Collective Molecular Activities of the Plant: Trifolium Pratense
Plant ID: NPO22104
Plant Latin Name: Trifolium Pratense
Taxonomy Genus: Trifolium
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
57577
Plant-of-the-World-Online:
n.a.
Country/Region:
Turkey; Albania; Italy; India; Sweden; China; RussiaTraditional Medicine System:
Indian Folk; TCM; HomeopathyMedicinal Functions:
Alterative; Antipsoriatic; Antiscrophulatic; Antispasmodic; Aperient; Cancer; Detergent; Diuretic; Expectorant; Miscellany; Sedative; Skin; Tonic
Turkey; Albania; Italy; India; Sweden; China; Russia
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
119 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
93 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
52 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98304
Ingredient ID: NPC92943
Ingredient ID: NPC92869
Ingredient ID: NPC90486
Ingredient ID: NPC85985
Ingredient ID: NPC85210
Ingredient ID: NPC81010
Ingredient ID: NPC80710
Ingredient ID: NPC74539
Ingredient ID: NPC73980
Ingredient ID: NPC72042
Ingredient ID: NPC71339
Ingredient ID: NPC70691
Ingredient ID: NPC7013
Ingredient ID: NPC6616
Ingredient ID: NPC65134
Ingredient ID: NPC5626
Ingredient ID: NPC53559
Ingredient ID: NPC502
Ingredient ID: NPC49074
Ingredient ID: NPC46254
Ingredient ID: NPC45638
Ingredient ID: NPC43246
Ingredient ID: NPC39927
Ingredient ID: NPC39426
Ingredient ID: NPC39064
Ingredient ID: NPC38742
Ingredient ID: NPC38212
Ingredient ID: NPC375265
Ingredient ID: NPC35544
Ingredient ID: NPC33415
Ingredient ID: NPC32991
Ingredient ID: NPC31279
Ingredient ID: NPC312132
Ingredient ID: NPC311988
Ingredient ID: NPC311783
Ingredient ID: NPC311255
Ingredient ID: NPC307176
Ingredient ID: NPC303644
Ingredient ID: NPC302857
Ingredient ID: NPC299480
Ingredient ID: NPC296071
Ingredient ID: NPC294412
Ingredient ID: NPC294409
Ingredient ID: NPC291428
Ingredient ID: NPC290076
Ingredient ID: NPC28828
Ingredient ID: NPC285973
Ingredient ID: NPC285776
Ingredient ID: NPC283170
Ingredient ID: NPC269242
Ingredient ID: NPC266597
Ingredient ID: NPC264784
Ingredient ID: NPC263089
Ingredient ID: NPC261644
Ingredient ID: NPC258476
Ingredient ID: NPC257124
Ingredient ID: NPC252587
Ingredient ID: NPC251666
Ingredient ID: NPC247553
Ingredient ID: NPC246328
Ingredient ID: NPC244315
Ingredient ID: NPC239039
Ingredient ID: NPC235260
Ingredient ID: NPC235190
Ingredient ID: NPC234560
Ingredient ID: NPC232375
Ingredient ID: NPC232141
Ingredient ID: NPC229113
Ingredient ID: NPC225709
Ingredient ID: NPC222696
Ingredient ID: NPC217226
Ingredient ID: NPC216825
Ingredient ID: NPC214971
Ingredient ID: NPC210456
Ingredient ID: NPC209560
Ingredient ID: NPC204388
Ingredient ID: NPC202992
Ingredient ID: NPC201174
Ingredient ID: NPC200838
Ingredient ID: NPC197396
Ingredient ID: NPC195355
Ingredient ID: NPC195265
Ingredient ID: NPC194654
Ingredient ID: NPC194653
Ingredient ID: NPC191103
Ingredient ID: NPC19003
Ingredient ID: NPC182468
Ingredient ID: NPC179987
Ingredient ID: NPC177996
Ingredient ID: NPC176819
Ingredient ID: NPC175771
Ingredient ID: NPC173208
Ingredient ID: NPC172625
Ingredient ID: NPC168290
Ingredient ID: NPC163984
Ingredient ID: NPC157663
Ingredient ID: NPC157340
Ingredient ID: NPC156222
Ingredient ID: NPC152384
Ingredient ID: NPC145463
Ingredient ID: NPC142989
Ingredient ID: NPC13990
Ingredient ID: NPC137949
Ingredient ID: NPC136913
Ingredient ID: NPC135585
Ingredient ID: NPC13449
Ingredient ID: NPC13304
Ingredient ID: NPC13143
Ingredient ID: NPC126004
Ingredient ID: NPC125085
Ingredient ID: NPC125062
Ingredient ID: NPC124639
Ingredient ID: NPC117299
Ingredient ID: NPC115919
Ingredient ID: NPC115723
Ingredient ID: NPC111690
Ingredient ID: NPC104190
Ingredient ID: NPC100773
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Therapeutic Target | Hydrolase | CDA | Cytidine deaminase | P32320 | CHEMBL4502 |
| Therapeutic Target | Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 155 | |
 Plant level | 2 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000176 | Alzheimer's Disease Prevention Trial | Alzheimer disease;memory impairment | Progesterone (NPC307176) | NP level |
| NCT00000295 | Progesterone Treatment in Female Smokers - 12 | nicotine dependence | Progesterone (NPC307176) | NP level |
| NCT00000430 | Low-Dose Hormone Replacement Therapy and Alendronate for Osteoporosis | Osteopenia;osteoporosis | Progesterone (NPC307176) | NP level |
| NCT00000466 | Postmenopausal Estrogen/Progestin Interventions (PEPI) | diabetes mellitus;Hypercholesterolemia;hypertension;menopause;Myocardial Ischemia;osteoporosis;thrombotic disease | Progesterone (NPC307176) | NP level |
| NCT00000555 | Women's Angiographic Vitamin and Estrogen Trial (WAVE) | menopause;Myocardial Ischemia | Progesterone (NPC307176) | NP level |
| NCT00000601 | Postmenopausal Hormone Therapy in Unstable Angina | intermediate coronary syndrome;menopause | Progesterone (NPC307176) | NP level |
| NCT00001481 | The Role of Hormones in Postpartum Mood Disorders | postpartum depression | Progesterone (NPC307176) | NP level |
| NCT00001696 | A Pharmacokinetic Study of Genistein, a Tyrosine Kinase Inhibitor | cancer | Genistein (NPC39426) | NP level |
| NCT00003667 | Combination Chemotherapy and Biological Therapy in Treating Patients With High-Risk Ewing's Sarcoma | sarcoma | Glycerin (NPC157340) | NP level |
| NCT00005025 | Gene Therapy in Treating Women With Refractory or Relapsed Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Peritoneal Cancer | fallopian tube cancer;ovarian cancer;peritoneum cancer | Thymidine (NPC71339) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1,AR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
NR3C1,DPP4,AKR1B1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
AR,TK1,KIT,MAPT
|
Acute pancreatitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DC31 |
NCT02110810
|
Adaptive immunity immunodeficiencyDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A01 |
NR3C1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
BLM,CA7,CYP2C9,CDA,CA9,NQO1,CA12,TSHR,GPR35,TK1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
BLM,CA14,CYP1B1,CA7,PGR,ALDH2,KIT,CYP2C9,DPP4,CA9,MAOB,LMNA,CA2,TK1
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
SERPINA6
NCT01126879,NCT01325311,NCT00546039 |
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
