Collective Molecular Activities of the Plant: Cyperus Haspan
Unknown.
Brazil; Madagascar; Bangladesh; Kenya; Sudan; Guinea; Mali; Costa Rica; Cambodia; Malawi; Ethiopia; Tanzania; Somalia; Peru; Laos; Nigeria; Bolivia; Cameroon; Cote d'Ivoire; Ecuador; Benin; Ghana; Australia; Iran; Cuba; Togo; Venezuela; Zambia; Japan; Papua New Guinea; Burkina Faso; Sri Lanka; Guatemala; Zimbabwe; China; Suriname; Thailand; Dominican Republic; Belize; Sierra Leone; Liberia; Georgia; Uganda; Pakistan; Gambia; Philippines; Indonesia; New Caledonia; United States; Paraguay; Mauritania; Vietnam; French Guiana; Guinea-Bissau; Guyana; Honduras; Nepal; Taiwan; Jamaica; Seychelles; Angola; Myanmar; Chad; Equatorial Guinea; Nicaragua; Mexico; India; Trinidad and Tobago; South Africa; Senegal; Congo; Mozambique; Colombia; Burundi; Gabon; Niger; Fiji; Comoros
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
39 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
39 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
12 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99865
Ingredient ID: NPC86246
Ingredient ID: NPC85698
Ingredient ID: NPC80181
Ingredient ID: NPC74458
Ingredient ID: NPC55726
Ingredient ID: NPC52005
Ingredient ID: NPC48527
Ingredient ID: NPC47781
Ingredient ID: NPC41587
Ingredient ID: NPC41271
Ingredient ID: NPC298579
Ingredient ID: NPC28255
Ingredient ID: NPC276842
Ingredient ID: NPC275561
Ingredient ID: NPC266331
Ingredient ID: NPC261607
Ingredient ID: NPC261004
Ingredient ID: NPC255580
Ingredient ID: NPC227941
Ingredient ID: NPC22448
Ingredient ID: NPC190456
Ingredient ID: NPC190207
Ingredient ID: NPC189029
Ingredient ID: NPC186363
Ingredient ID: NPC18453
Ingredient ID: NPC168400
Ingredient ID: NPC154923
Ingredient ID: NPC154650
Ingredient ID: NPC153297
Ingredient ID: NPC138306
Ingredient ID: NPC12529
Ingredient ID: NPC120926
Ingredient ID: NPC120464
Ingredient ID: NPC116087
Ingredient ID: NPC115597
Ingredient ID: NPC115168
Ingredient ID: NPC111114
Ingredient ID: NPC104657
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials |
|---|
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Coeliac diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA95 |
CYP1A1
|
Myotonic dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C71.0 |
CYP1A1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CYP1B1
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
CYP1A1
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
CYP1A1
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
CYP1A1
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
CYP1A1
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
CYP1B1
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CYP1A1
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
CYP1B1
|
Heart failure, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD1Z |
CYP1B1
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CYP1B1
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CYP1A1
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
CYP1B1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
