CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Centaurea Glastifolia

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO19343
Plant Latin Name: Centaurea Glastifolia
Taxonomy Genus: Centaurea
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 75647
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

16 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

15 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

16 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC83032

Ingredient ID: NPC40511

Ingredient ID: NPC309330

Ingredient ID: NPC265319

Ingredient ID: NPC246534

Ingredient ID: NPC243319

Ingredient ID: NPC237812

Ingredient ID: NPC226453

Ingredient ID: NPC20535

Ingredient ID: NPC174020

Ingredient ID: NPC163099

Ingredient ID: NPC15566

Ingredient ID: NPC13625

Ingredient ID: NPC136014

Ingredient ID: NPC112890

Ingredient ID: NPC111132

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450	Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Therapeutic Target	Enzyme	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Therapeutic Target	Small molecule receptor (family A GPCR)	HRH4	Histamine H4 receptor	Q9H3N8	CHEMBL3759
Therapeutic Target	Small molecule receptor (family A GPCR)	HRH3	Histamine H3 receptor	Q9Y5N1	CHEMBL264
Therapeutic Target	Small molecule receptor (family A GPCR)	HRH1	Histamine H1 receptor	P35367	CHEMBL231
Therapeutic Target	Structural protein	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Therapeutic Target	Transcription factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	96

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT01603446	L-arginine Therapy on Endothelium-dependent Vasodilation & Mitochondrial Metabolism in MELAS Syndrome	MELAS	Arginine (NPC226453)	NP level
NCT01388764	Safety, Tolerability and Effects of L-Arginine in Boys With Dystrophinopathy on Corticosteroids	Duchenne muscular dystrophy	Arginine (NPC226453)	NP level
NCT05470998	L-Arginine in Children Having Sickle Cell Disease With Increased Tricuspid Regurgitant Jet Velocity	sickle cell anemia	Arginine (NPC226453)	NP level
NCT02017249	Efficacy Study of Oral Arginine to Improve Immune Function in Glioblastoma Multiforme	glioblastoma multiforme	Arginine (NPC226453)	NP level
NCT00630383	Immunoregulation by Controlled Parasite Exposure in Multiple Sclerosis.	multiple sclerosis	Histamine (NPC111132)	NP level
NCT03580122	The Effect of Arginine on Classic Galactosemia	classic galactosemia	Arginine (NPC226453)	NP level
NCT01439555	Endothelial Facilitation in Alzheimer's Disease	Alzheimer disease	Arginine (NPC226453)	NP level
NCT00037869	High Dose I-131 Metaiodobenzylguanidine(MIBG) for Metastatic Neuroendocrine Tumors	metastasis;neuroendocrine neoplasm	Guanidine (NPC20535)	NP level
NCT00157521	L-Arginine in Pre-Eclampsia	preeclampsia	Arginine (NPC226453)	NP level
NCT04345705	Poly-ICLC (Hiltonol®) Vaccine In Malignant Pleural Mesothelioma	mesothelioma	Lysine (NPC112890)	NP level
NCT03640949	Vasopressin and Methylprednisolone for In-Hospital Cardiac Arrest	sudden cardiac arrest	Arginine (NPC226453)	NP level
NCT02618824	Role of Terminal Warm Blood Cardioplegia as Myocardial Protection in the Use of Histidine-Tryptophan-Ketoglutarate Cardioplegia in Complex Congenital Heart Surgery	congenital heart disease	Histidine (NPC237812)	NP level
NCT02388178	To Determine the Ability of a New Product Formulation to Remineralize an Early Caries Lesion by an In-situ Study	dental caries	Arginine (NPC226453)	NP level
NCT03068832	Neoepitope-based Personalized Vaccine Approach in Pediatric Patients With Recurrent Brain Tumors	brain neoplasm	Lysine (NPC112890)	NP level
NCT03861416	"Unifuzol®" in Patients With Peripheral Arterial Disease	peripheral arterial disease	Arginine (NPC226453)	NP level
NCT00513617	Effectiveness of Arginine as a Treatment for Sickle Cell Anemia	sickle cell anemia	Arginine (NPC226453)	NP level
NCT02129075	A Vaccine (CDX-1401) With or Without a Biologic Drug (CDX-301) for the Treatment of Patients With Stage IIB-IV Melanoma	cutaneous melanoma	Lysine (NPC112890)	NP level
NCT02291458	L-arginine and Brown Adipose Tissue	Glucose intolerance	Arginine (NPC226453)	NP level
NCT04201873	Pembrolizumab and a Vaccine (ATL-DC) for the Treatment of Surgically Accessible Recurrent Glioblastoma	glioblastoma multiforme	Lysine (NPC112890)	NP level
NCT01842139	Vaccine Therapy and Basiliximab in Treating Patients With Acute Myeloid Leukemia in Complete Remission	acute myeloid leukemia	Lysine (NPC112890)	NP level
NCT02744820	Multiple Ascending Dose Study of GMC-252-L-Lys Salt in Healthy Subjects and Type 2 Diabetics	type 2 diabetes mellitus	Lysine (NPC112890)	NP level
NCT03121677	Personalized Tumor Vaccine Strategy and PD-1 Blockade in Patients With Follicular Lymphoma	follicular lymphoma	Lysine (NPC112890)	NP level
NCT05025488	Mutant CALR-peptide Based Vaccine in Patients With Mutated CALR Myeloproliferative Neoplasm	essential thrombocythemia;myelofibrosis	Lysine (NPC112890)	NP level
NCT04616248	In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors	breast carcinoma	Lysine (NPC112890)	NP level
NCT03376620	Role of Topical Putrescine (Fibrostat) for Prevention of Hypertrophic Scars in Mammoplasty Patients	severe cutaneous adverse reaction	Putrescine (NPC309330)	NP level
NCT04750902	A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old Children	dental caries	Arginine (NPC226453)	NP level
NCT01783431	Study of Vaccination With Poly-ICLC and Peptide-pulsed Dendritic Cells	melanoma	Lysine (NPC112890)	NP level
NCT00974714	L-arginine Effects on Chronic Hypertension in Pregnancy	preeclampsia	Arginine (NPC226453)	NP level
NCT00917826	Study of Arginine Butyrate and Ganciclovir/Valganciclovir in EBV(+) Lymphoid Malignancies	lymphoma	Arginine (NPC226453)	NP level
NCT04054973	L-arginine Study for Persistent Symptoms of Schizophrenia	schizophrenia	Arginine (NPC226453)	NP level
NCT04535427	Role of L-Arginine Supplementation in the Treatment of Rheumatoid Arthritis	rheumatoid arthritis	Arginine (NPC226453)	NP level
NCT02756117	The Effect of Acute Lysine Administration on α-aminoadipic Acid	prediabetes syndrome	Lysine (NPC112890)	NP level
NCT02447874	Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease	sickle cell anemia	Arginine (NPC226453)	NP level
NCT04249336	Clinical Efficacy Of BioMin F, Colgate Sensitive Pro-Relief And Sensodyne Rapid Action Dentifrices In DH	allergic disease	Arginine (NPC226453)	NP level
NCT00056433	Evaluation of Hydroxyurea Plus L-arginine or Sildenafil to Treat Sickle Cell Anemia	sickle cell anemia	Arginine (NPC226453)	NP level
NCT01292070	Safety Evaluation of an Experimental Treatment, Intradermal Human Fcγ1-Fel d1 Fusion Protein (GFD), for Cat Allergy	allergic disease	Histamine (NPC111132)	NP level
NCT01188096	A Trial of Poly-ICLC in the Management of Recurrent Pediatric Low Grade Gliomas	brain neoplasm	Lysine (NPC112890)	NP level
NCT00200746	Treatment of Alcohol-Related Hepatitis With Arginine	Hepatitis, Alcoholic	Arginine (NPC226453)	NP level
NCT02440061	Ghrelin and Beta Cell Function in Diabetes	type 2 diabetes mellitus	Arginine (NPC226453)	NP level
NCT01989897	Effect of HSA or Saline Diluent on Immunotherapy Extract Stability as Determined by Graded ID Skin Tests	allergic rhinitis	Histamine (NPC111132)	NP level
NCT01142219	L-Arginine and Sickle Cell Disease	sickle cell anemia	Arginine (NPC226453)	NP level
NCT01263041	Effect of L-arginine and Glutamine on Preterm	Sepsis	Arginine (NPC226453)	NP level
NCT03606967	Testing the Addition of an Individualized Vaccine to Nab-Paclitaxel, Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer	breast carcinoma	Lysine (NPC112890)	NP level
NCT03088345	Early Use of Vasopressin in Post-Fontan Management	congenital heart disease	Arginine (NPC226453)	NP level
NCT05457959	Peptide-Pulsed Dendritic Cell Vaccination in Combination With Nivolumab and Ipilimumab for the Treatment of Recurrent and/or Progressive Diffuse Hemispheric Glioma, H3 G34-mutant	glioma	Lysine (NPC112890)	NP level
NCT03266965	Histaminergic Basis of Central Fatigue in Multiple Sclerosis - A Novel Approach	multiple sclerosis	Histidine (NPC237812)	NP level
NCT00052715	Biological Therapy and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme	Central Nervous System Neoplasm	Lysine (NPC112890)	NP level
NCT03359239	Atezolizumab Given in Combination With a Personalized Vaccine in Patients With Urothelial Cancer	urinary bladder cancer	Lysine (NPC112890)	NP level
NCT04764383	Histaminergic Basis of Fatigue in Multiple Sclerosis	multiple sclerosis	Histidine (NPC237812)	NP level
NCT04631536	Managing Endothelial Dysfunction in COVID-19 : A Randomized Controlled Trial at LAUMC	COVID-19	Arginine (NPC226453)	NP level
NCT02061449	Poly ICLC, Radiation, and Romidepsin for Advanced Cutaneous T Cell Lymphoma	Cutaneous T-cell lymphoma	Lysine (NPC112890)	NP level
NCT00047983	Omega-3 Fatty Acids That Affect the Immune System in Kidney Transplant Patients	kidney disease	Arginine (NPC226453)	NP level
NCT01719133	Skin Prick Tests With AllerT in Subjects Allergic to Birch Pollen	allergic rhinitis	Histamine (NPC111132)	NP level
NCT00280683	Effects of L-arginine Supplementation in Adults With Moderate to Severe Asthma	asthma	Arginine (NPC226453)	NP level
NCT00986609	MUC1 Vaccine for Triple-negative Breast Cancer	inflammatory breast carcinoma;triple-negative breast cancer	Lysine (NPC112890)	NP level
NCT00262730	Radiation Therapy and Temozolomide Followed by Temozolomide and Poly ICLC in Treating Patients With Newly Diagnosed GBM	glioblastoma multiforme	Lysine (NPC112890)	NP level
NCT01380678	Intralesional Bevacizumab Injection on Primary Pterygium	inflammation;pterygium	Histamine (NPC111132)	NP level
NCT00058123	Poly-ICLC in Treating Patients With Recurrent or Progressive Anaplastic Glioma	Central Nervous System Neoplasm	Lysine (NPC112890)	NP level
NCT00223717	Treatment of Supine Hypertension in Autonomic Failure	hypertension	Arginine (NPC226453)	NP level
NCT03162562	The Safety and Antitumor Activity of the Combination of Oregovomab and Hiltonol in Recurrent Advanced Ovarian Cancer	ovarian carcinoma	Lysine (NPC112890)	NP level
NCT01287585	Ph 3 ADI-PEG 20 Versus Placebo in Subjects With Advanced Hepatocellular Carcinoma Who Have Failed Prior Systemic Therapy	hepatocellular carcinoma	Arginine (NPC226453)	NP level
NCT02427581	Safety and Immunogenicity of a Personalized Synthetic Long Peptide Breast Cancer Vaccine Strategy in Patients With Persistent Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy	triple-negative breast cancer	Lysine (NPC112890)	NP level
NCT00719472	A Study of Rituximab Alternative Dosing Rate in Patients With Previously Untreated Diffuse Large B-cell or Follicular Non-Hodgkin's Lymphoma (RATE)	non-Hodgkins lymphoma	Histamine (NPC111132)	NP level
NCT03446456	Vasopressin and Pain Perception in the Brain	pain	Arginine (NPC226453)	NP level
NCT01607879	Use of β-hydroxy-β-methylbutyrate to Counteract Muscle Loss in Men With Prostate Cancer on Androgen Ablation	prostate cancer	Arginine (NPC226453)	NP level
NCT00134433	Endothelial Modulation for Angiogenic Therapy	coronary artery disease	Arginine (NPC226453)	NP level
NCT00006136	Phase II Study of Arginine Butyrate With or Without Epoetin Alfa in Patients With Thalassemia Intermedia	Beta-thalassemia	Arginine (NPC226453)	NP level
NCT00616304	Safety and Preliminary Efficacy of L-arginine in Severe Falciparum Malaria	Plasmodium falciparum malaria	Arginine (NPC226453)	NP level
NCT03679780	The Effect of Endothelin and L-Arginine on Racial Differences in Vasoconstriction	cardiovascular disease	Arginine (NPC226453)	NP level
NCT00405665	The Short Term Safety and Efficacy of Inhaled L-arginine in Patients With Cystic Fibrosis	cystic fibrosis	Arginine (NPC226453)	NP level
NCT00344916	Phase 1 Study of L-NMMA in Patients With Liver Cirrhosis	cirrhosis of liver	Arginine (NPC226453)	NP level
NCT05281926	A Phase I, Open-label Study to Assess the Safety and Efficacy of Poly-ICLC Plus Nivolumab in Unresectable Hepatocellular Carcinoma Patients	hepatocellular carcinoma	Lysine (NPC112890)	NP level
NCT02882217	Study to Assess Pharmacokinetics, Safety, and Tolerability of XC-8	asthma	Histamine (NPC111132)	NP level
NCT00387738	Efficacy and Safety Study of TOLAMBA™ in Ragweed-Allergic Adults	seasonal allergic rhinitis	Histamine (NPC111132)	NP level
NCT00005107	Role of Nitric Oxide in Cirrhosis: Relationship With Systemic Hemodynamics, Renal Function, Vasoactive Systems and Endotoxemia	cirrhosis of liver	Arginine (NPC226453)	NP level
NCT05042024	Supplementation With L-ornithine But Not L-arginine Increases Density of CD68+ and CD163+ Macrophages in Periodontitis	periodontitis	Arginine (NPC226453)	NP level
NCT00137124	L-Arginine Metabolism in Essential Hypertension	essential hypertension	Arginine (NPC226453)	NP level
NCT00677339	L-arginine and Vitamin D Adjunctive Therapy in Pulmonary Tuberculosis (TB)	pulmonary tuberculosis	Arginine (NPC226453)	NP level
NCT00345150	Effects of Inhibition of NO-Synthesis on Renal Hemodynamics and Sodium Excretion in Patients With Essential Hypertension and Healthy Controls	hypertension	Arginine (NPC226453)	NP level
NCT03956056	Neoantigen Peptide Vaccine Strategy in Pancreatic Cancer Patients Following Surgical Resection and Adjuvant Chemotherapy	pancreatic carcinoma	Lysine (NPC112890)	NP level
NCT00147368	Arginine Malaria Trial: Study of Adjunctive Arginine in Falciparum Malaria	Plasmodium falciparum malaria	Arginine (NPC226453)	NP level
NCT03166254	Personalized Therapeutic Anti-tumor Vaccine With Pembrolizumab and Standard of Care Chemotherapy in Squamous Non-Small Cell Lung Cancer and Extensive Stage Small Cell Lung Cancer	non-small cell lung carcinoma	Lysine (NPC112890)	NP level
NCT02929888	Study of Platelet Function After Administration of Aspirin Versus Lysine Acetylsalicylate in STEMI Patients	acute myocardial infarction	Lysine (NPC112890)	NP level
NCT00571766	Effects of Oral L-Arginine on Chronic Hypertension in Pregnancy	preeclampsia	Arginine (NPC226453)	NP level
NCT00344734	Effects of Acute L-NMMA Treatment on Renal Hemodynamics and Vasoactive Hormones in Patients With Congestive Heart Failure	congestive heart failure	Arginine (NPC226453)	NP level
NCT00408577	Prevention of Cardiac and Vascular Events in Patients With NGT/IGT.	cardiovascular disease	Arginine (NPC226453)	NP level
NCT05210504	Determinants of Alpha-aminoadipic Acid (2-AAA) and Relationship to Diabetes: Study 3	type 2 diabetes mellitus	Lysine (NPC112890)	NP level
NCT00345605	Arginine and Buphenyl in Patients With Argininosuccinic Aciduria (ASA), a Urea Cycle Disorder	argininosuccinic aciduria	Arginine (NPC226453)	NP level
NCT01324115	NG-Nitro-L-Arginine in Treating Patients With Advanced Solid Tumors	neoplasm	Arginine (NPC226453)	NP level
NCT00537355	An Evaluation of the Efficacy and Safety of TOLAMBA™ for Ragweed-Allergic Rhinitis in an Environmental Exposure Chamber	seasonal allergic rhinitis	Histamine (NPC111132)	NP level
NCT02516085	Improved Muscle Function in Duchenne Muscular Dystrophy Through L-Arginine and Metformin	Duchenne muscular dystrophy	Arginine (NPC226453)	NP level
NCT01266018	Study of ADI-PEG 20 in Patients With Relapsed Sensitive or Refractory Small Cell Lung Cancer	small cell lung carcinoma	Arginine (NPC226453)	NP level
NCT01112722	Apitox, Honeybee Toxin for Pain and Inflammation of Osteoarthritis	osteoarthritis, knee	Histamine (NPC111132)	NP level
NCT01920191	Phase I/II Trial of IMA950 Multi-peptide Vaccine Plus Poly-ICLC in Glioblastoma	neoplasm	Lysine (NPC112890)	NP level
NCT04364750	Biomarkers of Diet-microbiota Interactions in Irritable Bowel Syndrome	irritable bowel syndrome	Histidine (NPC237812)	NP level
NCT01796678	Arginine Therapy in Sickle Cell Disease-VOC Clinical Trial	pain	Arginine (NPC226453)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Vasomotor/allergic rhinitis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA08	HRH1,HRH4,HRH3 NCT00387738,NCT01989897,NCT00537355,NCT01719133
Multiple sclerosis Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A40	NFKB1 HRH4 NCT00630383,NCT04764383,NCT03266965
Sickle-cell disorder Disease Category: 03.Diseases of the blood or blood-forming organs Disease ICD-11 Code: 3A51	NCT01142219,NCT05470998,NCT02447874,NCT00513617,NCT00056433
Asthma Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA23	HRH4,HRH1 NCT00280683,NCT02882217
Rheumatoid arthritis Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA20	NFKB1,HRH1,HRH4 NCT04535427
Type 2 diabetes mellitus Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A11	NFKB1 NCT02440061,NCT05210504,NCT02744820
Atopic eczema Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA80	CYP3A4,HRH4,NFKB1
Schizophrenia Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A20	HRH1,HRH3 NCT04054973
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	HRH1,HRH3 NCT01439555
Allergic/hypersensitivity disorder Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A80-4A8Z	HRH1 NCT04249336,NCT01292070
Glioblastoma, primary, NOS Disease Category: X.Extension Codes Disease ICD-11 Code: XH0MB1	NCT02017249,NCT04201873,NCT00262730
Pre-eclampsia Disease Category: 18.Pregnancy, childbirth or the puerperium Disease ICD-11 Code: JA24	NCT00974714,NCT00571766,NCT00157521
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	BLM,HRH3,HRH1
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	BLM,LMNA,HRH1
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	BLM,HRH1,LMNA
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	BLM,LMNA,HRH2
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	HRH2,CYP3A4,NFKB1
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	BLM,LMNA,HRH1
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	BLM,CYP3A4,HRH3
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	NFKB1,CYP3A4
Anxiety Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MB24.3	CYP3A4,HRH1
Irritable bowel syndrome Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD91	NFKB1 NCT04364750
Sleep-wake disorder Disease Category: 07.Sleep-wake disorders Disease ICD-11 Code: 7A00-7B2Z	HRH1,HRH3
Attention deficit hyperactivity disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A05	HRH3,HRH1
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	NFKB1 NCT01842139
Psoriasis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA90	NFKB1,HRH4
Hepatic fibrosis/cirrhosis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB93	NCT00005107,NCT00344916
Dental caries Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA08.0	NCT02388178,NCT04750902
Duchenne muscular dystrophy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C70.1	NCT01388764,NCT02516085
Primary neoplasms of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00	NCT01188096,NCT03068832
Breast in situ carcinoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2E65	NCT04616248,NCT03606967
Pain, unspecified Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG3Z	NCT03446456,NCT01796678
Hepatocellular carcinoma, NOS Disease Category: X.Extension Codes Disease ICD-11 Code: XH4W48	NCT01287585,NCT05281926
Cardiovascular disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA00-BE2Z	NCT00408577,NCT03679780
Central nervous system disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A04-8D87	NCT00058123,NCT00052715
Breast cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C60-2C6Y	NCT02427581,NCT00986609
Malaria Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F40-1F45	NCT00616304,NCT00147368
Pulmonary hypertension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BB01	NCT00345150,NCT00223717
Neoplasms Disease Category: 02.Neoplasms Disease ICD-11 Code: 02	NCT01920191,NCT01324115
Structural developmental anomaly of heart or great vessels, unspecified Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LA8Z	NCT03088345,NCT02618824
Inflammatory bowel diseases, unspecified Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD7Z	HRH4,HRH2
Leishmaniasis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F54	BLM,HRH2
Other specified malignant neoplasms of kidney, except renal pelvis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90.Y	HRH1,HRH2
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	LMNA,HRH1
Urothelial carcinoma of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.2	BLM,CYP3A4
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	HRH3,HRH2
Malignant neoplasms of corpus uteri, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.Z	BLM,HRH3
Invasive carcinoma of breast Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C61	BLM,HRH3
Renal cell carcinoma, chromophobe type Disease Category: X.Extension Codes Disease ICD-11 Code: XH6153	CYP3A4,HRH2
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	BLM,HRH2
Gliomas of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.0	BLM,HRH1
Depression Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A70-6A7Z	HRH1
Breathing abnormality Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MD11	HRH1
Obesity Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5B80-5B81	HRH1
Choreiform disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A01	NFKB1
Acute/subacute hepatic failure Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB91	NFKB1
Nausea/vomiting Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MD90	HRH1
Skin and skin-structure infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F28-1G0Z	NFKB1
Oesophageal/gastroduodenal disorder Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD90	HRH2
Nasopharyngitis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA00	HRH1
Neuropathy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C0Z	HRH3
Fungal infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F29-1F2F	NFKB1
Substance abuse Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C40	HRH3
Insomnia Disease Category: 07.Sleep-wake disorders Disease ICD-11 Code: 7A00-7A0Z	HRH1
Morning sickness disorder Disease Category: 26.Supplementary Chapter Traditional Medicine Conditions - Module I Disease ICD-11 Code: SC00	HRH1
Conjunctiva disorder Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9A60	HRH1
Narcolepsy Disease Category: 07.Sleep-wake disorders Disease ICD-11 Code: 7A20	HRH3
Episodic vestibular syndrome Disease Category: 10.Diseases of the ear or mastoid process Disease ICD-11 Code: AB31	HRH1
Corneal disease Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9A76-9A78	HRH1
Parkinsonism Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A00	HRH1
Respiratory system disease Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB40-CB7Z	HRH1
Peptic ulcer Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA61	HRH2
Cough Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MD12	HRH1
Tension-type headache Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A81	HRH1
Mild neurocognitive disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6D71	HRH3
Chronic pain Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG30	HRH3
Muscular dystrophy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C70	NFKB1
Gastro-oesophageal reflux disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA22	HRH2
Lupus erythematosus Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A40	NFKB1
Bipolar disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A60	HRH1
Indeterminate colitis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD72	NFKB1
Pruritus Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EC90	HRH1
Diabetes mellitus, type unspecified Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A14	NFKB1
Dementia Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6D80-6D8Z	HRH3
Somnolence Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG42	HRH3
Cardiac arrest Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MC82	NCT03640949
Congestive heart failure Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD10	NCT00344734
Pterygium Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9A61.1	NCT01380678
Inflammatory carcinoma of breast Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C62	NCT00986609
Myelofibrosis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A22	NCT05025488
Non-small cell lung cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25	NCT03166254
Intermediate hyperglycaemia, unspecified Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A40.Z	NCT02756117
Unspecified adverse cutaneous reactions to medication Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EH7Z	NCT03376620
Periodontal disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA0C	NCT05042024
Mature T-cell lymphoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A90	NCT00917826
Thrombocytopenia Disease Category: 03.Diseases of the blood or blood-forming organs Disease ICD-11 Code: 3B64	NCT05025488
Malignant lymphoma, not elsewhere classified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B33.5	NCT00719472
Other specified disorders of carbohydrate absorption or transport Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C61.Y	NCT02291458
Cystic fibrosis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA25	NCT00405665
Melanoma of skin, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C30.Z	NCT02129075
COVID-19 Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D6Y	NCT04631536
Cutaneous T-cell lymphoma, NOS Disease Category: X.Extension Codes Disease ICD-11 Code: XH1951	NCT02061449
Alcoholic hepatitis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB94.1	NCT00200746
Malignant neoplasm of pancreas, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.Z	NCT03956056
Argininosuccinic aciduria Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C50.A0	NCT00345605
Prostate cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82	NCT01607879
Glioma, malignant Disease Category: X.Extension Codes Disease ICD-11 Code: XH4RQ3	NCT05457959
Galactose-1-phosphate uridyltransferase deficiency Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C51.40	NCT03580122
NA Disease Category: NA Disease ICD-11 Code: NA	NCT01380678
coronary artery disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA8Y-BA8Z	NCT00134433
Chronic kidney disease Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GB61	NCT00047983
Chronic arterial occlusive disease, unspecified Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD4Z	NCT03861416
Acute myocardial infarction Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA41	NCT02929888
Tuberculosis of the respiratory system Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1B10	NCT00677339
Melanoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C30	NCT01783431
Melasma Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED60.1	NCT01603446
Carcinomas of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.0	NCT03162562
Beta thalassaemia Disease Category: 03.Diseases of the blood or blood-forming organs Disease ICD-11 Code: 3A50.2	NCT00006136
Small cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.1	NCT01266018
Essential hypertension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA00	NCT00137124
Malignant neoplasm metastasis, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2E2Z	NCT00037869
Neuroendocrine carcinoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C34	NCT00037869
Osteoarthritis of knee Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA01	NCT01112722
Sepsis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1G40-1G41	NCT01263041
Follicular lymphoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A80	NCT03121677
Malignant neoplasms of bladder, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.Z	NCT03359239
Pleural mesothelioma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26	NCT04345705
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	HRH3
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	BLM
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	BLM
Squamous cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.2	BLM
West Nile virus infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D46	NFKB1
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	BLM
Superficial ovarian endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10.B4	LMNA
Malignant neoplasms of oesophagus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B70	BLM
Malignant neoplasms of thyroid gland, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D10.Z	HRH1
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	BLM
Chikungunya virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D40	LMNA
Carpal tunnel syndrome Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C10.0	HRH2

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Centaurea Glastifolia

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

16 All known Ingredients in Total

15 Ingredients with Acceptable Bioavailablity

16 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Vasomotor/allergic rhinitis

Multiple sclerosis

Sickle-cell disorder

Asthma

Rheumatoid arthritis

Type 2 diabetes mellitus

Atopic eczema

Schizophrenia

Alzheimer disease

Allergic/hypersensitivity disorder

Glioblastoma, primary, NOS

Pre-eclampsia

Pheochromocytoma

Malignant neoplasms of biliary tract, distal bile duct

Diffuse large B-cell lymphomas

Adenocarcinoma of pancreas

Malignant neoplasms of thymus

Glioblastoma of brain

Malignant neoplasms of adrenal gland

Solid tumour/cancer

Anxiety

Irritable bowel syndrome

Sleep-wake disorder

Attention deficit hyperactivity disorder

Acute myeloid leukaemia

Psoriasis

Hepatic fibrosis/cirrhosis

Dental caries

Duchenne muscular dystrophy

Primary neoplasms of brain

Breast in situ carcinoma

Pain, unspecified

Hepatocellular carcinoma, NOS

Cardiovascular disease

Central nervous system disease

Breast cancer

Malaria

Pulmonary hypertension

Neoplasms

Structural developmental anomaly of heart or great vessels, unspecified

Inflammatory bowel diseases, unspecified

Leishmaniasis

Other specified malignant neoplasms of kidney, except renal pelvis

Mesothelioma of pleura

Urothelial carcinoma of bladder

Cytomegaloviral disease

Malignant neoplasms of corpus uteri, unspecified

Invasive carcinoma of breast

Renal cell carcinoma, chromophobe type

Germ cell tumour of testis

Gliomas of brain

Depression

Breathing abnormality

Obesity

Choreiform disorder

Acute/subacute hepatic failure

Nausea/vomiting

Skin and skin-structure infection

Oesophageal/gastroduodenal disorder

Nasopharyngitis

Neuropathy

Fungal infection

Substance abuse

Insomnia