Collective Molecular Activities of the Plant: Trigonostemon Howii
Plant ID: NPO19424
Plant Latin Name: Trigonostemon Howii
Taxonomy Genus: Trigonostemon
Taxonomy Family: Euphorbiaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
33 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
11 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
16 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC97675
Ingredient ID: NPC97603
Ingredient ID: NPC5989
Ingredient ID: NPC58324
Ingredient ID: NPC471108
Ingredient ID: NPC469163
Ingredient ID: NPC328886
Ingredient ID: NPC328530
Ingredient ID: NPC327700
Ingredient ID: NPC323001
Ingredient ID: NPC322494
Ingredient ID: NPC322420
Ingredient ID: NPC318447
Ingredient ID: NPC317415
Ingredient ID: NPC305590
Ingredient ID: NPC303400
Ingredient ID: NPC296053
Ingredient ID: NPC265252
Ingredient ID: NPC259234
Ingredient ID: NPC259233
Ingredient ID: NPC222173
Ingredient ID: NPC218916
Ingredient ID: NPC214573
Ingredient ID: NPC20995
Ingredient ID: NPC204600
Ingredient ID: NPC19464
Ingredient ID: NPC193355
Ingredient ID: NPC182124
Ingredient ID: NPC181120
Ingredient ID: NPC170361
Ingredient ID: NPC16537
Ingredient ID: NPC163004
Ingredient ID: NPC153036
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Protein Kinase | PRKCA | Protein kinase C alpha | P17252 | CHEMBL299 |
| Therapeutic Target | Protein Kinase | PRKCB | Protein kinase C beta | P05771 | CHEMBL3045 |
| Therapeutic Target | Protein Kinase | PRKCG | Protein kinase C gamma | P05129 | CHEMBL2938 |
| Therapeutic Target | Protein Kinase | PRKCE | Protein kinase C epsilon | Q02156 | CHEMBL3582 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 2 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT01009931 | Phase II Study of TPA Plus Dexamethasone & CMT in Hematologic Malignancies | leukemia | Phorbol Myristate Acetate (NPC5989) | NP level |
| NCT01795924 | Safety and Efficacy Study of PD-616 Plus Cytarabine to Treat Acute Myelogenous Leukemia or Myelodysplastic Syndrome | acute myeloid leukemia;myelodysplastic syndrome | Phorbol Myristate Acetate (NPC5989) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
PRKCG
NCT01795924 |
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
PRKCG
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
PRKCB,PRKCD,PRKCG
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
PRKCG
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
PRKCE
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
PRKCE
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
PRKCB
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
PRKCQ,PRKCG
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
PRKCA,PRKCQ,PRKCB,PRKCG
|
Central nervous system diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A04-8D87 |
PRKCB
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
