Plant ID: NPO22043
Plant Latin Name: Hylomecon Japonica
Taxonomy Genus: Hylomecon
Taxonomy Family: Papaveraceae
NCBI TaxonomyDB:
72187
Plant-of-the-World-Online:
n.a.
China
Ingredient ID: NPC67978
Ingredient ID: NPC49075
Ingredient ID: NPC32141
Ingredient ID: NPC316870
Ingredient ID: NPC315274
Ingredient ID: NPC314828
Ingredient ID: NPC307065
Ingredient ID: NPC303581
Ingredient ID: NPC285117
Ingredient ID: NPC268214
Ingredient ID: NPC257362
Ingredient ID: NPC23614
Ingredient ID: NPC234392
Ingredient ID: NPC232604
Ingredient ID: NPC205686
Ingredient ID: NPC199402
Ingredient ID: NPC185639
Ingredient ID: NPC183367
Ingredient ID: NPC171426
Ingredient ID: NPC16452
Ingredient ID: NPC163969
Ingredient ID: NPC148693
Ingredient ID: NPC129276
Ingredient ID: NPC121400
Ingredient ID: NPC12053
Ingredient ID: NPC100079
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
Therapeutic Target | Nuclear hormone receptor subfamily 1 | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | CHEMBL235 |
Therapeutic Target | Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 49 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT01483248 | Human Menstrual Blood-derived Mesenchymal Stem Cells for Patients With Liver Cirrhosis | cirrhosis of liver | Ursodiol (NPC171426) | NP level |
NCT02823353 | Fenofibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis | primary biliary cirrhosis | Ursodiol (NPC171426) | NP level |
NCT03201952 | Examination of the Metabolic Effects of Direct Bile Salt Delivery to the Ileum in Humans | Glucose intolerance | Ursodiol (NPC171426) | NP level |
NCT05450887 | Efficacy and Safety of Obeticholic Acid in the Treatment of Primary Biliary Cholangitis | primary biliary cirrhosis | Ursodiol (NPC171426) | NP level |
NCT00134758 | Ursodeoxycholic Acid in the Treatment of Duodenal Adenomas in Familial Adenomatous Polyposis (FAP) Patients | Familial adenomatous polyposis | Ursodiol (NPC171426) | NP level |
NCT01088607 | Safety and Efficacy Study of Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis | sclerosing cholangitis | Ursodiol (NPC171426) | NP level |
NCT01904058 | Phase 2 Study to Evaluate LUM001 in Combination With Ursodeoxycholic Acid in Patients With Primary Biliary Cirrhosis | primary biliary cirrhosis | Ursodiol (NPC171426) | NP level |
NCT04834557 | Evaluating the Effect of Digoxin and Ursodeoxycholic Acid in Patients With Rheumatoid Arthritis | rheumatoid arthritis | Ursodiol (NPC171426) | NP level |
NCT01829698 | Efficacy and Safety Study of TUDCA Compare UDCA to Treatment Chronic Cholestatic Liver Disease-PBC | liver disease | Ursodiol (NPC171426) | NP level |
NCT05500937 | Effect of UDCA on the New Onset Diabetes and Glucose Intolerance Induced by Statin | diabetes mellitus | Ursodiol (NPC171426) | NP level |
NCT01857284 | Safety and Efficacy of Tauroursodeoxycholic Acid Versus Ursofalk in the Treatment of Adult Primary Biliary Cirrhosis | primary biliary cirrhosis | Ursodiol (NPC171426) | NP level |
NCT00873275 | Ursodiol, Combination Chemotherapy, and Bevacizumab in Treating Patients With Stage IV Colorectal Cancer | colorectal carcinoma | Ursodiol (NPC171426) | NP level |
NCT03056274 | Metformin in Intrahepatic Cholestasis of Pregnancy | pregnancy | Ursodiol (NPC171426) | NP level |
NCT00550862 | Study of INT 747 in Combination With URSO in Patients With Primay Biliary Cirrhosis (PBC) | primary biliary cirrhosis | Ursodiol (NPC171426) | NP level |
NCT02244944 | Ezetimibe-Ursodiol Combination Therapy on Biomarkers of Liver Function and Sterol Balance in Subjects With NAFLD | non-alcoholic fatty liver disease | Ursodiol (NPC171426) | NP level |
NCT05467553 | A Study to Compare P1101 Plus TAF With or Without UDCA in Patients With HBV and HDV Co-Infection | hepatitis D virus infection | Ursodiol (NPC171426) | NP level |
NCT00004784 | Phase III Randomized Study of Ursodiol With Vs Without Methotrexate for Primary Biliary Cirrhosis | primary biliary cirrhosis | Ursodiol (NPC171426) | NP level |
NCT01899703 | A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Repeat Doses of GSK2330672 Administration in Subjects With Primary Biliary Cirrhosis (PBC) and Symptoms of Pruritus | intrahepatic cholestasis | Ursodiol (NPC171426) | NP level |
NCT00514774 | Ursodiol in Huntington's Disease | Huntington disease | Ursodiol (NPC171426) | NP level |
NCT02965911 | Efficacy and Safety of Fenofibrate Combined With UDCA in PBC Patients With an Incomplete Biochemical Response to UDCA | primary biliary cirrhosis | Ursodiol (NPC171426) | NP level |
NCT01688375 | The Effect of Ursodeoxycholic Acid in Liver Functional Restoration of Patients With Obstructive Jaundice | obstructive jaundice | Ursodiol (NPC171426) | NP level |
NCT01226823 | Ursodeoxycholic Acid And Cholestasis Of Pregnancy | intrahepatic cholestasis | Ursodiol (NPC171426) | NP level |
NCT02823366 | Fenofibrate for Patients With Primary Biliary Cirrhosis Who Had An Inadequate Response to Ursodeoxycholic Acid | primary biliary cirrhosis | Ursodiol (NPC171426) | NP level |
NCT01440309 | Efficacy and Safety Study of Allogenic Mesenchymal Stem Cells for Patients With Refractory Primary Biliary Cirrhosis | primary biliary cirrhosis | Ursodiol (NPC171426) | NP level |
NCT02916290 | Fuzhenghuayu in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis | primary biliary cirrhosis | Ursodiol (NPC171426) | NP level |
NCT02420496 | Enteral Fish Oil is Superior to Ursodeoxycholic Acid (UDCA) and Placebo for the Treatment of Cholestasis in Infants | cholestasis;liver disease | Ursodiol (NPC171426) | NP level |
NCT00846963 | Ursodiol for Treating Parenteral Nutrition Associated Cholestasis in Neonates | cholestasis | Ursodiol (NPC171426) | NP level |
NCT00062023 | Comparison of Sulindac, Aspirin, and Ursodiol in Preventing Colorectal Cancer | colorectal carcinoma | Ursodiol (NPC171426) | NP level |
NCT03840005 | Trial of Ursodeoxycholic Acid (UDCA) for Parkinson's Disease: The "UP" Study | Parkinson disease | Ursodiol (NPC171426) | NP level |
NCT04956328 | Study of Obeticholic Acid(OCA) Combination With Ursodeoxycholic Acid (UDCA) in Patients With Primay Biliary Cirrhosis (PBC) | primary biliary cirrhosis | Ursodiol (NPC171426) | NP level |
NCT00059202 | Trial of High-dose Urso in Primary Sclerosing Cholangitis | sclerosing cholangitis | Ursodiol (NPC171426) | NP level |
NCT00746486 | Ursodeoxycholic Acid Plus Budesonide Versus Ursodeoxycholic Acid Alone in Primary Biliary Cirrhosis (PBC) | primary biliary cirrhosis | Ursodiol (NPC171426) | NP level |
NCT00200343 | Efficacy and Safety Study of Ursodeoxycholic Acid to Treat Chronic Hepatitis C | chronic hepatitis C virus infection | Ursodiol (NPC171426) | NP level |
NCT00004748 | Low-Dose Oral Methotrexate Versus Colchicine for Primary Biliary Cirrhosis | primary biliary cirrhosis | Ursodiol (NPC171426) | NP level |
NCT02967250 | Brain Bioenergetics in Parkinson's Disease and Response to Repeated Oral UDCA Treatment | Parkinson disease | Ursodiol (NPC171426) | NP level |
NCT00470171 | Pilot Study of Ursodesoxycholic Acid in Non-Alcoholic Steatohepatitis | inflammation | Ursodiol (NPC171426) | NP level |
NCT00808743 | Prevention of Progression of Duodenal Adenomas in Patients With Familial Adenomatous Polyposis | Familial adenomatous polyposis | Ursodiol (NPC171426) | NP level |
NCT02721862 | Effectiveness of Ursodeoxycholic Acid Use in the Prevention of Gallstone Formation After Sleeve Gastrectomy | cholelithiasis | Ursodiol (NPC171426) | NP level |
NCT04751188 | A Study to Assess Efficacy and Safety of Bezafibrate in Patients With Primary Biliary Cholangitis | primary biliary cirrhosis | Ursodiol (NPC171426) | NP level |
NCT02033876 | Ursodiol on Insulin Sensitivity, Gastric Emptying and Body Weight With Type 2 Diabetes on Metformin | type 2 diabetes mellitus | Ursodiol (NPC171426) | NP level |
NCT03586674 | Fibrates in Pediatric Cholestasis | cholestasis | Ursodiol (NPC171426) | NP level |
NCT03000218 | Evaluation of PK and Biomarkers After UDCA Administrations to Subjects Who Are Overweight and Have Liver Problems | obesity;Elevated hepatic transaminase | Ursodiol (NPC171426) | NP level |
NCT00285597 | Ursodeoxycholic Acid in Chronic Heart Failure | congestive heart failure | Ursodiol (NPC171426) | NP level |
NCT02916641 | Fuzhenghuayu for Patients With PBC Who Had An Inadequate Response to Ursodeoxycholic Acid | primary biliary cirrhosis | Ursodiol (NPC171426) | NP level |
NCT05416580 | Efficacy of Ursodeoxycholic Acid (UDCA) in Patients With Type 2 Diabetes | type 2 diabetes mellitus | Ursodiol (NPC171426) | NP level |
NCT02943707 | Autologous Bone Marrow Stem Cells Infusion for the Treatment of Liver Diseases. | liver disease | Ursodiol (NPC171426) | NP level |
NCT02937012 | Use of Bezafibrate in Patients With Primary Biliary Cirrhosis to Archive Complete Biochemical Response in Non-responders | primary biliary cirrhosis | Ursodiol (NPC171426) | NP level |
NCT04810156 | Treatment Efficacy of Corticosteroids and Mycophenolate Mofetil in Patients With Immune Related Hepatitis | drug-induced liver injury | Ursodiol (NPC171426) | NP level |
NCT03516006 | Umbilical Cord Mesenchymal Stem Cells in Primary Sclerosing Cholangitis | sclerosing cholangitis | Ursodiol (NPC171426) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Obstruction of bile ductDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DC10.02 |
NCT03586674,NCT01688375,NCT00846963,NCT02420496
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
PPARG
NCT02033876,NCT05416580 |
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
MAOA
NCT02967250,NCT03840005 |
Liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB90-DB10Z |
NCT01829698,NCT02420496,NCT02943707
|
Primary sclerosing cholangitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB96.2 |
NCT00059202,NCT01088607,NCT03516006
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
PPARG,MAOA
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
PPARG
NCT02244944 |
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
PPARG
NCT03000218 |
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
PPARG
NCT05500937 |
Other specified malignant neoplasms of colonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
NCT00134758,NCT00808743
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
NCT00873275,NCT00062023
|
Intrahepatic cholestasis, not elsewhere classifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB99.6 |
NCT01226823,NCT01899703
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
PPARG,LMNA
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
PPARG,LMNA
|
Primary biliary cholangitis, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB96.1Z |
NCT02916290,NCT02965911,NCT04956328,NCT00004784,NCT00004748,NCT04751188,NCT05450887,NCT02916641,NCT00746486,NCT01440309,NCT00550862,NCT01904058,NCT02823366,NCT01857284,NCT02937012,NCT02823353
|
Inborn lipid metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52 |
PPARG
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
CYP2D6
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
PPARG
|
Sjogren syndromeDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A43 |
PPARG
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
MAOA
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
PPARG
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
PPARG
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PPARG
|
Mood disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60-6E23 |
MAOA
|
General pain disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E43 |
MAOA
|
Nicotine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4A |
PPARG
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOA
|
MalariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F40-1F45 |
CYP2D6
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
PPARG
|
DepressionDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70-6A7Z |
MAOA
|
Skin tag/polypDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EK71 |
MAOA
|
Opioid use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C43 |
PPARG
|
GoutDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA25 |
PPARG
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
PPARG
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
MAOA
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
PPARG
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
NCT04834557
|
Pregnancy/childbirth/puerperium maternal infectionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JB63 |
NCT03056274
|
Huntington diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01.10 |
NCT00514774
|
Acute viral hepatitisDisease Category: NADisease ICD-11 Code: NA |
NCT03000218
|
Drug-induced or toxic liver disease, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB95.Z |
NCT04810156
|
CholelithiasisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DC11 |
NCT02721862
|
Chronic hepatitis DDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E51.2 |
NCT05467553
|
Congestive heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10 |
NCT00285597
|
Other specified disorders of carbohydrate absorption or transportDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C61.Y |
NCT03201952
|
Hepatic fibrosis/cirrhosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB93 |
NCT01483248
|
NADisease Category: NADisease ICD-11 Code: NA |
NCT00470171
|
Chronic hepatitis CDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E51.1 |
NCT00200343
|
Dengue fever, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D2Z |
MAOA
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
LMNA
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
LMNA
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
LMNA
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
LMNA
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CYP2D6
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CYP2D6
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA
|