Collective Molecular Activities of the Plant: Sophora Japonica
Plant ID: NPO20846
Plant Latin Name: Sophora Japonica
Taxonomy Genus: Sophora
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
3897
Plant-of-the-World-Online:
n.a.
Country/Region:
ChinaTraditional Medicine System:
TCMMedicinal Functions:
Abortifacient; Antibacterial; Anticholesterolemic; Antidiarrhoeal; Antiinflammatory; Antispasmodic; Diuretic; Emetic; Emollient; Febrifuge; Hypotensive; Purgative; Skin; Styptic; Tonic
China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
148 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
63 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
50 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98939
Ingredient ID: NPC98743
Ingredient ID: NPC96428
Ingredient ID: NPC96294
Ingredient ID: NPC95247
Ingredient ID: NPC94186
Ingredient ID: NPC90305
Ingredient ID: NPC89088
Ingredient ID: NPC88090
Ingredient ID: NPC85715
Ingredient ID: NPC83497
Ingredient ID: NPC79943
Ingredient ID: NPC79765
Ingredient ID: NPC79056
Ingredient ID: NPC76545
Ingredient ID: NPC76336
Ingredient ID: NPC75613
Ingredient ID: NPC725
Ingredient ID: NPC67518
Ingredient ID: NPC6616
Ingredient ID: NPC6072
Ingredient ID: NPC5383
Ingredient ID: NPC51204
Ingredient ID: NPC49579
Ingredient ID: NPC46803
Ingredient ID: NPC46747
Ingredient ID: NPC45782
Ingredient ID: NPC44328
Ingredient ID: NPC43300
Ingredient ID: NPC41346
Ingredient ID: NPC39426
Ingredient ID: NPC38656
Ingredient ID: NPC37661
Ingredient ID: NPC34700
Ingredient ID: NPC328772
Ingredient ID: NPC32441
Ingredient ID: NPC313163
Ingredient ID: NPC311566
Ingredient ID: NPC311485
Ingredient ID: NPC306207
Ingredient ID: NPC304769
Ingredient ID: NPC302770
Ingredient ID: NPC302556
Ingredient ID: NPC298825
Ingredient ID: NPC296970
Ingredient ID: NPC296020
Ingredient ID: NPC294815
Ingredient ID: NPC292893
Ingredient ID: NPC29280
Ingredient ID: NPC290598
Ingredient ID: NPC287349
Ingredient ID: NPC286388
Ingredient ID: NPC283389
Ingredient ID: NPC28239
Ingredient ID: NPC278948
Ingredient ID: NPC277222
Ingredient ID: NPC272085
Ingredient ID: NPC270797
Ingredient ID: NPC268356
Ingredient ID: NPC266483
Ingredient ID: NPC265885
Ingredient ID: NPC262093
Ingredient ID: NPC261566
Ingredient ID: NPC250828
Ingredient ID: NPC250069
Ingredient ID: NPC246469
Ingredient ID: NPC244486
Ingredient ID: NPC244315
Ingredient ID: NPC243728
Ingredient ID: NPC241471
Ingredient ID: NPC239881
Ingredient ID: NPC239312
Ingredient ID: NPC238100
Ingredient ID: NPC237435
Ingredient ID: NPC237255
Ingredient ID: NPC236726
Ingredient ID: NPC235839
Ingredient ID: NPC233169
Ingredient ID: NPC230861
Ingredient ID: NPC226087
Ingredient ID: NPC220210
Ingredient ID: NPC219876
Ingredient ID: NPC219090
Ingredient ID: NPC219040
Ingredient ID: NPC218109
Ingredient ID: NPC216230
Ingredient ID: NPC213182
Ingredient ID: NPC211913
Ingredient ID: NPC20791
Ingredient ID: NPC206264
Ingredient ID: NPC204145
Ingredient ID: NPC201248
Ingredient ID: NPC197896
Ingredient ID: NPC197396
Ingredient ID: NPC192877
Ingredient ID: NPC192818
Ingredient ID: NPC187512
Ingredient ID: NPC187508
Ingredient ID: NPC18729
Ingredient ID: NPC182321
Ingredient ID: NPC181465
Ingredient ID: NPC179950
Ingredient ID: NPC17810
Ingredient ID: NPC178014
Ingredient ID: NPC177771
Ingredient ID: NPC177731
Ingredient ID: NPC176740
Ingredient ID: NPC17521
Ingredient ID: NPC173637
Ingredient ID: NPC173582
Ingredient ID: NPC167922
Ingredient ID: NPC166409
Ingredient ID: NPC162822
Ingredient ID: NPC16194
Ingredient ID: NPC15970
Ingredient ID: NPC158306
Ingredient ID: NPC156654
Ingredient ID: NPC156457
Ingredient ID: NPC154599
Ingredient ID: NPC153502
Ingredient ID: NPC152538
Ingredient ID: NPC147086
Ingredient ID: NPC145708
Ingredient ID: NPC145112
Ingredient ID: NPC143326
Ingredient ID: NPC142860
Ingredient ID: NPC142754
Ingredient ID: NPC141078
Ingredient ID: NPC138374
Ingredient ID: NPC137949
Ingredient ID: NPC137816
Ingredient ID: NPC135846
Ingredient ID: NPC134909
Ingredient ID: NPC13444
Ingredient ID: NPC131624
Ingredient ID: NPC131207
Ingredient ID: NPC126004
Ingredient ID: NPC125062
Ingredient ID: NPC121270
Ingredient ID: NPC119441
Ingredient ID: NPC118378
Ingredient ID: NPC116841
Ingredient ID: NPC116775
Ingredient ID: NPC11232
Ingredient ID: NPC110942
Ingredient ID: NPC105095
Ingredient ID: NPC103728
Ingredient ID: NPC102449
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | Cysteine protease | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 61 | |
 Plant level | 1 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction;Myocardial Ischemia | Beta Carotene (NPC17810) | NP level |
| NCT00001696 | A Pharmacokinetic Study of Genistein, a Tyrosine Kinase Inhibitor | cancer | Genistein (NPC39426) | NP level |
| NCT00005827 | Genistein in Treating Patients With Stage II, Stage III, or Stage IV Prostate Cancer | prostate cancer | Genistein (NPC39426) | NP level |
| NCT00010686 | Dietary Phytoestrogens and Bone Metabolism | osteoporosis | Genistein (NPC39426) | NP level |
| NCT00016744 | Phenylbutyrate/Genistein Duotherapy in Delta F508-Homozygous(for Cystic Fibrosis) | cystic fibrosis | Genistein (NPC39426) | NP level |
| NCT00058266 | Genistein in Treating Patients With Localized Prostate Cancer Who Are Planning to Undergo Radical Prostatectomy | prostate cancer | Genistein (NPC39426) | NP level |
| NCT00118040 | Phase II Study of Isoflavone G-2535 (Genistein) in Patients With Bladder Cancer | urinary bladder carcinoma | Genistein (NPC39426) | NP level |
| NCT00244933 | Gemcitabine Hydrochloride and Genistein in Treating Women With Stage IV Breast Cancer | breast cancer | Genistein (NPC39426) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR,MAOB
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKB,KDR,AKR1B1,DPP4
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
MAPT,TP53,FLT3,AXL,CDK9,PIM1,SRC,AURKB,KDM1A
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
BLM,CDK1,NPSR1,CA7,SLCO1B1,XDH,CYP2C9,AURKB,TSHR,CA9,ACHE,CA12
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
NPSR1,ACHE,MAOB,CES1,BLM,CA7,POLB,AURKB,PIM1,CA9,AXL,CA14,XDH,CISD1,HSD17B2,CA2,ALOX5,ABCG2,CYP1B1,MET,CYP2C9,DPP4,ALOX15,RECQL
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
SLCO1B1,NOX4,ALOX15
NCT01325311,NCT01126879,NCT01912820,NCT00546039 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
NPSR1,NOX4,BLM,SLCO1B1,AURKB,CDK1,CYP19A1,MET,ALOX15
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
