Plant ID: NPO19087
Plant Latin Name: Garcinia Kola
Taxonomy Genus: Garcinia
Taxonomy Family: Clusiaceae
NCBI TaxonomyDB:
469930
Plant-of-the-World-Online:
n.a.
Ingredient ID: NPC82214
Ingredient ID: NPC77515
Ingredient ID: NPC75827
Ingredient ID: NPC69531
Ingredient ID: NPC63438
Ingredient ID: NPC62943
Ingredient ID: NPC62143
Ingredient ID: NPC479054
Ingredient ID: NPC479053
Ingredient ID: NPC479052
Ingredient ID: NPC479051
Ingredient ID: NPC479050
Ingredient ID: NPC44335
Ingredient ID: NPC292329
Ingredient ID: NPC280143
Ingredient ID: NPC260728
Ingredient ID: NPC25867
Ingredient ID: NPC255331
Ingredient ID: NPC254739
Ingredient ID: NPC239723
Ingredient ID: NPC224800
Ingredient ID: NPC215167
Ingredient ID: NPC198823
Ingredient ID: NPC195763
Ingredient ID: NPC186847
Ingredient ID: NPC186327
Ingredient ID: NPC185634
Ingredient ID: NPC169368
Ingredient ID: NPC150176
Ingredient ID: NPC150000
Ingredient ID: NPC136072
Ingredient ID: NPC125416
Ingredient ID: NPC120024
Ingredient ID: NPC119377
Ingredient ID: NPC118602
Ingredient ID: NPC117885
Ingredient ID: NPC106364
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
Drug Transporter | SLC superfamily of solute carriers | SLC22A3 | Solute carrier family 22 member 3 | O75751 | CHEMBL2073673 |
Drug Transporter | SLC superfamily of solute carriers | SLC47A1 | Multidrug and toxin extrusion protein 1 | Q96FL8 | CHEMBL1743126 |
Drug Transporter | SLC superfamily of solute carriers | SLC22A2 | Solute carrier family 22 member 2 | O15244 | CHEMBL1743122 |
Drug Transporter | SLC superfamily of solute carriers | SLC22A1 | Solute carrier family 22 member 1 | O15245 | CHEMBL5685 |
Drug Transporter | SLC superfamily of solute carriers | SLC47A2 | Multidrug and toxin extrusion protein 2 | Q86VL8 | CHEMBL1743127 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Therapeutic Target | Transcription factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 44 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT04679558 | Antibacterial Effect of Chlorhexidine Added to the Preventive Protocol in Adolescent Special Needs | dental caries | Chlorhexidine (NPC125416) | NP level |
NCT03757143 | Chlorhexidine-Alcohol Versus Povidone Iodine-Alcohol, Combined or Not With Use of a Bundle of New Devices, for Prevention of Intravascular-catheter Colonization and Catheter Failure | infection | Chlorhexidine (NPC125416) | NP level |
NCT00425451 | The Efficacy and Safety of PerioChip Plus (Flurbiprofen/Chlorhexidine) Formulation in the Therapy of Adult Periodontitis | periodontitis | Chlorhexidine (NPC125416) | NP level |
NCT03836781 | Teh Effect of Subgingival Irrigation Wif Ketorolac and Chlorhexidine in Patients Wif Chronic Periodontist | periodontitis | Chlorhexidine (NPC125416) | NP level |
NCT02756377 | A Comparison of Mouth Rinse Containing Alcohol-free Chlorhexidine With a Cetylpyridinium Chloride in Periodontal Diseases | periodontal disorder | Chlorhexidine (NPC125416) | NP level |
NCT00608959 | Study of Antimicrobial Activity of Omiganan 1% Gel vs. Chlorhexidine 2% for Topical Skin Antisepsis in Healthy Adult Subjects | infection | Chlorhexidine (NPC125416) | NP level |
NCT05069246 | The Clinical Assessment of Nigella Sativa Oil vs Chlorohexidine as a Therapeutic Aid for Gingivitis, Effect on Gingival IL-6 and IL-18 and Antimicrobial Efficacy. | gingivitis | Chlorhexidine (NPC125416) | NP level |
NCT01079663 | The Efficacy and Safety of Chlorhexidine Gluconate Chip (Periochip®) in Therapy of Symptoms in Patients With Peri-implantitis | Peri-Implantitis | Chlorhexidine (NPC125416) | NP level |
NCT04344236 | Gargling and Nasal Rinses to Reduce Oro- and Nasopharyngeal Viral Load in Patients With COVID-19 | COVID-19 | Chlorhexidine (NPC125416) | NP level |
NCT00067340 | Caries Transmission Prevention in Alaska Native Infants | dental caries | Chlorhexidine (NPC125416) | NP level |
NCT03669224 | Effect of Nano Care Gold on Marginal Integrity of Resin Composite | dental caries | Chlorhexidine (NPC125416) | NP level |
NCT03684993 | Caries Prevention and Side Effects of Gum Arabic and Licorice Extracts Versus Chlorhexidine in High Caries Risk Patients | dental caries | Chlorhexidine (NPC125416) | NP level |
NCT02396329 | Chlorhexidine Versus Povidone-Iodine Antisepsis for Reduction of Post Cesarean Section Surgical Site Infection | infection | Chlorhexidine (NPC125416) | NP level |
NCT02252588 | The Effect of Chlorhexidine on the Oral and Lung Microbiota in Chronic Obstructive Pulmonary Disease | chronic obstructive pulmonary disease | Chlorhexidine (NPC125416) | NP level |
NCT02545244 | Effectiveness of Black Tea Mouthwash on Plaque Formation | gingivitis | Chlorhexidine (NPC125416) | NP level |
NCT03503370 | Preventing Diabetic Foot Ulcers Through Cleaner Feet | diabetic foot | Chlorhexidine (NPC125416) | NP level |
NCT03773094 | Antibacterial Effect of Guava Leaves Extract Mouthwash Compared to Chlorhexidine Mouthwash in High Caries Risk Patients | dental caries | Chlorhexidine (NPC125416) | NP level |
NCT00972803 | The Effects of Pistacia Mutica on De Novo Dental Plaque Formation, Gingival Inflammation and Oral Microorganisms | gingivitis | Chlorhexidine (NPC125416) | NP level |
NCT01723501 | Chlorhexidine Skin Application for Prevention of Infection in Infants Weighing <1500 g at Birth | Neonatal sepsis | Chlorhexidine (NPC125416) | NP level |
NCT01040286 | The Efficacy and Safety of Flurbiprofen Chip Versus Chlorhexidine Chip (Periochip®) in Therapy of Adult Chronic Periodontitis | periodontitis | Chlorhexidine (NPC125416) | NP level |
NCT02560870 | Compare the Efficacy of Aloe Vera Mouthwash With Non- Alcoholic Chlorhexidine Mouthwash on Periodontal Diseases | periodontal disorder | Chlorhexidine (NPC125416) | NP level |
NCT03838575 | ROSSINI 2 - Reduction of Surgical Site Infection Using Several Novel Interventions | infection | Chlorhexidine (NPC125416) | NP level |
NCT02077920 | Methods of Chlorhexidine Cleansing to Prevent Ventilator-Associated Pneumonia (VAP) | ventilator-associated pneumonia | Chlorhexidine (NPC125416) | NP level |
NCT02753387 | Effect of Oral Preparation on Bacterial Colonization of the Pharyngeal Mucosa in Surgery of Head and Neck Cancer | bacterial disease | Chlorhexidine (NPC125416) | NP level |
NCT03853200 | Comparison of Antibacterial Efficacy of Three Final Irrigants | infection | Chlorhexidine (NPC125416) | NP level |
NCT01989416 | Effectiveness of Chlorhexidine Wipe for Prevention of Multidrug-resistant Organisms in Intensive Care Unit Patients | infection | Chlorhexidine (NPC125416) | NP level |
NCT00845819 | Study of Epidermal Growth Factor on Oral Mucositis Induced by Intensive Chemotherapy for Hematologic Malignancies | oral mucositis | Chlorhexidine (NPC125416) | NP level |
NCT04225065 | Chlorhexidine and/or Betadine Prep in Pediatric Arm Surgery Following Trauma | infection | Chlorhexidine (NPC125416) | NP level |
NCT04328753 | The Effect of SOW Mouthwash on the Level of IL_1β in GCF and Some Clinical Periodontal Parameters for Patients With Gingivitis | gingivitis | Chlorhexidine (NPC125416) | NP level |
NCT03700788 | 2% Chlorhexidine (CHX) vs CaOH2 (CH) Calcium Hydroxide Paste as an Intracanal Medicament | periodontitis | Chlorhexidine (NPC125416) | NP level |
NCT03640507 | Vaginal Preparation With Chlorhexidine-alcohol vs. Povidine-iodine vs. Saline | infection | Chlorhexidine (NPC125416) | NP level |
NCT02219776 | Decreasing Infection In Arthroscopic Shoulder Surgery | infection | Chlorhexidine (NPC125416) | NP level |
NCT02279381 | Neonatal Package Study in Rural District of Pakistan | infection | Chlorhexidine (NPC125416) | NP level |
NCT00560599 | A Randomized Clinical Trial to Prevent Recurrent CA-MRSA Infection | Staphylococcus aureus infection | Chlorhexidine (NPC125416) | NP level |
NCT00597688 | Role of Oral Chlorhexidine Gel in Prevention of Ventilator Associated Pneumonia | pneumonia | Chlorhexidine (NPC125416) | NP level |
NCT00707902 | Clinical Trial for Assessment of Safety and Efficacy of a Echinacea/Sage Spray Compared to a Chlorhexidine/Lidocaine Spray in the Treatment of Acute Sore Throats | pharyngitis | Chlorhexidine (NPC125416) | NP level |
NCT02208154 | Ecological Effects of Decolonisation Strategies in Intensive Care | bacteriemia | Chlorhexidine (NPC125416) | NP level |
NCT01083407 | Oral Care Interventions and Ventilator Associated Pneumonia in Critically Ill Children | pneumonia | Chlorhexidine (NPC125416) | NP level |
NCT03855527 | Effectiveness of Silver Diamine Fluoride as Cavity Disinfectant After Atraumatic Restorative Treatment in Primary Teeth | dental caries | Chlorhexidine (NPC125416) | NP level |
NCT00290290 | Efficacy Study of Antiseptic Preoperative Scrubs in Prevention of Postoperative Infections | infection | Chlorhexidine (NPC125416) | NP level |
NCT01361997 | Isopropyl Alcohol Against Chlorhexidine - Isopropyl Alcohol as Antiseptics to Prevent Hemoculture's Contamination | infectious disease | Chlorhexidine (NPC125416) | NP level |
NCT02414581 | Mouthwash With Chlorhexidine 0.12%/Ethyl Alcohol 7% Compared to Ethyl Alcohol 7% | neutropenia | Chlorhexidine (NPC125416) | NP level |
NCT03484507 | Parasitic Ulcer Treatment Trial Pilot | Acanthamoeba keratitis | Chlorhexidine (NPC125416) | NP level |
NCT00357877 | Prevention of Adult Caries Study (PACS) | dental caries | Chlorhexidine (NPC125416) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Dental cariesDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA08.0 |
NCT04679558,NCT03684993,NCT00067340,NCT03855527,NCT03669224,NCT00357877,NCT03773094
|
Periodontal diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA0C |
NCT01040286,NCT02560870,NCT02756377,NCT03700788,NCT00425451,NCT03836781
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
LMNA,SLC22A3,TDP1,TP53,SLC47A1
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
LMNA,SLC22A3,TDP1,SLC47A2,ALOX5
|
Gingival diseasesDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA0B |
NCT00972803,NCT02545244,NCT04328753,NCT05069246
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
TDP1,SLC47A2,TP53,ALOX5
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA,SLC47A1,SLC22A3,ALOX5
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
LMNA,TP53,ALOX5
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
TP53,ALOX5
|
PneumoniaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA40 |
NCT00597688,NCT01083407
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
TDP1,TP53
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
ALOX5,ALOX5
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
SLC22A2,SLC47A2
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
SLC22A2,LMNA
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA,SLC47A2
|
Herpes simplex infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F00 |
NCT03853200,NCT03838575,NCT00290290,NCT02279381,NCT00608959,NCT04225065,NCT02396329,NCT02219776,NCT03757143,NCT01989416,NCT03640507
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TP53
|
Esophageal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
TP53
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
TP53
|
Peritoneal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C51 |
TP53
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
ALOX5
|
Carcinoid syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B10 |
ALOX5
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
ALOX5
|
Transplant rejectionDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE84 |
TP53
|
Postoperative inflammationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-CA43 |
ALOX5
|
Pituitary gland disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A60-5A61 |
ALOX5
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
TP53
|
Stomach cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
TP53
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
ALOX5
|
Endometrial cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76 |
TP53
|
FilariasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F66 |
ALOX5
|
Lip/oral cavity/pharynx neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6E |
TP53
|
LiposarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B59 |
TP53
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
ALOX5
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
TP53
|
Cervical cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C77 |
TP53
|
Nasopharyngeal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6B |
ALOX5
|
Idiopathic interstitial pneumonitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03 |
ALOX5
|
Kidney failureDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB60-GB6Z |
TP53
|
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
TP53
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
TP53
|
Mature B-cell leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A82 |
TP53
|
Metastatic liver/bile duct neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D80 |
TP53
|
InfluenzaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E30-1E32 |
ALOX5
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
TP53
|
Bladder cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
TP53
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
TP53
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
ALOX5
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
TP53
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
SLC47A1
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
ALOX5
|
Fallopian tube cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C74 |
TP53
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
ALOX5
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
ALOX5
|
Ovarian dysfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80 |
TP53
|
Infection, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1H0Z |
NCT01361997
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
NCT02753387
|
NeutropeniaDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4B00 |
NCT02414581
|
Other specified pyogenic bacterial infection of skin and subcutaneous tissueDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1B7Y |
NCT00560599
|
NADisease Category: NADisease ICD-11 Code: NA |
NCT01079663
|
BacteraemiaDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MA15.0 |
NCT02208154
|
NasopharyngitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA00 |
NCT00707902
|
Sepsis of fetus or newbornDisease Category: 19.Certain conditions originating in the perinatal periodDisease ICD-11 Code: KA60 |
NCT01723501
|
COVID-19Disease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D6Y |
NCT04344236
|
Oral mucositisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA01 |
NCT00845819
|
Diabetic foot ulcerDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD54 |
NCT03503370
|
AcanthamoebiasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F50 |
NCT03484507
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
NCT02252588
|
Ventilation associated with injury or harm in therapeutic useDisease Category: 23.External causes of morbidity or mortalityDisease ICD-11 Code: PK81.0 |
NCT02077920
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
SLC22A1
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
SLC47A1
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
SLC22A3
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
LMNA
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
SLC47A1
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
SLC47A2
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
ALOX5
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
SLC47A1
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
SLC47A1
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
ALOX5
|