Collective Molecular Activities of the Plant: Phellodendron Chinense
Country/Region:
ChinaTraditional Medicine System:
TCMMedicinal Functions:
Antibacterial; Bitter; Cholagogue; Diuretic; Expectorant; Hypoglycaemic; Ophthalmic; Skin; Stomachic; Vasodilator
China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
119 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
96 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
69 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98356
Ingredient ID: NPC95381
Ingredient ID: NPC90998
Ingredient ID: NPC90652
Ingredient ID: NPC85130
Ingredient ID: NPC81775
Ingredient ID: NPC81246
Ingredient ID: NPC81218
Ingredient ID: NPC79549
Ingredient ID: NPC78096
Ingredient ID: NPC77572
Ingredient ID: NPC7106
Ingredient ID: NPC70744
Ingredient ID: NPC6973
Ingredient ID: NPC59567
Ingredient ID: NPC53069
Ingredient ID: NPC51957
Ingredient ID: NPC4669
Ingredient ID: NPC44101
Ingredient ID: NPC41178
Ingredient ID: NPC38928
Ingredient ID: NPC36229
Ingredient ID: NPC36108
Ingredient ID: NPC34861
Ingredient ID: NPC34770
Ingredient ID: NPC328725
Ingredient ID: NPC326069
Ingredient ID: NPC325859
Ingredient ID: NPC325789
Ingredient ID: NPC325617
Ingredient ID: NPC322969
Ingredient ID: NPC31941
Ingredient ID: NPC318561
Ingredient ID: NPC318205
Ingredient ID: NPC316926
Ingredient ID: NPC310392
Ingredient ID: NPC310120
Ingredient ID: NPC308267
Ingredient ID: NPC306669
Ingredient ID: NPC305367
Ingredient ID: NPC305016
Ingredient ID: NPC302857
Ingredient ID: NPC300969
Ingredient ID: NPC296482
Ingredient ID: NPC293487
Ingredient ID: NPC290613
Ingredient ID: NPC29
Ingredient ID: NPC28469
Ingredient ID: NPC278799
Ingredient ID: NPC27838
Ingredient ID: NPC278068
Ingredient ID: NPC276588
Ingredient ID: NPC265082
Ingredient ID: NPC263265
Ingredient ID: NPC263098
Ingredient ID: NPC262870
Ingredient ID: NPC262635
Ingredient ID: NPC261831
Ingredient ID: NPC259732
Ingredient ID: NPC25810
Ingredient ID: NPC257347
Ingredient ID: NPC256270
Ingredient ID: NPC251258
Ingredient ID: NPC250222
Ingredient ID: NPC248355
Ingredient ID: NPC232623
Ingredient ID: NPC231382
Ingredient ID: NPC230301
Ingredient ID: NPC226143
Ingredient ID: NPC223632
Ingredient ID: NPC216459
Ingredient ID: NPC21429
Ingredient ID: NPC210460
Ingredient ID: NPC210437
Ingredient ID: NPC207721
Ingredient ID: NPC20535
Ingredient ID: NPC202768
Ingredient ID: NPC202605
Ingredient ID: NPC202557
Ingredient ID: NPC195291
Ingredient ID: NPC194493
Ingredient ID: NPC194283
Ingredient ID: NPC193798
Ingredient ID: NPC188953
Ingredient ID: NPC183485
Ingredient ID: NPC17273
Ingredient ID: NPC171409
Ingredient ID: NPC170526
Ingredient ID: NPC169595
Ingredient ID: NPC167976
Ingredient ID: NPC166040
Ingredient ID: NPC16452
Ingredient ID: NPC164203
Ingredient ID: NPC16107
Ingredient ID: NPC16066
Ingredient ID: NPC15667
Ingredient ID: NPC156422
Ingredient ID: NPC142703
Ingredient ID: NPC141612
Ingredient ID: NPC138488
Ingredient ID: NPC138487
Ingredient ID: NPC13826
Ingredient ID: NPC137949
Ingredient ID: NPC137153
Ingredient ID: NPC132097
Ingredient ID: NPC131885
Ingredient ID: NPC131624
Ingredient ID: NPC12987
Ingredient ID: NPC127674
Ingredient ID: NPC12053
Ingredient ID: NPC120464
Ingredient ID: NPC117986
Ingredient ID: NPC117237
Ingredient ID: NPC114721
Ingredient ID: NPC114526
Ingredient ID: NPC106786
Ingredient ID: NPC106295
Ingredient ID: NPC104278
Ingredient ID: NPC100980
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Therapeutic Target | Fatty acid binding protein family | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Membrane receptor | SIGMAR1 | Sigma opioid receptor | Q99720 | CHEMBL287 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 28 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00037869 | High Dose I-131 Metaiodobenzylguanidine(MIBG) for Metastatic Neuroendocrine Tumors | metastasis;neuroendocrine neoplasm | Guanidine (NPC20535) | NP level |
| NCT00425009 | Therapeutic Effects of Berberine in Patients With Type 2 Diabetes | type 2 diabetes mellitus | Berberine (NPC53069) | NP level |
| NCT00633282 | Role of Pioglitazone and Berberine in Treatment of Non-Alcoholic Fatty Liver Disease | non-alcoholic fatty liver disease | Berberine (NPC53069) | NP level |
| NCT00638196 | Placebo vs. Linoleic Acid Controlled Assessment of Treatment Efficacy in MS | multiple sclerosis | Oleic Acid (NPC261831) | NP level |
| NCT00966836 | Prevention of Transplant Atherosclerosis With Everolimus and Anti-cytomegalovirus Therapy | cytomegalovirus infection | Phenol (NPC100980) | NP level |
| NCT01197040 | Evaluation of Low Dose Corticosteroids Efficiency, Associated With Myfortic ® in the Treatment of Nephrotic Syndrome | nephrotic syndrome | Phenol (NPC100980) | NP level |
| NCT01468415 | Efficiency Comparison Between Methylprednisolone and Phenol 8% Treatment Using a Trans Sacral Approach - on Lower Back Pain and Limbs | Back pain | Phenol (NPC100980) | NP level |
| NCT01631383 | Pharmacokinetic and Safety Evaluation of L-tetrahydropalmatine (l-THP) With Cocaine Exposure in People With a History of Cocaine Use | cocaine dependence | Tetrahydropalmatine (NPC210437) | NP level |
| NCT01661764 | Fish Oil Supplementation, Nutrigenomics and Colorectal Cancer Prevention | colorectal adenoma | Oleic Acid (NPC261831) | NP level |
| NCT01792310 | A Phase 1/2A Study of LAM561 in Adult Patients With Advanced Solid Tumours | glioma | Oleic Acid (NPC261831) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
CHRM1
|
Abnormal micturitionDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MF50 |
CHRM1
|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOA
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PPARA,AKR1B1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
CDK9
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
Acute upper respiratory infectionDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA07 |
DRD3,DRD2
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,THPO,ACHE,F2,CA9,CYP2D6
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA,ADORA2A,ACHE,F2,PTGS2,DRD1,CYP1B1,CA9,SNCA,DRD2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
