Collective Molecular Activities of the Plant: Chrysanthemum Indicum
Country/Region:
China; IndiaTraditional Medicine System:
Indian Folk; TCM; Unani; Ayurveda; SiddhaUzbekistan; India; Taiwan; China; Japan
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
460 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
359 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
188 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99480
Ingredient ID: NPC9880
Ingredient ID: NPC98555
Ingredient ID: NPC98246
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Ingredient ID: NPC88152
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Ingredient ID: NPC143586
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Ingredient ID: NPC141777
Ingredient ID: NPC141765
Ingredient ID: NPC141273
Ingredient ID: NPC13991
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Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Therapeutic Target | Cysteine protease | CASP6 | Caspase-6 | P55212 | CHEMBL3308 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | NOS1 | Nitric-oxide synthase, brain | P29475 | CHEMBL3568 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 166 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00002801 | Combination Chemotherapy and Radiation Therapy in Treating Patients With Colorectal Cancer | colorectal carcinoma | Uracil (NPC27699) | NP level |
| NCT00003925 | Combination Chemotherapy In Treating Patients With Advanced Cancer | neoplasm | Uracil (NPC27699) | NP level |
| NCT00004860 | Fluorouracil-Uracil and Leucovorin in Treating Elderly Patients With Metastatic Colorectal Cancer | colorectal carcinoma | Uracil (NPC27699) | NP level |
| NCT00005608 | Fluorouracil-Uracil and Leucovorin in Treating Women With Metastatic Breast Cancer | breast cancer | Uracil (NPC27699) | NP level |
| NCT00009815 | Combination Chemotherapy in Treating Patients With Advanced Solid Tumors | neoplasm | Uracil (NPC27699) | NP level |
| NCT00009828 | Paclitaxel Combined With Fluorouracil-Uracil and Leucovorin in Treating Patients With Solid Tumors | neoplasm | Uracil (NPC27699) | NP level |
| NCT00027495 | Curcumin for the Prevention of Colon Cancer | colorectal carcinoma | Curcumin (NPC109083) | NP level |
| NCT00037089 | A Phase II Study of Paclitaxel, UFT, and Leucovorin in Patients With Metastatic Esophageal Cancer | neoplasm of esophagus | Uracil (NPC27699) | NP level |
| NCT00099710 | Curcumin in Patients With Mild to Moderate Alzheimer's Disease | Alzheimer disease | Curcumin (NPC109083) | NP level |
| NCT00118989 | Curcumin for the Chemoprevention of Colorectal Cancer | Familial adenomatous polyposis | Curcumin (NPC109083) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB,MAOA,TYR
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKB,AKR1B1,KDR,DPP4
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
CDK8,FLT3,KDM1A,NFKB1,PIM1,GSK3B,TP53,SRC,AURKB,TOP2A,AXL
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
NCT03718507 |
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CYP2C9,CDK1,MMP9,TOP2A,MMP1,CA7,TTR,TSHR,PTGES,XDH,NR1I2,MMP12,ACHE,AKR1B10,NPSR1,AURKB,CA12,THPO
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CYP2C9,CNR2,CISD1,RECQL,MMP1,LMNA,OR51E2,ABCG2,DPP4,HSD17B2,MMP2,ALOX5,CYP1B1,APP,SNCA,ALOX15,CA7,TTR,AXL,PTGES,NOS2,CA2,XDH,PIM1,POLB,MET,NR1I2,MAOB,ACHE,AKR1B10,NPSR1,AURKB,HIF1A,DRD1,CYP2C19
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
