00586209,NCT00131508,NCT04684381
Unspecified malignant neoplasms of unspecified sites Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D4Z	NCT01952847,NCT00003170,NCT01983969,NCT00455247
Mature T-cell lymphoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A90	NCT02701673,NCT01983969,NCT02589145,NCT02961816
Sepsis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1G40-1G41	NCT00005775,NCT01263041,NCT00395161,NCT00133978
Duchenne muscular dystrophy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C70.1	NCT00016653,NCT00018109,NCT00296621
Polyneuropathy, unspecified Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C0Z	NCT02024191,NCT00195013,NCT02215083
Type 2 diabetes mellitus Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A11	NCT00673894,NCT03947879
Thalassaemia Disease Category: 03.Diseases of the blood or blood-forming organs Disease ICD-11 Code: 3A50	NCT00586209,NCT00125788
Oral mucositis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA01	NCT02282839,NCT00006994
Unspecified undernutrition Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5B7Z	NCT00338221,NCT00133562
Nosocomial Disease Category: X.Extension Codes Disease ICD-11 Code: XB25	NCT01704430
Infectious gastroenteritis or colitis without specification of infectious agent Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A40.Z	NCT00133406
Preterm newborn, unspecified Disease Category: 19.Certain conditions originating in the perinatal period Disease ICD-11 Code: KA21.4Z	NCT00005775
Periodontal disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA0C	NCT00010634
Intrauterine growth restriction, unspecified Disease Category: 19.Certain conditions originating in the perinatal period Disease ICD-11 Code: KA20.1Z	NCT00005775
Chronic kidney disease Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GB61	NCT01353638
Multiple myeloma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A83	NCT02114502
Diabetes mellitus, type unspecified Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A14	NCT02351323
Adenocarcinoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D40	NCT04634539
coronary artery disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA8Y-BA8Z	NCT01478126
Colorectal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B91	NCT01087658
Classical organic aciduria Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C50.E0	NCT00645879
Heart failure Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD10-BD1Z	NCT01534663
Unspecific body region injury Disease Category: 22.Injury, poisoning or certain other consequences of external causes Disease ICD-11 Code: ND56	NCT01250782
Breast cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C60-2C6Y	NCT02012608
Atopic eczema Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA80	NCT04019769
Generalised anxiety disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6B00	NCT04274114
Cystic fibrosis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA25	NCT01051999
Multi organ failure Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG4A	NCT00133978
Crohn disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD70	NCT00838149
Neoplasms Disease Category: 02.Neoplasms Disease ICD-11 Code: 02	NCT00003898
Prostate cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82	NCT01607879
Irritable bowel syndrome Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD91	NCT01414244
COVID-19 Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D6Y	NCT04909905
Clostridium difficile enterocolitis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A04	NCT02053350
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	BLM
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	BLM
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	BLM
Leishmaniasis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F54	BLM
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	BLM
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	BLM
Squamous cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.2	BLM
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	BLM
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	BLM
Malignant neoplasms of oesophagus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B70	BLM
Urothelial carcinoma of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.2	BLM
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	BLM
Malignant neoplasms of corpus uteri, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.Z	BLM
Invasive carcinoma of breast Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C61	BLM
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	BLM
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	BLM
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	BLM
Gliomas of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.0	BLM

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Gnidia Involucrata

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

3 All known Ingredients in Total

2 Ingredients with Acceptable Bioavailablity

1 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Sickle-cell disorder

Unspecified malignant neoplasms of unspecified sites

Mature T-cell lymphoma

Sepsis

Duchenne muscular dystrophy

Polyneuropathy, unspecified

Type 2 diabetes mellitus

Thalassaemia

Oral mucositis

Unspecified undernutrition

Nosocomial

Infectious gastroenteritis or colitis without specification of infectious agent

Preterm newborn, unspecified

Periodontal disease

Intrauterine growth restriction, unspecified

Chronic kidney disease

Multiple myeloma

Diabetes mellitus, type unspecified

Adenocarcinoma

coronary artery disease

Colorectal cancer

Classical organic aciduria

Heart failure

Unspecific body region injury

Breast cancer

Atopic eczema

Generalised anxiety disorder

Cystic fibrosis

Multi organ failure

Crohn disease

Neoplasms

Prostate cancer

Irritable bowel syndrome

COVID-19

Clostridium difficile enterocolitis

Pheochromocytoma

Malignant neoplasms of biliary tract, distal bile duct

Hepatoblastoma

Leishmaniasis

Adenocarcinoma of stomach

Diffuse large B-cell lymphomas

Squamous cell carcinoma of bronchus or lung

Adenocarcinoma of pancreas

Hepatocellular carcinoma of liver

Malignant neoplasms of oesophagus

Urothelial carcinoma of bladder

Adenocarcinoma of bronchus or lung

Malignant neoplasms of corpus uteri, unspecified

Invasive carcinoma of breast

Glioblastoma of brain

Germ cell tumour of testis

Malignant neoplasms of adrenal gland

Gliomas of brain

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities