Collective Molecular Activities of the Plant: Anethum Graveolens
Country/Region:
Italy; Finland; India; Jordan; China; Iraq; Russia; BulgariaTraditional Medicine System:
Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; TCMMedicinal Functions:
Antihalitosis; Aromatic; Carminative; Diuretic; Galactogogue; Stimulant; Stomachic
Brazil; Turkey; Italy; Bangladesh; Sudan; France; Bahamas; Ethiopia; Somalia; Peru; Nigeria; Cameroon; Ghana; Belarus; Algeria; Cuba; Cape Verde; Russia; China; Belgium; Jordan; Dominican Republic; Iraq; Spain; Ukraine; Eritrea; Netherlands; Libya; Tanzania; Finland; United States; Morocco; Kenya; Switzerland; Haiti; Bulgaria; Jamaica; Romania; Albania; Angola; Portugal; Chad; Trinidad and Tobago; Tunisia; India; Austria; Mozambique; Greece; Hungary; Niger
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
182 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
158 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
110 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99734
Ingredient ID: NPC94366
Ingredient ID: NPC94167
Ingredient ID: NPC93888
Ingredient ID: NPC92943
Ingredient ID: NPC92869
Ingredient ID: NPC90566
Ingredient ID: NPC90486
Ingredient ID: NPC88566
Ingredient ID: NPC85813
Ingredient ID: NPC85210
Ingredient ID: NPC81010
Ingredient ID: NPC78312
Ingredient ID: NPC76145
Ingredient ID: NPC74539
Ingredient ID: NPC73980
Ingredient ID: NPC72042
Ingredient ID: NPC71339
Ingredient ID: NPC70691
Ingredient ID: NPC68391
Ingredient ID: NPC65134
Ingredient ID: NPC62765
Ingredient ID: NPC62045
Ingredient ID: NPC60151
Ingredient ID: NPC58970
Ingredient ID: NPC55412
Ingredient ID: NPC53559
Ingredient ID: NPC502
Ingredient ID: NPC491218
Ingredient ID: NPC49074
Ingredient ID: NPC490332
Ingredient ID: NPC489907
Ingredient ID: NPC46254
Ingredient ID: NPC45727
Ingredient ID: NPC43246
Ingredient ID: NPC424
Ingredient ID: NPC40277
Ingredient ID: NPC38742
Ingredient ID: NPC38212
Ingredient ID: NPC34764
Ingredient ID: NPC33415
Ingredient ID: NPC32991
Ingredient ID: NPC329460
Ingredient ID: NPC328447
Ingredient ID: NPC323463
Ingredient ID: NPC322254
Ingredient ID: NPC317120
Ingredient ID: NPC313955
Ingredient ID: NPC31279
Ingredient ID: NPC312132
Ingredient ID: NPC311783
Ingredient ID: NPC311255
Ingredient ID: NPC309330
Ingredient ID: NPC302857
Ingredient ID: NPC301586
Ingredient ID: NPC300326
Ingredient ID: NPC300059
Ingredient ID: NPC298505
Ingredient ID: NPC296071
Ingredient ID: NPC294902
Ingredient ID: NPC294548
Ingredient ID: NPC293628
Ingredient ID: NPC291473
Ingredient ID: NPC290843
Ingredient ID: NPC290319
Ingredient ID: NPC28913
Ingredient ID: NPC28828
Ingredient ID: NPC284038
Ingredient ID: NPC283170
Ingredient ID: NPC281686
Ingredient ID: NPC279661
Ingredient ID: NPC279121
Ingredient ID: NPC278642
Ingredient ID: NPC27836
Ingredient ID: NPC272614
Ingredient ID: NPC269919
Ingredient ID: NPC269242
Ingredient ID: NPC267801
Ingredient ID: NPC265305
Ingredient ID: NPC264784
Ingredient ID: NPC264020
Ingredient ID: NPC263089
Ingredient ID: NPC262505
Ingredient ID: NPC261644
Ingredient ID: NPC260837
Ingredient ID: NPC259134
Ingredient ID: NPC258476
Ingredient ID: NPC257124
Ingredient ID: NPC255042
Ingredient ID: NPC252587
Ingredient ID: NPC251666
Ingredient ID: NPC247553
Ingredient ID: NPC244315
Ingredient ID: NPC242580
Ingredient ID: NPC241258
Ingredient ID: NPC239039
Ingredient ID: NPC237812
Ingredient ID: NPC235260
Ingredient ID: NPC235190
Ingredient ID: NPC232375
Ingredient ID: NPC232247
Ingredient ID: NPC232141
Ingredient ID: NPC231738
Ingredient ID: NPC229347
Ingredient ID: NPC226453
Ingredient ID: NPC226027
Ingredient ID: NPC225710
Ingredient ID: NPC225709
Ingredient ID: NPC220765
Ingredient ID: NPC219876
Ingredient ID: NPC219143
Ingredient ID: NPC216825
Ingredient ID: NPC215632
Ingredient ID: NPC214971
Ingredient ID: NPC213876
Ingredient ID: NPC213749
Ingredient ID: NPC210456
Ingredient ID: NPC208793
Ingredient ID: NPC20791
Ingredient ID: NPC204388
Ingredient ID: NPC203468
Ingredient ID: NPC202992
Ingredient ID: NPC201844
Ingredient ID: NPC200838
Ingredient ID: NPC199072
Ingredient ID: NPC197087
Ingredient ID: NPC195355
Ingredient ID: NPC193989
Ingredient ID: NPC191103
Ingredient ID: NPC190810
Ingredient ID: NPC19003
Ingredient ID: NPC189436
Ingredient ID: NPC187770
Ingredient ID: NPC185755
Ingredient ID: NPC182468
Ingredient ID: NPC179987
Ingredient ID: NPC17810
Ingredient ID: NPC177112
Ingredient ID: NPC176819
Ingredient ID: NPC175771
Ingredient ID: NPC174246
Ingredient ID: NPC172625
Ingredient ID: NPC169749
Ingredient ID: NPC168290
Ingredient ID: NPC167400
Ingredient ID: NPC165302
Ingredient ID: NPC163984
Ingredient ID: NPC161593
Ingredient ID: NPC157340
Ingredient ID: NPC152451
Ingredient ID: NPC152384
Ingredient ID: NPC150950
Ingredient ID: NPC147983
Ingredient ID: NPC146422
Ingredient ID: NPC145463
Ingredient ID: NPC144023
Ingredient ID: NPC13990
Ingredient ID: NPC138113
Ingredient ID: NPC137958
Ingredient ID: NPC137949
Ingredient ID: NPC135539
Ingredient ID: NPC13449
Ingredient ID: NPC133183
Ingredient ID: NPC13304
Ingredient ID: NPC13143
Ingredient ID: NPC126681
Ingredient ID: NPC125085
Ingredient ID: NPC125062
Ingredient ID: NPC119949
Ingredient ID: NPC118429
Ingredient ID: NPC117529
Ingredient ID: NPC117299
Ingredient ID: NPC116775
Ingredient ID: NPC115919
Ingredient ID: NPC11433
Ingredient ID: NPC112890
Ingredient ID: NPC111888
Ingredient ID: NPC111690
Ingredient ID: NPC110899
Ingredient ID: NPC105246
Ingredient ID: NPC104190
Ingredient ID: NPC100773
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2B6 | Cytochrome P450 2B6 | P20813 | CHEMBL4729 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A4 | Serotonin transporter | P31645 | CHEMBL228 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A3 | Dopamine transporter | Q01959 | CHEMBL238 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A2 | Norepinephrine transporter | P23975 | CHEMBL222 |
| Therapeutic Target | 5HT3 receptor | HTR3A | Serotonin 3a (5-HT3a) receptor | P46098 | CHEMBL1899 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 812 | |
 Plant level | 1 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000116 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | macular degeneration | Ascorbate (NPC187770);Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract | Beta Carotene (NPC17810);Ascorbate (NPC187770) | NP level |
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00000372 | Glycine and D-Cycloserine in Schizophrenia | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
NCT00694564
|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2,ESR1
NCT03522922,NCT03090048 |
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
HTR2A,AURKB,AKR1B1,HTR2C,KDR,DPP4,FFAR1,NR3C1
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
MAPT,GSK3B,SRC,PIM1,NFKB1,TOP2A,AXL,TK1,TP53,AURKB,FLT3
NCT00329498,NCT01842139,NCT00184054 |
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT02929888
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
