Collective Molecular Activities of the Plant: Paullinia Cupana
Plant ID: NPO21254
Plant Latin Name: Paullinia Cupana
Taxonomy Genus: Paullinia
Taxonomy Family: Sapindaceae
Plant External Links:
NCBI TaxonomyDB:
392747
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
17 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
8 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
2 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC58064
Ingredient ID: NPC316375
Ingredient ID: NPC314243
Ingredient ID: NPC309408
Ingredient ID: NPC307846
Ingredient ID: NPC305427
Ingredient ID: NPC278404
Ingredient ID: NPC261855
Ingredient ID: NPC251269
Ingredient ID: NPC174318
Ingredient ID: NPC164381
Ingredient ID: NPC141577
Ingredient ID: NPC1363
Ingredient ID: NPC117103
Ingredient ID: NPC112367
Ingredient ID: NPC112318
Ingredient ID: NPC10960
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 Plant level | 3 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT01540019 | Paullinia Cupana for Anorexia in Oncologic Patients | Cancer-related Problem/Condition|Anorexia|Loss of Weight | Paullinia Cupana | Plant level As single plant |
| NCT01043913 | Guarana (Paullinia Cupana) for Breast Cancer Chemotherapy-related Fatigue | Signs and Symptoms|Neoplasms|Neoplasms by Site|Fatigue|Breast Neoplasms|Breast Diseases | Paullinia Cupana | Plant level As plant Extract |
| NCT00615316 | Guaraná for Radiation Related Fatigue in Breast Cancer Patients | Fatigue | Paullinia Cupana | Plant level As single plant |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
FatigueDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG22 |
NCT01043913,NCT00615316
|
Certain specified disorders of breastDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB23 |
NCT01043913
|
Neoplasms of unknown behaviour of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F95 |
NCT01043913
|
NeoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 02 |
NCT01043913
|
Neoplasms of unknown behaviour of unspecified siteDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F9Z |
NCT01043913
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
