Ingredient ID: NPC92381
Ingredient ID: NPC62042
Ingredient ID: NPC61620
Ingredient ID: NPC4460
Ingredient ID: NPC325325
Ingredient ID: NPC273100
Ingredient ID: NPC254416
Ingredient ID: NPC237649
Ingredient ID: NPC22195
Ingredient ID: NPC21190
Ingredient ID: NPC197239
Ingredient ID: NPC176262
Ingredient ID: NPC166958
Ingredient ID: NPC165081
Ingredient ID: NPC162656
Ingredient ID: NPC159362
Ingredient ID: NPC151618
Ingredient ID: NPC147628
Ingredient ID: NPC141953
Ingredient ID: NPC129026
Ingredient ID: NPC117579
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Nuclear hormone receptor subfamily 1 | THRA | Thyroid hormone receptor alpha | P10827 | CHEMBL1860 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 12 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT05316922 | TSH Suppression During Radiotherapy on Thyroid Site to Prevent Iatrogenic Hypothyroidism in Pediatric Cancer Patients | hypothyroidism | Levothyroxine (NPC197239) | NP level |
NCT01528839 | Supraphysiological Doses of Levothyroxine as Adjunctive Therapy in Bipolar Depression | bipolar disorder | Levothyroxine (NPC197239) | NP level |
NCT01950260 | Early Levothyroxine Post Radioactive Iodine | Graves disease | Levothyroxine (NPC197239) | NP level |
NCT05412979 | A Study Evaluating the Safety and Efficacy of Hormone Replacement Therapy With ST-1891 Compared to Levothyroxine in Patients With Primary Hypothyroidism | hypothyroidism | Levothyroxine (NPC197239) | NP level |
NCT03627611 | Identification of Non-responders to Levothyroxine Therapy | hypothyroidism | Levothyroxine (NPC197239) | NP level |
NCT03106935 | Recurrent Pregnancy Loss and Thyroid Disease | pregnancy | Levothyroxine (NPC197239) | NP level |
NCT01486667 | Thyroxin Treatment in Sub Clinical Hypothyroidism, on the Apnea Hypopnea Index Score, Lipids and Highly Sensitive CRP | Disorder of lipid metabolism | Levothyroxine (NPC197239) | NP level |
NCT03102177 | Effect of Age, Weight and Sex on Levothyroxine Pharmacokinetics | hypothyroidism | Levothyroxine (NPC197239) | NP level |
NCT03053115 | Combined Replacement Therapy With Levothyroxine and Liothyronine in Thyroidectomized Patients | hypothyroidism | Levothyroxine (NPC197239) | NP level |
NCT02090907 | Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hypothyroidism | hypothyroidism | Levothyroxine (NPC197239) | NP level |
NCT00403390 | Generic vs. Name-Brand Levothyroxine | congenital hypothyroidism | Levothyroxine (NPC197239) | NP level |
NCT02920385 | A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Levothyroxine and the Influence of Co-administered Tablets on the Pharmacokinetics of Semaglutide Administered Orally in Healthy Subjects. | diabetes mellitus | Levothyroxine (NPC197239) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Hypo-thyroidismDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A00 |
THRA,THRB
NCT05316922,NCT03102177,NCT05412979,NCT03627611,NCT03053115,NCT02090907 |
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
THRA,CDK5R1,LMNA
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
THRB,CDK5R1,LMNA
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
THRA,THRB
|
Inborn lipid metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52 |
THRB
NCT01486667 |
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CDK5R1,LMNA
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
THRB,CDK5R1
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
THRA
|
Thyrotoxicosis with diffuse goitreDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A02.0 |
NCT01950260
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
NCT02920385
|
Congenital hypothyroidismDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A00.0 |
NCT00403390
|
Pregnancy/childbirth/puerperium maternal infectionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JB63 |
NCT03106935
|
Bipolar disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60 |
NCT01528839
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
CDK5R1
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
THRB
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
CDK5R1
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
CDK5R1
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
CDK5R1
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
LMNA
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
CDK5R1
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
LMNA
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CDK5R1
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
CDK5R1
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CDK5R1
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
THRB
|