Collective Molecular Activities of the Plant: Paeonia Suffruticosa
Plant ID: NPO22550
Plant Latin Name: Paeonia Suffruticosa
Taxonomy Genus: Paeonia
Taxonomy Family: Paeoniaceae
Plant External Links:
NCBI TaxonomyDB:
45171
Plant-of-the-World-Online:
n.a.
Country/Region:
South KoreaTraditional Medicine System:
KampoMedicinal Functions:
Analgesic; Antibacterial; Antiinflammatory; Antipyretic; Antispasmodic; Emmenagogue; Sedative; Styptic; Tonic
South Korea
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
121 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
35 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
65 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98365
Ingredient ID: NPC96423
Ingredient ID: NPC88358
Ingredient ID: NPC88176
Ingredient ID: NPC81010
Ingredient ID: NPC80360
Ingredient ID: NPC77493
Ingredient ID: NPC76270
Ingredient ID: NPC73559
Ingredient ID: NPC70744
Ingredient ID: NPC66700
Ingredient ID: NPC64925
Ingredient ID: NPC62765
Ingredient ID: NPC61477
Ingredient ID: NPC52975
Ingredient ID: NPC50898
Ingredient ID: NPC49290
Ingredient ID: NPC477627
Ingredient ID: NPC477623
Ingredient ID: NPC477617
Ingredient ID: NPC47272
Ingredient ID: NPC469519
Ingredient ID: NPC469459
Ingredient ID: NPC469456
Ingredient ID: NPC469448
Ingredient ID: NPC469438
Ingredient ID: NPC469417
Ingredient ID: NPC469415
Ingredient ID: NPC469397
Ingredient ID: NPC469396
Ingredient ID: NPC41744
Ingredient ID: NPC40577
Ingredient ID: NPC34066
Ingredient ID: NPC3357
Ingredient ID: NPC329148
Ingredient ID: NPC322726
Ingredient ID: NPC318826
Ingredient ID: NPC307605
Ingredient ID: NPC303429
Ingredient ID: NPC302857
Ingredient ID: NPC301598
Ingredient ID: NPC29884
Ingredient ID: NPC29883
Ingredient ID: NPC297987
Ingredient ID: NPC297719
Ingredient ID: NPC294282
Ingredient ID: NPC293568
Ingredient ID: NPC293378
Ingredient ID: NPC290690
Ingredient ID: NPC288259
Ingredient ID: NPC285875
Ingredient ID: NPC285184
Ingredient ID: NPC283530
Ingredient ID: NPC280725
Ingredient ID: NPC275088
Ingredient ID: NPC272016
Ingredient ID: NPC265784
Ingredient ID: NPC264145
Ingredient ID: NPC262911
Ingredient ID: NPC262450
Ingredient ID: NPC260005
Ingredient ID: NPC251701
Ingredient ID: NPC250447
Ingredient ID: NPC248540
Ingredient ID: NPC248294
Ingredient ID: NPC247629
Ingredient ID: NPC245506
Ingredient ID: NPC23988
Ingredient ID: NPC233538
Ingredient ID: NPC23253
Ingredient ID: NPC225710
Ingredient ID: NPC219876
Ingredient ID: NPC218685
Ingredient ID: NPC21835
Ingredient ID: NPC213935
Ingredient ID: NPC213723
Ingredient ID: NPC20791
Ingredient ID: NPC204998
Ingredient ID: NPC203124
Ingredient ID: NPC195114
Ingredient ID: NPC192689
Ingredient ID: NPC192402
Ingredient ID: NPC19125
Ingredient ID: NPC19044
Ingredient ID: NPC188217
Ingredient ID: NPC186098
Ingredient ID: NPC183051
Ingredient ID: NPC18197
Ingredient ID: NPC181360
Ingredient ID: NPC179498
Ingredient ID: NPC17733
Ingredient ID: NPC176740
Ingredient ID: NPC176325
Ingredient ID: NPC17150
Ingredient ID: NPC16728
Ingredient ID: NPC16512
Ingredient ID: NPC16388
Ingredient ID: NPC161626
Ingredient ID: NPC160785
Ingredient ID: NPC159200
Ingredient ID: NPC15658
Ingredient ID: NPC154149
Ingredient ID: NPC151516
Ingredient ID: NPC149002
Ingredient ID: NPC148185
Ingredient ID: NPC147722
Ingredient ID: NPC141724
Ingredient ID: NPC141331
Ingredient ID: NPC133430
Ingredient ID: NPC130683
Ingredient ID: NPC130520
Ingredient ID: NPC129588
Ingredient ID: NPC128610
Ingredient ID: NPC120012
Ingredient ID: NPC119900
Ingredient ID: NPC117943
Ingredient ID: NPC116775
Ingredient ID: NPC113212
Ingredient ID: NPC110899
Ingredient ID: NPC104222
Ingredient ID: NPC100551
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 80 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00218946 | Nasogastric Tube in Premature Babies - Pain and Treatment | premature birth | Sucrose (NPC130683) | NP level |
| NCT00249951 | Alkaline Citrate Treatment to Lower the Risk of Nephrocalcinosis in Preterm Infants | Nephrocalcinosis | Citric Acid (NPC293378) | NP level |
| NCT00361322 | Efficacy and Safety of a Preparation Containing an Antibiotic and Anti-Inflammatory Agent in Acne Vulgaris | acne | Salicylic Acid (NPC100551) | NP level |
| NCT00425074 | Pharmacodynamic-pharmacokinetic Trial, of Slow Release ASA, in the Platelet Functionalism. | cardiovascular disease | Salicylic Acid (NPC100551) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791) | NP level |
| NCT00482560 | Analgesic Effect of Breast Feeding vs Sucrose in Neonatal Screening | pain | Sucrose (NPC130683) | NP level |
| NCT00501059 | A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease | cardiovascular disease | Salicylic Acid (NPC100551) | NP level |
| NCT00501254 | Pharmacodynamic Trial, of Slow Release ASA, in Platelet Functionalism, a Long Term Treatment Period | cardiovascular disease | Salicylic Acid (NPC100551) | NP level |
| NCT00519207 | Evaluation of Topical Liposomal Lidocaine and Oral Sucrose for Treatment of Pain in Newborns Undergoing Venipuncture | pain | Sucrose (NPC130683) | NP level |
| NCT00787059 | AC6 Gene Transfer for CHF | congestive heart failure | Sucrose (NPC130683) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
NCT00361322,NCT01706263,NCT04490967,NCT02755545,NCT03832647,NCT02524665,NCT01706250
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Actinic keratosisDisease Category: X.Extension CodesDisease ICD-11 Code: XH36H6 |
NCT02289768
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1,DPP4,AURKB,KDR
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT01294462
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
AURKB,SRC,TP53,PIM1,AXL,FLT3
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT03718507
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,ACHE,NPSR1,CYP2C9,XDH,TTR,THPO,CDK1,AURKB,CA7
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
