Collective Molecular Activities of the Plant: Senna Spectabilis
Plant ID: NPO22441
Plant Latin Name: Senna Spectabilis
Taxonomy Genus: Senna
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
347003
Plant-of-the-World-Online:
n.a.
Country/Region:
Brazil; ChinaTraditional Medicine System:
TCMBrazil; China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
46 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
35 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
30 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC89749
Ingredient ID: NPC81010
Ingredient ID: NPC77572
Ingredient ID: NPC70744
Ingredient ID: NPC67978
Ingredient ID: NPC67917
Ingredient ID: NPC67377
Ingredient ID: NPC55983
Ingredient ID: NPC54379
Ingredient ID: NPC53069
Ingredient ID: NPC48053
Ingredient ID: NPC46744
Ingredient ID: NPC46451
Ingredient ID: NPC31311
Ingredient ID: NPC308267
Ingredient ID: NPC306973
Ingredient ID: NPC302642
Ingredient ID: NPC29883
Ingredient ID: NPC282420
Ingredient ID: NPC268470
Ingredient ID: NPC268334
Ingredient ID: NPC245561
Ingredient ID: NPC232071
Ingredient ID: NPC2314
Ingredient ID: NPC219913
Ingredient ID: NPC216459
Ingredient ID: NPC215019
Ingredient ID: NPC208657
Ingredient ID: NPC207757
Ingredient ID: NPC186255
Ingredient ID: NPC186128
Ingredient ID: NPC180832
Ingredient ID: NPC171409
Ingredient ID: NPC164014
Ingredient ID: NPC157220
Ingredient ID: NPC152331
Ingredient ID: NPC141704
Ingredient ID: NPC138487
Ingredient ID: NPC137100
Ingredient ID: NPC137001
Ingredient ID: NPC131204
Ingredient ID: NPC124569
Ingredient ID: NPC116895
Ingredient ID: NPC116027
Ingredient ID: NPC111888
Ingredient ID: NPC100079
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | CHEMBL235 |
| Therapeutic Target | Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | DRD2 | Dopamine D2 receptor | P14416 | CHEMBL217 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | DRD1 | Dopamine D1 receptor | P21728 | CHEMBL2056 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | DRD4 | Dopamine D4 receptor | P21917 | CHEMBL219 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | DRD3 | Dopamine D3 receptor | P35462 | CHEMBL234 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 79 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000776 | Dexamethasone in Cryptococcal Meningitis | intracranial hypertension;cryptococcal meningitis | Amphotericin B (NPC67917) | NP level |
| NCT00001017 | Comparison of Fluconazole and Amphotericin B in the Treatment of Brain Infections in Patients With AIDS | cryptococcal meningitis | Amphotericin B (NPC67917) | NP level |
| NCT00001107 | Comparison of Two Treatments to Prevent Invasive Fungal Infections in Patients Who Have Received Liver Transplants | candidiasis | Amphotericin B (NPC67917) | NP level |
| NCT00001646 | Voriconazole vs. Amphotericin B in the Treatment of Invasive Aspergillosis | aspergillosis | Amphotericin B (NPC67917) | NP level |
| NCT00002159 | A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis | blastomycosis;histoplasmosis | Amphotericin B (NPC67917) | NP level |
| NCT00002277 | A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections | fungal infectious disease | Amphotericin B (NPC67917) | NP level |
| NCT00002316 | The Safety and Effectiveness of RMP-7 Plus Amphotericin B in Patients With HIV and Cryptococcal Meningitis | cryptococcal meningitis | Amphotericin B (NPC67917) | NP level |
| NCT00002742 | Antifungal Therapy for Fever and Neutropenia in Patients Receiving Treatment for Hematologic Cancer | chronic myeloproliferative disorder;leukemia;multiple myeloma;myelodysplastic syndrome;infection | Amphotericin B (NPC67917) | NP level |
| NCT00003031 | Comparison of Voriconazole and Amphotericin B in Treating Patients With Aspergillosis | aspergillosis | Amphotericin B (NPC67917) | NP level |
| NCT00003315 | Liposomal Amphotericin B With or Without Sargramostim in Treating Patients With Invasive Fungal Infection | infection | Amphotericin B (NPC67917) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOA
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PPARG,AKR1B1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NCT03187691,NCT00451711,NCT00418951
|
Acute upper respiratory infectionDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA07 |
DRD3,DRD2
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
THPO,ACHE,CYP2D6
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ACHE,SNCA,CYP1B1,DRD2,CA2,DRD1,PPARG,LMNA
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
DRD1
|
AdenocarcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D40 |
NCT03486496
|
Allergic/hypersensitivity disorderDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A80-4A8Z |
DRD4,DRD5,DRD2,DRD1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
