Collective Molecular Activities of the Plant: Buxus Sempervirens
Plant ID: NPO19205
Plant Latin Name: Buxus Sempervirens
Taxonomy Genus: Buxus
Taxonomy Family: Buxaceae
Plant External Links:
NCBI TaxonomyDB:
4002
Plant-of-the-World-Online:
340317-1
Collective Molecular Activities of the Plant: Buxus Sempervirens
Country/Region:
China; Italy; IndiaTraditional Medicine System:
Indian Folk; TCM; HomeopathyMedicinal Functions:
Alterative; Antiperiodic; Antirheumatic; Cathartic; Cholagogue; Diaphoretic; Febrifuge; Homeopathy; Narcotic; Odontalgic; Oxytoxic; Sedative; Tonic; Vermifuge
Turkey; Portugal; Albania; Iran; Libya; Algeria; Italy; India; France; Switzerland; Morocco; Austria; China; United Kingdom; Greece; Belgium; Germany; New Zealand; United States; Russia; Spain
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
169 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
92 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
64 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99965
Ingredient ID: NPC97210
Ingredient ID: NPC96102
Ingredient ID: NPC94237
Ingredient ID: NPC92815
Ingredient ID: NPC9112
Ingredient ID: NPC90334
Ingredient ID: NPC89842
Ingredient ID: NPC89657
Ingredient ID: NPC87706
Ingredient ID: NPC83284
Ingredient ID: NPC79298
Ingredient ID: NPC78093
Ingredient ID: NPC75389
Ingredient ID: NPC75052
Ingredient ID: NPC74258
Ingredient ID: NPC73631
Ingredient ID: NPC73050
Ingredient ID: NPC64506
Ingredient ID: NPC64144
Ingredient ID: NPC6193
Ingredient ID: NPC61236
Ingredient ID: NPC60653
Ingredient ID: NPC59006
Ingredient ID: NPC54965
Ingredient ID: NPC48899
Ingredient ID: NPC478277
Ingredient ID: NPC478276
Ingredient ID: NPC478275
Ingredient ID: NPC478274
Ingredient ID: NPC478273
Ingredient ID: NPC478272
Ingredient ID: NPC478271
Ingredient ID: NPC478270
Ingredient ID: NPC44295
Ingredient ID: NPC43063
Ingredient ID: NPC42045
Ingredient ID: NPC41482
Ingredient ID: NPC3930
Ingredient ID: NPC38772
Ingredient ID: NPC3452
Ingredient ID: NPC32771
Ingredient ID: NPC313186
Ingredient ID: NPC312790
Ingredient ID: NPC312481
Ingredient ID: NPC311506
Ingredient ID: NPC311047
Ingredient ID: NPC305001
Ingredient ID: NPC304309
Ingredient ID: NPC304276
Ingredient ID: NPC303822
Ingredient ID: NPC299654
Ingredient ID: NPC298278
Ingredient ID: NPC297101
Ingredient ID: NPC295843
Ingredient ID: NPC290005
Ingredient ID: NPC286799
Ingredient ID: NPC28657
Ingredient ID: NPC281547
Ingredient ID: NPC281016
Ingredient ID: NPC280447
Ingredient ID: NPC280371
Ingredient ID: NPC280224
Ingredient ID: NPC280121
Ingredient ID: NPC279591
Ingredient ID: NPC278681
Ingredient ID: NPC278214
Ingredient ID: NPC278091
Ingredient ID: NPC275060
Ingredient ID: NPC273469
Ingredient ID: NPC271640
Ingredient ID: NPC268826
Ingredient ID: NPC267759
Ingredient ID: NPC259817
Ingredient ID: NPC259264
Ingredient ID: NPC256645
Ingredient ID: NPC254190
Ingredient ID: NPC25012
Ingredient ID: NPC247852
Ingredient ID: NPC239511
Ingredient ID: NPC236347
Ingredient ID: NPC235460
Ingredient ID: NPC235413
Ingredient ID: NPC233478
Ingredient ID: NPC232564
Ingredient ID: NPC232533
Ingredient ID: NPC230301
Ingredient ID: NPC228293
Ingredient ID: NPC226656
Ingredient ID: NPC226575
Ingredient ID: NPC225743
Ingredient ID: NPC225609
Ingredient ID: NPC224553
Ingredient ID: NPC220765
Ingredient ID: NPC217822
Ingredient ID: NPC217801
Ingredient ID: NPC217440
Ingredient ID: NPC216531
Ingredient ID: NPC216392
Ingredient ID: NPC215696
Ingredient ID: NPC213956
Ingredient ID: NPC213761
Ingredient ID: NPC20620
Ingredient ID: NPC204717
Ingredient ID: NPC200361
Ingredient ID: NPC198938
Ingredient ID: NPC193295
Ingredient ID: NPC191012
Ingredient ID: NPC190537
Ingredient ID: NPC190229
Ingredient ID: NPC189863
Ingredient ID: NPC188463
Ingredient ID: NPC186544
Ingredient ID: NPC186445
Ingredient ID: NPC185287
Ingredient ID: NPC184586
Ingredient ID: NPC184555
Ingredient ID: NPC184101
Ingredient ID: NPC181943
Ingredient ID: NPC18188
Ingredient ID: NPC180792
Ingredient ID: NPC171171
Ingredient ID: NPC171126
Ingredient ID: NPC171014
Ingredient ID: NPC170801
Ingredient ID: NPC166763
Ingredient ID: NPC166002
Ingredient ID: NPC16270
Ingredient ID: NPC162379
Ingredient ID: NPC161252
Ingredient ID: NPC159753
Ingredient ID: NPC158092
Ingredient ID: NPC157380
Ingredient ID: NPC157154
Ingredient ID: NPC156704
Ingredient ID: NPC155182
Ingredient ID: NPC153589
Ingredient ID: NPC153354
Ingredient ID: NPC15056
Ingredient ID: NPC150228
Ingredient ID: NPC149785
Ingredient ID: NPC149683
Ingredient ID: NPC14811
Ingredient ID: NPC146786
Ingredient ID: NPC146221
Ingredient ID: NPC143676
Ingredient ID: NPC142927
Ingredient ID: NPC142397
Ingredient ID: NPC139459
Ingredient ID: NPC138897
Ingredient ID: NPC138299
Ingredient ID: NPC137462
Ingredient ID: NPC1359
Ingredient ID: NPC13326
Ingredient ID: NPC132054
Ingredient ID: NPC131593
Ingredient ID: NPC127581
Ingredient ID: NPC126870
Ingredient ID: NPC124275
Ingredient ID: NPC11847
Ingredient ID: NPC113425
Ingredient ID: NPC112936
Ingredient ID: NPC112776
Ingredient ID: NPC11105
Ingredient ID: NPC107217
Ingredient ID: NPC103491
Ingredient ID: NPC103007
Ingredient ID: NPC10158
Ingredient ID: NPC100596
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | 5HT3 receptor | HTR3A | Serotonin 3a (5-HT3a) receptor | P46098 | CHEMBL1899 |
| Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Therapeutic Target | GABA-A receptor | GABRR1 | GABA receptor rho-1 subunit | P24046 | CHEMBL3561 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Therapeutic Target | Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
| Therapeutic Target | Oxidoreductase | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Therapeutic Target | Oxidoreductase | MPO | Myeloperoxidase | P05164 | CHEMBL2439 |
| Therapeutic Target | Peptide receptor (family A GPCR) | OPRM1 | Mu opioid receptor | P35372 | CHEMBL233 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 334 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000335 | Activity Monitoring Assessment of Opiate Withdrawal - 4 | opioid dependence | Morphine (NPC232533) | NP level |
| NCT00009841 | Gene Therapy in Treating Patients With Advanced Head and Neck Cancer | head and neck malignant neoplasia | Cholesterol (NPC28657) | NP level |
| NCT00121524 | Effects of Epinephrine and Intravenous (I.V.) Needle on Cardiopulmonary Resuscitation (CPR) Outcome | cardiac arrest | Epinephrine (NPC236347) | NP level |
| NCT00134212 | Dopexamine and Norepinephrine Compared With Epinephrine Alone in Septic Shock | septic shock | Epinephrine (NPC236347) | NP level |
| NCT00136682 | Patient-Controlled Epidural Analgesia (PCEA) for Patients Who Have Had Major Open Gynecologic Surgery | pain | Morphine (NPC232533) | NP level |
| NCT00142519 | Comparison of A Single Dose Combination of Methadone and Morphine With Morphine Alone for Treating Post-operative Pain | pain | Morphine (NPC232533) | NP level |
| NCT00142896 | Tramadol to Reduce Opioid Withdrawal Symptoms | opioid dependence | Morphine (NPC232533) | NP level |
| NCT00155233 | Interaction Between Nalbuphine and Morphine in PCA | pain | Morphine (NPC232533) | NP level |
| NCT00195910 | Safety and Efficacy Study of Hydromorphone and Morphine | pain | Morphine (NPC232533) | NP level |
| NCT00201539 | Double Bedtime Dosing During Immediate-release Morphine Administration to Cancer Patients | cancer | Morphine (NPC232533) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abnormal micturitionDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MF50 |
ADRB3
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
HTR2C,ADRB3,ADRB1,HTR2A
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NCT03825887
|
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT01186445
|
Acute painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG31 |
OPRM1
|
Acute upper respiratory infectionDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA07 |
DRD3,DRD2
|
Adaptive immunity immunodeficiencyDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A01 |
GABRA5
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
HTR3A,OPRD1,CA7,HTR2C,SLC6A11,OPRK1,GABRR1,GABRA5,BLM,ADRA2A,GABRA3,HTR2B,GABBR2,CA12,F2,HTR1D
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ADRB3,CA7,ADRA1B,GABRR1,HTR1B,HTR3C,DRD2,BLM,HTR2A,LMNA,HTR7,GABRA3,HTR2B,GABBR2,GABRA2,F2,HTR1D
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
HTR2C,GABRA3,BLM,F2,GABRR1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
