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Collective Molecular Activities of the Plant: Cneoridium Dumosum


Example Image
PLANiTS DNA barcode

Click for details-----ITS

NA

Click for details-----ITS1

NA

Click for details-----ITS2

NA
Taxonomic Information

Plant ID: NPO20604
Plant Latin Name: Cneoridium Dumosum
Taxonomy Genus: Cneoridium
Taxonomy Family: Rutaceae

Plant External Links:

NCBI TaxonomyDB: 452765
Plant-of-the-World-Online: n.a.

Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary

Overview of Ingredients

22 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.


4 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

13 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.





Ingredient Structrual Cards

Ingredient ID: NPC73855

Ingredient ID: NPC65333

Ingredient ID: NPC39834

Ingredient ID: NPC271744

Ingredient ID: NPC27124

Ingredient ID: NPC268342

Ingredient ID: NPC253491

Ingredient ID: NPC250436

Ingredient ID: NPC241162

Ingredient ID: NPC24031

Ingredient ID: NPC231644

Ingredient ID: NPC225710

Ingredient ID: NPC220825

Ingredient ID: NPC21209

Ingredient ID: NPC210632

Ingredient ID: NPC20791

Ingredient ID: NPC178134

Ingredient ID: NPC176740

Ingredient ID: NPC175118

Ingredient ID: NPC169749

Ingredient ID: NPC134542

Ingredient ID: NPC110899

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Target Type: Individual Protein of Homo sapiens
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
.

Detailed Information of Target Proteins

Target Type Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Drug Transporter ATP-binding cassette ABCB1 P-glycoprotein 1 P08183 CHEMBL4302
Therapeutic Target Cysteine protease CASP6 Caspase-6 P55212 CHEMBL3308
Cytochrome P450 Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Therapeutic Target DNA methyltransferase DNMT1 DNA (cytosine-5)-methyltransferase 1 P26358 CHEMBL1993
Therapeutic Target Enzyme RECQL ATP-dependent DNA helicase Q1 P46063 CHEMBL1293236
Therapeutic Target Enzyme APEX1 DNA-(apurinic or apyrimidinic site) lyase P27695 CHEMBL5619
Therapeutic Target Enzyme POLB DNA polymerase beta P06746 CHEMBL2392
Therapeutic Target Enzyme HPGD 15-hydroxyprostaglandin dehydrogenase [NAD+] P15428 CHEMBL1293255
Therapeutic Target Enzyme NOX4 NADPH oxidase 4 Q9NPH5 CHEMBL1250375
Therapeutic Target Enzyme ALOX12 Arachidonate 12-lipoxygenase P18054 CHEMBL3687
Therapeutic Target Hydrolase ACHE Acetylcholinesterase P22303 CHEMBL220
Therapeutic Target Isomerase TOP2A DNA topoisomerase II alpha P11388 CHEMBL1806
Therapeutic Target Lyase GLO1 Glyoxalase I Q04760 CHEMBL2424
Therapeutic Target Lysine demethylase KDM4E Lysine-specific demethylase 4D-like B2RXH2 CHEMBL1293226
Therapeutic Target Methyl-lysine/arginine binding protein L3MBTL1 Lethal(3)malignant brain tumor-like protein 1 Q9Y468 CHEMBL1287622
Therapeutic Target Miscellaneous ion channel BCL2 Apoptosis regulator Bcl-2 P10415 CHEMBL4860
Therapeutic Target Other cytosolic protein HSPA1A Heat shock 70 kDa protein 1 P0DMV8 CHEMBL5460
Therapeutic Target Other nuclear protein RAD52 DNA repair protein RAD52 homolog P43351 CHEMBL2362978
Therapeutic Target Oxidoreductase AKR1B1 Aldose reductase P15121 CHEMBL1900
Therapeutic Target Oxidoreductase HSD17B10 Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Q99714 CHEMBL4159
Therapeutic Target Oxidoreductase PGD 6-phosphogluconate dehydrogenase P52209 CHEMBL3404
Therapeutic Target Peptide receptor (family A GPCR) NPSR1 Neuropeptide S receptor Q6W5P4 CHEMBL5162
Therapeutic Target Phosphodiesterase TDP1 Tyrosyl-DNA phosphodiesterase 1 Q9NUW8 CHEMBL1075138
Therapeutic Target Protein Kinase AXL Tyrosine-protein kinase receptor UFO P30530 CHEMBL4895
Therapeutic Target Protein Kinase DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Q13627 CHEMBL2292
Therapeutic Target Protein Kinase TEK Tyrosine-protein kinase TIE-2 Q02763 CHEMBL4128
Therapeutic Target Protein Kinase CSNK2A1 Casein kinase II alpha P68400 CHEMBL3629
Therapeutic Target Protein Kinase IGF1R Insulin-like growth factor I receptor P08069 CHEMBL1957
Therapeutic Target Protein Kinase MET Hepatocyte growth factor receptor P08581 CHEMBL3717
Therapeutic Target Protein Kinase NUAK1 NUAK family SNF1-like kinase 1 O60285 CHEMBL5784
Therapeutic Target Protein Kinase FLT3 Tyrosine-protein kinase receptor FLT3 P36888 CHEMBL1974
Therapeutic Target Protein Kinase EGFR Epidermal growth factor receptor erbB1 P00533 CHEMBL203
Therapeutic Target Protein Kinase CDK1 Cyclin-dependent kinase 1 P06493 CHEMBL308
Therapeutic Target Protein Kinase YES1 Tyrosine-protein kinase YES P07947 CHEMBL2073
Therapeutic Target Protein Kinase SRC Tyrosine-protein kinase SRC P12931 CHEMBL267
Therapeutic Target Protein Kinase INSR Insulin receptor P06213 CHEMBL1981
Therapeutic Target Protein Kinase PIM1 Serine/threonine-protein kinase PIM1 P11309 CHEMBL2147
Therapeutic Target Protein Kinase KDR Vascular endothelial growth factor receptor 2 P35968 CHEMBL279
Therapeutic Target Protein Kinase AURKB Serine/threonine-protein kinase Aurora-B Q96GD4 CHEMBL2185
Drug Transporter SLC superfamily of solute carriers SLC22A6 Solute carrier family 22 member 6 Q4U2R8 CHEMBL1641347
Therapeutic Target Small molecule receptor (family A GPCR) GPR35 G-protein coupled receptor 35 Q9HC97 CHEMBL1293267
Therapeutic Target Structural protein LMNA Prelamin-A/C P02545 CHEMBL1293235
Therapeutic Target Threonine protease PSMB5 Proteasome Macropain subunit MB1 P28074 CHEMBL4662
Therapeutic Target Transcription factor SMAD3 Mothers against decapentaplegic homolog 3 P84022 CHEMBL1293258
Therapeutic Target Transferase POLI DNA polymerase iota Q9UNA4 CHEMBL5391
Therapeutic Target Transferase POLH DNA polymerase eta Q9Y253 CHEMBL5542
Therapeutic Target Transferase FUT7 Alpha-(1,3)-fucosyltransferase 7 Q11130 CHEMBL3596077
Clinical Trials Summary
Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type Number of clinical trials
NP level75
Clinical trial details
NCT ID Title Condition Form in clinical use Associated by plant or compound
NCT00625391 Green Tea and Tai Chi for Bone Health osteoporosis Epigalocatechin Gallate (NPC250436) NP level
NCT00091325 Green Tea Extract (Polyphenon E) in Preventing Cancer in Healthy Participants neoplasm Epigalocatechin Gallate (NPC250436) NP level
NCT04853199 Quercetin In The Treatment Of SARS-COV 2 COVID-19 Quercetin (NPC20791) NP level
NCT02891538 Chemopreventive Effects of Epigallocatechin Gallate (EGCG) in Colorectal Cancer (CRC) Patients malignant colon neoplasm Epigalocatechin Gallate (NPC250436) NP level
NCT04907253 Quercetin in Coronary Artery By-pass Surgery coronary artery disease Quercetin (NPC20791) NP level
NCT00459407 Defined Green Tea Catechins in Treating Patients With Prostate Cancer Undergoing Surgery to Remove the Prostate prostate adenocarcinoma Epigalocatechin Gallate (NPC250436) NP level
NCT01394796 Egcg, a dyrk1a Inhibitor as Therapeutic Tool for Reversing Cognitive Deficits in Down Syndrome Individuals. Down syndrome Epigalocatechin Gallate (NPC250436) NP level
NCT00836719 Safety of Polyphenon E in Multiple Sclerosis Pilot Study multiple sclerosis Epigalocatechin Gallate (NPC250436) NP level
NCT01183767 Sunphenon Epigallocatechin-Gallate (EGCg) in Duchenne Muscular Dystrophy Duchenne muscular dystrophy Epigalocatechin Gallate (NPC250436) NP level
NCT01839344 Effects of Quercetin on Blood Sugar and Blood Vessel Function in Type 2 Diabetes. type 2 diabetes mellitus Quercetin (NPC20791) NP level
NCT00567905 Effect of Green Tea Extract on Type 2 Diabetes type 2 diabetes mellitus Epigalocatechin Gallate (NPC250436) NP level
NCT05276895 Effect of Natural Senolytic Agents & NLRP3 Inhibitors on Osteoarthritis osteoarthritis Quercetin (NPC20791) NP level
NCT01348204 Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators cystic fibrosis Quercetin (NPC20791) NP level
NCT01438320 Q-Trial in Patients With Hepatitis C chronic hepatitis C virus infection Quercetin (NPC20791) NP level
NCT01705652 Study to Assess the Activity of Nexrutine® in Prostate Cancer Patients prostate cancer Rutin (NPC176740) NP level
NCT00461942 Efficacy and Safety of Green Tea Polyphenol in De Novo Parkinson's Disease Patients Parkinson disease Epigalocatechin Gallate (NPC250436) NP level
NCT01720147 Quercetin in Children With Fanconi Anemia; a Pilot Study Fanconi anemia Quercetin (NPC20791) NP level
NCT02008721 Progression Rate of MSA Under EGCG Supplementation as Anti-Aggregation-Approach multiple system atrophy Epigalocatechin Gallate (NPC250436) NP level
NCT01744587 Epstein-Barr Virus Reactivation and the Effect of EGCG on Virus Reactivation in Remission Patients nasopharyngeal neoplasm Epigalocatechin Gallate (NPC250436) NP level
NCT02329600 Evaluation of Green Tea as Antioxidant Agent in Management of Oral Lichen Planus oral lichen planus Epigalocatechin Gallate (NPC250436) NP level
NCT04177693 Pharmacokinetics and Hepatic Safety of EGCG uterine fibroid Epigalocatechin Gallate (NPC250436) NP level
NCT01708278 Beneficial Effects of Quercetin in Chronic Obstructive Pulmonary Disease (COPD) chronic obstructive pulmonary disease Quercetin (NPC20791) NP level
NCT04011618 Effect of Ellagic Ácid on the Components of Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion metabolic syndrome Ellagic Acid (NPC178134) NP level
NCT03989271 Biological Effects of Quercetin in COPD chronic obstructive pulmonary disease Quercetin (NPC20791) NP level
NCT02832271 Green Tea Extract for Endometriosis Treatment endometriosis Epigalocatechin Gallate (NPC250436) NP level
NCT05422885 Safety and Feasibility of Dasatinib and Quercetin in Adults at Risk for Alzheimer's Disease aging Quercetin (NPC20791) NP level
NCT01357681 Effects of EGCG (Epigallocatechin Gallate) in Huntington's Disease (ETON-Study) Huntington disease Epigalocatechin Gallate (NPC250436) NP level
NCT01340599 Defined Green Tea Catechin Extract in Treating Patients With Localized Prostate Cancer Undergoing Surgery prostate cancer Epigalocatechin Gallate (NPC250436) NP level
NCT00816478 Effect of Oral Galactose on Focal Segmental Glomerulosclerosis (FSGS) Permeability Factor focal segmental glomerulosclerosis Galactose (NPC21209) NP level
NCT01912820 Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery prostate adenocarcinoma Quercetin (NPC20791);Epigalocatechin Gallate (NPC250436) NP level
NCT04733534 An Open-Label Intervention Trial to Reduce Senescence and Improve Frailty in Adult Survivors of Childhood Cancer childhood cancer Quercetin (NPC20791) NP level
NCT01375101 Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus oral lichen planus Quercetin (NPC20791) NP level
NCT00455416 Dietary Intervention in Follicular Lymphoma follicular lymphoma Ellagic Acid (NPC178134);Quercetin (NPC20791);Epigalocatechin Gallate (NPC250436) NP level
NCT02015312 A Trial for the Treatment of Cardiac AL-Amyloidosis With the Green Tea Compound Epigallocatechin-3-gallate (TAME-AL) AL amyloidosis Epigalocatechin Gallate (NPC250436) NP level
NCT00233935 Defined Green Tea Catechin Extract in Preventing Esophageal Cancer in Patients With Barrett's Esophagus Barrett's esophagus Epigalocatechin Gallate (NPC250436) NP level
NCT03278925 Defined Green Tea Catechin Extract in Preventing Liver Cancer in Participants With Cirrhosis cirrhosis of liver Epigalocatechin Gallate (NPC250436) NP level
NCT05062486 A Study to Evaluate the Safety and Efficacy of RQC for AMD age-related macular degeneration Quercetin (NPC20791) NP level
NCT01060345 A Pilot Study of Chemo-prevention of Green Tea in Women With Ductal Carcinoma in Situ breast ductal carcinoma in situ Epigalocatechin Gallate (NPC250436) NP level
NCT00799890 Sunphenon in Progressive Forms of Multiple Sclerosis multiple sclerosis Epigalocatechin Gallate (NPC250436) NP level
NCT02875691 Effect of Green Tea on Treatment of Lupus systemic lupus erythematosus Epigalocatechin Gallate (NPC250436) NP level
NCT00525668 Sunphenon Epigallocatechin-gallate (EGCg) in Relapsing-remitting Multiple Sclerosis (SuniMS Study) relapsing-remitting multiple sclerosis Epigalocatechin Gallate (NPC250436) NP level
NCT01855971 "Using Epigallocatechin Gallate (EGCG) and Cognitive Training to Modulate Cognitive Performance in Patients With Fragile X Syndrome" (TESFX) fragile X syndrome Epigalocatechin Gallate (NPC250436) NP level
NCT01433289 Study to Evaluate Safety and Toxicity of Polyphenon E (EGCG) in HIV-1-Infected Individuals HIV infection Epigalocatechin Gallate (NPC250436) NP level
NCT00516243 Defined Green Tea Catechin Extract in Treating Women With Hormone Receptor Negative Stage I-III Breast Cancer breast cancer Epigalocatechin Gallate (NPC250436) NP level
NCT00816504 Effect of Galactose on Permeblity Factor in Patients With FSGS and CKD Stage 5 focal segmental glomerulosclerosis Galactose (NPC21209) NP level
NCT04553666 Reducing Frailty for Older Cancer Survivors Using Supplements inflammation Epigalocatechin Gallate (NPC250436) NP level
NCT00363805 Green Tea or Polyphenon E in Preventing Lung Cancer in Former Smokers With Chronic Obstructive Pulmonary Disease lung cancer Epigalocatechin Gallate (NPC250436) NP level
NCT00676793 A Study of the Effect of Polyphenon E (Green Tea Extract) on Breast Cancer Progression breast cancer Epigalocatechin Gallate (NPC250436) NP level
NCT00707252 Study of Polyphenon E in Addition to Erlotinib in Advanced Non Small Cell Lung Cancer non-small cell lung carcinoma Epigalocatechin Gallate (NPC250436) NP level
NCT00942422 Green Tea Extract in Treating Patients With Monoclonal Gammopathy of Undetermined Significance and/or Smoldering Multiple Myeloma multiple myeloma Epigalocatechin Gallate (NPC250436) NP level
NCT00951964 Treatment of Epidermolysis Bullosa Dystrophica by Polyphenon E (Epigallocatechin 3 Gallate) Dystrophic epidermolysis bullosa Epigalocatechin Gallate (NPC250436) NP level
NCT05364008 FRIEND: Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate uterine fibroid Epigalocatechin Gallate (NPC250436) NP level
NCT04851821 The Effectiveness of Phytotherapy in SARS-COV2(COVID-19) COVID-19 Quercetin (NPC20791) NP level
NCT00005828 Green Tea Extract in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy prostate cancer Epigalocatechin Gallate (NPC250436) NP level
NCT05456022 Therapeutic Efficacy of Quercetin Versus Its Encapsulated Nanoparticle on Tongue Squamous Cell Carcinoma Cell Line mouth neoplasm Quercetin (NPC20791) NP level
NCT01451723 Safety and Neuroprotective Effects of Polyphenon E in MS multiple sclerosis Epigalocatechin Gallate (NPC250436) NP level
NCT04946383 Safety and Effectivness of Quercetin & Dasatinib on Epigenetic Aging aging Quercetin (NPC20791) NP level
NCT00596011 Study of Polyphenon E in Men With High-grade Prostatic Intraepithelial Neoplasia benign prostatic hyperplasia Epigalocatechin Gallate (NPC250436) NP level
NCT02731495 Effect of Epigallocatechin -3-gallate Supplementation in Traumatic Brain Injury Patients brain injury Epigalocatechin Gallate (NPC250436) NP level
NCT00951834 Sunphenon EGCg (Epigallocatechin-Gallate) in the Early Stage of Alzheimer´s Disease Alzheimer disease Epigalocatechin Gallate (NPC250436) NP level
NCT00262743 Green Tea Extract in Treating Patients With Stage 0, Stage I, or Stage II Chronic Lymphocytic Leukemia leukemia Epigalocatechin Gallate (NPC250436) NP level
NCT03943459 Sirtuin-1 and Advanced Glycation End-products in Postmenopausal Women With Coronary Disease coronary artery disease Quercetin (NPC20791) NP level
NCT00917735 Green Tea and Reduction of Breast Cancer Risk breast cancer Epigalocatechin Gallate (NPC250436) NP level
NCT00814255 Novel Therapies for Resistant FSGS (FONTII): Phase II Clinical Trial focal segmental glomerulosclerosis Galactose (NPC21209) NP level
NCT02226484 Can Quercetin Increase Claudin-4 and Improve Esophageal Barrier Function in GERD? gastroesophageal reflux disease Quercetin (NPC20791) NP level
NCT00088946 Erlotinib and Green Tea Extract (Polyphenon® E) in Preventing Cancer Recurrence in Former Smokers Who Have Undergone Surgery for Bladder Cancer urinary bladder cancer Epigalocatechin Gallate (NPC250436) NP level
NCT01699711 Normalization of dyrk1A and APP Function as an Approach to Improve Cognitive Performance and Decelerate AD Progression in DS Subjects: Epigallocatechin Gallate as Therapeutic Tool Down syndrome Epigalocatechin Gallate (NPC250436) NP level
NCT00003197 Green Tea Extract in Treating Patients With Advanced Solid Tumors neoplasm Epigalocatechin Gallate (NPC250436) NP level
NCT00449982 Efficacy and Safety Study of Polyphenon E to Treat External Genital Warts anogenital venereal wart Epigalocatechin Gallate (NPC250436) NP level
NCT00676780 Green Tea Extract and Prostate Cancer prostate cancer Epigalocatechin Gallate (NPC250436) NP level
NCT02627898 Effect of Green Tea Extract on Arterial Stiffness in Type 2 Diabetes Mellitus type 2 diabetes mellitus Epigalocatechin Gallate (NPC250436) NP level
NCT03928847 Fibroblast Specific Inhibition of LOXL2 and TGFbeta1 Signaling in Patients With Pulmonary Fibrosis. idiopathic pulmonary fibrosis Epigalocatechin Gallate (NPC250436) NP level
NCT00666562 Green Tea Extract in Treating Patients With Nonmetastatic Bladder Cancer urinary bladder cancer Epigalocatechin Gallate (NPC250436) NP level
NCT04898023 Zinc and Green Tea Extract for Community Respiratory Viral Infections viral disease Epigalocatechin Gallate (NPC250436) NP level
NCT02848131 Senescence in Chronic Kidney Disease chronic kidney disease Quercetin (NPC20791) NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

 How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
 ❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant
Association Type & Detailed Evidence
Multiple myeloma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A83
 INSR,SRC,KDR,TERT,AXL,IGF1R,BCL2,FLT3
 NCT00942422
Pheochromocytoma
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH3854
 MET,XDH,NOX4,SNCA,BCL2,ELAVL3,APP,ACHE,FUT7
Adenocarcinoma of stomach
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B72.0
 CDK1,NPSR1,MET,NOX4,AURKB,ALOX15,CYP19A1,TOP2A,TERT
Malignant neoplasms of oesophagus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B70
 CDK1,NPSR1,HSPA1A,NOX4,AURKB,ALOX15,ACHE,TOP2A,TERT
Colorectal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B91
 TERT,KDR,IGF1R,EGFR,MET,TOP2A,FLT3,TP53
Ovarian cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C73
 TP53,TERT,MET,FLT3,SRC,TOP2A,BCL2,KDR
Pancreatic cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C10
 DNMT1,SRC,TP53,IGF1R,EGFR,TOP2A,TERT,BCL2
Stomach cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B72
 TOP2A,MET,EGFR,BCL2,HSPA1A,TP53,KDR,HSPA1B
Squamous cell carcinoma of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.2
 CDK1,NPSR1,XDH,ALOX12,PGD,AURKB,TOP2A,TERT
Cytomegaloviral disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D82
 ELAVL3,CYP1A1,ACHE,KDM4E,ALOX15,GPR35,HPGD,ABCB1
Adenocarcinoma of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.0
 CDK1,NPSR1,XDH,AURKB,ACHE,TOP2A,GPR35,TERT
Myelodysplastic syndrome
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A37
 TP53,AXL,BCL2,KDR,EGFR,TERT,DNMT1
Brain cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00
 EGFR,KDR,TOP2A,SRC,TERT,TP53,MET
Malignant haematopoietic neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B33
 AURKB,TOP2A,FLT3,CDK1,TP53,SRC,BCL2
Prostate cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C82
 TERT,AURKB,BCL2
 NCT01340599,NCT00005828,NCT00676780,NCT01705652
Liver cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12
 TOP2A,EGFR,IGF1R,MET,KDR,TERT,CSNK2A1
Melanoma of skin
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C30
 NOX4,BCL2,APP,FUT7,IGF1R,TERT,ABCG2
Glioblastoma of brain
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00.00
 CYP1B1,CSNK2A3,MET,KDR,CYP19A1,LMNA,POLH
Myeloproliferative neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A20
 TEK,TERT,SRC,BCL2,DNMT1,FLT3
Superficial ovarian endometriosis
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA10.B4
 SNCA,PGAM1,INSR,SRC,ACHE,LMNA
Urothelial carcinoma of bladder
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C94.2
 CDK1,AKR1B1,CYP1A2,AURKB,TOP2A,TERT
Chikungunya virus disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D40
 GPR35,EGFR,XDH,CYP19A1,LMNA,AXL
Invasive carcinoma of breast
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C61
 CDK1,ELAVL3,AURKB,FUT7,TOP2A,TERT
Renal cell carcinoma, chromophobe type
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH6153
 MET,AURKB,CYP1A2,CYP1A1,TOP2A,TERT
Mature B-cell leukaemia
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A82
 SRC,TP53,BCL2,EGFR,AXL
Motor neuron disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8B60
 HSPA1A,SRC,BCL2,IGF1R,HSPA1B
BCR-ABL1-negative chronic myeloid leukaemia
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A41
 BCL2,HSPA1A,SRC,FLT3,HSPA1B
Mature B-cell lymphoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A85
 TEK,FLT3,BCL2,CDK1,TOP2A
Head and neck cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D42
 TP53,TERT,KDR,MET,EGFR
Pain, unspecified
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MG3Z
 ACHE,INSR,AKR1B1,ALOX5,IGF1R
Melanoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C30
 MET,KDR,BCL2,EGFR,TERT
Multiple sclerosis
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A40
 TOP2A,SRC
 NCT01451723,NCT00836719,NCT00799890
Adenocarcinoma of prostate
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C82.0
 NOX4,ALOX15,TERT
 NCT01912820,NCT00459407
Malignant neoplasms of thyroid gland, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D10.Z
 CYP1B1,MET,XDH,NOX4,ALOX5
Glaucoma
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9C61
 TERT,MET,ACHE,AKR1B1
Retinopathy
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9B71
 IGF1R,TEK,APEX1,APP
Psoriasis
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA90
 FLT3,BCL2,ALOX5,TOP2A
Peritoneal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C51
 SRC,FLT3,TP53,KDR
Acute diabete complication
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A2Y
 KDR,AKR1B1,INSR,AURKB
Parkinsonism
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A00
 SRC,ACHE,SNCA
 NCT00461942
Neuropathy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C0Z
 AKR1B1,HSPA1B,CYP19A1,HSPA1A
Non-small cell lung cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25
 EGFR,MET,KDR
 NCT00707252
Malignant digestive organ neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C11
 HSPA1B,HSPA1A,SRC,KDR
Diffuse large B-cell lymphoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A81
 TOP2A,BCL2,FLT3,DNMT1
Type 2 diabetes mellitus
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A11
 INSR
 NCT00567905,NCT02627898,NCT01839344
Systemic lupus erythematosus
Disease Category: 04.Diseases of the immune system
Disease ICD-11 Code: 4A40.0
 YES1,CYP1A1,ACHE
 NCT02875691
Leishmaniasis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F54
 AKR1B1,NOX4,FLT3,FUT7
Malignant neoplasm metastasis in lymph nodes of head, face or neck
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D60.0
 NPSR1,NOX4,AURKB,TERT
West Nile virus infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D46
 MET,CYP19A1,ACHE,AXL
Other specified malignant neoplasms ofcolon
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B90.Y
 NPSR1,MET,NOX4,CYP1A1
Other specified malignant neoplasms of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.Y
 CDK1,XDH,AURKB,TOP2A
Human immunodeficiency virus disease without mention of tuberculosis or malaria
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1C62
 FLT3,GPR35,AXL,MET
Carpal tunnel syndrome
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C10.0
 CYP1B1,SMAD3,NOX4,FUT7
Chronic kidney disease
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GB61
 IGF1R,XDH
 NCT02848131
Cardiovascular disease
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA00-BE2Z
 MET,SRC,KDR
Influenza
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1E30-1E32
 XDH,GLO1,ALOX5
Diabetic foot ulcer
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD54
 HSPA1A,EGFR,HSPA1B
Nasopharyngeal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B6B
 EGFR,CDK1,ALOX5
Herpes simplex infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F00
 SMAD3,HSPA1B,HSPA1A
Metastatic malignant neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D50-2E09
 AXL,HSPA1B,HSPA1A
Rheumatoid arthritis
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA20
 AKR1B1,ALOX5,ABCG2
Renal cell carcinoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C90
 KDR,EGFR,MET
Pleomorphic sarcoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B54
 KDR,SRC,MET
Pituitary gland disorder
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A60-5A61
 IGF1R,PGD,ALOX5
Chronic arterial occlusive disease
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD4Z
 MET,TP53,TEK
Chronic pain
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MG30
 EGFR,KDR,FLT3
Metastatic lymph node neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D60
 EGFR,MET,KDR
NA
Disease Category: NA
Disease ICD-11 Code: NA
 NOX4,MET
 NCT04553666
Bladder cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C94
 TOP2A,DNMT1,TP53
Follicular lymphoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A80
 BCL2,TOP2A
 NCT00455416
Focal/segmental autonomic disorder
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8D8A
 NCT00816478,NCT00814255,NCT00816504
Zika virus disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D48
 SMAD3,AXL,ACHE
Myotonic dystrophy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C71.0
 TOP2A,HPGD,CYP1A1
Polycystic ovary syndrome
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A80.1
 FUT7,HPGD,POLH
Ebola virus disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D60.01
 MET,AXL,ACHE
Diffuse large B-cell lymphomas
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A81
 NOX4,KDR,NUAK1,ACHE,TOP2A,EGFR,TDP1,TEK,AURKB,HSD17B10,DNMT1,AKR1B1,LMNA,PSMB5,AXL,CSNK2A2,CDK1,GLO1,TP53,CSNK2A1,BCL2,SRC,MAPKAPK5,POLH,CASP6,MET,APEX1,TERT,RECQL
Mesothelioma of pleura
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C26.0
 KDR,PGD,TOP2A,EGFR,TDP1,GALNT2,FLT3,AURKB,PIM1,DNMT1,LMNA,AXL,CSNK2A2,CDK1,ABCB1,XDH,SRC,FUT7,BACE1,POLH,CASP6,ALOX5,MET,SNCA,APEX1,HPGD,ALOX15,TERT,RECQL
Solid tumour/cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00-2F9Z
 TEK,CSNK2A1,FLT3,ALOX5,HSPA1A,TP53,AXL,PIM1,EGFR,APP,XDH,TOP2A,TERT,IGF1R,HSPA1B,CDK1,BCL2,APEX1,YES1,MET,AURKB,DNMT1,SRC,POLB,ABCB1,KDR
Germ cell tumour of testis
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C80.2
 NPSR1,NOX4,KDR,ALOX12,NUAK1,PGAM1,PGD,ACHE,RAD52,APP,TEK,AKR1B1,GLO1,CDK1,XDH,SMAD3,SLC22A6,MAPKAPK5,FUT7,CASP6,ALOX5,ABCG2,MET,SNCA,HPGD
Serous cystadenoma,borderline malignancy of ovary
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C73.4
 NOX4,ALOX12,PGD,TDP1,CYP1A2,DNMT1,PSMB5,GLO1,YES1,TP53,CSNK2A1,XDH,FUT7,POLH,CASP6,ALOX5,CSNK2A3,MET,ELAVL3,APEX1,HPGD,ALOX15,TERT
Adenocarcinoma of pancreas
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C10.0
 NPSR1,NUAK1,PGAM1,PGD,ACHE,POLB,APP,TEK,AURKB,PIM1,LMNA,AXL,ABCB1,XDH,FUT7,ALOX5,ABCG2,CYP1B1,MET,SNCA,ALOX15,TERT,RECQL
Carcinosarcoma of uterus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76.43
 NPSR1,PGAM1,PGD,TOP2A,TDP1,GALNT2,POLB,AURKB,HSD17B10,AKR1B1,PSMB5,GLO1,YES1,TP53,XDH,CYP19A1,FUT7,CASP6,MET,ELAVL3,ALOX15,TERT
Malignant neoplasms of biliary tract, distal bile duct
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C15
 NOX4,ALOX12,NUAK1,TOP2A,IGF1R,AURKB,DNMT1,AKR1B1,GPR35,LMNA,CDK1,TP53,CSNK2A1,BCL2,SRC,ALOX5,L3MBTL1,CSNK2A3,ELAVL3,SMAD3,TERT
Anogenital warts
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1A95
 TOP2A
 NCT00449982
Gastrointestinal stromal tumour
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B5B
 SRC,KDR
Chronic myelomonocytic leukaemia
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A40
 FLT3,BCL2
Mature T-cell lymphoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A90
 EGFR,TOP2A
Idiopathic interstitial pneumonitis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CB03
 FLT3,ALOX5
Ischemia
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8B10-8B11
 EGFR,SRC
Kaposi sarcoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B57
 DNMT1,TOP2A
Asthma
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA23
 ALOX5,TOP2A
Postoperative inflammation
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1A00-CA43
 ALOX5,SRC
Endometrial cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76
 SRC,TP53
Endometriosis
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA10
 CYP19A1
 NCT02832271
Thyroid cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D10
 KDR,MET
Fallopian tube cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C74
 SRC,TP53
Unspecific body region injury
Disease Category: 22.Injury, poisoning or certain other consequences of external causes
Disease ICD-11 Code: ND56
 EGFR,MET
Ovarian dysfunction
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A80
 BCL2,TP53
Thrombosis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DB61-GB90
 AKR1B1,TOP2A
Bacterial infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1A00-1C4Z
 TOP2A,ABCB1
Dystrophic epidermolysis bullosa
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EC32
 APP
 NCT00951964
Cervical cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C77
 TP53,SRC
Unspecified viral infection of unspecified site
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D9Z
 FLT3
 NCT04898023
Thrombocytopenia
Disease Category: 03.Diseases of the blood or blood-forming organs
Disease ICD-11 Code: 3B64
 ALOX5,KDR
Amyloidosis
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5D00
 APP
 NCT02015312
Complete trisomy 21
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LD40.0
 NCT01394796,NCT01699711
Uterine fibroid
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2E66
 NCT04177693,NCT05364008
Lichen planus
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA91
 NCT01375101,NCT02329600
Chronic obstructive pulmonary disease
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA22
 NCT01708278,NCT03989271
Ageing associated decline in intrinsic capacity
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MG2A
 NCT05422885,NCT04946383
COVID-19
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D6Y
 NCT04853199,NCT04851821
Malignant neoplasms of bladder, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C94.Z
 NCT00666562,NCT00088946
coronary artery disease
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA8Y-BA8Z
 NCT04907253,NCT03943459
Neoplasms
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 02
 NCT00091325,NCT00003197
Coeliac disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA95
 CDK1,CYP1A1
Osteoarthritis, unspecified
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA0Z
 CDK1,TOP2A
Dengue fever, unspecified
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D2Z
 AURKB,ABCG2
Heart failure, unspecified
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD1Z
 CYP1B1,ABCG2
Hepatocellular carcinoma of liver
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12.02
 CDK1,NOX4,SLC22A6,AURKB,CYP19A1,DNMT1,TOP2A,GPR35,TERT,L3MBTL1,CDK1,AURKB,SRC,CYP19A1,TOP2A,TERT
Breast cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C60-2C6Y
 KDR,MET,IGF1R,TOP2A,EGFR,TEK,BCL2,CYP19A1,SRC,AXL,TERT,CDK1
 NCT00676793,NCT00516243,NCT00917735
Lung cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25
 ALOX5,AXL,TERT,TOP2A,FLT3,CDK1,KDR,BCL2,MET,DNMT1,EGFR,IGF1R,ABCB1
 NCT00363805
Other specified malignant neoplasms of kidney, except renal pelvis
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C90.Y
 MET,XDH,AURKB,ACHE,CYP19A1,TOP2A,TERT,ALOX5,AURKB,FUT7,TOP2A,GPR35,TERT,ALOX5
Malignant neoplasms of thymus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C27
 CYP1B1,AKR1B1,GALNT2,FLT3,APEX1,HSD17B10,ACHE,DNMT1,ALOX15,HPGD,PSMB5,FUT7
Hepatoblastoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12.01
 CDK1,TOP2A,AKR1B1,NOX4,NUAK1,AURKB,SRC,CYP19A1,IGF1R,GPR35,L3MBTL1
Malignant neoplasms of adrenal gland
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D11
 CDK1,MET,NOX4,SNCA,AURKB,HPGD,CYP19A1,FUT7,TOP2A,TERT,GLO1
Acute myeloid leukaemia
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A60
 TERT,TP53,AXL,FLT3,BCL2,TOP2A,AURKB,SRC,DNMT1,PIM1
Alzheimer disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A20
 TOP2A,BACE1,KDR,ACHE,INSR,APP,FLT3,MET,SNCA
 NCT00951834
Malignant neoplasms of corpus uteri, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76.Z
 NPSR1,PGD,CYP1A1,TOP2A,AURKB,GPR35,CDK1,XDH,ALOX15,TERT
Lysosomal disease
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C56
 INSR
Cataract
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9B10
 AKR1B1
Bone/articular cartilage neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2F7B
 FLT3
Coronavirus infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D92
 CSNK2A1
Liposarcoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B59
 TP53
Lip/oral cavity/pharynx neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B6E
 TP53
Human immunodeficiency virus disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1C60-1C62
 FLT3
Parasitic worm infestation
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F90
 ACHE
HIV-infected patients with tuberculosis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1B10-1B14
 TOP2A
Psychotic disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A20-6A25
 INSR
Ischemic heart disease
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA40-BA6Z
 MET
Mastocytosis
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A21
 FLT3
Extraocular muscle disorder
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9C82
 IGF1R
Autonomic nervous system disorder
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8D87
 SNCA
Kidney failure
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GB60-GB6Z
 TP53
Diabetes mellitus, type unspecified
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A14
 INSR
Epidermal dysplasias
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EK90
 SRC
Colon cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B90
 EGFR
Malignant mesenchymal neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B5D-2B5Y
 EGFR
Heart failure
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD10-BD1Z
 XDH
Encephalopathy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8E47
 XDH
Atopic eczema
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA80
 ALOX5
Digestive organ benign neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2E92
 KDR
Gout
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA25
 XDH
Biliary tract cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C17
 MET
Liver disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DB90-DB9Z
 MET
Oesophageal/gastroduodenal disorder
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD90
 ACHE
Chemoprotection
Disease Category: NA
Disease ICD-11 Code: N.A.
 TOP2A
Crohn disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD70
 INSR
Schizophrenia
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A20
 AKR1B1
Multiple structural anomalies syndrome
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LD2F
 IGF1R
Unspecific substance harmful effect
Disease Category: 22.Injury, poisoning or certain other consequences of external causes
Disease ICD-11 Code: NE6Z
 ACHE
Skin postprocedural disorder
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EL8Y
 EGFR
Desmoid tumour
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2F7C
 APP
Otitis externa
Disease Category: 10.Diseases of the ear or mastoid process
Disease ICD-11 Code: AA00-AA13
 TOP2A
Urinary tract infection
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GC08
 TOP2A
Thrombocytosis
Disease Category: 03.Diseases of the blood or blood-forming organs
Disease ICD-11 Code: 3B63
 TERT
Leiomyosarcoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B58
 SRC
Substance abuse
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6C40
 ACHE
Angina pectoris
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA40
 EGFR
Filariasis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F66
 ALOX5
Esophageal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B70
 TP53
Ocular cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D00-2D07
 APEX1
Type-1/2 diabete
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A10-5A11
 INSR
Synovial sarcoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B5A
 SRC
Testicular cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C80
 EGFR
Diagnostic imaging
Disease Category: NA
Disease ICD-11 Code: N.A.
 APP
Common warts
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1E80
 TOP2A
Carcinoid syndrome
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5B10
 ALOX5
Mineral deficiency
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5B5K
 XDH
Spinal cord/cranial nerve neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A02
 EGFR
Pediculosis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1G00
 ACHE
Syphilis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1A61-1A6Z
 TOP2A
Oesophagitis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA24
 CYP19A1
Metastatic biliary tract neoplasms
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C14-2C17
 EGFR
Inflammatory arthropathy
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA2Z
 FLT3
Hypopharyngeal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B6D
 EGFR
Fungal infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F29-1F2F
 ALOX5
Dementia
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6D80-6D8Z
 ACHE
Cushing syndrome
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A70
 CYP19A1
Irritable bowel syndrome
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD91
 ABCG2
Metastatic liver/bile duct neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D80
 TP53
Gonococcal infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1A70-1A7Z
 TOP2A
Thyrotoxicosis
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A02
 IGF1R
Urethral cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C93
 EGFR
Mild neurocognitive disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6D71
 ACHE
Respiratory system disease
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CB40-CB7Z
 TOP2A
Intracerebral haemorrhage
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8B00
 EGFR
Inborn purine/pyrimidine/nucleotide metabolism error
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C55
 XDH
Transplanted organ/tissue
Disease Category: 24.Factors influencing health status or contact with health services
Disease ICD-11 Code: QB63
 FLT3
Hepatitis virus infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1E50-1E51
 EGFR
Phakomatoses/hamartoneoplastic syndrome
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LD2D
 FLT3
Osteosarcoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B51
 SRC
Metastatic digestive system neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D8Y
 SRC
Transplant rejection
Disease Category: 22.Injury, poisoning or certain other consequences of external causes
Disease ICD-11 Code: NE84
 TP53
Otitis media
Disease Category: 10.Diseases of the ear or mastoid process
Disease ICD-11 Code: AA80-AB0Z
 TOP2A
Myasthenia gravis
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C6Y
 ACHE
Relapsing-remitting multiple sclerosis
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A40.0
 NCT00525668
Huntington disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A01.10
 NCT01357681
Unspecified malignant neoplasms of unspecified sites
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D4Z
 NCT04733534
Columnar metaplastic epithelium of the oesophagus, unspecified
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA23.Z
 NCT00233935
Fragile X chromosome
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LD55
 NCT01855971
Malignant neoplasms of colon
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B90
 NCT02891538
Cystic fibrosis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA25
 NCT01348204
Osteoporosis
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FB83.1
 NCT00625391
Leukaemia
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A60-2B33
 NCT00262743
Intracranial injury, unspecified
Disease Category: 22.Injury, poisoning or certain other consequences of external causes
Disease ICD-11 Code: NA07.Z
 NCT02731495
Malignant neoplasms of other or unspecified parts of mouth
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B66
 NCT05456022
Prostate hyperplasia
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA90
 NCT00596011
Macular degeneration
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9B75
 NCT05062486
Idiopathic pulmonary fibrosis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CB03.4
 NCT03928847
Duchenne muscular dystrophy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C70.1
 NCT01183767
Malignant neoplasms of nasopharynx
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B6B
 NCT01744587
Congenital aplastic anaemia
Disease Category: 03.Diseases of the blood or blood-forming organs
Disease ICD-11 Code: 3A70.0
 NCT01720147
Hepatic fibrosis/cirrhosis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DB93
 NCT03278925
Chronic hepatitis C
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1E51.1
 NCT01438320
Osteoarthritis
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA00-FA05
 NCT05276895
Multiple system atrophy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8D87.0
 NCT02008721
Ductal carcinoma in situ of breast
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2E65.2
 NCT01060345
Gastro-oesophageal reflux disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA22
 NCT02226484
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecified
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1C62.Z
 NCT01433289
Metabolic disorder
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C50-5D2Z
 NCT04011618
Myelodysplastic syndromes, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A3Z
 PIM1
Inflammatory bowel diseases, unspecified
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD7Z
 NOX4
Tetralogy of Fallot
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LA88.2
 ABCG2
Systemic sclerosis
Disease Category: 04.Diseases of the immune system
Disease ICD-11 Code: 4A42
 NOX4
Chronic rhinosinusitis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA0A
 CYP1A1
Dilated cardiomyopathy
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BC43.0
 ABCG2
Lyme borreliosis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1C1G
 MET
Gliomas of brain
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00.0
 NOX4

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network 
Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Plant Ingredients  
3. Collective Molecular Proteins  
4. Collective Enriched Activities  
5. Plant molecular targets overlapping with DEGs  
6. Associated clinical trials  
7. Associated Human Diseases  
>> Targets derived from weak experimental activities
About Us

The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD) and School of Pharmacy, Fudan University.

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Principle Investigator:
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Prof. Zeng Xian
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Developer & Maintainer:
Ph.D. Student Dongyue Hou
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Mr. Hanbo Lin
hblin19@fudan.edu.cn
Ms. Yuhan Feng
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