Plant ID: NPO19694
Plant Latin Name: Senecio Scandens
Taxonomy Genus: Senecio
Taxonomy Family: Asteraceae
NCBI TaxonomyDB:
189247
Plant-of-the-World-Online:
n.a.
Depurative; Febrifuge; Ophthalmic
India; China
Ingredient ID: NPC98620
Ingredient ID: NPC97663
Ingredient ID: NPC92562
Ingredient ID: NPC88789
Ingredient ID: NPC86227
Ingredient ID: NPC82374
Ingredient ID: NPC81010
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Ingredient ID: NPC7349
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Ingredient ID: NPC71703
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Ingredient ID: NPC6984
Ingredient ID: NPC69445
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Ingredient ID: NPC65133
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Ingredient ID: NPC59581
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Ingredient ID: NPC57249
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Ingredient ID: NPC49457
Ingredient ID: NPC48623
Ingredient ID: NPC4605
Ingredient ID: NPC43728
Ingredient ID: NPC43300
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Ingredient ID: NPC36061
Ingredient ID: NPC34550
Ingredient ID: NPC32977
Ingredient ID: NPC32021
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Ingredient ID: NPC313528
Ingredient ID: NPC312800
Ingredient ID: NPC311987
Ingredient ID: NPC311621
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Ingredient ID: NPC310604
Ingredient ID: NPC31032
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Ingredient ID: NPC303511
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Ingredient ID: NPC301702
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Ingredient ID: NPC29883
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Ingredient ID: NPC29
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Ingredient ID: NPC282773
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Ingredient ID: NPC280076
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Ingredient ID: NPC27765
Ingredient ID: NPC275463
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Ingredient ID: NPC272804
Ingredient ID: NPC27184
Ingredient ID: NPC269888
Ingredient ID: NPC26906
Ingredient ID: NPC264317
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Ingredient ID: NPC260837
Ingredient ID: NPC260115
Ingredient ID: NPC255568
Ingredient ID: NPC25495
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Ingredient ID: NPC250630
Ingredient ID: NPC243728
Ingredient ID: NPC243702
Ingredient ID: NPC23963
Ingredient ID: NPC239051
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Ingredient ID: NPC235401
Ingredient ID: NPC230301
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Ingredient ID: NPC228614
Ingredient ID: NPC224684
Ingredient ID: NPC220210
Ingredient ID: NPC219809
Ingredient ID: NPC219124
Ingredient ID: NPC218109
Ingredient ID: NPC217922
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Ingredient ID: NPC216630
Ingredient ID: NPC216330
Ingredient ID: NPC212315
Ingredient ID: NPC209970
Ingredient ID: NPC209846
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Ingredient ID: NPC201889
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Ingredient ID: NPC193471
Ingredient ID: NPC192638
Ingredient ID: NPC188568
Ingredient ID: NPC18772
Ingredient ID: NPC183993
Ingredient ID: NPC179950
Ingredient ID: NPC179694
Ingredient ID: NPC1788
Ingredient ID: NPC17839
Ingredient ID: NPC178104
Ingredient ID: NPC176300
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Ingredient ID: NPC172337
Ingredient ID: NPC171736
Ingredient ID: NPC168465
Ingredient ID: NPC167976
Ingredient ID: NPC165967
Ingredient ID: NPC165003
Ingredient ID: NPC162973
Ingredient ID: NPC162168
Ingredient ID: NPC16157
Ingredient ID: NPC160309
Ingredient ID: NPC16009
Ingredient ID: NPC15970
Ingredient ID: NPC158040
Ingredient ID: NPC156654
Ingredient ID: NPC155847
Ingredient ID: NPC150878
Ingredient ID: NPC143586
Ingredient ID: NPC13991
Ingredient ID: NPC138811
Ingredient ID: NPC132976
Ingredient ID: NPC127546
Ingredient ID: NPC121158
Ingredient ID: NPC12075
Ingredient ID: NPC118867
Ingredient ID: NPC117172
Ingredient ID: NPC115798
Ingredient ID: NPC114239
Ingredient ID: NPC111888
Ingredient ID: NPC110899
Ingredient ID: NPC1075
Ingredient ID: NPC107122
Ingredient ID: NPC106791
Ingredient ID: NPC103006
Ingredient ID: NPC100980
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
Therapeutic Target | Fatty acid binding protein family | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Therapeutic Target | Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Therapeutic Target | Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
Therapeutic Target | Metallo protease | MMP12 | Matrix metalloproteinase 12 | P39900 | CHEMBL4393 |
Therapeutic Target | Metallo protease | MMP9 | Matrix metalloproteinase 9 | P14780 | CHEMBL321 |
Therapeutic Target | Metallo protease | MMP1 | Matrix metalloproteinase-1 | P03956 | CHEMBL332 |
Therapeutic Target | Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
Therapeutic Target | Nuclear hormone receptor subfamily 1 | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Therapeutic Target | Nuclear hormone receptor subfamily 1 | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
Therapeutic Target | Oxidoreductase | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | P28845 | CHEMBL4235 |
Therapeutic Target | Oxidoreductase | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
Therapeutic Target | Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
Therapeutic Target | Protein Kinase | FLT3 | Tyrosine-protein kinase receptor FLT3 | P36888 | CHEMBL1974 |
Therapeutic Target | Protein Kinase | MKNK1 | MAP kinase-interacting serine/threonine-protein kinase MNK1 | Q9BUB5 | CHEMBL4718 |
Therapeutic Target | Protein Kinase | MKNK2 | MAP kinase signal-integrating kinase 2 | Q9HBH9 | CHEMBL4204 |
Therapeutic Target | Serine protease | DPP4 | Dipeptidyl peptidase IV | P27487 | CHEMBL284 |
Therapeutic Target | Small molecule receptor (family A GPCR) | DRD1 | Dopamine D1 receptor | P21728 | CHEMBL2056 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Therapeutic Target | Transcription factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
Therapeutic Target | Transcription factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Therapeutic Target | Transcription factor | RELA | Nuclear factor NF-kappa-B p65 subunit | Q04206 | CHEMBL5533 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 32 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT04403568 | Testing the Synergism of Phytonutrients, Curcumin and Ursolic Acid, to Target Molecular Pathways in the Prostate | prostate cancer | Ursolic Acid (NPC51700) | NP level |
NCT00004810 | Phase II Placebo-Controlled Study of 4-Aminosalicylic Acid for Ulcerative Colitis | ulcerative colitis | Aminosalicylic Acid (NPC301702) | NP level |
NCT04514510 | Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects With Stable Sickle Cell Disease | sickle cell anemia | Isoquercetin (NPC179950) | NP level |
NCT03216876 | A Study Of Ursolic Acid For Primary Sclerosing Cholangitis | sclerosing cholangitis | Ursolic Acid (NPC51700) | NP level |
NCT02728349 | Tolerance and Pharmacokinetic Study of Chlorogenic Acid to Advanced Glioblastoma | glioblastoma multiforme | Chlorogenic Acid (NPC302857) | NP level |
NCT01468415 | Efficiency Comparison Between Methylprednisolone and Phenol 8% Treatment Using a Trans Sacral Approach - on Lower Back Pain and Limbs | Back pain | Phenol (NPC100980) | NP level |
NCT04474626 | Isoquercetin in Sickle Cell Anemia | sickle cell anemia | Isoquercetin (NPC179950) | NP level |
NCT00417690 | High Dose Oral 4-Aminosalicylic Acid (PASER®) to Control Acute Flares of Mild to Moderate Crohn's Disease | Crohn's disease | Aminosalicylic Acid (NPC301702) | NP level |
NCT00638196 | Placebo vs. Linoleic Acid Controlled Assessment of Treatment Efficacy in MS | multiple sclerosis | Oleic Acid (NPC261831) | NP level |
NCT04648917 | GASC1 Inhibitor Caffeic Acid for Squamous Esophageal Cell Cancer (ESCC) | esophageal cancer | Caffeic Acid (NPC294902) | NP level |
NCT02552888 | Nitrite, Isoquercetin and Endothelial Dysfunction (NICE) Trial | chronic kidney disease | Isoquercetin (NPC179950) | NP level |
NCT01792310 | A Phase 1/2A Study of LAM561 in Adult Patients With Advanced Solid Tumours | glioma | Oleic Acid (NPC261831) | NP level |
NCT02351622 | Caffeic Acid Tablets as a Second-line Therapy for ITP | autoimmune thrombocytopenic purpura | Caffeic Acid (NPC294902) | NP level |
NCT00966836 | Prevention of Transplant Atherosclerosis With Everolimus and Anti-cytomegalovirus Therapy | cytomegalovirus infection | Phenol (NPC100980) | NP level |
NCT04733651 | Study to Investigate the Clinical Efficacy of Isoquercetin in Patients With COVID-19 | COVID-19 | Isoquercetin (NPC179950) | NP level |
NCT01197040 | Evaluation of Low Dose Corticosteroids Efficiency, Associated With Myfortic ® in the Treatment of Nephrotic Syndrome | nephrotic syndrome | Phenol (NPC100980) | NP level |
NCT03758014 | Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Grade IV GBM Patients | glioblastoma multiforme | Chlorogenic Acid (NPC302857) | NP level |
NCT02446795 | Isoquercetin as an Adjunct Therapy in Patients With Kidney Cancer Receiving First-line Sunitinib: a Phase I/II Trial | renal cell carcinoma | Isoquercetin (NPC179950) | NP level |
NCT01989897 | Effect of HSA or Saline Diluent on Immunotherapy Extract Stability as Determined by Graded ID Skin Tests | allergic rhinitis | Phenol (NPC100980) | NP level |
NCT02099240 | Patients Response to Early Switch To Oral:Osteomyelitis Study | osteomyelitis | Aminosalicylic Acid (NPC301702) | NP level |
NCT02621060 | Effect of Chlorogenic Acid on Patients With Impaired Glucose Tolerance | abnormal glucose tolerance | Chlorogenic Acid (NPC302857) | NP level |
NCT02337933 | Effect of Ursolic Acid Administration on Insulin Sensitivity and Metabolic Syndrome | metabolic syndrome | Ursolic Acid (NPC51700) | NP level |
NCT02245204 | Phase I Studies of Chlorogenic Acid for Injection for Tolerance and Pharmacokinetic of Advanced Cancers | cancer | Chlorogenic Acid (NPC302857) | NP level |
NCT03751592 | Phase Ib/IIa Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Advanced Lung Cancer | lung cancer | Chlorogenic Acid (NPC302857) | NP level |
NCT00346502 | Evaluation of 20% Betulinic Acid Ointment for Treatment of Dysplastic Nevi (Moderate to Severe Dysplasia) | dysplastic nevus | Betulinic Acid (NPC264317) | NP level |
NCT01661764 | Fish Oil Supplementation, Nutrigenomics and Colorectal Cancer Prevention | colorectal adenoma | Oleic Acid (NPC261831) | NP level |
NCT04622865 | Masitinib Combined With Isoquercetin and Best Supportive Care in Hospitalized Patients With Moderate and Severe COVID-19 | COVID-19 | Isoquercetin (NPC179950) | NP level |
NCT00495521 | High Dose Oral 4-Aminosalicylic Acid (PASER®) to Control Acute Flares of Mild to Moderate Crohn's Disease in Children | Crohn's disease | Aminosalicylic Acid (NPC301702) | NP level |
NCT04536090 | Study of Isoquercetin (IQC-950AN) Plus Standard of Care Versus Standard of Care Only for the Treatment of COVID-19 | COVID-19 | Isoquercetin (NPC179950) | NP level |
NCT03444298 | A Study of Gamma Tocopherol-enriched Supplement on Lower Airway Responses to Inhaled Wood Smoke in Healthy Adults | asthma;inflammation | (2R)-2,7,8-Trimethyl-2-[(4R,8R)-4,8,12-Trimethyltridecyl]-3,4-Dihydrochromen-6-Ol (NPC48623) | NP level |
NCT02136342 | Phase 1 Trial of Chlorogenic Acid in Patients With Advanced Cancer | cancer | Chlorogenic Acid (NPC302857) | NP level |
NCT00701987 | Safety, Tolerability, and Preliminary Efficacy Study of ALS-357 in Patients With Cutaneous Metastatic Melanoma | melanoma | Betulinic Acid (NPC264317) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
NOX4,MMP12,MMP9,AKR1B1,DPP4,TSHR,FLT3,MMP1,MMP2
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
MMP12,MMP9,CA7,CA12,TSHR,XDH,MMP1,OR51E2,F2
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
RORC,MMP12,MMP9,KDM1A,MMP1,MMP2,FLT3
NCT03751592 |
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
MMP9,RORC
HSD11B1,MMP1,MMP12,MMP9 NCT00417690,NCT00495521 |
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
NOX4,MMP12,CA7,DPP4,CA12,XDH,MMP1,CYP1B1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
MMP12,MMP9,CA7,CA12,TSHR,XDH,MMP1,F2
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CSNK2A3,LMNA,DPP4,FABP5,CA2,CA12,TSHR,CYP1B1
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
DPP4,NFKB1,FLT3,RORC,RELA
MMP12,FABP5 |
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
MMP12,MMP9,CA2,CYP1A1,XDH,MMP1,F2
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
MMP1,AKR1B1,RELA,NFKB1,MMP9,CA2
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
MKNK2,CA12,CA14,MKNK1,CA4,CA2
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
NFKB1,RELA,PPARA,F2,DPP4,HSD11B1
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
NOX4,MMP12,MMP9,DRD1,MMP1,F2
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
FABP4,NOX4,MMP12,MMP9,MMP1,F2
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
NOX4,DPP4,OR51E2,CYP1B1,MMP2,HSD11B1
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
RORC,RELA,F2,NFKB1
NCT00638196 |
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1,GSK3B,RELA,FLT3,KDM1A
|
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
NOX4,MMP12,MMP9,MMP1,HSD11B1
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
NOX4,MMP12,CYP1A1,MMP1,F2
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
MMP12,MMP9,CA12,XDH,MMP1
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
MMP9,AKR1B1,CA2,CYP1A2,MMP1
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
KDM4E,MMP9,CA14,CA2,CYP1A1
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
MMP1,MMP2,HIF1A,MMP9
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
PPARA,DPP4,NFKB1,RELA
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
HSD11B1,CA4,CA2,AKR1B1
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
MKNK2,KDM1A,MKNK1,HIF1A
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA14,CA12,CA2,CA4
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
HSD11B1,DPP4,PPARA,AKR1B1
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
FLT3,MKNK1,MKNK2
NCT01661764 |
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
MMP9,MMP2,MMP12
NCT02446795 |
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
MMP12,F2,CA4
NCT03444298 |
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
CA14,CA4,F2,RORC
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
DPP4,CA4,CA2,LMNA
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
NOX4,MMP12,MMP9,MMP1
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
MMP12,MMP9,CYP1A1,MMP1
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA,XDH,MMP2,HIF1A
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
MMP12,MMP9,CA12,MMP1
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CA2,CYP1A1,CA12,CYP1A2
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
CA2,CA12,CA4
|
Myeloproliferative neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A20 |
KDM1A,GSK3B,FLT3
|
Metabolic disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5D2Z |
DPP4,HSD11B1
NCT02337933 |
Lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40 |
HSD11B1,RELA,NFKB1
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
KDM1A,FLT3,DPP4
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
PPARA
FABP4,MMP9 |
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
MKNK1,CSNK2A1,MKNK2
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
HSD11B1,PPARA,CES1
|
COVID-19Disease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D6Y |
NCT04622865,NCT04536090,NCT04733651
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
MMP9,CA12,MMP2
|
Pneumonia due to PseudomonasaeruginosaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA40.05 |
MMP12,DPP4,MMP9
|
Systemic sclerosisDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A42 |
FABP4,NOX4,MMP1
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
NOX4,FABP5,OR51E2
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
NOX4,MMP12,MMP9
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
XDH,CA2
|
Muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70 |
NFKB1,RELA
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
MMP1,MMP2
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
PPARA,F2
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
GSK3B,DRD1
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
DPP4,F2
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
CES1,DPP4
|
ThrombosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB61-GB90 |
F2,AKR1B1
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
DRD1,AKR1B1
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
NFKB1,RELA
|
Ulcerative colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD71 |
MMP9
NCT00004810 |
Inborn lipid metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52 |
HSD11B1,PPARA
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
RELA,NFKB1
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
XDH
NCT02552888 |
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
RELA,NFKB1
|
GoutDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA25 |
PPARA,XDH
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
HIF1A,DRD1
|
InfluenzaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E30-1E32 |
XDH,HSD11B1
|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
MMP9,F2
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
HSD11B1,FLT3
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
RELA,NFKB1
|
Skin and skin-structure infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F28-1G0Z |
NFKB1,RELA
|
Irritable bowel syndromeDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD91 |
RELA,NFKB1
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
RELA,NFKB1
|
NADisease Category: NADisease ICD-11 Code: NA |
NOX4
NCT03444298 |
Sickle-cell disorderDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3A51 |
NCT04474626,NCT04514510
|
Glioblastoma, primary, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH0MB1 |
NCT02728349,NCT03758014
|
Unspecified malignant neoplasms of unspecified sitesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D4Z |
NCT02245204,NCT02136342
|
Coeliac diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA95 |
TSHR,CYP1A1
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
NFKB1,DPP4
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
MMP9,CYP1A1
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
FABP4,HSD17B10,AKR1B1,RECQL,OR51E2,MMP2,HSD11B1,FABP5,KDM1A,TRIM24,LMNA,TDP1,MMP1,CSNK2A2,NOX4,CA12,TSHR,PPARA
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
PPARA,GSK3B,CA12,CA4,NFKB1,CSNK2A1,KDM1A,CA14,CA2,RELA,FLT3,MKNK1,HIF1A,RORC,MKNK2,MMP9,XDH
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA7,LMNA,CES1,CA14,DPP4,OR51E2,CA2,RECQL,XDH,DRD1,CYP1B1,MMP2,MMP1,F2,HSD11B1,HIF1A
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
HSD17B10,MMP12,MMP9,CA7,CA14,AKR1B1,DPP4,CA2,FABP5,KDM1A,TDP1,TSHR,XDH,MMP1,RORC
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
CA7,DPP4,RECQL,OR51E2,MMP9,MMP12,LMNA,TDP1,FLT3,DRD1,MMP1,CSNK2A2,CA12,XDH
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
FABP4,NOX4,MMP12,MMP9,FABP5,CA12,CA4,MMP1,OR51E2,MMP12,MMP9,CA12,MMP1,TRIM24
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
NOX4,MMP12,CSNK2A3,MMP9,FABP5,CA2,TDP1,CA12,TSHR,CYP1A2,XDH,MMP1,RORC
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
NOX4,CA14,AKR1B1,DPP4,FABP5,CA12,XDH,CA4,DRD1,MMP1,MMP2,F2,HIF1A
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
CSNK2A3,AKR1B1,OR51E2,MMP2,HIF1A,MMP9,FABP5,CA4,MMP12,LMNA,MMP1,NOX4
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
FABP4,NOX4,MMP12,MMP9,AKR1B1,OR51E2,FABP5,CA12,CA4,TRIM24,MMP1,MMP2
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
NOX4,MMP12,MMP9,CA14,CA2,FABP5,XDH,CA4,MMP1,OR51E2,RORC
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
HSD17B10,MMP12,MMP9,NFKB1,DPP4,AKR1B1,FABP5,FLT3,TRIM24,DRD1,CYP1B1
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
MMP9,FABP5,XDH,MMP12,MMP9,FABP5,TSHR,MMP1,OR51E2,F2
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
NOX4,MMP12,MMP9,CA7,DPP4,OR51E2,FABP5,CA12,CA4,MMP1
|
Bone/articular cartilage neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F7B |
FLT3
|
Synthesis disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52-5C59 |
CES1
|
Peritoneal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C51 |
FLT3
|
Cocaine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C45 |
DRD1
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
CA2
|
Ewing sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B52 |
KDM1A
|
Myotonic disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C71 |
GSK3B
|
Chronic myelomonocytic leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A40 |
FLT3
|
Mature B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A85 |
FLT3
|
Peroxisomal diseaseDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C57 |
CES1
|
Autoimmune diseaseDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40-4A45 |
RORC
|
Hypo-thyroidismDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A00 |
TSHR
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
F2
|
CataractDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B10 |
AKR1B1
|
Duodenal ulcerDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA63 |
CA2
|
BCR-ABL1-negative chronic myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A41 |
FLT3
|
Inborn purine/pyrimidine/nucleotide metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C55 |
XDH
|
Unspecified viral infection of unspecified siteDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D9Z |
FLT3
|
Hepatic fibrosis/cirrhosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB93 |
MMP2
|
Adrenomedullary hyperfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A75 |
HIF1A
|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
FLT3
|
DyslipidemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80-5C81 |
PPARA
|
Tic disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A05 |
DRD1
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
AKR1B1
|
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
FLT3
|
Coagulation defectDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B10 |
F2
|
Mineral deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B5K |
XDH
|
Fragile X chromosomeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD55 |
GSK3B
|
Phakomatoses/hamartoneoplastic syndromeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD2D |
FLT3
|
Idiopathic interstitial pneumonitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03 |
FLT3
|
Allergic/hypersensitivity disorderDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A80-4A8Z |
DRD1
|
OsteosarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B51 |
GSK3B
|
Diffuse large B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
FLT3
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
KDM1A
|
Stomach cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
MMP9
|
Cerebral ischaemic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B11 |
F2
|
Inborn metabolism deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5C59 |
CA14
|
Thyroid cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10 |
TSHR
|
Nutritional deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B50-5B71 |
F2
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Inflammatory arthropathyDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA2Z |
FLT3
|
Coronary thrombosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA43 |
F2
|
Psychotic disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20-6A25 |
DRD1
|
HyperlipidemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
PPARA
|
Myasthenia gravisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C6Y |
HSD11B1
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
HSD11B1
|
Transplanted organ/tissueDisease Category: 24.Factors influencing health status or contact with health servicesDisease ICD-11 Code: QB63 |
FLT3
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
FLT3
|
Coronavirus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D92 |
CSNK2A1
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
AKR1B1
|
Autism spectrum disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A02 |
DPP4
|
Human immunodeficiency virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C60-1C62 |
FLT3
|
EncephalopathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E47 |
XDH
|
MastocytosisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A21 |
FLT3
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
DRD1
|
Low bone mass disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83 |
CA2
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F2
|
Essential hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00 |
CA2
|
Osteomyelitis or osteitisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB84 |
NCT02099240
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
NCT04403568
|
Immune thrombocytopenic purpuraDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64.10 |
NCT02351622
|
Dysplastic naevusDisease Category: X.Extension CodesDisease ICD-11 Code: XH9035 |
NCT00346502
|
Esophageal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
NCT04648917
|
Vasomotor/allergic rhinitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA08 |
NCT01989897
|
Primary sclerosing cholangitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB96.2 |
NCT03216876
|
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
NCT00701987
|
Glioma, malignantDisease Category: X.Extension CodesDisease ICD-11 Code: XH4RQ3 |
NCT01792310
|
Impaired glucose toleranceDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A40.1 |
NCT02621060
|
Spinal painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME84 |
NCT01468415
|
Congenital cytomegalovirus infectionDisease Category: 19.Certain conditions originating in the perinatal periodDisease ICD-11 Code: KA62.3 |
NCT00966836
|
Nephritic syndromeDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB40 |
NCT01197040
|
Myelodysplastic syndromes, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A3Z |
TSHR
|
Idiopathic pulmonary fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03.4 |
MMP12
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
CA7
|
Myotonic dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C71.0 |
CYP1A1
|
Malignant neoplasms of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
FABP4
|
KeratoconusDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A78.50 |
CA4
|
Pre-eclampsiaDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA24 |
CA4
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
NOX4
|
Malignant neoplasms of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
FABP4
|
Polycystic ovary syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80.1 |
MMP12
|
Heart failure, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD1Z |
CYP1B1
|
Malaria, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F4Z |
MMP9
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
FLT3
|
Malignant neoplasm of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
FABP4
|
Lyme borreliosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C1G |
MMP9
|