Collective Molecular Activities of the Plant: Erythrina Sacleuxii
Plant ID: NPO20150
Plant Latin Name: Erythrina Sacleuxii
Taxonomy Genus: Erythrina
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
1899109
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
44 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
23 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
33 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC95594
Ingredient ID: NPC92117
Ingredient ID: NPC90829
Ingredient ID: NPC85694
Ingredient ID: NPC83670
Ingredient ID: NPC74595
Ingredient ID: NPC67917
Ingredient ID: NPC51700
Ingredient ID: NPC49627
Ingredient ID: NPC49599
Ingredient ID: NPC482074
Ingredient ID: NPC468984
Ingredient ID: NPC42853
Ingredient ID: NPC40702
Ingredient ID: NPC314743
Ingredient ID: NPC30583
Ingredient ID: NPC304741
Ingredient ID: NPC29883
Ingredient ID: NPC289196
Ingredient ID: NPC281131
Ingredient ID: NPC270689
Ingredient ID: NPC264317
Ingredient ID: NPC263548
Ingredient ID: NPC259166
Ingredient ID: NPC253662
Ingredient ID: NPC239966
Ingredient ID: NPC225723
Ingredient ID: NPC225710
Ingredient ID: NPC225616
Ingredient ID: NPC213659
Ingredient ID: NPC20791
Ingredient ID: NPC200574
Ingredient ID: NPC178383
Ingredient ID: NPC178134
Ingredient ID: NPC172250
Ingredient ID: NPC169749
Ingredient ID: NPC149875
Ingredient ID: NPC144118
Ingredient ID: NPC139546
Ingredient ID: NPC127684
Ingredient ID: NPC121171
Ingredient ID: NPC116775
Ingredient ID: NPC107775
Ingredient ID: NPC101658
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Drug Transporter | SLC superfamily of solute carriers | SLC22A6 | Solute carrier family 22 member 6 | Q4U2R8 | CHEMBL1641347 |
| Therapeutic Target | Cysteine protease | CASP6 | Caspase-6 | P55212 | CHEMBL3308 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 234 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000776 | Dexamethasone in Cryptococcal Meningitis | intracranial hypertension;cryptococcal meningitis | Amphotericin B (NPC67917) | NP level |
| NCT00001017 | Comparison of Fluconazole and Amphotericin B in the Treatment of Brain Infections in Patients With AIDS | cryptococcal meningitis | Amphotericin B (NPC67917) | NP level |
| NCT00001107 | Comparison of Two Treatments to Prevent Invasive Fungal Infections in Patients Who Have Received Liver Transplants | candidiasis | Amphotericin B (NPC67917) | NP level |
| NCT00001646 | Voriconazole vs. Amphotericin B in the Treatment of Invasive Aspergillosis | aspergillosis | Amphotericin B (NPC67917) | NP level |
| NCT00002159 | A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis | blastomycosis;histoplasmosis | Amphotericin B (NPC67917) | NP level |
| NCT00002277 | A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections | fungal infectious disease | Amphotericin B (NPC67917) | NP level |
| NCT00002316 | The Safety and Effectiveness of RMP-7 Plus Amphotericin B in Patients With HIV and Cryptococcal Meningitis | cryptococcal meningitis | Amphotericin B (NPC67917) | NP level |
| NCT00002742 | Antifungal Therapy for Fever and Neutropenia in Patients Receiving Treatment for Hematologic Cancer | chronic myeloproliferative disorder;leukemia;multiple myeloma;myelodysplastic syndrome;infection | Amphotericin B (NPC67917) | NP level |
| NCT00003031 | Comparison of Voriconazole and Amphotericin B in Treating Patients With Aspergillosis | aspergillosis | Amphotericin B (NPC67917) | NP level |
| NCT00003315 | Liposomal Amphotericin B With or Without Sargramostim in Treating Patients With Invasive Fungal Infection | infection | Amphotericin B (NPC67917) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKB,KDR,INSR,AKR1B1,DPP4
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
PIM1,AXL,TOP2A,FLT3,RELA,AURKB,SRC,TP53
NCT00451711,NCT00418951,NCT03187691 |
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
RELA
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,CDK1,AURKB,ACHE,XDH,GPR35,NPSR1,TOP2A,CA7,ADRA2A,CYP2C9
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
RECQL,POLB,ACHE,XDH,DRD1,MET,LMNA,AURKB,PIM1,CYP1B1,CA7,HSD17B2,DPP4,CISD1,CES1,FUT7,NPSR1,ALOX15,SNCA,ALOX5,CYP2C9,NUAK1,TEK,AXL,ABCG2
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
ALOX15,NOX4
NCT01912820 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CDK1,NOX4,AURKB,NPSR1,DRD1,TOP2A,ALOX15,CYP19A1,MET
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
