Collective Molecular Activities of the Plant: Allium Ampeloprasum
Country/Region:
Turkey; Italy; Iraq; IndiaTraditional Medicine System:
Medicinal Functions:
Anthelmintic; Antiasthmatic; Anticholesterolemic; Antiseptic; Antispasmodic; Cholagogue; Diaphoretic; Diuretic; Expectorant; Febrifuge; Stimulant; Stings; Stomachic; Tonic; Vasodilator
Turkey; Italy; Turkmenistan; France; Ethiopia; Ireland; Argentina; Ecuador; Uzbekistan; Australia; Iran; Algeria; Cuba; Russia; Haiti; Iraq; Spain; Ukraine; Libya; United States; Morocco; Belarus; Dominican Republic; Bulgaria; Pakistan; Romania; Albania; Portugal; Mexico; Egypt; India; United Kingdom; Tunisia; Greece; Cyprus
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
124 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
75 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
51 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99643
Ingredient ID: NPC96361
Ingredient ID: NPC95412
Ingredient ID: NPC94454
Ingredient ID: NPC94167
Ingredient ID: NPC93888
Ingredient ID: NPC93746
Ingredient ID: NPC92778
Ingredient ID: NPC8981
Ingredient ID: NPC85813
Ingredient ID: NPC85728
Ingredient ID: NPC85488
Ingredient ID: NPC83963
Ingredient ID: NPC83241
Ingredient ID: NPC74306
Ingredient ID: NPC73436
Ingredient ID: NPC72678
Ingredient ID: NPC70754
Ingredient ID: NPC63458
Ingredient ID: NPC62045
Ingredient ID: NPC60151
Ingredient ID: NPC60063
Ingredient ID: NPC55412
Ingredient ID: NPC55066
Ingredient ID: NPC491218
Ingredient ID: NPC490427
Ingredient ID: NPC490424
Ingredient ID: NPC489907
Ingredient ID: NPC46828
Ingredient ID: NPC44742
Ingredient ID: NPC424
Ingredient ID: NPC37825
Ingredient ID: NPC33509
Ingredient ID: NPC328447
Ingredient ID: NPC317120
Ingredient ID: NPC313955
Ingredient ID: NPC311043
Ingredient ID: NPC305034
Ingredient ID: NPC304246
Ingredient ID: NPC299704
Ingredient ID: NPC295644
Ingredient ID: NPC294548
Ingredient ID: NPC290319
Ingredient ID: NPC282602
Ingredient ID: NPC281686
Ingredient ID: NPC275823
Ingredient ID: NPC272614
Ingredient ID: NPC270122
Ingredient ID: NPC269980
Ingredient ID: NPC269919
Ingredient ID: NPC267102
Ingredient ID: NPC264763
Ingredient ID: NPC264395
Ingredient ID: NPC254100
Ingredient ID: NPC2496
Ingredient ID: NPC248128
Ingredient ID: NPC247686
Ingredient ID: NPC244322
Ingredient ID: NPC242580
Ingredient ID: NPC242417
Ingredient ID: NPC239913
Ingredient ID: NPC237812
Ingredient ID: NPC229625
Ingredient ID: NPC228346
Ingredient ID: NPC226453
Ingredient ID: NPC226027
Ingredient ID: NPC222151
Ingredient ID: NPC219143
Ingredient ID: NPC216908
Ingredient ID: NPC21632
Ingredient ID: NPC214721
Ingredient ID: NPC213876
Ingredient ID: NPC208793
Ingredient ID: NPC208740
Ingredient ID: NPC20791
Ingredient ID: NPC203468
Ingredient ID: NPC199072
Ingredient ID: NPC198561
Ingredient ID: NPC195713
Ingredient ID: NPC194414
Ingredient ID: NPC189436
Ingredient ID: NPC188795
Ingredient ID: NPC187770
Ingredient ID: NPC187488
Ingredient ID: NPC186282
Ingredient ID: NPC185755
Ingredient ID: NPC18345
Ingredient ID: NPC181945
Ingredient ID: NPC181610
Ingredient ID: NPC179438
Ingredient ID: NPC17810
Ingredient ID: NPC174486
Ingredient ID: NPC174246
Ingredient ID: NPC171327
Ingredient ID: NPC17066
Ingredient ID: NPC169749
Ingredient ID: NPC169656
Ingredient ID: NPC1682
Ingredient ID: NPC168150
Ingredient ID: NPC167400
Ingredient ID: NPC166575
Ingredient ID: NPC154662
Ingredient ID: NPC152451
Ingredient ID: NPC150950
Ingredient ID: NPC147983
Ingredient ID: NPC138686
Ingredient ID: NPC137958
Ingredient ID: NPC137453
Ingredient ID: NPC13648
Ingredient ID: NPC136181
Ingredient ID: NPC136014
Ingredient ID: NPC135434
Ingredient ID: NPC130683
Ingredient ID: NPC130401
Ingredient ID: NPC126681
Ingredient ID: NPC124893
Ingredient ID: NPC124370
Ingredient ID: NPC124173
Ingredient ID: NPC116775
Ingredient ID: NPC11433
Ingredient ID: NPC112890
Ingredient ID: NPC106266
Ingredient ID: NPC105451
Ingredient ID: NPC102149
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | Cysteine protease | CASP6 | Caspase-6 | P55212 | CHEMBL3308 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 594 | |
 Plant level | 1 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000116 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Beta Carotene (NPC17810);Ascorbate (NPC187770) | NP level |
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00000372 | Glycine and D-Cycloserine in Schizophrenia | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction | Pyridoxine (NPC269919);Beta Carotene (NPC17810);Folic Acid (NPC147983);Ascorbate (NPC187770) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
NCT00694564
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
NCT03090048,NCT03522922
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
FFAR1,KDR,AURKB,DPP4
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TOP2A,NFKB1,AXL,FLT3,PIM1,TP53,SRC,AURKB,BCL2
NCT00184054,NCT00329498,NCT01842139 |
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT02929888
|
Acute promyelocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH1A50 |
NCT03624270
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT03718507,NCT04404387
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
