Collective Molecular Activities of the Plant: Posoqueria Latifolia
Unknown.
Brazil; Belize; Honduras; Peru; Suriname; Cuba; El Salvador; Venezuela; Mexico; Costa Rica; Guatemala; French Guiana; Colombia; Guyana; Bolivia; Nicaragua; Ecuador
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
72 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
59 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
27 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC92943
Ingredient ID: NPC92869
Ingredient ID: NPC90486
Ingredient ID: NPC85210
Ingredient ID: NPC74539
Ingredient ID: NPC73980
Ingredient ID: NPC72042
Ingredient ID: NPC71339
Ingredient ID: NPC70691
Ingredient ID: NPC65134
Ingredient ID: NPC53559
Ingredient ID: NPC502
Ingredient ID: NPC49074
Ingredient ID: NPC46254
Ingredient ID: NPC43246
Ingredient ID: NPC38742
Ingredient ID: NPC38212
Ingredient ID: NPC33415
Ingredient ID: NPC32991
Ingredient ID: NPC31279
Ingredient ID: NPC312132
Ingredient ID: NPC311783
Ingredient ID: NPC311255
Ingredient ID: NPC302857
Ingredient ID: NPC296071
Ingredient ID: NPC28828
Ingredient ID: NPC283170
Ingredient ID: NPC269242
Ingredient ID: NPC264784
Ingredient ID: NPC263089
Ingredient ID: NPC261644
Ingredient ID: NPC258476
Ingredient ID: NPC257124
Ingredient ID: NPC252587
Ingredient ID: NPC251666
Ingredient ID: NPC244315
Ingredient ID: NPC239039
Ingredient ID: NPC235260
Ingredient ID: NPC235190
Ingredient ID: NPC232375
Ingredient ID: NPC232141
Ingredient ID: NPC225709
Ingredient ID: NPC216825
Ingredient ID: NPC214971
Ingredient ID: NPC210456
Ingredient ID: NPC204388
Ingredient ID: NPC202992
Ingredient ID: NPC200838
Ingredient ID: NPC195355
Ingredient ID: NPC191103
Ingredient ID: NPC19003
Ingredient ID: NPC182468
Ingredient ID: NPC179987
Ingredient ID: NPC176819
Ingredient ID: NPC175771
Ingredient ID: NPC172625
Ingredient ID: NPC168290
Ingredient ID: NPC163984
Ingredient ID: NPC157340
Ingredient ID: NPC152384
Ingredient ID: NPC145463
Ingredient ID: NPC13990
Ingredient ID: NPC137949
Ingredient ID: NPC13449
Ingredient ID: NPC13304
Ingredient ID: NPC13143
Ingredient ID: NPC125085
Ingredient ID: NPC117299
Ingredient ID: NPC115919
Ingredient ID: NPC111690
Ingredient ID: NPC104190
Ingredient ID: NPC100773
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Therapeutic Target | Hydrolase | CDA | Cytidine deaminase | P32320 | CHEMBL4502 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Other cytosolic protein | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Therapeutic Target | Transferase | TK1 | Thymidine kinase, cytosolic | P04183 | CHEMBL2883 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 26 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00003667 | Combination Chemotherapy and Biological Therapy in Treating Patients With High-Risk Ewing's Sarcoma | sarcoma | Glycerin (NPC157340) | NP level |
| NCT00005025 | Gene Therapy in Treating Women With Refractory or Relapsed Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Peritoneal Cancer | fallopian tube cancer;ovarian cancer;peritoneum cancer | Thymidine (NPC71339) | NP level |
| NCT00210080 | A Study to Diagnose Lung Cancer by Sputum Cytology (01-312) | lung cancer | Uridine (NPC43246) | NP level |
| NCT00243711 | A Multi-Center Randomized Study to Evaluate the Efficacy and Safety of an Investigational Lubricant Eye Drop | dry eye syndrome | Glycerin (NPC157340) | NP level |
| NCT00322764 | Phase II Study to Assess RG2417 in the Treatment of Bipolar I Depression | bipolar disorder | Uridine (NPC43246) | NP level |
| NCT00533195 | Comparison of UVA1 Phototherapy Versus Photochemotherapy for Patients With Severe Generalized Atopic Dermatitis | atopic eczema | Bergapten (NPC74539) | NP level |
| NCT00580606 | A Randomized, Double-Blind Placebo-Controlled Peanut Sublingual Immunotherapy Trial | peanut allergic reaction | Glycerin (NPC157340) | NP level |
| NCT00619203 | Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis | bacterial meningitis | Glycerin (NPC157340) | NP level |
| NCT00691197 | Safety and Acceptability of Using a Rewetting Drop With Contact Lens Wear | Abnormality of refraction | Glycerin (NPC157340) | NP level |
| NCT00841256 | Multicenter Trial of Sublingual Immunotherapy With a Solution of Grass Pollen Allergen Extract in Children | allergic conjunctivitis | Glycerin (NPC157340) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TK1,MAPT
|
Acute pancreatitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DC31 |
NCT02110810
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,CDA,CA9,TK1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA,TK1,CA9
|
Allergic conjunctivitisDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A60.02 |
NCT00841256
|
Allergic/hypersensitivity disorderDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A80-4A8Z |
NCT02936830
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
MAPT
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
NCT00533195,NCT03901144
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA12
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
