CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Ardisia Macrocarpa

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PLANiTS DNA barcode

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Taxonomic Information

Plant ID: NPO22395
Plant Latin Name: Ardisia Macrocarpa
Taxonomy Genus: Ardisia
Taxonomy Family: Primulaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

99 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

27 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

49 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC97444

Ingredient ID: NPC9634

Ingredient ID: NPC90769

Ingredient ID: NPC89880

Ingredient ID: NPC85376

Ingredient ID: NPC82847

Ingredient ID: NPC81698

Ingredient ID: NPC77719

Ingredient ID: NPC7095

Ingredient ID: NPC69394

Ingredient ID: NPC6332

Ingredient ID: NPC60548

Ingredient ID: NPC60509

Ingredient ID: NPC57030

Ingredient ID: NPC55887

Ingredient ID: NPC51700

Ingredient ID: NPC48568

Ingredient ID: NPC37454

Ingredient ID: NPC35659

Ingredient ID: NPC33695

Ingredient ID: NPC31801

Ingredient ID: NPC306799

Ingredient ID: NPC304876

Ingredient ID: NPC303454

Ingredient ID: NPC300414

Ingredient ID: NPC296250

Ingredient ID: NPC294902

Ingredient ID: NPC294555

Ingredient ID: NPC291416

Ingredient ID: NPC286206

Ingredient ID: NPC286146

Ingredient ID: NPC282054

Ingredient ID: NPC278768

Ingredient ID: NPC275861

Ingredient ID: NPC266489

Ingredient ID: NPC265395

Ingredient ID: NPC264317

Ingredient ID: NPC261969

Ingredient ID: NPC26033

Ingredient ID: NPC257213

Ingredient ID: NPC256142

Ingredient ID: NPC250696

Ingredient ID: NPC250046

Ingredient ID: NPC249983

Ingredient ID: NPC249657

Ingredient ID: NPC249471

Ingredient ID: NPC249375

Ingredient ID: NPC246778

Ingredient ID: NPC242262

Ingredient ID: NPC241278

Ingredient ID: NPC239827

Ingredient ID: NPC239502

Ingredient ID: NPC237549

Ingredient ID: NPC23250

Ingredient ID: NPC230929

Ingredient ID: NPC230301

Ingredient ID: NPC228204

Ingredient ID: NPC22519

Ingredient ID: NPC221482

Ingredient ID: NPC215932

Ingredient ID: NPC213552

Ingredient ID: NPC205522

Ingredient ID: NPC201562

Ingredient ID: NPC198539

Ingredient ID: NPC198455

Ingredient ID: NPC195727

Ingredient ID: NPC195202

Ingredient ID: NPC187861

Ingredient ID: NPC184045

Ingredient ID: NPC183542

Ingredient ID: NPC182869

Ingredient ID: NPC181148

Ingredient ID: NPC18074

Ingredient ID: NPC1786

Ingredient ID: NPC178177

Ingredient ID: NPC168799

Ingredient ID: NPC163699

Ingredient ID: NPC161239

Ingredient ID: NPC160951

Ingredient ID: NPC15917

Ingredient ID: NPC158333

Ingredient ID: NPC156913

Ingredient ID: NPC154819

Ingredient ID: NPC14958

Ingredient ID: NPC146307

Ingredient ID: NPC145379

Ingredient ID: NPC142415

Ingredient ID: NPC133217

Ingredient ID: NPC129546

Ingredient ID: NPC127857

Ingredient ID: NPC121712

Ingredient ID: NPC1173

Ingredient ID: NPC115400

Ingredient ID: NPC114410

Ingredient ID: NPC112523

Ingredient ID: NPC112216

Ingredient ID: NPC108824

Ingredient ID: NPC10776

Ingredient ID: NPC101043

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450	Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450	Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450	Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Therapeutic Target	Enzyme	CES1	Acyl coenzyme A:cholesterol acyltransferase	P23141	CHEMBL2265
Therapeutic Target	Enzyme	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Therapeutic Target	Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Therapeutic Target	Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Therapeutic Target	Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Therapeutic Target	Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Therapeutic Target	Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Therapeutic Target	Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Therapeutic Target	Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Therapeutic Target	Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Therapeutic Target	Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Therapeutic Target	Nuclear hormone receptor subfamily 1	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Therapeutic Target	Nuclear hormone receptor subfamily 1	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Therapeutic Target	Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Therapeutic Target	Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Therapeutic Target	Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Therapeutic Target	Surface antigen	F3	Coagulation factor III	P13726	CHEMBL4081
Therapeutic Target	Transcription factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Therapeutic Target	Transcription factor	RELA	Nuclear factor NF-kappa-B p65 subunit	Q04206	CHEMBL5533

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	7

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT03216876	A Study Of Ursolic Acid For Primary Sclerosing Cholangitis	sclerosing cholangitis	Ursolic Acid (NPC51700)	NP level
NCT02337933	Effect of Ursolic Acid Administration on Insulin Sensitivity and Metabolic Syndrome	metabolic syndrome	Ursolic Acid (NPC51700)	NP level
NCT00701987	Safety, Tolerability, and Preliminary Efficacy Study of ALS-357 in Patients With Cutaneous Metastatic Melanoma	melanoma	Betulinic Acid (NPC264317)	NP level
NCT04403568	Testing the Synergism of Phytonutrients, Curcumin and Ursolic Acid, to Target Molecular Pathways in the Prostate	prostate cancer	Ursolic Acid (NPC51700)	NP level
NCT04648917	GASC1 Inhibitor Caffeic Acid for Squamous Esophageal Cell Cancer (ESCC)	esophageal cancer	Caffeic Acid (NPC294902)	NP level
NCT02351622	Caffeic Acid Tablets as a Second-line Therapy for ITP	autoimmune thrombocytopenic purpura	Caffeic Acid (NPC294902)	NP level
NCT00346502	Evaluation of 20% Betulinic Acid Ointment for Treatment of Dysplastic Nevi (Moderate to Severe Dysplasia)	dysplastic nevus	Betulinic Acid (NPC264317)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	AKR1B10,CA14,TDP1,RORC,AURKB,MMP9,MMP1,CA9,CA7
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	AKR1B10,TDP1,RORC,MMP9,MMP1,AURKA,CA9,PTPRC,CYP1A2
Squamous cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.2	AKR1B10,AURKB,MMP9,F2,MMP1,AURKA,CA9,CA7,CA6
Malignant neoplasms of corpus uteri, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.Z	AKR1B10,AURKB,MMP9,F2,MMP1,AURKA,CA9,CYP1A1,CA6
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	F3,AURKB,MMP9,MMP2,AURKA,MMP1,CA9,CA5B
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	AKR1B10,NFKB1,MMP9,CA5A,CYP1B1,CA9,PTPRC,CA6
Lung cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25	AURKA,CDC25B,MMP2,KDR,RORC,MMP1,MMP9
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	AKR1B10,AURKB,MMP9,MMP2,MMP1,AURKA,CA5B
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	AURKB,MMP9,F2,MMP1,AURKA,CA6,CDC25B
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	CA14,MMP2,F2,MMP1,PTPRC,KDR,CDC25B
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	AURKB,MMP9,MMP1,AURKA,CA9,CA7,CA5B
Breast cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C60-2C6Y	CA9,CA14,CA6,KDR,PTPN1,AURKA
Leishmaniasis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F54	AKR1B10,MMP9,MMP2,MMP1,PTPN1,CDC25B
Malignant neoplasm metastasis in lymph nodes of head, face or neck Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D60.0	AURKB,MMP9,F2,MMP1,AURKA,CA9
Other specified malignant neoplasms ofcolon Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B90.Y	F2,MMP1,CA9,CYP1A1,CA6,CDC25B
Other specified malignant neoplasms of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.Y	AKR1B10,AURKB,MMP9,MMP1,AURKA,CA9
Urothelial carcinoma of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.2	AURKB,MMP9,MMP1,AURKA,CA9,CYP1A2
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	AURKA,NFKB1,RELA,AURKB,PTPRC
Malignant neoplasms of oesophagus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B70	AURKB,MMP9,MMP1,AURKA,CDC25B
Invasive carcinoma of breast Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C61	AURKB,MMP9,MMP1,AURKA,CA9
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	AKR1B10,CYP1B1,KDR,CA9,PTPRC
Rheumatoid arthritis Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA20	RELA,MMP1,NFKB1,MMP9
Psoriasis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA90	RELA,NFKB1,RORC AKR1B10
Acute diabete complication Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A2Y	AURKB,PTPN1,AURKA,KDR
Renal cell carcinoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90	MMP2,KDR,MMP9,CA9
Multiple sclerosis Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A40	RORC,RELA,NFKB1,F2
Brain cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00	MMP9,MMP1,MMP2,KDR
Crohn disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD70	MMP9,RORC MMP9,MMP1
Type 2 diabetes mellitus Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A11	PTPN1,RELA,F2,NFKB1
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	CA14,RORC,MMP9,MMP1
Tetralogy of Fallot Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LA88.2	CA14,F3,RORC,F2
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	CA14,KDM4E,MMP9,CYP1A1
Chronic rhinosinusitis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA0A	MMP9,CA9,CYP1A1,MMP1
Renal cell carcinoma, chromophobe type Disease Category: X.Extension Codes Disease ICD-11 Code: XH6153	AURKB,AURKA,CYP1A2,CYP1A1
Prostate cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82	AURKA,AURKB NCT04403568
Malignant haematopoietic neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B33	PTPRC,AURKA,AURKB
Pancreatic cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10	F3,MMP1,MMP2
Systemic lupus erythematosus Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A40.0	F3,MMP9,CYP1A1
Malignant neoplasms of thyroid gland, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D10.Z	MMP1,CYP1B1,CA7
Chikungunya virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D40	F3,MMP2,CA5A
Carpal tunnel syndrome Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C10.0	MMP2,CYP1B1,CA5B
Indeterminate colitis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD72	NFKB1,RELA
Bacterial infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A00-1C4Z	CA6,CA14
Skin and skin-structure infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F28-1G0Z	RELA,NFKB1
Bleeding disorder Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA20-GA21	F2,F3
Atopic eczema Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA80	NFKB1,RELA
Diabetes mellitus, type unspecified Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A14	NFKB1,RELA
Stomach cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72	KDR,MMP9
Fungal infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F29-1F2F	NFKB1,RELA
Mature T-cell lymphoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A90	CA9,PTPRC
Muscular dystrophy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C70	RELA,NFKB1
Ischaemic/haemorrhagic stroke Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B20	MMP9,F2
Liver cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12	AURKA,KDR
Irritable bowel syndrome Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD91	NFKB1,RELA
Thrombocytopenia Disease Category: 03.Diseases of the blood or blood-forming organs Disease ICD-11 Code: 3B64	KDR,F2
Acute/subacute hepatic failure Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB91	NFKB1,RELA
Lupus erythematosus Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A40	RELA,NFKB1
Cardiovascular disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA00-BE2Z	KDR,F2
Melanoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C30	KDR NCT00701987
Metabolic disorder Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C50-5D2Z	PTPN1 NCT02337933
Choreiform disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A01	NFKB1,RELA
Inflammatory bowel diseases, unspecified Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD7Z	MMP9,MMP1
Osteoarthritis, unspecified Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA0Z	MMP9,MMP2
Gliomas of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.0	AKR1B10,MMP9
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	AKR1B10,RECQL,CA14,AURKB,CES1,MMP2,F2,PTPN1,AURKA,MMP1,CYP1B1,CA9,CA7,PTPRC,CDC25B
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	AKR1B10,AURKB,MMP9,MMP1,AURKA,CA9,AKR1B10,AURKB,MMP9,MMP1,AURKA,CA9,CDC25B
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	AKR1B10,RECQL,TDP1,AURKB,MMP9,MMP1,AURKA,CA9,KDR,CA7,PTPRC,CDC25B
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	KDR,RELA,AURKA,RORC,F3,CA6,NFKB1,MMP9,CA14,CA9,AURKB
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	RECQL,F3,TDP1,AURKB,MMP2,MMP1,PTPN1,AURKA,CA5A,CA9,KDR
Other specified malignant neoplasms of kidney, except renal pelvis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90.Y	AKR1B10,AURKB,MMP9,CA9,AURKB,MMP9,F2,MMP1,CA9,PTPRC
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	AKR1B10,AURKB,MMP9,F2,MMP1,AURKA,CA5A,CA9,CA7,CA6
Diffuse large B-cell lymphoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	PTPRC
Obesity Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5B80-5B81	PTPN1
Hepatic fibrosis/cirrhosis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB93	MMP2
Head and neck cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D42	KDR
Myocardial infarction Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA41-BA43	F2
Seborrhoeic dermatitis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA81	CA6
Ovarian cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73	KDR
Metastatic lymph node neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D60	KDR
Coronary thrombosis Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA43	F2
Postoperative inflammation Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A00-CA43	PTPN1
Transplanted organ/tissue Disease Category: 24.Factors influencing health status or contact with health services Disease ICD-11 Code: QB63	PTPRC
Multiple myeloma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A83	KDR
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	KDR
Ophthalmic devices/implants/grafts injury Disease Category: 23.External causes of morbidity or mortality Disease ICD-11 Code: PK97	PTPN1
Malignant digestive organ neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C11	KDR
Angina pectoris Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA40	F2
Non-small cell lung cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25	KDR
Nasopharyngeal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B6B	CDC25B
Chronic arterial occlusive disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD4Z	CES1
Asthma Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA23	F2
Peroxisomal disease Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C57	CES1
Acute respiratory distress syndrome Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB00	F3
Autoimmune disease Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A40-4A45	RORC
Synthesis disorder Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C52-5C59	CES1
Ulcerative colitis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD71	MMP9
Thrombosis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB61-GB90	F2
Nutritional deficiency Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5B50-5B71	F2
BCR-ABL1-negative chronic myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A41	PTPRC
Colorectal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B91	KDR
Peritoneal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C51	KDR
Cerebral ischaemic stroke Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B11	F2
Inborn metabolism deficiency Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C50-5C59	CA14
Coagulation defect Disease Category: 03.Diseases of the blood or blood-forming organs Disease ICD-11 Code: 3B10	F2
Digestive organ benign neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2E92	KDR
Hyper-lipoproteinaemia Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C80	CES1
Gastrointestinal stromal tumour Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B5B	KDR
Acne vulgaris Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED80	MMP2
Chronic pain Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG30	KDR
Myelodysplastic syndrome Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A37	KDR
Transplant rejection Disease Category: 22.Injury, poisoning or certain other consequences of external causes Disease ICD-11 Code: NE84	PTPRC
Thyroid cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D10	KDR
Pleomorphic sarcoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B54	KDR
Esophageal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B70	NCT04648917
Primary sclerosing cholangitis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB96.2	NCT03216876
Dysplastic naevus Disease Category: X.Extension Codes Disease ICD-11 Code: XH9035	NCT00346502
Immune thrombocytopenic purpura Disease Category: 03.Diseases of the blood or blood-forming organs Disease ICD-11 Code: 3B64.10	NCT02351622
Coeliac disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA95	CYP1A1
Dengue fever, unspecified Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D2Z	AURKB
Atrial fibrillation Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BC81.3	CA7
Non-alcoholic fatty liver disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB92	MMP9
Myotonic dystrophy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C71.0	CYP1A1
Keratoconus Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9A78.50	CA6
West Nile virus infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D46	NFKB1
Melanoma of skin Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C30	PTPRC
Pneumonia due to Pseudomonasaeruginosa Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA40.05	MMP9
Systemic sclerosis Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A42	MMP1
Heart failure, unspecified Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD1Z	CYP1B1
Malaria, unspecified Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F4Z	MMP9
Lyme borreliosis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1C1G	MMP9

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Ardisia Macrocarpa

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Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

99 All known Ingredients in Total

27 Ingredients with Acceptable Bioavailablity

49 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Carcinosarcoma of uterus

Serous cystadenoma,borderline malignancy of ovary

Squamous cell carcinoma of bronchus or lung

Malignant neoplasms of corpus uteri, unspecified

Malignant neoplasms of biliary tract, distal bile duct

Malignant neoplasms of thymus

Lung cancer

Hepatoblastoma

Adenocarcinoma of stomach

Germ cell tumour of testis

Malignant neoplasms of adrenal gland

Breast cancer

Leishmaniasis

Malignant neoplasm metastasis in lymph nodes of head, face or neck

Other specified malignant neoplasms ofcolon

Other specified malignant neoplasms of bronchus or lung

Urothelial carcinoma of bladder

Acute myeloid leukaemia

Malignant neoplasms of oesophagus

Invasive carcinoma of breast

Glioblastoma of brain

Rheumatoid arthritis

Psoriasis

Acute diabete complication

Renal cell carcinoma

Multiple sclerosis

Brain cancer

Crohn disease

Type 2 diabetes mellitus

Pheochromocytoma

Tetralogy of Fallot

Cytomegaloviral disease

Chronic rhinosinusitis

Renal cell carcinoma, chromophobe type

Prostate cancer

Malignant haematopoietic neoplasm

Pancreatic cancer

Systemic lupus erythematosus

Malignant neoplasms of thyroid gland, unspecified

Chikungunya virus disease

Carpal tunnel syndrome

Indeterminate colitis

Bacterial infection

Skin and skin-structure infection

Bleeding disorder

Atopic eczema

Diabetes mellitus, type unspecified

Stomach cancer

Fungal infection

Mature T-cell lymphoma

Muscular dystrophy

Ischaemic/haemorrhagic stroke

Liver cancer

Irritable bowel syndrome

Thrombocytopenia

Acute/subacute hepatic failure

Lupus erythematosus

Cardiovascular disease

Melanoma

Metabolic disorder

Choreiform disorder

Inflammatory bowel diseases, unspecified

Osteoarthritis, unspecified

Gliomas of brain