Collective Molecular Activities of the Plant: Terminalia Bellirica
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PLANiTS DNA barcode
Taxonomic Information
Used in Medicines
Country/Region:
IndiaTraditional Medicine System:
Indian Folk; Unani; Ayurveda; SiddhaGeographical Distribution
Bangladesh; Myanmar; Nepal; India; Cambodia; Mauritius; Trinidad and Tobago; Vietnam; China; Laos; Sri Lanka; Thailand
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary
Overview of Ingredients
17 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
4 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
9 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC96145
Ingredient ID: NPC80749
Ingredient ID: NPC7839
Ingredient ID: NPC264145
Ingredient ID: NPC225710
Ingredient ID: NPC217545
Ingredient ID: NPC187770
Ingredient ID: NPC184993
Ingredient ID: NPC178134
Ingredient ID: NPC173872
Ingredient ID: NPC16080
Ingredient ID: NPC142291
Ingredient ID: NPC14030
Ingredient ID: NPC130348
Ingredient ID: NPC119107
Ingredient ID: NPC119094
Ingredient ID: NPC113621
Classification of Human Proteins Collectively Targeted by the Plant
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
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Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Cysteine protease | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Therapeutic Target | Enzyme | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Therapeutic Target | Enzyme | PKM | Pyruvate kinase isozymes M1/M2 | P14618 | CHEMBL1075189 |
| Therapeutic Target | Isomerase | TOP1 | DNA topoisomerase I | P11387 | CHEMBL1781 |
| Therapeutic Target | Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Therapeutic Target | Other cytosolic protein | HSPA1A | Heat shock 70 kDa protein 1 | P0DMV8 | CHEMBL5460 |
| Therapeutic Target | Oxidoreductase | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Therapeutic Target | Protein Kinase | INSR | Insulin receptor | P06213 | CHEMBL1981 |
| Therapeutic Target | Protein Kinase | TEK | Tyrosine-protein kinase TIE-2 | Q02763 | CHEMBL4128 |
| Therapeutic Target | Protein Kinase | IGF1R | Insulin-like growth factor I receptor | P08069 | CHEMBL1957 |
| Therapeutic Target | Protein Kinase | MET | Hepatocyte growth factor receptor | P08581 | CHEMBL3717 |
| Therapeutic Target | Protein Kinase | SRC | Tyrosine-protein kinase SRC | P12931 | CHEMBL267 |
| Therapeutic Target | Protein Kinase | KDR | Vascular endothelial growth factor receptor 2 | P35968 | CHEMBL279 |
| Therapeutic Target | Protein Kinase | NUAK1 | NUAK family SNF1-like kinase 1 | O60285 | CHEMBL5784 |
| Therapeutic Target | Protein Kinase | EGFR | Epidermal growth factor receptor erbB1 | P00533 | CHEMBL203 |
| Therapeutic Target | Protein Kinase | CSNK2A1 | Casein kinase II alpha | P68400 | CHEMBL3629 |
| Drug Transporter | SLC superfamily of solute carriers | SLC22A6 | Solute carrier family 22 member 6 | Q4U2R8 | CHEMBL1641347 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA2B | Alpha-2b adrenergic receptor | P18089 | CHEMBL1942 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | GPR35 | G-protein coupled receptor 35 | Q9HC97 | CHEMBL1293267 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Therapeutic Target | Transcription factor | SMAD3 | Mothers against decapentaplegic homolog 3 | P84022 | CHEMBL1293258 |
| Therapeutic Target | Transferase | POLH | DNA polymerase eta | Q9Y253 | CHEMBL5542 |
| Therapeutic Target | Transferase | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Q11130 | CHEMBL3596077 |
| Therapeutic Target | Transferase | POLI | DNA polymerase iota | Q9UNA4 | CHEMBL5391 |
Clinical Trials Summary
Overview
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 151 | |
Clinical trial details
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT01319734 | Vitamin C Supplementation Plus Hypoglycemic Agents Versus Hypoglycemic Agents Alone in Type 2 Diabetes Mellitus | type 2 diabetes mellitus | Ascorbate (NPC187770) | NP level |
| NCT04011618 | Effect of Ellagic Ácid on the Components of Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion | metabolic syndrome | Ellagic Acid (NPC178134) | NP level |
| NCT03872011 | Vitamin C, Thiamine and Hydrocortisone for the Treatment of Septic Shock | septic shock | Ascorbate (NPC187770) | NP level |
| NCT02083575 | Role of Vitamin C to Augment Iron Chelation With DFP or DFX | beta-thalassemia major | Ascorbate (NPC187770) | NP level |
| NCT05029037 | High-dose Intravenous Vitamin C (HDIVC) as Adjuvant Therapy in Critical Patients With Positive COVID-19. A Pilot Randomized Controlled Dose-comparison Trial. | COVID-19 | Ascorbate (NPC187770) | NP level |
| NCT00803530 | Study of Association of Arsenic Trioxide (ATO) and Ascorbic Acid in Myelodysplastic Syndromes | myelodysplastic syndrome | Ascorbate (NPC187770) | NP level |
| NCT03066115 | Impact of NOS, COX, and ROS Inhibition on Cerebral Blood Flow Regulation | hypoxia | Ascorbate (NPC187770) | NP level |
| NCT04999137 | Evaluation of Safety and Dosing of a Vitamin C Bundle for Sepsis Treatment in Africa | Sepsis;septic shock | Ascorbate (NPC187770) | NP level |
| NCT02905591 | A Phase 2 Study Adding Ascorbate to Chemotherapy and Radiation Therapy for NSCLC | non-small cell lung carcinoma | Ascorbate (NPC187770) | NP level |
| NCT04046094 | Intravenous (IV) Vitamin C With Chemotherapy for Cisplatin Ineligible Bladder Cancer Patients | urinary bladder cancer | Ascorbate (NPC187770) | NP level |
| NCT04832009 | Reversing Glucose and Lipid-mediated Vascular Dysfunction | hypertension | Ascorbate (NPC187770) | NP level |
| NCT03509662 | Vitamin C in Post-cardiac Arrest | cardiac arrest | Ascorbate (NPC187770) | NP level |
| NCT00484510 | High Dose Ascorbic Acid Treatment of CMT1A | Charcot-Marie-Tooth disease type 1A | Ascorbate (NPC187770) | NP level |
| NCT02793648 | Effectiveness of Ascorbic Acid and Tocopherol for Depression in Elderly. | depressive disorder | Ascorbate (NPC187770) | NP level |
| NCT00631111 | Study Evaluating the Efficacy of an Ibuprofen Effervescent Tablet in the Treatment of Post-Surgical Dental Pain | pain | Ascorbate (NPC187770) | NP level |
| NCT02168270 | Temozolomide and Ascorbic Acid in Treating Patients With Recurrent High-Grade Glioma | anaplastic astrocytoma;anaplastic oligodendroglioma;gliosarcoma | Ascorbate (NPC187770) | NP level |
| NCT03680274 | Lessening Organ Dysfunction With VITamin C | COVID-19;Sepsis | Ascorbate (NPC187770) | NP level |
| NCT00329498 | L-Ascorbic Acid Depletion to Treat Acute Myeloid Leukemia and Myelodysplastic Syndromes | acute myeloid leukemia;myelodysplastic syndrome | Ascorbate (NPC187770) | NP level |
| NCT01295450 | Study to Evaluate the Efficacy and Tolerability of Apevinat BC Compared to Vitamin Complex | Anorexia | Ascorbate (NPC187770) | NP level |
| NCT04921189 | Steroid, Thiamine and Ascorbic Acid for Comatose Out-of-hospital Cardiac Arrest Survivors | cardiac arrest | Ascorbate (NPC187770) | NP level |
| NCT02344355 | A Phase 2 Trial of High-Dose Ascorbate in Glioblastoma Multiforme | glioblastoma multiforme | Ascorbate (NPC187770) | NP level |
| NCT03508726 | High Dose Ascorbate With Preoperative Radiation in Patients With Locally Advanced Soft Tissue Sarcomas | soft tissue sarcoma | Ascorbate (NPC187770) | NP level |
| NCT00006021 | Arsenic Trioxide Plus Vitamin C in Treating Patients With Recurrent or Refractory Multiple Myeloma | multiple myeloma | Ascorbate (NPC187770) | NP level |
| NCT01580683 | Vitamin C and Atrial Fibrillation After Cardiac Surgery | atrial fibrillation | Ascorbate (NPC187770) | NP level |
| NCT04783792 | The Effect of Phenolic Compounds in Osteoarthritis; a Nutritional Intervention | osteoarthritis | Ascorbate (NPC187770) | NP level |
| NCT01752491 | A Phase I Trial of High-Dose Ascorbate in Glioblastoma Multiforme | glioblastoma multiforme | Ascorbate (NPC187770) | NP level |
| NCT03188445 | Intravenous Iron Isomaltoside Versus Oral Iron Supplementation for Treatment of Iron Deficiency in Pregnancy. | Iron deficiency anemia | Ascorbate (NPC187770) | NP level |
| NCT03602235 | High Dose Ascorbic Acid for Plasma Cell Disorders | multiple myeloma | Ascorbate (NPC187770) | NP level |
| NCT01364805 | New Treatment Option for Pancreatic Cancer | pancreatic carcinoma | Ascorbate (NPC187770) | NP level |
| NCT00626444 | Pilot Trial of Intravenous Vitamin C in Refractory Non-Hodgkin Lymphoma (NHL) | non-Hodgkins lymphoma | Ascorbate (NPC187770) | NP level |
| NCT03624270 | Oral Arsenic Trioxide for Newly Diagnosed Acute Promyelocytic Leukaemia | acute promyelocytic leukemia | Ascorbate (NPC187770) | NP level |
| NCT00661544 | Arsenic Trioxide With Ascorbic Acid and Melphalan for Myeloma Patients | multiple myeloma | Ascorbate (NPC187770) | NP level |
| NCT04035096 | The Effectiveness of High-dose Intravenous Vitamin c With Very Low Carbohydrate Diet for Terminal Colon Cancer Patients | malignant colon neoplasm | Ascorbate (NPC187770) | NP level |
| NCT01057615 | Effect of Fish Oil and Vitamin C on Exercise-Induced Bronchoconstriction and Airway Inflammation in Asthma | asthma | Ascorbate (NPC187770) | NP level |
| NCT00211562 | Adjunctive Supplementation of Antioxidants (Vitamins E + C) Plus Omega-3 Fatty Acids | schizophrenia | Ascorbate (NPC187770) | NP level |
| NCT02631668 | the Efficacy and Safety of Vitamin C for Iron Supplementation in Adult IDA Patients | anemia (phenotype) | Ascorbate (NPC187770) | NP level |
| NCT02186158 | Interest of Ascorbic Acid in the Management of Pneumonia in Elderly People Hospitalized. | pneumonia | Ascorbate (NPC187770) | NP level |
| NCT02969681 | Vitamin C Intravenously With Chemotherapy in Advanced Colorectal Cancer | colorectal neoplasm | Ascorbate (NPC187770) | NP level |
| NCT04801511 | Preoperative IMRT With Concurrent High-dose Vitamin C and mFOLFOX6 in Locally Advanced Rectal Cancer | rectum cancer | Ascorbate (NPC187770) | NP level |
| NCT00258245 | Arsenic Trioxide and Ascorbic Acid Combined With Bortezomib, Thalidomide, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma or Plasma Cell Leukemia | multiple myeloma | Ascorbate (NPC187770) | NP level |
| NCT02734147 | High Dose Intravenous Ascorbic Acid in Severe Sepsis | Sepsis | Ascorbate (NPC187770) | NP level |
| NCT01080352 | Vitamin C as an Anti-cancer Drug | prostate adenocarcinoma | Ascorbate (NPC187770) | NP level |
| NCT04395768 | International ALLIANCE Study of Therapies to Prevent Progression of COVID-19 | COVID-19 | Ascorbate (NPC187770) | NP level |
| NCT02107976 | Famine From Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes | diabetes mellitus | Ascorbate (NPC187770) | NP level |
| NCT03964688 | Effect of Vitamin C in Autologous Stem Cell Transplantations | multiple myeloma | Ascorbate (NPC187770) | NP level |
| NCT01905150 | Ph 2 Trial of Vitamin C & G-FLIP (Low Doses Gemcitabine, 5FU, Leucovorin, Irinotecan, Oxaliplatin) for Pancreatic Cancer | pancreatic carcinoma | Ascorbate (NPC187770) | NP level |
| NCT00388856 | Antioxidant Supplementation in Pregnant Women With Low Antioxidant Status | preeclampsia | Ascorbate (NPC187770) | NP level |
| NCT03908333 | High Dose Ascorbic Acid and Nanoparticle Paclitaxel Protein Bound and Cisplatin and Gemcitabine (AA NABPLAGEM) in Patients Who Have Metastatic Pancreatic Cancer | pancreatic ductal adenocarcinoma | Ascorbate (NPC187770) | NP level |
| NCT02868151 | Effect of Oral Vitamin C in Assessing the Severity of Oral Mucositis in Chemoradiation of Head and Neck Cancers | oral mucositis | Ascorbate (NPC187770) | NP level |
| NCT02390505 | Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery | complex regional pain syndrome | Ascorbate (NPC187770) | NP level |
| NCT00441207 | Study of High-Dose Intravenous (IV) Vitamin C Treatment in Patients With Solid Tumors | cancer | Ascorbate (NPC187770) | NP level |
| NCT03451266 | Effects of Vitamin C Administration on Extravascular Lung Water in Patients With Severe Features of Preeclampsia | preeclampsia | Ascorbate (NPC187770) | NP level |
| NCT00184054 | Trial of Arsenic Trioxide With Ascorbic Acid in the Treatment of Adult Non-Acute Promyelocytic Leukemia (APL) Acute Myelogenous Leukemia | acute myeloid leukemia | Ascorbate (NPC187770) | NP level |
| NCT03418038 | Ascorbic Acid and Combination Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma or Clonal Cytopenia of Undetermined Significance | Hodgkins lymphoma | Ascorbate (NPC187770) | NP level |
| NCT02730364 | An Efficacy and Safety Study of Theraflu Night Powder as Oral Solution for Cold and Flu | respiratory tract infectious disorder | Ascorbate (NPC187770) | NP level |
| NCT04344184 | SAFEty Study of Early Infusion of Vitamin C for Treatment of Novel Coronavirus Acute Lung Injury (SAFE EVICT CORONA-ALI) | acute lung injury;COVID-19 | Ascorbate (NPC187770) | NP level |
| NCT03649633 | Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock | septic shock | Ascorbate (NPC187770) | NP level |
| NCT05501548 | Phase II Study of PARP Inhibitor Olaparib and IV Ascorbate in Castration Resistant Prostate Cancer | prostate cancer | Ascorbate (NPC187770) | NP level |
| NCT03887169 | Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene. | pulmonary alveolar proteinosis | Ascorbate (NPC187770) | NP level |
| NCT02225886 | Ascorbic Acid Administration in the Treatment of Anemia in Chronic Hemodialysed Patients | anemia (phenotype) | Ascorbate (NPC187770) | NP level |
| NCT04900792 | A Safety Study of Pharmacologic Ascorbate and Ferumoxytol in Addition to Standard of Care Chemoradiation in Glioblastoma | glioblastoma multiforme | Ascorbate (NPC187770) | NP level |
| NCT04928495 | Clinical Trial With N-acetylcysteine and Bromhexine for COVID-19 | COVID-19 | Ascorbate (NPC187770) | NP level |
| NCT02521077 | Intravenous Ascorbic Acid in Women Receiving Adjuvant or Neo-Adjuvant Chemotherapy for Early Stage Breast Cancer | Fatigue | Ascorbate (NPC187770) | NP level |
| NCT00734695 | Comparing the Use of Vitamin c (Ascorbic Acid) in Eye Burn in Subconjunctival Injection to Topical or Oral Treatment. | burn | Ascorbate (NPC187770) | NP level |
| NCT01005303 | Micronutrient Supplementation in Patients With Heart Failure | heart failure | Ascorbate (NPC187770) | NP level |
| NCT00067899 | Oxidative Stress and Vitamin E Requirements | nicotine dependence | Ascorbate (NPC187770) | NP level |
| NCT00000555 | Women's Angiographic Vitamin and Estrogen Trial (WAVE) | menopause;Myocardial Ischemia | Ascorbate (NPC187770) | NP level |
| NCT02833701 | Bevacizumab and Ascorbic Acid in Patients Treating With Recurrent High Grade Glioma | glioblastoma multiforme | Ascorbate (NPC187770) | NP level |
| NCT01107730 | Vitamin C for Prophylaxis of Post-operative Atrial Fibrillation in On-pump Cardiac Surgery Procedures | atrial fibrillation | Ascorbate (NPC187770) | NP level |
| NCT01426490 | The Effects of Vitamin B-6 Status on Homocysteine, Oxidative Stress, One-carbon Metabolism and Methylation: Cross-section, Case-control, Intervention and Follow-up Studies in Colorectal Cancer | colorectal carcinoma | Ascorbate (NPC187770) | NP level |
| NCT00325572 | Evaluation and Treatment of Copper/Zinc Imbalance in Children With Autism | autism | Ascorbate (NPC187770) | NP level |
| NCT01550510 | Research Study of IV Vitamin C in Combination With Irinotecan vs Irinotecan Alone for Advanced Colorectal CA | colorectal adenocarcinoma | Ascorbate (NPC187770) | NP level |
| NCT03592693 | Vitamin C, Hydrocortisone and Thiamine for Septic Shock | septic shock | Ascorbate (NPC187770) | NP level |
| NCT02369822 | Trial of Vitamin C as Add on Therapy for Children With Idiopathic Epilepsy | epilepsy | Ascorbate (NPC187770) | NP level |
| NCT05283954 | Use of a Combined Regimen of Fluoxetine, Prednisolone and Ivermectin in the Treatment of Mild COVID-19 to Prevent Disease Progression Progression in Papua New Guinea | COVID-19 | Ascorbate (NPC187770) | NP level |
| NCT04354428 | Treatment for COVID-19 in High-Risk Adult Outpatients | COVID-19 | Ascorbate (NPC187770) | NP level |
| NCT02780505 | Assessment of the Effect of Vitamin C on Anemia in Patients With Continuous Ambulatory Peritoneal Dialysis | anemia (phenotype) | Ascorbate (NPC187770) | NP level |
| NCT04553666 | Reducing Frailty for Older Cancer Survivors Using Supplements | inflammation | Ascorbate (NPC187770) | NP level |
| NCT02424201 | Comparative Study on the Effects of Sublingual Misoprostol in Addition to Standard AMTSL in Low Risk Parturients in LASUTH, Ikeja. | postpartum hemorrhage | Ascorbate (NPC187770) | NP level |
| NCT03522922 | Efficacy of Microneedling With Topical Vitamin C in Treatment of Acne Scarring | acne | Ascorbate (NPC187770) | NP level |
| NCT04268849 | Trial of IV vs Oral Iron Treatment of Iron Deficiency Anemia in the Post-Operative Bariatric Surgical Patient | Iron deficiency anemia | Ascorbate (NPC187770) | NP level |
| NCT00633581 | Efficacy of Vitamin C Injection on Fatigue in Workers After Work | Fatigue | Ascorbate (NPC187770) | NP level |
| NCT03175341 | Intravenous Ascorbic Acid Supplementation in Neoadjuvant Chemotherapy for Breast Cancer | breast cancer | Ascorbate (NPC187770) | NP level |
| NCT04401150 | Lessening Organ Dysfunction With VITamin C - COVID-19 | COVID-19 | Ascorbate (NPC187770) | NP level |
| NCT00920413 | Oral Vitamin C for Correction of Anemia in Patients Receiving Peritoneal Dialysis | anemia (phenotype) | Ascorbate (NPC187770) | NP level |
| NCT03697239 | High Dose Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM) in Patients Who Have Metastatic Pancreatic Cancer | pancreatic ductal adenocarcinoma | Ascorbate (NPC187770) | NP level |
| NCT00085345 | Melphalan, Arsenic Trioxide, and Ascorbic Acid in Treating Patients With Relapsed or Refractory Multiple Myeloma | multiple myeloma | Ascorbate (NPC187770) | NP level |
| NCT02791906 | Targeting Central Pulsatile Hemodynamics in Chronic Kidney Disease | chronic kidney disease | Ascorbate (NPC187770) | NP level |
| NCT02516670 | Docetaxel With or Without Ascorbic Acid in Treating Patients With Metastatic Prostate Cancer | metastatic prostate cancer | Ascorbate (NPC187770) | NP level |
| NCT04261036 | Vitamin C for the Prevention of UTI in Women Who Undergo Elective Gynecological Surgeries | urinary tract infection | Ascorbate (NPC187770) | NP level |
| NCT03334409 | Pazopanib Hydrochloride With or Without Ascorbic Acid in Treating Patients With Kidney Cancer That Is Metastatic or Cannot Be Removed by Surgery | clear cell renal carcinoma | Ascorbate (NPC187770) | NP level |
| NCT02735707 | Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia | COVID-19;influenza;pneumonia | Ascorbate (NPC187770) | NP level |
| NCT00112879 | Arsenic Trioxide, Ascorbic Acid, Dexamethasone, and Thalidomide in Treating Patients With Multiple Myeloma | multiple myeloma | Ascorbate (NPC187770) | NP level |
| NCT03015675 | IV Ascorbic Acid in Advanced Gastric Cancer | gastric cancer | Ascorbate (NPC187770) | NP level |
| NCT01852890 | Gemcitabine, Ascorbate, Radiation Therapy for Pancreatic Cancer, Phase I | pancreatic neoplasm | Ascorbate (NPC187770) | NP level |
| NCT02678234 | An Efficacy and Safety Study of Theraflu Day Powder as Oral Solution for Cold and Flu | respiratory tract infectious disorder | Ascorbate (NPC187770) | NP level |
| NCT02655913 | Safety and Efficacy of Vitamin C Infusion in Combination With Local mEHT to Treat Non Small Cell Lung Cancer | non-small cell lung carcinoma | Ascorbate (NPC187770) | NP level |
| NCT01050621 | Trial of Chemotherapy Plus Intravenous Vitamin C in Patients With Advanced Cancer for Whom Chemotherapy Alone is Only Marginally Effective | cancer | Ascorbate (NPC187770) | NP level |
| NCT04482686 | Trial of Combination Therapy to Treat COVID-19 Infection | COVID-19;severe acute respiratory syndrome | Ascorbate (NPC187770) | NP level |
| NCT00953212 | Prophylaxis to Reduce Postoperative Atrial Fibrillation in Cardiac Surgery | atrial fibrillation;atrial flutter | Ascorbate (NPC187770) | NP level |
| NCT02420314 | Pharmacological Ascorbate for Lung Cancer | non-small cell lung carcinoma | Ascorbate (NPC187770) | NP level |
| NCT01590303 | Outcome Following Vitamin C Administration in Sepsis | Sepsis | Ascorbate (NPC187770) | NP level |
| NCT02297399 | Improvement of Tolerance of Bowel Cleansing Before Colonoscopy in Diabetic Patients | diabetes mellitus | Ascorbate (NPC187770) | NP level |
| NCT01502280 | Fluorescence-guided Surgery for Low- and High-grade Gliomas | glioma | Ascorbate (NPC187770) | NP level |
| NCT00469209 | Velcade, Trisenox, Vitamin C and Melphalan for Myeloma Patients | multiple myeloma | Ascorbate (NPC187770) | NP level |
| NCT03148236 | Vitamin C in Atrial Fibrillation Ablation | atrial fibrillation | Ascorbate (NPC187770) | NP level |
| NCT01891747 | A Phase I Study of High-dose L-methylfolate in Combination With Temozolomide and Bevacizumab in Recurrent High Grade Glioma | malignant glioma | Ascorbate (NPC187770) | NP level |
| NCT03437902 | Impact of Rutin and Vitamin C Combination on Oxidative Stress, Insulin Sensitivity and Lipid Profile in Type 2 Diabetic Patients | type 2 diabetes mellitus | Ascorbate (NPC187770) | NP level |
| NCT03509350 | Vitamin C, Thiamine, and Steroids in Sepsis | Sepsis | Ascorbate (NPC187770) | NP level |
| NCT02602483 | Exploratory Study To Assess the Efficacy and Safety of a Triple Combination for Acute Pain Treatment in Patients With Temporomandibular Joint Disorders (TMJD). | temporomandibular joint disorder | Ascorbate (NPC187770) | NP level |
| NCT03828929 | Effect of IV Vitamin C, Thiamine, and Steroids on Mortality of Septic Shock | septic shock | Ascorbate (NPC187770) | NP level |
| NCT04279535 | Topical Vitamin C for Treatment of Basal Cell Cancer | basal cell carcinoma | Ascorbate (NPC187770) | NP level |
| NCT02109315 | Vitamin C and Liraglutide Effects on Hypoglycemia-induced Oxidative Stress, Inflammation and Endothelial Dysfunction in Type 1 Diabetes. | type 1 diabetes mellitus | Ascorbate (NPC187770) | NP level |
| NCT02206425 | Ixazomib as a Replacement for Carfilzomib and Bortezomib for Multiple Myeloma Patients | multiple myeloma | Ascorbate (NPC187770) | NP level |
| NCT04363216 | Pharmacologic Ascorbic Acid as an Activator of Lymphocyte Signaling for COVID-19 Treatment | COVID-19 | Ascorbate (NPC187770) | NP level |
| NCT04715022 | Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study) | hypertension | Ascorbate (NPC187770) | NP level |
| NCT00284427 | Safety of Antioxidants During GYN Cancer Care | cervical cancer;ovarian cancer | Ascorbate (NPC187770) | NP level |
| NCT01587963 | High Dose Vitamin C in the Critically Ill Patient | Shock | Ascorbate (NPC187770) | NP level |
| NCT03224572 | The Effect of Vitamin C on Quality of Life of Terminal Cancer Patients | ascorbic acid deficiency | Ascorbate (NPC187770) | NP level |
| NCT04370288 | Clinical Application of Methylene Blue for Treatment of Covid-19 Patients | COVID-19 | Ascorbate (NPC187770) | NP level |
| NCT00317811 | Bortezomib, Ascorbic Acid, and Melphalan in Treating Patients With Newly Diagnosed Multiple Myeloma | multiple myeloma | Ascorbate (NPC187770) | NP level |
| NCT01715597 | Study on the Effect of Intravenous Ascorbic Acid on Intraoperative Blood Loss in Women With Uterine Myoma | uterine fibroid | Ascorbate (NPC187770) | NP level |
| NCT03799094 | Vitamin C and Tyrosine Kinase Inhibitor in Lung Cancer Patients With Epidermal Growth Factor Receptor Mutations | non-small cell lung carcinoma | Ascorbate (NPC187770) | NP level |
| NCT04898023 | Zinc and Green Tea Extract for Community Respiratory Viral Infections | viral disease | Ascorbate (NPC187770) | NP level |
| NCT00000600 | Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-Up | carotid artery disease;cerebral atherosclerosis;heart disease | Ascorbate (NPC187770) | NP level |
| NCT01014546 | Arsenic Trioxide With or Without Ascorbic Acid in Treating Patients With Myelofibrosis | essential thrombocythemia;polycythemia vera;primary myelofibrosis | Ascorbate (NPC187770) | NP level |
| NCT00634998 | Vitamin C Supplementation as a Preventive Treatment of Diabetic Peripheral Neuropathy | diabetic neuropathy | Ascorbate (NPC187770) | NP level |
| NCT00271635 | Ascorbic Acid Treatment in CMT1A Trial (AATIC) | Charcot-Marie-Tooth disease | Ascorbate (NPC187770) | NP level |
| NCT01555489 | Assessing the Efficacy and Safety of IV Vitamin C in Combination With Standard Chemotherapy for Pancreatic Ca | pancreatic carcinoma | Ascorbate (NPC187770) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Ascorbate (NPC187770) | NP level |
| NCT04404387 | Lessening Organ Dysfunction With VITamin C in Septic ARDS | acute respiratory distress syndrome | Ascorbate (NPC187770) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Ellagic Acid (NPC178134) | NP level |
| NCT04334512 | A Study of Quintuple Therapy to Treat COVID-19 Infection | COVID-19 | Ascorbate (NPC187770) | NP level |
| NCT04328961 | Hydroxychloroquine for COVID-19 Post-exposure Prophylaxis (PEP) | COVID-19 | Ascorbate (NPC187770) | NP level |
| NCT04347889 | Preventing COVID-19 in Healthcare Workers With HCQ: A RCT | COVID-19 | Ascorbate (NPC187770) | NP level |
| NCT03800667 | Vitamin C for the Prevention of UTI in Women Who Undergo Elective GYN Surgeries | urinary tract infection | Ascorbate (NPC187770) | NP level |
| NCT04335084 | A Study of Hydroxychloroquine, Vitamin C, Vitamin D, and Zinc for the Prevention of COVID-19 Infection | COVID-19 | Ascorbate (NPC187770) | NP level |
| NCT02606773 | "Novo C Plus" Vitamin C Containing Dietary Supplement Bioavailability in Healthy Subjects | ascorbic acid deficiency | Ascorbate (NPC187770) | NP level |
| NCT00227682 | Arsenic Trioxide, Thalidomide, Dexamethasone, and Ascorbic Acid in Treating Patients With Relapsed or Refractory Multiple Myeloma | multiple myeloma | Ascorbate (NPC187770) | NP level |
| NCT03541486 | A Clinical Trial Evaluating the Effect of Pharmacological Ascorbate on Radiation Therapy for Pancreatic Cancer Patients | pancreatic neoplasm | Ascorbate (NPC187770) | NP level |
| NCT04516681 | IV Ascorbic Acid in Peritoneal Metastatic Colorectal Cancer | colorectal carcinoma | Ascorbate (NPC187770) | NP level |
| NCT01587261 | Vitamin C for Severe Thermal Injuries | injury | Ascorbate (NPC187770) | NP level |
| NCT00954525 | Intravenous Vitamin C in Combination With Standard Chemotherapy for Pancreatic Cancer | pancreatic carcinoma | Ascorbate (NPC187770) | NP level |
| NCT03797443 | High Dose Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM) in Patients Who Have Metastatic Pancreatic Cancer | pancreatic carcinoma | Ascorbate (NPC187770) | NP level |
| NCT04357782 | Administration of Intravenous Vitamin C in Novel Coronavirus Infection (COVID-19) and Decreased Oxygenation | hypoxia;COVID-19 | Ascorbate (NPC187770) | NP level |
| NCT03223519 | COMBOPROFEN for Treatment of Muscular Pain Associated With Delayed Onset Muscle Soreness (DOMS) | muscular disease | Ascorbate (NPC187770) | NP level |
| NCT04446104 | A Preventive Treatment for Migrant Workers at High-risk of COVID-19 | COVID-19 | Ascorbate (NPC187770) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction;Myocardial Ischemia | Ascorbate (NPC187770) | NP level |
| NCT05009355 | The Effect of Vitamin C on GCF Total Oxidant Capacity in Smoker Patients With Periodontitis | ascorbic acid deficiency | Ascorbate (NPC187770) | NP level |
| NCT03410030 | Trial of Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM) | pancreatic ductal adenocarcinoma | Ascorbate (NPC187770) | NP level |
| NCT03333278 | The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial | Sepsis;septic shock | Ascorbate (NPC187770) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
APEX1,FUT7,POLH,TDP1,ELAVL3,HPGD,CSNK2A1,MET,PKM
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
NUAK1,TOP1,FUT7,LMNA,POLB,RECQL,BLM,MET,TEK
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
IGF1R,TOP1,MET,EGFR,KDR
NCT01426490,NCT02969681,NCT04516681 |
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
MET,IGF1R,TEK,KDR,SRC,TOP1,EGFR
NCT03175341 |
Non-small cell lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
MET,KDR,EGFR
NCT02905591,NCT02655913,NCT03799094,NCT02420314 |
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
NUAK1,IGF1R,GPR35,AKR1B1,SRC,BLM,PKM
|
Stomach cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
EGFR,HSPA1A,KDR,HSPA1B,MET,TOP1
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
AKR1B1,ADRA2B,IGF1R,PKM,INSR
NCT00631111 |
SepsisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1G40-1G41 |
NCT01590303,NCT03680274,NCT03333278,NCT04999137,NCT03509350,NCT02734147
|
Septic shockDisease Category: X.Extension CodesDisease ICD-11 Code: XS26 |
NCT03592693,NCT04999137,NCT03872011,NCT03333278,NCT03649633,NCT03828929
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
GPR35,BLM,PKM,SLC22A6,SRC,PKM
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
KDM4E,USP2,GPR35,ELAVL3,HPGD,ADRA2B
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
APEX1,HSD17B10,FUT7,AKR1B1,GALNT2,HPGD
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
KDR,EGFR,IGF1R,MET,TOP1
|
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
MET,SRC,TOP1,KDR
NCT00284427 |
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
TOP1,SRC,KDR,EGFR,MET
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
TOP1,PKM,MET,EGFR,KDR
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
CSNK2A1,KDR,IGF1R,MET,EGFR
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
KDR,TOP1,EGFR
NCT00803530,NCT00329498 |
Malignant neoplasm of pancreas, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.Z |
NCT01364805,NCT00954525,NCT01905150,NCT03797443,NCT01555489
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
USP2,GPR35,LMNA,ADRA2B,EGFR
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA,KDR,POLH,BLM,MET
|
Motor neuron diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B60 |
HSPA1B,SRC,HSPA1A,IGF1R
|
Malignant digestive organ neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C11 |
SRC,KDR,HSPA1B,HSPA1A
|
Glioblastoma, primary, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH0MB1 |
NCT02344355,NCT02833701,NCT04900792,NCT01752491
|
AnemiaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3A00-3A9Z |
NCT02780505,NCT02631668,NCT00920413,NCT02225886
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
NCT00953212,NCT01580683,NCT01107730,NCT03148236
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
FUT7,ELAVL3,BLM,MET
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
FUT7,HPGD,BLM,MET
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
INSR,AKR1B1,KDR
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
KDR,MET,INSR
|
Pleomorphic sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B54 |
SRC,KDR,MET
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
MET,KDR,EGFR
|
BCR-ABL1-negative chronic myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A41 |
HSPA1B,SRC,HSPA1A
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
SRC,IGF1R,EGFR
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
AKR1B1,HSPA1A,HSPA1B
|
Gastrointestinal stromal tumourDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B5B |
TOP1,KDR,SRC
|
Metastatic lymph node neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60 |
EGFR,KDR,MET
|
RetinopathyDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B71 |
IGF1R,APEX1,TEK
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
INSR
NCT02107976,NCT02297399 |
Diabetic foot ulcerDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD54 |
HSPA1B,EGFR,HSPA1A
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
SRC,KDR,MET
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
SRC
NCT00184054,NCT00329498 |
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
EGFR,MET,KDR
|
Herpes simplex infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F00 |
HSPA1B,SMAD3,HSPA1A
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
INSR
NCT01319734,NCT03437902 |
Unspecific body region injuryDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: ND56 |
MET,EGFR
NCT01587261 |
Vitamin C deficiency, unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B56.Z |
NCT05009355,NCT02606773,NCT03224572
|
AdenocarcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D40 |
NCT03697239,NCT03908333,NCT03410030
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
FUT7,AKR1B1,BLM
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
MET,FUT7,GPR35
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
INSR,SRC,LMNA
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
GPR35,BLM,PKM
|
Polycystic ovary syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80.1 |
FUT7,POLH,HPGD
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
FUT7,ELAVL3,BLM
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
ADRA2B,SMAD3,FUT7
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
EGFR,TOP1
|
Mature B-cell leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A82 |
SRC,EGFR
|
Myeloproliferative neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A20 |
SRC,TEK
|
Metastatic malignant neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D50-2E09 |
HSPA1A,HSPA1B
|
Thyroid cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10 |
KDR,MET
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
KDR
NCT01014546 |
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
KDR,EGFR
|
Mature B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A85 |
TOP1,TEK
|
Peritoneal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C51 |
SRC,KDR
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
MET,AKR1B1
|
Cervical cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C77 |
SRC
NCT00284427 |
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
AKR1B1
NCT00211562 |
IschemiaDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B10-8B11 |
EGFR,SRC
|
Ischemic heart diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40-BA6Z |
MET
NCT00000600 |
NADisease Category: NADisease ICD-11 Code: NA |
MET
NCT04553666 |
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
TEK,MET
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
IGF1R
NCT02791906 |
CataractDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B10 |
AKR1B1
NCT00000161 |
AsphyxiaDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD11.1 |
NCT04357782,NCT03066115
|
Cardiac arrestDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MC82 |
NCT03509662,NCT04921189
|
Iron deficiency anaemiaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3A00 |
NCT03188445,NCT04268849
|
Pre-eclampsiaDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA24 |
NCT00388856,NCT03451266
|
Ischaemic heart diseases, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA6Z |
NCT00000541,NCT00000555
|
FatigueDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG22 |
NCT00633581,NCT02521077
|
Urinary tract infectionDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GC08 |
NCT03800667,NCT04261036
|
Glioma, malignantDisease Category: X.Extension CodesDisease ICD-11 Code: XH4RQ3 |
NCT01891747,NCT01502280
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
NCT04832009,NCT04715022
|
Unspecified malignant neoplasms of unspecified sitesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D4Z |
NCT01050621,NCT00441207
|
PneumoniaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA40 |
NCT02735707,NCT02186158
|
Malignant neoplasm of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
NCT01852890,NCT03541486
|
Upper respiratory tract disorderDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0Z |
NCT02678234,NCT02730364
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
BLM,MET
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
BLM,ADRA2B
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
FUT7,IGF1R
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
HSPA1A,BLM
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
AKR1B1,BLM
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
GPR35,BLM
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
MET,GPR35
|
COVID-19Disease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D6Y |
NCT04334512,NCT05029037,NCT04344184,NCT04335084,NCT04347889,NCT04328961,NCT04370288,NCT04395768,NCT03680274,NCT05283954,NCT04363216,NCT04357782,NCT04446104,NCT04401150,NCT04482686,NCT04354428,NCT02735707,NCT04928495
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
APEX1,HSD17B10,AKR1B1,RECQL,CSNK2A1,NUAK1,USP2,SRC,BLM,EGFR,LMNA,TDP1,MET,CSNK2A2,KDR,POLH,TEK
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
INSR,KDR,SRC,IGF1R
NCT02206425,NCT00661544,NCT00085345,NCT00258245,NCT03964688,NCT03602235,NCT00317811,NCT00112879,NCT00006021,NCT00227682,NCT00469209 |
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
APEX1,CSNK2A2,TOP1,FUT7,LMNA,KDR,POLH,SRC,GALNT2,TDP1,RECQL,HPGD,MET,EGFR
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
TEK,SRC,CSNK2A1,EGFR,IGF1R,KDR,TOP1,HSPA1A,PKM,MET,POLB,APEX1,HSPA1B
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
NUAK1,TOP1,FUT7,KDR,TEK,AKR1B1,RAD52,SMAD3,HPGD,BLM,MET,SLC22A6
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
NUAK1,IGF1R,GPR35,LMNA,AKR1B1,SRC,ELAVL3,SMAD3,BLM,CSNK2A1,PKM
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
HSD17B10,TOP1,FUT7,POLB,AKR1B1,GALNT2,TDP1,ELAVL3,MET,PKM
|
Hepatitis virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E50-1E51 |
EGFR
|
Colon cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90 |
EGFR
|
Type-1/2 diabeteDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A10-5A11 |
INSR
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
SRC
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
INSR
|
Human immunodeficiency virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C60-1C62 |
TOP1
|
Urethral cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C93 |
EGFR
|
Psychotic disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20-6A25 |
INSR
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
ADRA2B
|
Postoperative inflammationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-CA43 |
SRC
|
Biliary tract cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C17 |
MET
|
Epidermal dysplasiasDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EK90 |
SRC
|
Esophageal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
TOP1
|
Extraocular muscle disorderDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C82 |
IGF1R
|
ThyrotoxicosisDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A02 |
IGF1R
|
Ocular cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D00-2D07 |
APEX1
|
Nasopharyngeal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6B |
EGFR
|
Digestive organ benign neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E92 |
KDR
|
Intracerebral haemorrhageDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B00 |
EGFR
|
ThrombosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB61-GB90 |
AKR1B1
|
Metastatic digestive system neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D8Y |
SRC
|
Testicular cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80 |
EGFR
|
OsteosarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B51 |
SRC
|
Spinal cord/cranial nerve neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A02 |
EGFR
|
Pituitary gland disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A60-5A61 |
IGF1R
|
Lysosomal diseaseDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C56 |
INSR
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
AKR1B1
|
Endometrial cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76 |
SRC
|
Metastatic biliary tract neoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C14-2C17 |
EGFR
|
LeiomyosarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B58 |
SRC
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
TOP1
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
EGFR
|
Synovial sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B5A |
SRC
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
SRC
|
Hypopharyngeal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6D |
EGFR
|
Skin postprocedural disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EL8Y |
EGFR
|
Fallopian tube cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C74 |
SRC
|
Malignant mesenchymal neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B5D-2B5Y |
EGFR
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
SRC
|
Multiple structural anomalies syndromeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD2F |
IGF1R
|
Liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB90-DB9Z |
MET
|
Coronavirus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D92 |
CSNK2A1
|
General pain disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E43 |
ADRA2B
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
NCT05501548
|
Macro reentrant atrial tachycardia, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.2Z |
NCT00953212
|
Astrocytoma, anaplasticDisease Category: X.Extension CodesDisease ICD-11 Code: XH96C7 |
NCT02168270
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
NCT03522922
|
Postpartum haemorrhageDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA43 |
NCT02424201
|
Nicotine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4A |
NCT00067899
|
Clear cell renal cell carcinoma, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH46F1 |
NCT03334409
|
Hodgkin lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B30 |
NCT03418038
|
Disorders of muscles, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB3Z |
NCT03223519
|
MyelofibrosisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A22 |
NCT01014546
|
MenopauseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA30.0 |
NCT00000555
|
Malignant neoplasm metastasis in male genital organsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E06 |
NCT02516670
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
NCT00000541
|
Other specified malignant neoplasms of colonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
NCT01550510
|
Malignant neoplasms of bladder, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.Z |
NCT04046094
|
Malignant neoplasms of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
NCT03015675
|
Unspecified viral infection of unspecified siteDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D9Z |
NCT04898023
|
Oral mucositisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA01 |
NCT02868151
|
Severe acute respiratory syndromeDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D65 |
NCT04482686
|
Autism spectrum disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A02 |
NCT00325572
|
ShockDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG40 |
NCT01587963
|
Hereditary sensory or autonomic neuropathy, unspecifiedDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C21.Z |
NCT00271635
|
Beta thalassaemiaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3A50.2 |
NCT02083575
|
Follicular lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A80 |
NCT00455416
|
Temporomandibular joint disordersDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA0E.8 |
NCT02602483
|
Macular degenerationDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B75 |
NCT00000161
|
Uterine fibroidDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E66 |
NCT01715597
|
AnorexiaDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG43.7 |
NCT01295450
|
Metabolic disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5D2Z |
NCT04011618
|
Type1diabetesmellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A10 |
NCT02109315
|
Malignant neoplasms of colonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90 |
NCT04035096
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT04404387
|
Polycythaemia veraDisease Category: X.Extension CodesDisease ICD-11 Code: XH0453 |
NCT01014546
|
Diabetic polyneuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C03.0 |
NCT00634998
|
Cerebrovascular diseases, unspecifiedDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B2Z |
NCT00000600
|
Injury of lung, unspecifiedDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NB32.3Z |
NCT04344184
|
Burn and burn infectionDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: ND90-NE2Z |
NCT00734695
|
Basal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C32 |
NCT04279535
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
NCT01005303
|
Pulmonary alveolar proteinosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB04.31 |
NCT03887169
|
Depressive disorders, unspecifiedDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A7Z |
NCT02793648
|
OsteoarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA00-FA05 |
NCT04783792
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
NCT01080352
|
Rectum cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B92 |
NCT04801511
|
Complex regional pain syndromeDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30.04 |
NCT02390505
|
Duplications of the short arm of chromosome 17Disease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD41.G1 |
NCT00484510
|
Soft tissue disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB56 |
NCT03508726
|
Oligodendroglioma, anaplasticDisease Category: X.Extension CodesDisease ICD-11 Code: XH8844 |
NCT02168270
|
Asymptomatic stenosis of intracranial or extracranial arteryDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD55 |
NCT00000600
|
GliosarcomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH9RC8 |
NCT02168270
|
Epilepsy/seizureDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A61-8A6Z |
NCT02369822
|
InfluenzaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E30-1E32 |
NCT02735707
|
Malignant lymphoma, not elsewhere classifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33.5 |
NCT00626444
|
Acute promyelocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH1A50 |
NCT03624270
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
NCT01057615
|
Myelodysplastic syndromes, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A3Z |
ADRA2B
|
Zika virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D48 |
SMAD3
|
Myotonic dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C71.0 |
HPGD
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
MET
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
MET
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
ADRA2B
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
MET
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
MET
|
Ebola virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D60.01 |
MET
|
Lyme borreliosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C1G |
MET
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
BLM
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
Plant-Targeted Human Disease Network
>> Targets derived from weak experimental activities
