Collective Molecular Activities of the Plant: Forsythia Viridissima
Country/Region:
South Korea; ChinaTraditional Medicine System:
TCMMedicinal Functions:
Antibacterial; Antifungal; Antispasmodic; Emmenagogue
United States; Japan; South Korea; China; South Africa
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
153 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
103 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
99 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC96769
Ingredient ID: NPC93211
Ingredient ID: NPC88789
Ingredient ID: NPC88085
Ingredient ID: NPC84868
Ingredient ID: NPC81515
Ingredient ID: NPC79056
Ingredient ID: NPC78551
Ingredient ID: NPC76145
Ingredient ID: NPC75161
Ingredient ID: NPC75121
Ingredient ID: NPC71853
Ingredient ID: NPC71703
Ingredient ID: NPC71506
Ingredient ID: NPC70744
Ingredient ID: NPC68889
Ingredient ID: NPC68779
Ingredient ID: NPC65606
Ingredient ID: NPC64176
Ingredient ID: NPC62829
Ingredient ID: NPC62765
Ingredient ID: NPC61604
Ingredient ID: NPC52472
Ingredient ID: NPC51758
Ingredient ID: NPC51700
Ingredient ID: NPC51400
Ingredient ID: NPC4982
Ingredient ID: NPC4826
Ingredient ID: NPC478705
Ingredient ID: NPC478704
Ingredient ID: NPC478703
Ingredient ID: NPC478702
Ingredient ID: NPC478701
Ingredient ID: NPC478700
Ingredient ID: NPC45844
Ingredient ID: NPC45727
Ingredient ID: NPC44751
Ingredient ID: NPC44328
Ingredient ID: NPC42503
Ingredient ID: NPC40432
Ingredient ID: NPC40249
Ingredient ID: NPC3649
Ingredient ID: NPC34764
Ingredient ID: NPC3295
Ingredient ID: NPC311987
Ingredient ID: NPC307050
Ingredient ID: NPC302857
Ingredient ID: NPC301161
Ingredient ID: NPC300894
Ingredient ID: NPC300776
Ingredient ID: NPC300017
Ingredient ID: NPC299706
Ingredient ID: NPC29883
Ingredient ID: NPC296337
Ingredient ID: NPC296108
Ingredient ID: NPC294902
Ingredient ID: NPC290613
Ingredient ID: NPC29
Ingredient ID: NPC288537
Ingredient ID: NPC287660
Ingredient ID: NPC285776
Ingredient ID: NPC281131
Ingredient ID: NPC27843
Ingredient ID: NPC278102
Ingredient ID: NPC276753
Ingredient ID: NPC27184
Ingredient ID: NPC26906
Ingredient ID: NPC264910
Ingredient ID: NPC264711
Ingredient ID: NPC264317
Ingredient ID: NPC264125
Ingredient ID: NPC262789
Ingredient ID: NPC260425
Ingredient ID: NPC255662
Ingredient ID: NPC252821
Ingredient ID: NPC252558
Ingredient ID: NPC251666
Ingredient ID: NPC249281
Ingredient ID: NPC246947
Ingredient ID: NPC246287
Ingredient ID: NPC246255
Ingredient ID: NPC246165
Ingredient ID: NPC239039
Ingredient ID: NPC23845
Ingredient ID: NPC232375
Ingredient ID: NPC23188
Ingredient ID: NPC230301
Ingredient ID: NPC229882
Ingredient ID: NPC228346
Ingredient ID: NPC227670
Ingredient ID: NPC227168
Ingredient ID: NPC22229
Ingredient ID: NPC22150
Ingredient ID: NPC216630
Ingredient ID: NPC216385
Ingredient ID: NPC215632
Ingredient ID: NPC215089
Ingredient ID: NPC214584
Ingredient ID: NPC213749
Ingredient ID: NPC209970
Ingredient ID: NPC208616
Ingredient ID: NPC20791
Ingredient ID: NPC205673
Ingredient ID: NPC200903
Ingredient ID: NPC200210
Ingredient ID: NPC199046
Ingredient ID: NPC198658
Ingredient ID: NPC197396
Ingredient ID: NPC197316
Ingredient ID: NPC196983
Ingredient ID: NPC190810
Ingredient ID: NPC189262
Ingredient ID: NPC188238
Ingredient ID: NPC180871
Ingredient ID: NPC179950
Ingredient ID: NPC177112
Ingredient ID: NPC176814
Ingredient ID: NPC176740
Ingredient ID: NPC175955
Ingredient ID: NPC173996
Ingredient ID: NPC168855
Ingredient ID: NPC167976
Ingredient ID: NPC166442
Ingredient ID: NPC166362
Ingredient ID: NPC161557
Ingredient ID: NPC16070
Ingredient ID: NPC158079
Ingredient ID: NPC157338
Ingredient ID: NPC145038
Ingredient ID: NPC144023
Ingredient ID: NPC142415
Ingredient ID: NPC141777
Ingredient ID: NPC13991
Ingredient ID: NPC139546
Ingredient ID: NPC138113
Ingredient ID: NPC137949
Ingredient ID: NPC135088
Ingredient ID: NPC131981
Ingredient ID: NPC125062
Ingredient ID: NPC12278
Ingredient ID: NPC120840
Ingredient ID: NPC11719
Ingredient ID: NPC115207
Ingredient ID: NPC114239
Ingredient ID: NPC113733
Ingredient ID: NPC111888
Ingredient ID: NPC110942
Ingredient ID: NPC110899
Ingredient ID: NPC108598
Ingredient ID: NPC1075
Ingredient ID: NPC105585
Ingredient ID: NPC102091
Ingredient ID: NPC101594
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 48 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00330096 | Effects of Hesperidin on Bone Mineral Density and Bone Metabolism of Postmenopausal Women | osteoporosis | Hesperidin (NPC79056) | NP level |
| NCT00346502 | Evaluation of 20% Betulinic Acid Ointment for Treatment of Dysplastic Nevi (Moderate to Severe Dysplasia) | dysplastic nevus | Betulinic Acid (NPC264317) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791) | NP level |
| NCT00701987 | Safety, Tolerability, and Preliminary Efficacy Study of ALS-357 in Patients With Cutaneous Metastatic Melanoma | melanoma | Betulinic Acid (NPC264317) | NP level |
| NCT01119534 | Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin | Cough | Camphor (NPC131981) | NP level |
| NCT01348204 | Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators | cystic fibrosis | Quercetin (NPC20791) | NP level |
| NCT01375101 | Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus | oral lichen planus | Quercetin (NPC20791) | NP level |
| NCT01438320 | Q-Trial in Patients With Hepatitis C | chronic hepatitis C virus infection | Quercetin (NPC20791) | NP level |
| NCT01705652 | Study to Assess the Activity of Nexrutine® in Prostate Cancer Patients | prostate cancer | Rutin (NPC176740) | NP level |
| NCT01708278 | Beneficial Effects of Quercetin in Chronic Obstructive Pulmonary Disease (COPD) | chronic obstructive pulmonary disease | Quercetin (NPC20791) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PTPN1,AKR1B1,AURKB,KDR
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TP53,AXL,NFKB1,KDM1A,AURKB,RELA,PTPRC,PIM1,FLT3,SRC
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
RELA,NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
NPSR1,CA7,CA12,MMP9,MMP1,TSHR,AURKB,CA9,F2,ACHE,AKR1B10,CDK1,XDH
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
OR51E2,ALOX5,CYP1B1,NPSR1,CA7,CA14,ALOX15,NAPRT,CES1,MAOB,ABCG2,SNCA,PIM1,RECQL,CDC25B,PTPN1,PTPRC,POLB,DRD1,MMP1,CA2,MMP2,LMNA,AXL,CYP2C19,AURKB,CA9,F2,MET,ACHE,AKR1B10,XDH
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
OR51E2,FABP5,NOX4,ALOX15
NCT01912820 |
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
