Collective Molecular Activities of the Plant: Artemisia Dracunculus
Plant ID: NPO21334
Plant Latin Name: Artemisia Dracunculus
Taxonomy Genus: Artemisia
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
72341
Plant-of-the-World-Online:
n.a.
Country/Region:
Switzerland; China; IndiaTraditional Medicine System:
Indian Folk; TCMMedicinal Functions:
Antiscorbutic; Appetizer; Diuretic; Emmenagogue; Febrifuge; Hypnotic; Odontalgic; Stomachic; Vermifuge
Switzerland; India; China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
126 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
108 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
74 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99734
Ingredient ID: NPC94167
Ingredient ID: NPC92943
Ingredient ID: NPC92869
Ingredient ID: NPC91475
Ingredient ID: NPC90486
Ingredient ID: NPC85210
Ingredient ID: NPC83187
Ingredient ID: NPC74539
Ingredient ID: NPC74384
Ingredient ID: NPC73980
Ingredient ID: NPC72042
Ingredient ID: NPC71853
Ingredient ID: NPC71339
Ingredient ID: NPC70691
Ingredient ID: NPC65134
Ingredient ID: NPC60173
Ingredient ID: NPC55412
Ingredient ID: NPC53559
Ingredient ID: NPC502
Ingredient ID: NPC49074
Ingredient ID: NPC489907
Ingredient ID: NPC474157
Ingredient ID: NPC46634
Ingredient ID: NPC46254
Ingredient ID: NPC43246
Ingredient ID: NPC38742
Ingredient ID: NPC38212
Ingredient ID: NPC33415
Ingredient ID: NPC32991
Ingredient ID: NPC32441
Ingredient ID: NPC312800
Ingredient ID: NPC31279
Ingredient ID: NPC312132
Ingredient ID: NPC311783
Ingredient ID: NPC311255
Ingredient ID: NPC31090
Ingredient ID: NPC308744
Ingredient ID: NPC302857
Ingredient ID: NPC29883
Ingredient ID: NPC296071
Ingredient ID: NPC294902
Ingredient ID: NPC292792
Ingredient ID: NPC28828
Ingredient ID: NPC287331
Ingredient ID: NPC283170
Ingredient ID: NPC279121
Ingredient ID: NPC279026
Ingredient ID: NPC272524
Ingredient ID: NPC269919
Ingredient ID: NPC269242
Ingredient ID: NPC269023
Ingredient ID: NPC265305
Ingredient ID: NPC264784
Ingredient ID: NPC263089
Ingredient ID: NPC261644
Ingredient ID: NPC259134
Ingredient ID: NPC258476
Ingredient ID: NPC257124
Ingredient ID: NPC252587
Ingredient ID: NPC2517
Ingredient ID: NPC251666
Ingredient ID: NPC247553
Ingredient ID: NPC246558
Ingredient ID: NPC246165
Ingredient ID: NPC244315
Ingredient ID: NPC240722
Ingredient ID: NPC239039
Ingredient ID: NPC235260
Ingredient ID: NPC235190
Ingredient ID: NPC232375
Ingredient ID: NPC232141
Ingredient ID: NPC230775
Ingredient ID: NPC225709
Ingredient ID: NPC216825
Ingredient ID: NPC214971
Ingredient ID: NPC210456
Ingredient ID: NPC210092
Ingredient ID: NPC209632
Ingredient ID: NPC20791
Ingredient ID: NPC205649
Ingredient ID: NPC204388
Ingredient ID: NPC202992
Ingredient ID: NPC201844
Ingredient ID: NPC200838
Ingredient ID: NPC195355
Ingredient ID: NPC191103
Ingredient ID: NPC19003
Ingredient ID: NPC187770
Ingredient ID: NPC182840
Ingredient ID: NPC182468
Ingredient ID: NPC181715
Ingredient ID: NPC179987
Ingredient ID: NPC17810
Ingredient ID: NPC176819
Ingredient ID: NPC176740
Ingredient ID: NPC176309
Ingredient ID: NPC175771
Ingredient ID: NPC173996
Ingredient ID: NPC172625
Ingredient ID: NPC167400
Ingredient ID: NPC163984
Ingredient ID: NPC157340
Ingredient ID: NPC152384
Ingredient ID: NPC150950
Ingredient ID: NPC147983
Ingredient ID: NPC145463
Ingredient ID: NPC13990
Ingredient ID: NPC138113
Ingredient ID: NPC137949
Ingredient ID: NPC13755
Ingredient ID: NPC13449
Ingredient ID: NPC13304
Ingredient ID: NPC13143
Ingredient ID: NPC130306
Ingredient ID: NPC125085
Ingredient ID: NPC125062
Ingredient ID: NPC117299
Ingredient ID: NPC116775
Ingredient ID: NPC115919
Ingredient ID: NPC114594
Ingredient ID: NPC111888
Ingredient ID: NPC111690
Ingredient ID: NPC110899
Ingredient ID: NPC104190
Ingredient ID: NPC100773
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2B6 | Cytochrome P450 2B6 | P20813 | CHEMBL4729 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A4 | Serotonin transporter | P31645 | CHEMBL228 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A2 | Norepinephrine transporter | P23975 | CHEMBL222 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A3 | Dopamine transporter | Q01959 | CHEMBL238 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 996 | |
 Plant level | 1 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000116 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Ascorbate (NPC187770);Beta Carotene (NPC17810) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction | Ascorbate (NPC187770);Folic Acid (NPC147983);Pyridoxine (NPC269919);Beta Carotene (NPC17810) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | Myocardial Ischemia | Folic Acid (NPC147983);Beta Carotene (NPC17810);Pyridoxine (NPC269919) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | Myocardial Ischemia | Ascorbate (NPC187770) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2,ESR1
NCT03090048,NCT03522922 |
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
FFAR1,AURKB,AKR1B1,DPP4,NR3C1,KDR
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT05305898,NCT00855257
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
AXL,NFKB1,FLT3,PIM1,GSK3B,AURKB,TP53,SRC,MAPT,TK1
NCT00329498,NCT00184054 |
Acute painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG31 |
SLC6A2
|
Acute pancreatitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DC31 |
NCT02110810
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
