Collective Molecular Activities of the Plant: Gentiana Macrophylla
Country/Region:
ChinaTraditional Medicine System:
TCMMedicinal Functions:
Analgesic; Antiinflammatory; Antipyretic; Antirheumatic; Hypotensive
China; Russia; Mongolia
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
59 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
27 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
21 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC95392
Ingredient ID: NPC87419
Ingredient ID: NPC81996
Ingredient ID: NPC73490
Ingredient ID: NPC55830
Ingredient ID: NPC55715
Ingredient ID: NPC53558
Ingredient ID: NPC53545
Ingredient ID: NPC35185
Ingredient ID: NPC321804
Ingredient ID: NPC315566
Ingredient ID: NPC309264
Ingredient ID: NPC307851
Ingredient ID: NPC307699
Ingredient ID: NPC300969
Ingredient ID: NPC30030
Ingredient ID: NPC29063
Ingredient ID: NPC290613
Ingredient ID: NPC29
Ingredient ID: NPC289547
Ingredient ID: NPC287986
Ingredient ID: NPC287539
Ingredient ID: NPC286657
Ingredient ID: NPC279481
Ingredient ID: NPC279444
Ingredient ID: NPC277932
Ingredient ID: NPC27636
Ingredient ID: NPC273448
Ingredient ID: NPC260268
Ingredient ID: NPC255885
Ingredient ID: NPC255662
Ingredient ID: NPC250498
Ingredient ID: NPC250109
Ingredient ID: NPC249614
Ingredient ID: NPC248355
Ingredient ID: NPC243728
Ingredient ID: NPC230301
Ingredient ID: NPC225660
Ingredient ID: NPC220157
Ingredient ID: NPC217201
Ingredient ID: NPC214153
Ingredient ID: NPC213469
Ingredient ID: NPC209846
Ingredient ID: NPC190731
Ingredient ID: NPC184054
Ingredient ID: NPC176361
Ingredient ID: NPC170204
Ingredient ID: NPC167504
Ingredient ID: NPC15924
Ingredient ID: NPC157287
Ingredient ID: NPC156327
Ingredient ID: NPC144633
Ingredient ID: NPC142415
Ingredient ID: NPC141273
Ingredient ID: NPC125275
Ingredient ID: NPC107039
Ingredient ID: NPC101806
Ingredient ID: NPC10147
Ingredient ID: NPC101051
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Therapeutic Target | Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
| Therapeutic Target | Surface antigen | F3 | Coagulation factor III | P13726 | CHEMBL4081 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 3 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT03452488 | A Double-blind, Placebo Controlled, Randomized INTerventional Clinical Trial (SARA-INT) | sarcopenia | 20-Hydroxyecdysone (NPC260268) | NP level |
| NCT04472728 | Testing the Efficacy and Safety of BIO101 for the Prevention of Respiratory Deterioration in COVID-19 Patients | COVID-19 | 20-Hydroxyecdysone (NPC260268) | NP level |
| NCT04827537 | Anti-protozoal Effect of Steroid Hormone 20-hydroxyecdysone | giardiasis | 20-Hydroxyecdysone (NPC260268) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PTPN1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
PTPRC
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
F2,AKR1B10
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
AKR1B10,PTPRC,PTPN1,F2,CDC25B,CES1
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2,CDC25B
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
|
BCR-ABL1-negative chronic myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A41 |
PTPRC
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F2,F3
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
