Collective Molecular Activities of the Plant: Ligusticum Tenuissimum
Plant ID: NPO2154
Plant Latin Name: Ligusticum Tenuissimum
Taxonomy Genus: Ligusticum
Taxonomy Family: Apiaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Country/Region:
South KoreaTraditional Medicine System:
South Korea
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
73 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
65 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
39 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99480
Ingredient ID: NPC91574
Ingredient ID: NPC90226
Ingredient ID: NPC86538
Ingredient ID: NPC85813
Ingredient ID: NPC84030
Ingredient ID: NPC83628
Ingredient ID: NPC70744
Ingredient ID: NPC59570
Ingredient ID: NPC52230
Ingredient ID: NPC51189
Ingredient ID: NPC51146
Ingredient ID: NPC45270
Ingredient ID: NPC43114
Ingredient ID: NPC4079
Ingredient ID: NPC39068
Ingredient ID: NPC37947
Ingredient ID: NPC37622
Ingredient ID: NPC36408
Ingredient ID: NPC32098
Ingredient ID: NPC31371
Ingredient ID: NPC31069
Ingredient ID: NPC30594
Ingredient ID: NPC304208
Ingredient ID: NPC300649
Ingredient ID: NPC297643
Ingredient ID: NPC291255
Ingredient ID: NPC290613
Ingredient ID: NPC290189
Ingredient ID: NPC290078
Ingredient ID: NPC29
Ingredient ID: NPC287550
Ingredient ID: NPC286931
Ingredient ID: NPC268164
Ingredient ID: NPC256405
Ingredient ID: NPC249009
Ingredient ID: NPC243728
Ingredient ID: NPC242314
Ingredient ID: NPC240817
Ingredient ID: NPC236355
Ingredient ID: NPC230301
Ingredient ID: NPC229262
Ingredient ID: NPC227049
Ingredient ID: NPC223468
Ingredient ID: NPC218918
Ingredient ID: NPC217226
Ingredient ID: NPC215894
Ingredient ID: NPC214909
Ingredient ID: NPC213935
Ingredient ID: NPC20410
Ingredient ID: NPC198023
Ingredient ID: NPC187568
Ingredient ID: NPC187061
Ingredient ID: NPC184049
Ingredient ID: NPC183670
Ingredient ID: NPC182794
Ingredient ID: NPC176309
Ingredient ID: NPC16728
Ingredient ID: NPC15912
Ingredient ID: NPC14917
Ingredient ID: NPC148671
Ingredient ID: NPC147343
Ingredient ID: NPC143639
Ingredient ID: NPC142104
Ingredient ID: NPC139619
Ingredient ID: NPC138347
Ingredient ID: NPC135077
Ingredient ID: NPC133600
Ingredient ID: NPC130683
Ingredient ID: NPC120926
Ingredient ID: NPC1108
Ingredient ID: NPC108759
Ingredient ID: NPC105557
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2A6 | Cytochrome P450 2A6 | P11509 | CHEMBL5282 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Oxidoreductase | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | FFAR1 | Free fatty acid receptor 1 | O14842 | CHEMBL4422 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | FFAR4 | G-protein coupled receptor 120 | Q5NUL3 | CHEMBL5339 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Therapeutic Target | Unclassified protein | SNCA | Alpha-synuclein | P37840 | CHEMBL6152 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 45 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00005092 | Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer | leukemia;multiple myeloma;myelodysplastic syndrome | Psoralen (NPC51146) | NP level |
| NCT00029679 | Borage Oil and Ginkgo Biloba (EGb 761) in Asthma | asthma | Linoleic Acid (NPC85813) | NP level |
| NCT00204932 | Effects of CLA Supplements on Body Weight and Fat Oxidation | obesity | Linoleic Acid (NPC85813) | NP level |
| NCT00218946 | Nasogastric Tube in Premature Babies - Pain and Treatment | premature birth | Sucrose (NPC130683) | NP level |
| NCT00299559 | Kinetics of Etheric Oils, Smart Textiles vs. Ointment | common cold | Menthol (NPC223468) | NP level |
| NCT00482560 | Analgesic Effect of Breast Feeding vs Sucrose in Neonatal Screening | pain | Sucrose (NPC130683) | NP level |
| NCT00519207 | Evaluation of Topical Liposomal Lidocaine and Oral Sucrose for Treatment of Pain in Newborns Undergoing Venipuncture | pain | Sucrose (NPC130683) | NP level |
| NCT00607945 | Dietary Fatty Acids as Complementary Therapy in Type 2 Diabetes Mellitus | type 2 diabetes mellitus | Linoleic Acid (NPC85813) | NP level |
| NCT00787059 | AC6 Gene Transfer for CHF | congestive heart failure | Sucrose (NPC130683) | NP level |
| NCT00908791 | Proof of Principle Trial to Determine if Nutritional Supplement Conjugated Linoleic Acid (CLA) Can Modulate the Lipogenic Pathway in Breast Cancer Tissue | breast cancer | Linoleic Acid (NPC85813) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
FFAR1
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT03718507
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
F2,AKR1C3
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA,ALOX15,FABP3,FFAR4,SNCA,F2,AKR1C3
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
ALOX15
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
ALOX15,F2
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
SNCA
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
NCT00029679 |
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
NCT02086864
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
