Collective Molecular Activities of the Plant: Astragalus Complanatus
Plant ID: NPO20554
Plant Latin Name: Astragalus Complanatus
Taxonomy Genus: Astragalus
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
47064
Plant-of-the-World-Online:
n.a.
Country/Region:
ChinaTraditional Medicine System:
TCMMedicinal Functions:
Hepatic; Kidney; Ophthalmic
China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
78 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
40 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
38 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC9880
Ingredient ID: NPC89069
Ingredient ID: NPC88789
Ingredient ID: NPC87828
Ingredient ID: NPC8705
Ingredient ID: NPC80710
Ingredient ID: NPC77272
Ingredient ID: NPC7355
Ingredient ID: NPC66052
Ingredient ID: NPC61851
Ingredient ID: NPC58176
Ingredient ID: NPC55786
Ingredient ID: NPC54472
Ingredient ID: NPC54264
Ingredient ID: NPC48853
Ingredient ID: NPC45165
Ingredient ID: NPC44751
Ingredient ID: NPC43371
Ingredient ID: NPC40249
Ingredient ID: NPC327818
Ingredient ID: NPC324696
Ingredient ID: NPC319449
Ingredient ID: NPC319108
Ingredient ID: NPC309318
Ingredient ID: NPC301585
Ingredient ID: NPC300956
Ingredient ID: NPC294548
Ingredient ID: NPC292988
Ingredient ID: NPC290613
Ingredient ID: NPC290437
Ingredient ID: NPC29
Ingredient ID: NPC281131
Ingredient ID: NPC280943
Ingredient ID: NPC275470
Ingredient ID: NPC265885
Ingredient ID: NPC261931
Ingredient ID: NPC255634
Ingredient ID: NPC252928
Ingredient ID: NPC230301
Ingredient ID: NPC225778
Ingredient ID: NPC223817
Ingredient ID: NPC216630
Ingredient ID: NPC215104
Ingredient ID: NPC209970
Ingredient ID: NPC20791
Ingredient ID: NPC205093
Ingredient ID: NPC202716
Ingredient ID: NPC196490
Ingredient ID: NPC190300
Ingredient ID: NPC189036
Ingredient ID: NPC184457
Ingredient ID: NPC181465
Ingredient ID: NPC179950
Ingredient ID: NPC178233
Ingredient ID: NPC173996
Ingredient ID: NPC173582
Ingredient ID: NPC171736
Ingredient ID: NPC166894
Ingredient ID: NPC159096
Ingredient ID: NPC15568
Ingredient ID: NPC155612
Ingredient ID: NPC154932
Ingredient ID: NPC154186
Ingredient ID: NPC153995
Ingredient ID: NPC152989
Ingredient ID: NPC149184
Ingredient ID: NPC14682
Ingredient ID: NPC143799
Ingredient ID: NPC135391
Ingredient ID: NPC135088
Ingredient ID: NPC133671
Ingredient ID: NPC131981
Ingredient ID: NPC12050
Ingredient ID: NPC116775
Ingredient ID: NPC10990
Ingredient ID: NPC108860
Ingredient ID: NPC108489
Ingredient ID: NPC102449
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 38 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00374881 | A Study of the Safety and Efficacy of Combination Therapy With Morphine, Phenylephrine and Sorbitol in Human Subjects | pain | Sorbitol (NPC66052) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791) | NP level |
| NCT01119534 | Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin | Cough | Camphor (NPC131981) | NP level |
| NCT01348204 | Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators | cystic fibrosis | Quercetin (NPC20791) | NP level |
| NCT01375101 | Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus | oral lichen planus | Quercetin (NPC20791) | NP level |
| NCT01438320 | Q-Trial in Patients With Hepatitis C | chronic hepatitis C virus infection | Quercetin (NPC20791) | NP level |
| NCT01474499 | A Trial of Docusate Sodium and Sorbitol Rectal Solution for the in Patients With Constipation | Constipation | Sorbitol (NPC66052) | NP level |
| NCT01528969 | Effect of Xylitol on Oral Microbiota in Children | bacterial disease | Sorbitol (NPC66052) | NP level |
| NCT01708278 | Beneficial Effects of Quercetin in Chronic Obstructive Pulmonary Disease (COPD) | chronic obstructive pulmonary disease | Quercetin (NPC20791) | NP level |
| NCT01720147 | Quercetin in Children With Fanconi Anemia; a Pilot Study | Fanconi anemia | Quercetin (NPC20791) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR,MAOA
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
KDR,DPP4,AURKB
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
AURKB,SRC,FLT3,AXL,TP53,PIM1,KDM1A
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CDK1,F2,NPSR1,CA7,NR1I2,XDH,CYP2C9,AURKB,ACHE,CA12
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
NPSR1,ACHE,CA7,NR1I2,POLB,AURKB,PIM1,AXL,XDH,OR51E2,CISD1,HSD17B2,CA2,ALOX5,F2,ABCG2,CYP1B1,MET,CYP2C9,DPP4,ALOX15,RECQL
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
OR51E2,NOX4,FABP5,ALOX15
NCT01912820 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CDK1,F2,NPSR1,MET,NOX4,AURKB,CYP19A1,ALOX15
|
Ageing associated decline in intrinsic capacityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG2A |
NCT04946383,NCT05422885
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
KDR,ACHE,MAOA,MET,FLT3
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
