Collective Molecular Activities of the Plant: Hypericum Japonicum
Plant ID: NPO21963
Plant Latin Name: Hypericum Japonicum
Taxonomy Genus: Hypericum
Taxonomy Family: Hypericaceae
Plant External Links:
NCBI TaxonomyDB:
282542
Plant-of-the-World-Online:
n.a.
Country/Region:
Guinea; Vietnam; China; IndiaTraditional Medicine System:
Indian Folk; TCMMedicinal Functions:
Antiphlogistic; Depurative; Febrifuge; Vulnerary
Guinea; Vietnam; China; India
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
148 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
87 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
84 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC88924
Ingredient ID: NPC88789
Ingredient ID: NPC86642
Ingredient ID: NPC85813
Ingredient ID: NPC81775
Ingredient ID: NPC80981
Ingredient ID: NPC7965
Ingredient ID: NPC78377
Ingredient ID: NPC71639
Ingredient ID: NPC67508
Ingredient ID: NPC66117
Ingredient ID: NPC64176
Ingredient ID: NPC62290
Ingredient ID: NPC61558
Ingredient ID: NPC57897
Ingredient ID: NPC57788
Ingredient ID: NPC54321
Ingredient ID: NPC54145
Ingredient ID: NPC5322
Ingredient ID: NPC51700
Ingredient ID: NPC49168
Ingredient ID: NPC483027
Ingredient ID: NPC483026
Ingredient ID: NPC483025
Ingredient ID: NPC483024
Ingredient ID: NPC483023
Ingredient ID: NPC483022
Ingredient ID: NPC483021
Ingredient ID: NPC483020
Ingredient ID: NPC483019
Ingredient ID: NPC483018
Ingredient ID: NPC483017
Ingredient ID: NPC483016
Ingredient ID: NPC483015
Ingredient ID: NPC47844
Ingredient ID: NPC47135
Ingredient ID: NPC46941
Ingredient ID: NPC43276
Ingredient ID: NPC41163
Ingredient ID: NPC40018
Ingredient ID: NPC34429
Ingredient ID: NPC321549
Ingredient ID: NPC317111
Ingredient ID: NPC310562
Ingredient ID: NPC304838
Ingredient ID: NPC304072
Ingredient ID: NPC302857
Ingredient ID: NPC301398
Ingredient ID: NPC30069
Ingredient ID: NPC299326
Ingredient ID: NPC294591
Ingredient ID: NPC288589
Ingredient ID: NPC282974
Ingredient ID: NPC282694
Ingredient ID: NPC281131
Ingredient ID: NPC275463
Ingredient ID: NPC27532
Ingredient ID: NPC275122
Ingredient ID: NPC274613
Ingredient ID: NPC273326
Ingredient ID: NPC272651
Ingredient ID: NPC27202
Ingredient ID: NPC27133
Ingredient ID: NPC270783
Ingredient ID: NPC266447
Ingredient ID: NPC266396
Ingredient ID: NPC264317
Ingredient ID: NPC262911
Ingredient ID: NPC262505
Ingredient ID: NPC254696
Ingredient ID: NPC254284
Ingredient ID: NPC254199
Ingredient ID: NPC249040
Ingredient ID: NPC246180
Ingredient ID: NPC244705
Ingredient ID: NPC243728
Ingredient ID: NPC242580
Ingredient ID: NPC238376
Ingredient ID: NPC236761
Ingredient ID: NPC236202
Ingredient ID: NPC233443
Ingredient ID: NPC23158
Ingredient ID: NPC230920
Ingredient ID: NPC230301
Ingredient ID: NPC227986
Ingredient ID: NPC224874
Ingredient ID: NPC22098
Ingredient ID: NPC218109
Ingredient ID: NPC215242
Ingredient ID: NPC213508
Ingredient ID: NPC210560
Ingredient ID: NPC20791
Ingredient ID: NPC207429
Ingredient ID: NPC204989
Ingredient ID: NPC204353
Ingredient ID: NPC202742
Ingredient ID: NPC20175
Ingredient ID: NPC199978
Ingredient ID: NPC199977
Ingredient ID: NPC198778
Ingredient ID: NPC197396
Ingredient ID: NPC196293
Ingredient ID: NPC194208
Ingredient ID: NPC1940
Ingredient ID: NPC192744
Ingredient ID: NPC190930
Ingredient ID: NPC181225
Ingredient ID: NPC179950
Ingredient ID: NPC178134
Ingredient ID: NPC176869
Ingredient ID: NPC173638
Ingredient ID: NPC172945
Ingredient ID: NPC171928
Ingredient ID: NPC170526
Ingredient ID: NPC167976
Ingredient ID: NPC166846
Ingredient ID: NPC165651
Ingredient ID: NPC164877
Ingredient ID: NPC164859
Ingredient ID: NPC164646
Ingredient ID: NPC161532
Ingredient ID: NPC156654
Ingredient ID: NPC155763
Ingredient ID: NPC154172
Ingredient ID: NPC151708
Ingredient ID: NPC149203
Ingredient ID: NPC14662
Ingredient ID: NPC143799
Ingredient ID: NPC142703
Ingredient ID: NPC140689
Ingredient ID: NPC139891
Ingredient ID: NPC138883
Ingredient ID: NPC137096
Ingredient ID: NPC135353
Ingredient ID: NPC135088
Ingredient ID: NPC134584
Ingredient ID: NPC134570
Ingredient ID: NPC133646
Ingredient ID: NPC125575
Ingredient ID: NPC123965
Ingredient ID: NPC123658
Ingredient ID: NPC113928
Ingredient ID: NPC113404
Ingredient ID: NPC110899
Ingredient ID: NPC108811
Ingredient ID: NPC106392
Ingredient ID: NPC106200
Ingredient ID: NPC101475
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Drug Transporter | SLC superfamily of solute carriers | SLC22A6 | Solute carrier family 22 member 6 | Q4U2R8 | CHEMBL1641347 |
| Therapeutic Target | Enzyme | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | ABHD12 | Monoacylglycerol lipase ABHD12 | Q8N2K0 | CHEMBL5516 |
| Therapeutic Target | Enzyme | DAGLB | Sn1-specific diacylglycerol lipase beta | Q8NCG7 | CHEMBL5521 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 110 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00001723 | Safety and Efficacy of Xenical in Children and Adolescents With Obesity-Related Diseases | obesity | Orlistat (NPC47135) | NP level |
| NCT00029679 | Borage Oil and Ginkgo Biloba (EGb 761) in Asthma | asthma | Linoleic Acid (NPC85813) | NP level |
| NCT00115063 | LOSS- Louisiana Obese Subjects Study | obesity | Orlistat (NPC47135) | NP level |
| NCT00120432 | Single Dose of 1% Tropicamide and 10% Phenylephrine for Pupillary Dilation | eye disease | Phenylephrine (NPC137096) | NP level |
| NCT00204932 | Effects of CLA Supplements on Body Weight and Fat Oxidation | obesity | Linoleic Acid (NPC85813) | NP level |
| NCT00212199 | Effectiveness of Brief Counseling for Weight Management | obesity | Orlistat (NPC47135) | NP level |
| NCT00227448 | Induced Hypertension for Acute Ischemic Stroke | Ischemic stroke | Phenylephrine (NPC137096) | NP level |
| NCT00276016 | The Effects of Phenylephrine Compared With Those of Placebo and Pseudoephedrine on Nasal Congestion in Subjects With Seasonal Allergic Rhinitis (SAR)(P04579) | seasonal allergic rhinitis | Phenylephrine (NPC137096) | NP level |
| NCT00276263 | Sarcosine Preventive Therapy for Individuals At High Risk for Schizophrenia | schizophrenia | Sarcosine (NPC134570) | NP level |
| NCT00328276 | Sarcosine (N-Methylglycine) Monotherapy for Schizophrenia | schizophrenia | Sarcosine (NPC134570) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOA
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
INSR,KDR,AURKB,FFAR1,CNR1,AKR1B1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TP53,RELA,PIM1,AURKB,KDM1A,SRC,FLT3,AXL
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
RELA
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE,GPR35,XDH,CA12,CDK1,AKR1C3,AURKB,CA7,ADRA2A,F2,NPSR1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ALPI,CA14,RECQL,POLB,ACHE,XDH,FFAR4,MET,LMNA,ADRA1B,AKR1C3,AURKB,PIM1,GSTP1,FABP3,CA7,CYP1B1,ABHD6,LIPG,PLA2G7,CA2,CES1,F2,NPSR1,ALOX15,LIPC,ALOX5,NUAK1,TEK,AXL,ABCG2,HIF1A
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
PLA2G7,ALOX15,PNLIP,NOX4
NCT01912820 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
MET,CDK1,AURKB,LIPG,PLA2G7,F2,NPSR1,ALOX15,LIPC,CYP19A1,NOX4
|
Adrenomedullary hyperfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A75 |
HIF1A
|
Ageing associated decline in intrinsic capacityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG2A |
NCT04946383,NCT05422885
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
