Collective Molecular Activities of the Plant: Uvaria Calamistrata
Plant ID: NPO210
Plant Latin Name: Uvaria Calamistrata
Taxonomy Genus: Uvaria
Taxonomy Family: Annonaceae
Plant External Links:
NCBI TaxonomyDB:
672966
Plant-of-the-World-Online:
n.a.
Country/Region:
VietnamTraditional Medicine System:
Vietnam
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
154 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
69 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
59 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC9893
Ingredient ID: NPC97444
Ingredient ID: NPC96218
Ingredient ID: NPC95983
Ingredient ID: NPC94967
Ingredient ID: NPC93189
Ingredient ID: NPC90803
Ingredient ID: NPC88642
Ingredient ID: NPC86538
Ingredient ID: NPC85813
Ingredient ID: NPC84938
Ingredient ID: NPC81340
Ingredient ID: NPC78263
Ingredient ID: NPC76878
Ingredient ID: NPC76310
Ingredient ID: NPC74765
Ingredient ID: NPC74461
Ingredient ID: NPC73906
Ingredient ID: NPC7172
Ingredient ID: NPC69984
Ingredient ID: NPC67132
Ingredient ID: NPC66577
Ingredient ID: NPC64370
Ingredient ID: NPC64160
Ingredient ID: NPC62498
Ingredient ID: NPC60357
Ingredient ID: NPC55678
Ingredient ID: NPC54152
Ingredient ID: NPC50786
Ingredient ID: NPC49279
Ingredient ID: NPC47566
Ingredient ID: NPC475159
Ingredient ID: NPC473712
Ingredient ID: NPC473649
Ingredient ID: NPC44001
Ingredient ID: NPC42897
Ingredient ID: NPC40839
Ingredient ID: NPC40775
Ingredient ID: NPC37871
Ingredient ID: NPC37541
Ingredient ID: NPC3630
Ingredient ID: NPC33721
Ingredient ID: NPC3357
Ingredient ID: NPC32222
Ingredient ID: NPC31759
Ingredient ID: NPC311094
Ingredient ID: NPC31089
Ingredient ID: NPC309437
Ingredient ID: NPC309237
Ingredient ID: NPC309211
Ingredient ID: NPC308886
Ingredient ID: NPC307994
Ingredient ID: NPC306544
Ingredient ID: NPC304309
Ingredient ID: NPC303870
Ingredient ID: NPC3025
Ingredient ID: NPC302327
Ingredient ID: NPC299616
Ingredient ID: NPC297643
Ingredient ID: NPC296552
Ingredient ID: NPC293378
Ingredient ID: NPC290753
Ingredient ID: NPC289959
Ingredient ID: NPC286233
Ingredient ID: NPC2833
Ingredient ID: NPC27563
Ingredient ID: NPC273410
Ingredient ID: NPC273385
Ingredient ID: NPC26974
Ingredient ID: NPC265442
Ingredient ID: NPC265033
Ingredient ID: NPC259138
Ingredient ID: NPC258923
Ingredient ID: NPC247385
Ingredient ID: NPC247266
Ingredient ID: NPC243945
Ingredient ID: NPC242712
Ingredient ID: NPC241533
Ingredient ID: NPC239406
Ingredient ID: NPC237781
Ingredient ID: NPC236709
Ingredient ID: NPC236382
Ingredient ID: NPC231377
Ingredient ID: NPC230725
Ingredient ID: NPC224344
Ingredient ID: NPC220860
Ingredient ID: NPC220576
Ingredient ID: NPC218852
Ingredient ID: NPC218525
Ingredient ID: NPC218484
Ingredient ID: NPC216630
Ingredient ID: NPC214217
Ingredient ID: NPC213919
Ingredient ID: NPC205577
Ingredient ID: NPC204121
Ingredient ID: NPC203837
Ingredient ID: NPC202189
Ingredient ID: NPC201404
Ingredient ID: NPC199072
Ingredient ID: NPC198704
Ingredient ID: NPC19868
Ingredient ID: NPC19676
Ingredient ID: NPC196703
Ingredient ID: NPC195221
Ingredient ID: NPC192186
Ingredient ID: NPC190796
Ingredient ID: NPC183220
Ingredient ID: NPC182239
Ingredient ID: NPC179831
Ingredient ID: NPC178552
Ingredient ID: NPC172164
Ingredient ID: NPC167931
Ingredient ID: NPC167400
Ingredient ID: NPC165765
Ingredient ID: NPC163728
Ingredient ID: NPC163093
Ingredient ID: NPC163062
Ingredient ID: NPC161279
Ingredient ID: NPC161120
Ingredient ID: NPC157422
Ingredient ID: NPC157414
Ingredient ID: NPC156461
Ingredient ID: NPC155182
Ingredient ID: NPC154477
Ingredient ID: NPC154097
Ingredient ID: NPC150950
Ingredient ID: NPC150329
Ingredient ID: NPC147983
Ingredient ID: NPC145722
Ingredient ID: NPC144682
Ingredient ID: NPC144213
Ingredient ID: NPC14313
Ingredient ID: NPC142850
Ingredient ID: NPC140229
Ingredient ID: NPC139131
Ingredient ID: NPC136014
Ingredient ID: NPC130683
Ingredient ID: NPC129372
Ingredient ID: NPC125829
Ingredient ID: NPC121022
Ingredient ID: NPC120398
Ingredient ID: NPC119578
Ingredient ID: NPC116775
Ingredient ID: NPC114874
Ingredient ID: NPC114011
Ingredient ID: NPC11301
Ingredient ID: NPC109813
Ingredient ID: NPC108032
Ingredient ID: NPC107473
Ingredient ID: NPC105246
Ingredient ID: NPC105032
Ingredient ID: NPC104332
Ingredient ID: NPC102253
Ingredient ID: NPC100551
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Therapeutic Target | Methyl-lysine/arginine binding protein | SMN1 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Therapeutic Target | Oxidoreductase | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | P37059 | CHEMBL2789 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 297 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction;Myocardial Ischemia | Folic Acid (NPC147983) | NP level |
| NCT00000553 | HDL-Atherosclerosis Treatment Study (HATS) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000599 | Cholesterol-Lowering Atherosclerosis Study (CLAS) | carotid artery disease;cerebral atherosclerosis;Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00002650 | High-Dose Folic Acid in Preventing Colorectal Cancer in Patients Who Have Had Polyps Surgically Removed | colorectal carcinoma | Folic Acid (NPC147983) | NP level |
| NCT00024310 | Paclitaxel, Folic Acid, and Lometrexol in Treating Patients With Locally Advanced or Metastatic Solid Tumors | neoplasm | Folic Acid (NPC147983) | NP level |
| NCT00029679 | Borage Oil and Ginkgo Biloba (EGb 761) in Asthma | asthma | Linoleic Acid (NPC85813) | NP level |
| NCT00033722 | Lometrexol Plus Folic Acid in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer | lung cancer | Folic Acid (NPC147983) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
NCT01706263,NCT01706250,NCT02524665,NCT03832647,NCT00361322,NCT04490967,NCT02755545
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Actinic keratosisDisease Category: X.Extension CodesDisease ICD-11 Code: XH36H6 |
NCT02289768
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
FFAR1,DPP4
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257,NCT01294462
|
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT00781404
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT04588441,NCT03718507
|
Acute ST elevation myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41.0 |
NCT00284323,NCT01747174
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
AKR1C3,CA7,CA12,CYP2C9
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
