Collective Molecular Activities of the Plant: Gastrodia Elata
Plant ID: NPO22309
Plant Latin Name: Gastrodia Elata
Taxonomy Genus: Gastrodia
Taxonomy Family: Orchidaceae
Plant External Links:
NCBI TaxonomyDB:
91201
Plant-of-the-World-Online:
n.a.
Country/Region:
South Korea; ChinaTraditional Medicine System:
TCM; KampoMedicinal Functions:
Analgesic; Antispasmodic; Aphrodisiac; Carminative; Cholagogue; Sedative; Tonic
South Korea; China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
102 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
62 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
46 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC9812
Ingredient ID: NPC94366
Ingredient ID: NPC87118
Ingredient ID: NPC82948
Ingredient ID: NPC76639
Ingredient ID: NPC7617
Ingredient ID: NPC72004
Ingredient ID: NPC70756
Ingredient ID: NPC67644
Ingredient ID: NPC66700
Ingredient ID: NPC66655
Ingredient ID: NPC66628
Ingredient ID: NPC66110
Ingredient ID: NPC62670
Ingredient ID: NPC61198
Ingredient ID: NPC60523
Ingredient ID: NPC60350
Ingredient ID: NPC56610
Ingredient ID: NPC49976
Ingredient ID: NPC47834
Ingredient ID: NPC45040
Ingredient ID: NPC43246
Ingredient ID: NPC41484
Ingredient ID: NPC329546
Ingredient ID: NPC323787
Ingredient ID: NPC323434
Ingredient ID: NPC309190
Ingredient ID: NPC305205
Ingredient ID: NPC302001
Ingredient ID: NPC300478
Ingredient ID: NPC299710
Ingredient ID: NPC29883
Ingredient ID: NPC297658
Ingredient ID: NPC29601
Ingredient ID: NPC293619
Ingredient ID: NPC293378
Ingredient ID: NPC290613
Ingredient ID: NPC29
Ingredient ID: NPC289758
Ingredient ID: NPC285445
Ingredient ID: NPC284039
Ingredient ID: NPC278102
Ingredient ID: NPC27699
Ingredient ID: NPC275104
Ingredient ID: NPC274689
Ingredient ID: NPC27176
Ingredient ID: NPC269242
Ingredient ID: NPC257885
Ingredient ID: NPC250178
Ingredient ID: NPC249045
Ingredient ID: NPC248962
Ingredient ID: NPC244411
Ingredient ID: NPC243728
Ingredient ID: NPC242419
Ingredient ID: NPC241737
Ingredient ID: NPC241258
Ingredient ID: NPC236709
Ingredient ID: NPC230301
Ingredient ID: NPC224995
Ingredient ID: NPC224792
Ingredient ID: NPC224243
Ingredient ID: NPC22098
Ingredient ID: NPC220089
Ingredient ID: NPC219913
Ingredient ID: NPC216714
Ingredient ID: NPC216630
Ingredient ID: NPC213935
Ingredient ID: NPC212436
Ingredient ID: NPC207940
Ingredient ID: NPC207246
Ingredient ID: NPC206079
Ingredient ID: NPC205941
Ingredient ID: NPC203719
Ingredient ID: NPC194198
Ingredient ID: NPC187911
Ingredient ID: NPC187011
Ingredient ID: NPC186653
Ingredient ID: NPC18335
Ingredient ID: NPC180346
Ingredient ID: NPC180058
Ingredient ID: NPC172439
Ingredient ID: NPC169749
Ingredient ID: NPC16728
Ingredient ID: NPC163105
Ingredient ID: NPC157519
Ingredient ID: NPC156461
Ingredient ID: NPC150962
Ingredient ID: NPC142753
Ingredient ID: NPC13710
Ingredient ID: NPC135716
Ingredient ID: NPC133544
Ingredient ID: NPC130683
Ingredient ID: NPC124513
Ingredient ID: NPC121395
Ingredient ID: NPC117129
Ingredient ID: NPC116139
Ingredient ID: NPC113610
Ingredient ID: NPC111897
Ingredient ID: NPC111888
Ingredient ID: NPC108908
Ingredient ID: NPC106484
Ingredient ID: NPC10437
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Therapeutic Target | Cysteine protease | CASP6 | Caspase-6 | P55212 | CHEMBL3308 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Hydrolase | CDA | Cytidine deaminase | P32320 | CHEMBL4502 |
| Therapeutic Target | Isomerase | TOP2A | DNA topoisomerase II alpha | P11388 | CHEMBL1806 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 157 | |
 Plant level | 1 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00002801 | Combination Chemotherapy and Radiation Therapy in Treating Patients With Colorectal Cancer | colorectal carcinoma | Uracil (NPC27699) | NP level |
| NCT00003925 | Combination Chemotherapy In Treating Patients With Advanced Cancer | neoplasm | Uracil (NPC27699) | NP level |
| NCT00004860 | Fluorouracil-Uracil and Leucovorin in Treating Elderly Patients With Metastatic Colorectal Cancer | colorectal carcinoma | Uracil (NPC27699) | NP level |
| NCT00005608 | Fluorouracil-Uracil and Leucovorin in Treating Women With Metastatic Breast Cancer | breast cancer | Uracil (NPC27699) | NP level |
| NCT00009815 | Combination Chemotherapy in Treating Patients With Advanced Solid Tumors | neoplasm | Uracil (NPC27699) | NP level |
| NCT00009828 | Paclitaxel Combined With Fluorouracil-Uracil and Leucovorin in Treating Patients With Solid Tumors | neoplasm | Uracil (NPC27699) | NP level |
| NCT00037089 | A Phase II Study of Paclitaxel, UFT, and Leucovorin in Patients With Metastatic Esophageal Cancer | neoplasm of esophagus | Uracil (NPC27699) | NP level |
| NCT00062972 | Improving Memory in Patients With Multiple Sclerosis | multiple sclerosis | Glucose, Liquid (NPC289758) | NP level |
| NCT00091507 | IMMEDIATE Trial - Out of Hospital Administration of Glucose, Insulin and Potassium. | congestive heart failure;intermediate coronary syndrome;myocardial infarction | Glucose, Liquid (NPC289758) | NP level |
| NCT00152178 | The Comparative Trial of UFT + TAM With CMF + TAM in Adjuvant Therapy for Breast Cancer (CUBC) | breast cancer | Uracil (NPC27699) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TOP2A,PIM1
NCT00926731 |
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT00781404
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT04588441,NCT03718507
|
Acute ST elevation myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41.0 |
NCT01747174,NCT00284323
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE,CDA,TSHR,F2,TOP2A
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ADORA3,ACHE,PIM1,SNCA,LMNA,DRD1,OR51E2,F2,RECQL,CYP1B1,POLB,ADORA2A
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
OR51E2,FABP5
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
