Collective Molecular Activities of the Plant: Curcuma Kwangsiensis
Country/Region:
ChinaTraditional Medicine System:
TCMChina
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
454 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
389 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
199 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99886
Ingredient ID: NPC99506
Ingredient ID: NPC99480
Ingredient ID: NPC99358
Ingredient ID: NPC9880
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Ingredient ID: NPC143639
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Ingredient ID: NPC141777
Ingredient ID: NPC141699
Ingredient ID: NPC14112
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Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 | Cytochrome P450 family 5 | TBXAS1 | Thromboxane-A synthase | P24557 | CHEMBL1835 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Therapeutic Target | Fatty acid binding protein family | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
| Therapeutic Target | Isomerase | PTGES | Prostaglandin E synthase | O14684 | CHEMBL5658 |
| Therapeutic Target | Lyase | GLO1 | Glyoxalase I | Q04760 | CHEMBL2424 |
| Therapeutic Target | Methyl-lysine/arginine binding protein | SMN1 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 173 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00001521 | Three Drug Combination Therapy Versus Conventional Treatment of Children With Congenital Adrenal Hyperplasia | congenital adrenal hyperplasia | Hydrocortisone (NPC18509) | NP level |
| NCT00002471 | Combination Chemotherapy in Treating Patients With Acute B-Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma | leukemia;lymphoma | Hydrocortisone (NPC18509) | NP level |
| NCT00002494 | Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia | leukemia;lymphoma | Hydrocortisone (NPC18509) | NP level |
| NCT00002552 | Chemotherapy Plus Bone Marrow Transplantation in Treating Patients With Refractory Non-Hodgkin's Lymphoma, Hodgkin's Disease, or Multiple Myeloma | multiple myeloma | Hydrocortisone (NPC18509) | NP level |
| NCT00002700 | Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia | leukemia;lymphoma | Hydrocortisone (NPC18509) | NP level |
| NCT00002704 | Radiation Therapy and Chemotherapy in Treating Children With CNS Relapse From Acute Lymphoblastic Leukemia | leukemia | Hydrocortisone (NPC18509) | NP level |
| NCT00002744 | Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia | leukemia | Hydrocortisone (NPC18509) | NP level |
| NCT00002756 | Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia | leukemia | Hydrocortisone (NPC18509) | NP level |
| NCT00002757 | TITLE:Less Intensive Therapy for Children With Non-Hodgkin's Lymphoma | leukemia;lymphoma | Hydrocortisone (NPC18509) | NP level |
| NCT00002760 | Antiandrogen Withdrawal in Treating Patients With Hormone-Refractory Prostate Cancer | prostate cancer | Hydrocortisone (NPC18509) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
AR
|
Acquired adrenocortical insufficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A74.0 |
NCT01847690,NCT01063569
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOA
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
FFAR1,NR3C1,PPARA
|
Acute erythroid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60.35 |
NCT00002798
|
Acute leukaemias of ambiguous lineageDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A61 |
NCT04898894,NCT02419755
|
Acute megakaryoblastic leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60.36 |
NCT00002798
|
Acute monocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH9NE2 |
NCT00002798
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1,AR,TP53
NCT04293562,NCT02270788,NCT03071276,NCT00002798 |
Acute myelomonocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH78Y4 |
NCT00002798
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
